LOCUS HUMTRKPOA 2701 bp mRNA linear HUM 03-AUG-1993
DEFINITION Human trk proto-oncogene insert of pLM6.
ACCESSION M23102
VERSION M23102.1
KEYWORDS cell surface receptor; proto-oncogene; tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2701)
AUTHORS Martin-Zanca,D., Oskam,R., Mitra,G., Copeland,T. and Barbacid,M.
TITLE Molecular and biochemical characterization of the human trk
proto-oncogene
JOURNAL Mol. Cell. Biol. 9 (1), 24-33 (1989)
PUBMED 2927393
COMMENT Original source text: Human hematopoietic cells, cell line K 562
cDNA to mRNA (bases 32 to 2701, and DNA (bases 1 to 31).
Draft entry and computer-readable sequence for [1] kindly provided
by M.Barbacid, 29-MAR-1989.
FEATURES Location/Qualifiers
source 1..2701
/db_xref="H-InvDB:HIT000194873"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA 37..2701
/product="trk tyrosine-specific protein kinase mRNA"
CDS 121..2493
/note="trk tyrosine-specific protein kinase"
/codon_start=1
/protein_id="AAA36770.1"
/translation="MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHG
SSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSG
LRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQ
RWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVE
GRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNLTCWAENDVGRAEV
SVQVNVSFPASVQLHTAVEMHHWSIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLE
PAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIP
DTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL
APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAV
ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTM
LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL
ERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG"
sig_peptide 121..216
/note="trk tyrosine-specific protein kinase signal
peptide"
mat_peptide 217..2490
/product="trk tyrosine-specific protein kinase mature
peptide"
BASE COUNT 476 a 838 c 861 g 526 t
ORIGIN Unreported.
1 gccctttcct ggcggctggg tctttaacac cgcccagcgc acatgtcggg ggaggcctgg
61 cagctgcagc tgggagcgca cagacggctg ccccgcctga gcgaggcggg cgccgccgcg
121 atgctgcgag gcggacggcg cgggcagctt ggctggcaca gctgggctgc ggggccgggc
181 agcctgctgg cttggctgat actggcatct gcgggcgccg caccctgccc cgatgcctgc
241 tgcccccacg gctcctcggg actgcgatgc acccgggatg gggccctgga tagcctccac
301 cacctgcccg gcgcagagaa cctgactgag ctctacatcg agaaccagca gcatctgcag
361 catctggagc tccgtgatct gaggggcctg ggggagctga gaaacctcac catcgtgaag
421 agtggtctcc gtttcgtggc gccagatgcc ttccatttca ctcctcggct cagtcgcctg
481 aatctctcct tcaacgctct ggagtctctc tcctggaaaa ctgtgcaggg cctctcctta
541 caggaactgg tcctgtcggg gaaccctctg cactgttctt gtgccctgcg ctggctacag
601 cgctgggagg aggagggact gggcggagtg cctgaacaga agctgcagtg tcatgggcaa
661 gggcccctgg cccacatgcc caatgccagc tgtggtgtgc ccacgctgaa ggtccaggtg
721 cccaatgcct cggtggatgt gggggacgac gtgctgctgc ggtgccaggt ggaggggcgg
781 ggcctggagc aggccggctg gatcctcaca gagctggagc agtcagccac ggtgatgaaa
841 tctgggggtc tgccatccct ggggctgacc ctggccaatg tcaccagtga cctcaacagg
901 aagaacttga cgtgctgggc agagaacgat gtgggccggg cagaggtctc tgttcaggtc
961 aacgtctcct tcccggccag tgtgcagctg cacacggcgg tggagatgca ccactggtcg
1021 atccccttct ctgtggatgg gcagccggca ccgtctctgc gctggctctt caatggctcc
1081 gtgctcaatg agaccagctt catcttcact gagttcctgg agccggcagc caatgagacc
1141 gtgcggcacg ggtgtctgcg cctcaaccag cccacccacg tcaacaacgg caactacacg
1201 ctgctggctg ccaacccctt cggccaggcc tccgcctcca tcatggctgc cttcatggac
1261 aaccctttcg agttcaaccc cgaggacccc atccctgaca ctaacagcac atctggagac
1321 ccggtggaga agaaggacga aacacctttt ggggtctcgg tggctgtggg cctggccgtc
1381 tttgcctgcc tcttcctttc tacgctgctc cttgtgctca acaaatgtgg acggagaaac
1441 aagtttggga tcaaccgccc ggctgtgctg gctccagagg atgggctggc catgtccctg
1501 catttcatga cattgggtgg cagctccctg tcccccaccg agggcaaagg ctctgggctc
1561 caaggccaca tcatcgagaa cccacaatac ttcagtgatg cctgtgttca ccacatcaag
1621 cgccgggaca tcgtgctcaa gtgggagctg ggggagggcg cctttgggaa ggtcttcctt
1681 gctgagtgcc acaacctcct gcctgagcag gacaagatgc tggtggctgt caaggcactg
1741 aaggaggcgt ccgagagtgc tcggcaggac ttccaacgtg aggctgagct gctcaccatg
1801 ctgcagcacc agcacatcgt gcgcttcttc ggcgtctgca ccgagggccg ccccctgctc
1861 atggtcttcg agtatatgcg gcacggggac ctcaaccgct tcctccgatc ccatggaccc
1921 gatgccaagc tgctggctgg tggggaggat gtggctccag gccccctggg tctggggcag
1981 ctgctggccg tggctagcca ggtcgctgcg gggatggtgt acctggcggg tctgcatttt
2041 gtgcaccggg acctggccac acgcaactgt ctagtgggcc agggactggt ggtcaagatt
2101 ggtgattttg gcatgagcag ggatatctac agcaccgact attaccgtgt gggaggccgc
2161 accatgctgc ccattcgctg gatgccgccc gagagcatcc tgtaccgtaa gttcaccacc
2221 gagagcgacg tgtggagctt cggcgtggtg ctctgggaga tcttcaccta cggcaagcag
2281 ccctggtacc agctctccaa cacggaggca atcgactgca tcacgcaggg acgtgagttg
2341 gagcggccac gtgcctgccc accagaggtc tacgccatca tgcggggctg ctggcagcgg
2401 gagccccagc aacgccacag catcaaggat gtgcacgccc ggctgcaagc cctggcccag
2461 gcacctcctg tctacctgga tgtcctgggc tagggggccg gcccaggggc tgggagtggt
2521 tagccggaat actggggcct gccctcagca tcccccatag ctcccagcag ccccagggtg
2581 atctcgaagt atctaattcg ccctcagcat gtgggaaggg acaggtgggg gctgggagta
2641 gaggatgttc ctgcttctct aggcaaggtc ccgtcatagc aattatattt attatccctt
2701 g
//