LOCUS HUMMDR3 3924 bp mRNA linear HUM 11-JUN-1993
DEFINITION Human membrane glycoprotein P (mdr3) mRNA, complete cds.
ACCESSION M23234
VERSION M23234.1
KEYWORDS P-glycoprotein; membrane glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3924)
AUTHORS van der Bliek,A.M., Kooiman,P.M., Schneider,C. and Borst,P.
TITLE Sequence of mdr3 cDNA encoding a human P-glycoprotein
JOURNAL Gene 71 (2), 401-411 (1988)
PUBMED 2906314
COMMENT Original source text: Human liver, cDNA to mRNA, clone 3.27.
Draft entry and computer-readable sequence for [1] kindly provided
by P. Borst, 21-MAR-1989.
FEATURES Location/Qualifiers
source 1..3924
/db_xref="H-InvDB:HIT000194881"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA <1..3924
/product="mdr3 mRNA"
CDS 33..3872
/note="P-glycoprotein"
/codon_start=1
/protein_id="AAA36207.1"
/translation="MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLT
LFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSL
LNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQ
EIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTL
VIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKEL
ERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAM
TVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKG
NLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE
GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKE
ANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE
SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVY
FKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD
VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFG
PGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQ
DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQL
TLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERK
FESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD
VILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKF
EGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDP
LAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVS
AAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA
LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ
KGIYFSMVSVQAGTQNL"
BASE COUNT 1145 a 790 c 977 g 1012 t
ORIGIN
1 cctgccagac acgcgcgagg ttcgaggctg agatggatct tgaggcggca aagaacggaa
61 cagcctggcg ccccacgagc gcggagggcg actttgaact gggcatcagc agcaaacaaa
121 aaaggaaaaa aacgaagaca gtgaaaatga ttggagtatt aacattgttt cgatactccg
181 attggcagga taaattgttt atgtcgctgg gtaccatcat ggccatagct cacggatcag
241 gtctccccct catgatgata gtatttggag agatgactga caaatttgtt gatactgcag
301 gaaacttctc ctttccagtg aacttttcct tgtcgctgct aaatccaggc aaaattctgg
361 aagaagaaat gactagatat gcatattact actcaggatt gggtgctgga gttcttgttg
421 ctgcctatat acaagtttca ttttggactt tggcagctgg tcgacagatc aggaaaatta
481 ggcagaagtt ttttcatgct attctacgac aggaaatagg atggtttgac atcaatgaca
541 ccactgaact caatacgcgg ctaacagatg acatctccaa aatcagtgaa ggaattggtg
601 acaaggttgg aatgttcttt caagcagtag ccacgttttt tgcaggattc atagtgggat
661 tcatcagagg atggaagctc acccttgtga taatggccat cagccctatt ctaggactct
721 ctgcagccgt ttgggcaaag atactctcgg catttagtga caaagaacta gctgcttatg
781 caaaagcagg cgccgtggca gaagaggctc tgggggccat caggactgtg atagctttcg
841 ggggccagaa caaagagctg gaaaggtatc agaaacattt agaaaatgcc aaagagattg
901 gaattaaaaa agctatttca gcaaacattt ccatgggtat tgccttcctg ttaatatatg
961 catcatatgc actggccttc tggtatggat ccactctagt catatcaaaa gaatatacta
1021 ttggaaatgc aatgacagtt tttttttcaa tcctaattgg agctttcagt gttggccagg
1081 ctgccccatg tattgatgct tttgccaatg caagaggagc agcatatgtg atctttgata
1141 ttattgataa taatcctaaa attgacagtt tttcagagag aggacacaaa ccagacagca
1201 tcaaagggaa tttggagttc aatgatgttc acttttctta cccttctcga gctaacgtca
1261 agatcttgaa gggcctcaac ctgaaggtgc agagtgggca gacggtggcc ctggttggaa
1321 gtagtggctg tgggaagagc acaacggtcc agctgataca gaggctctat gaccctgatg
1381 agggcacaat taacattgat gggcaggata ttaggaactt taatgtaaac tatctgaggg
1441 aaatcattgg tgtggtgagt caggagccgg tgctgttttc caccacaatt gctgaaaata
1501 tttgttatgg ccgtggaaat gtaaccatgg atgagataaa gaaagctgtc aaagaggcca
1561 acgcctatga gtttatcatg aaattaccac agaaatttga caccctggtt ggagagagag
1621 gggcccagct gagtggtggg cagaagcaga ggatcgccat tgcacgtgcc ctggttcgca
1681 accccaagat ccttctgctg gatgaggcca cgtcagcatt ggacacagaa agtgaagctg
1741 aggtacaggc agctctggat aaggccagag aaggccggac caccattgtg atagcacacc
1801 gactgtctac ggtccgaaat gcagatgtca tcgctgggtt tgaggatgga gtaattgtgg
1861 agcaaggaag ccacagcgaa ctgatgaaga aggaaggggt gtacttcaaa cttgtcaaca
1921 tgcagacatc aggaagccag atccagtcag aagaatttga actaaatgat gaaaaggctg
1981 ccactagaat ggccccaaat ggctggaaat ctcgcctatt taggcattct actcagaaaa
2041 accttaaaaa ttcacaaatg tgtcagaaga gccttgatgt ggaaaccgat ggacttgaag
2101 caaatgtgcc accagtgtcc tttctgaagg tcctgaaact gaataaaaca gaatggccct
2161 actttgtcgt gggaacagta tgtgccattg ccaatggggg gcttcagccg gcattttcag
2221 tcatattctc agagatcata gcgatttttg gaccaggcga tgatgcagtg aagcagcaga
2281 agtgcaacat attctctttg attttcttat ttctgggaat tatttctttt tttactttct
2341 tccttcaggg tttcacgttt gggaaagctg gcgagatcct caccagaaga ctgcggtcaa
2401 tggcttttaa agcaatgcta agacaggaca tgagctggtt tgatgaccat aaaaacagta
2461 ctggtgcact ttctacaaga cttgccacag atgctgccca agtccaagga gccacaggaa
2521 ccaggttggc tttaattgca cagaatatag ctaaccttgg aactggtatt atcatatcat
2581 ttatctacgg ttggcagtta accctattgc tattagcagt tgttccaatt attgctgtgt
2641 caggaattgt tgaaatgaaa ttgttggctg gaaatgccaa aagagataaa aaagaactgg
2701 aagctgctgg aaagattgca acagaggcaa tagaaaatat taggacagtt gtgtctttga
2761 cccaggaaag aaaatttgaa tcaatgtatg ttgaaaaatt gtatggacct tacaggaatt
2821 ctgtgcagaa ggcacacatc tatggaatta cttttagtat ctcacaagca tttatgtatt
2881 tttcctatgc cggttgtttt cgatttggtg catatctcat tgtgaatgga catatgcgct
2941 tcagagatgt tattctggtg ttttctgcaa ttgtatttgg tgcagtggct ctaggacatg
3001 ccagttcatt tgctccagac tatgctaaag ctaagctgtc tgcagcccac ttattcatgc
3061 tgtttgaaag acaacctctg attgacagct acagtgaaga ggggctgaag cctgataaat
3121 ttgaaggaaa tataacattt aatgaagtcg tgttcaacta tcccacccga gcaaacgtgc
3181 cagtgcttca ggggctgagc ctggaggtga agaaaggcca gacactagcc ctggtgggca
3241 gcagtggctg tgggaagagc acggtggtcc agctcctgga gcggttctac gaccccttgg
3301 cggggacagt gcttctcgat ggtcaagaag caaagaaact caatgtccag tggctcagag
3361 ctcaactcgg aatcgtgtct caggagccta tcctatttga ctgcagcatt gccgagaata
3421 ttgcctatgg agacaacagc cgggttgtat cacaggatga aattgtgagt gcagccaaag
3481 ctgccaacat acatcctttc atcgagacgt taccccacaa atatgaaaca agagtgggag
3541 ataaggggac tcagctctca ggaggtcaaa aacagaggat tgctattgcc cgagccctca
3601 tcagacaacc tcaaatcctc ctgttggatg aagctacatc agctctggat actgaaagtg
3661 aaaaggttgt ccaagaagcc ctggacaaag ccagagaagg ccgcacctgc attgtgattg
3721 ctcaccgcct gtccaccatc cagaatgcag acttaatagt ggtgtttcag aatgggagag
3781 tcaaggagca tggcacgcat cagcagctgc tggcacagaa aggcatctat ttttcaatgg
3841 tcagtgtcca ggctgggaca cagaacttat gaacttttgc tacagtatat tttaaaaata
3901 aattcaaatt attctaccca tttt
//