LOCUS       HUMDEFB                  451 bp    mRNA    linear   HUM 07-NOV-1994
DEFINITION  Human defensin mRNA, complete cds, clone HNP-3.
ACCESSION   M23281
VERSION     M23281.1
KEYWORDS    cytotoxic protein; defensin; microcidal protein; neutrophil
            protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Daher,K.A., Lehrer,R.I., Ganz,T. and Kronenberg,M.
  TITLE     Isolation and characterization of human defensin cDNA clones
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7327-7331 (1988)
   PUBMED   3174637
COMMENT     Original source text: Human bone marrow promyelocyte cell line
            HL-60, cDNA to mRNA, clone HNP-3.
            Submission form for [1] kindly provided by M.Kronenberg,
            01-JAN-1989.
FEATURES             Location/Qualifiers
     source          1..451
                     /db_xref="H-InvDB:HIT000194884"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="8p23-p22"
     gene            1..451
                     /gene="DEF1"
     CDS             51..335
                     /gene="DEF1"
                     /note="defensin precursor"
                     /codon_start=1
                     /protein_id="AAA52304.1"
                     /db_xref="GDB:G00-120-745"
                     /translation="MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVV
                     VSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC"
     sig_peptide     51..107
                     /gene="DEF1"
                     /note="defensin signal peptide"
     mat_peptide     243..332
                     /gene="DEF1"
                     /product="defensin"
BASE COUNT          108 a          126 c          109 g          108 t
ORIGIN      
        1 tctgccctct ctggtcaccc tgcctagcta gaggatctgt gaccccagcc atgaggaccc
       61 tcgccatcct tgctgccatt ctcctggtgg ccctgcaggc ccaggctgag ccactccagg
      121 caagagctga tgaggttgct gcagccccgg agcagattgc agcggacatc ccagaagtgg
      181 ttgtttccct tgcatgggac gaaagcttgg ctccaaagca tccaggctca aggaaaaaca
      241 tggactgcta ttgcagaata ccagcgtgca ttgcaggaga acgtcgctat ggaacctgca
      301 tctaccaggg aagactctgg gcattctgct gctgagcttg cagaaaaaga aaaatgagct
      361 caaaatttgc tttgagacta cagggaattg ctattactcc tgtaccttct gctcaatttc
      421 ctttcctcat ctcaaataaa tgccttgtta c
//