LOCUS HUMIRBP 4275 bp mRNA linear HUM 11-JUN-1993
DEFINITION Human interphotoreceptor retinoid-binding protein (IRBP) mRNA,
complete cds.
ACCESSION M22453
VERSION M22453.1
KEYWORDS IRBP; glycolipoprotein; interphotoreceptor retinol-binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4275)
AUTHORS Si,J.S., Borst,D.E., Redmond,T.M. and Nickerson,J.M.
TITLE Cloning of cDNAs encoding human interphotoreceptor retinoid-binding
protein (IRBP) and comparison with bovine IRBP sequences
JOURNAL Gene 80 (1), 99-108 (1989)
PUBMED 2792773
COMMENT Original source text: Human adult retina, cDNA to mRNA, clones
pIRBP[18-3500,19-1000,20-700].
Draft entry and computer-readable sequence [1] kindly submitted by
J.Nickerson, 08-FEB-1989.
IRBP is a secretory protein synthesized by photorecepto cells and
found in high concentration in the interphotoreceptor space; much
less is found in the pineal.
FEATURES Location/Qualifiers
source 1..4275
/db_xref="H-InvDB:HIT000194841"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA <1..4275
/product="IRBP mRNA"
CDS 116..3859
/note="IRBP precursor"
/codon_start=1
/protein_id="AAA36126.1"
/translation="MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPEN
LLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQV
PALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLM
GTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLG
ERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDF
FFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQ
EVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGP
TETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADA
SVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFT
TYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVG
EITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALD
KAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESL
ASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLP
GQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCS
YFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFA
HTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEP
DITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRY
SRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIK
FSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGP
TSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSV
TAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGS
SWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL"
sig_peptide 116..166
/note="IRBP signal peptide (put.); putative"
mat_peptide 182..3856
/product="interphotoreceptor retinoid binding protein"
BASE COUNT 856 a 1328 c 1261 g 830 t
ORIGIN Chromosome 10q11.2-10q21.1.
1 tgtccaccag ctgagaagga caaagggcgg aaggcagctg cacagagcag ggccacggcc
61 ttgcacacag tccagggagc ttttgtgcag gagccaggcc tccccctggg tccccatgat
121 gagagaatgg gttctgctca tgtccgtgct gctctgtggc ctggctggcc ccacacacct
181 gttccagcca agcctggtgc tggacatggc caaggtcctc ttggataact actgcttccc
241 ggagaacctg ctgggcatgc aggaagccat ccagcaggcc atcaagagcc atgagattct
301 gagcatctca gacccgcaga cgctggccag tgtgctgaca gccggggtgc agagctccct
361 gaacgatcct cgcctggtca tctcctatga gcccagcacc cccgagcctc ccccacaagt
421 cccagcactc accagcctct cagaagagga actgcttgcc tggctgcaaa ggggcctccg
481 ccatgaggtt ctggagggta atgtgggcta cctgcgggtg gacagcgtcc cgggccagga
541 ggtgctgagc atgatggggg agttcctggt ggcccacgtg tgggggaatc tcatgggcac
601 ctccgcctta gtgctggatc tccggcactg cacaggaggc caggtctctg gcattcccta
661 catcatctcc tacctgcacc cagggaacac catcctgcac gtggacacta tctacaaccg
721 cccctccaac accaccacgg agatctggac cttgccccag gtcctgggag aaaggtacgg
781 tgccgacaag gatgtggtgg tcctcaccag cagccagacc aggggcgtgg ccgaggacat
841 cgcgcacatc cttaagcaga tgcgcagggc catcgtggtg ggcgagcgga ctgggggagg
901 ggccctggac ctccggaagc tgaggatagg cgagtctgac ttcttcttca cggtgcccgt
961 gtccaggtcc ctggggcccc ttggtggagg cagccagacg tgggagggca gcggggtgct
1021 gccctgtgtg gggactccgg ccgagcaggc cctggagaaa gccctggcca tcctcactct
1081 gcgcagcgcc cttccagggg tagtccactg cctccaggag gtcctgaagg actactacac
1141 gctggtggac cgtgtgccca ccctgctgca gcacttggcc agcatggact tctccacggt
1201 ggtctccgag gaagatctgg tcaccaagct caatgccggc ctgcaggctg cgtctgagga
1261 tcccaggctc ctggtgcgag ccatcgggcc cacagaaact ccttcttggc ccgcgcccga
1321 cgctgcagcc gaagactcac caggggtggc cccagagttg cctgaggacg aggctatccg
1381 gcaagcactg gtggactctg tgttccaggt gtcggtgctg ccaggcaatg tgggctacct
1441 gcgcttcgat agttttgctg acgcctccgt cctgggtgtg ttggccccat atgtcctgcg
1501 ccaggtgtgg gagccgctac aggacacgga gcacctcatc atggacctgc gccacaaccc
1561 tggagggcca tcctctgctg tgcccctgct cctgtcctac ttccagggcc ctgaggccgg
1621 ccccgtgcac ctcttcacca cctatgatcg ccgcaccaac atcacgcagg agcacttcag
1681 ccacatggag ctcccgggcc cacgctacag cacccaacgt ggggtgtatc tgctcaccag
1741 ccaccgcacc gccacggccg cggaggagtt cgccttcctt atgcagtcgc tgggctgggc
1801 cacactggta ggtgagatca ccgcgggcaa cctgctgcac acccgcacgg tgccgctgct
1861 ggacacaccc gaaggcagcc tcgcgctcac cgtgccggtc ctcaccttca tcgacaatca
1921 cggcgaggcc tggctgggtg gtggagtggt gcccgatgcc atcgtgctgg ccgaggaggc
1981 cctggacaaa gcccaggaag tgctggagtt ccaccaaagc ctgggggcct tggtggaggg
2041 cacagggcac ctgctggagg cccactatgc tcggccagag gtcgtggggc agaccagtgc
2101 cctcctgcgg gccaagctgg cccagggcgc ctaccgcaca gctgtggact tggagtctct
2161 ggcctctcag ctcacagcag acctccagga ggtgtctggg gaccaccgct tgctagtgtt
2221 ccacagccct ggcgagctgg tggtagagga agcaccccca ccaccccctg ctgtcccctc
2281 tccagaggag ctcacctacc ttattgaggc cctgttcaag acagaggtgc tgcccggcca
2341 gctgggctac ctgcgttttg acgccatggc tgaactggag acagtgaagg ccgtggggcc
2401 acagctggtg cggctggtat ggcaacagct ggtggacacg gctgcgctgg tgatcgacct
2461 gcgctacaac cctggcagct actccacggc catcccgctg ctctgctcct acttctttga
2521 ggcagagccc cgccagcacc tgtattctgt ctttgacagg gccacctcaa aagtcacgga
2581 ggtgtggacc ttgccccagg tcgccggcca gcgctacggc tcacacaagg acctctacat
2641 cctgatgagc cacaccagtg gctctgcggc cgaggccttt gcacacacca tgcaggacct
2701 gcagcgggcc acggtcattg gggagcccac ggccggaggc gcactctctg tgggcatcta
2761 ccaggtgggc agcagcccct tatatgcatc catgcccacc cagatggcca tgagtgccac
2821 cacaggcaag gcctgggacc tggctggtgt ggagcccgac atcactgtgc ccatgagcga
2881 agccctttcc atagcccagg acatagtggc tctgcgtgcc aaggtgccca cggtgctgca
2941 gacggccggg aagctggtgg ctgataacta tgcctctgcc gagctggggg ccaagatggc
3001 caccaaactg agcggtctgc agagccgcta ctccagggtg acctcagaag tggccctagc
3061 cgagatcctg ggggctgacc tgcagatgct ctccggagac ccacacctga aggcagccca
3121 tatccctgag aatgccaagg accgcattcc tggaattgtg cccatgcaga tcccttcccc
3181 tgaagtattt gaagagctga tcaagttttc cttccacact aacgtgcttg aggacaacat
3241 tggctacttg aggtttgaca tgtttgggga cggtgagctg ctcacccagg tctccaggct
3301 gctggtggag cacatctgga agaagatcat gcacacggat gccatgatca tcgacatgag
3361 gttcaacatc ggtggcccca catcctccat tcccatcttg tgctcctact tctttgatga
3421 aggccctcca gttctgctgg acaagatcta cagccggcct gatgactctg tcagtgaact
3481 ctggacacac gcccaggttg taggtgaacg ctatggctcc aagaagagca tggtcattct
3541 gaccagcagt gtgacggccg gcaccgcgga ggagttcacc tatatcatga agaggctggg
3601 ccgggccctg gtcattgggg aggtgaccag tgggggctgc cagccaccac agacctacca
3661 cgtggatgac accaacctct acctcactat ccccacggcc cgttctgtgg gggcctcgga
3721 tggcagctcc tgggaagggg tgggggtgac accccatgtg gttgtccctg cagaagaggc
3781 tctcgccagg gccaaggaga tgctccagca caaccagctg agggtgaagc ggagcccagg
3841 cctgcaggac cacctgtagg gaagggcccc ataggcagag ccccagggca gacagaacct
3901 ctgggacaca caccaagggc actcctgcag gtggcccggc ctgaggttcc caggagcagc
3961 aaaggggcct gctgagctct ggttaggtta cagctggagg tgtgtatata tacacacaca
4021 cacatgtata tacacatata tatgtgtatg tatatatatg tatatatata tggcttttca
4081 ataaccacct aaattttaac aaaggttcct tctaagtggt agaacttggg gtggtatttt
4141 taccttcctt cttcatactt tgctcttttt cttaaatact cattaatgtg catatatcat
4201 tattttcaga tgcagctatc attattccaa aatacaaaat aaagaagata aaataaatta
4261 tatacccgag ccatt
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