LOCUS HUMADH2C2 2415 bp mRNA linear HUM 30-OCT-1994
DEFINITION Human class I alcohol dehydrogenase (ADH2) beta-1 subunit mRNA,
complete cds.
ACCESSION M21692
VERSION M21692.1
KEYWORDS alcohol dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 166 to 185; 1134 to 1150)
AUTHORS Xu,Y.L., Carr,L.G., Bosron,W.F., Li,T.K. and Edenberg,H.J.
TITLE Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3
loci following DNA sequence amplification
JOURNAL Genomics 2 (3), 209-214 (1988)
PUBMED 3397059
REFERENCE 2 (bases 1 to 2415)
AUTHORS Edenberg,H.J., Dailey,T.L. and Zhang,K.
TITLE Human alcohol dehydrogenase cDNAs: Structure and expression
JOURNAL (in) Weiner,H., Flynn,T.G. and Liss,A.R. (Eds.);
ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM 2, Vol. 2:
181-192;
Alan R. Liss, Publisher, NY (1989)
COMMENT Original source text: Human liver, cDNA to mRNA.
Draft entry and printed copy of sequence for [(in) Weiner,H.,
Flynn,T.G. and Liss,A.R. (Eds.);Enzymology and Molecular Biology]
kindly provided by
H.J.Edenberg, 25-APR-1989.
The other ADH2 beta-1 subunit entries can be found under accession
numbers D00137 M24308-M24317 X03350.
FEATURES Location/Qualifiers
source 1..2415
/db_xref="H-InvDB:HIT000194802"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q21-q23"
gene 1..2415
/gene="ADH2"
mRNA <1..2415
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
mRNA <1..1751
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
mRNA <1..1620
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
mRNA <1..1415
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
mRNA <1..1411
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
mRNA <1..1408
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
mRNA <1..1373
/gene="ADH2"
/note="ADH2 mRNA (alt.)"
CDS 33..1160
/gene="ADH2"
/note="alcohol dehydrogenase beta-1 subunit (EC 1.1.1.1)"
/codon_start=1
/protein_id="AAA51592.1"
/db_xref="GDB:G00-119-651"
/translation="MSTAGKVMKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAV
GICRTDDHVVSGKLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCR
VCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAK
IDAASKLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAA
RIIAVDINKDKFAKAKVLGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTM
MASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVA
DFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF"
variation 175
/gene="ADH2"
/note="g in ADH2-1; a in ADH2-2"
variation 1139
/gene="ADH2"
/note="c in ADH2-1; t in ADH2-3"
BASE COUNT 708 a 467 c 533 g 707 t
ORIGIN Chromosome 4q21-q25.
1 gtctgctggt gggcagagaa gacagaaacg acatgagcac agcaggaaaa gtaatgaaat
61 gcaaagcagc tgtgctatgg gaggtaaaga aacccttttc cattgaggat gtggaggttg
121 cacctcctaa ggcttatgaa gttcgcatta agatggtggc tgtaggaatc tgtcgcacag
181 atgaccacgt ggttagtggc aaactggtga ccccccttcc tgtgatttta ggccatgagg
241 cagccggcat cgtggagagt gttggagaag gggtgactac agtcaaacca ggtgataaag
301 tcatcccgct ctttactcct cagtgtggaa aatgcagagt ttgtaaaaac ccggagagca
361 actactgctt gaaaaatgat ctaggcaatc cccgggggac cctgcaggat ggcaccagga
421 ggttcacctg cagggggaag cccattcacc acttccttgg caccagcacc ttctcccagt
481 acacggtggt ggatgagaat gcagtggcca aaattgatgc agcctcgaaa ctggagaaag
541 tctgcctcat tggctgtgga ttctcgactg gttatgggtc tgcagttaac gttgccaagg
601 tcaccccagg ctctacctgt gctgtgtttg gcctgggagg ggtcggccta tctgctgtta
661 tgggctgtaa agcagctgga gcagccagaa tcattgcggt ggacatcaac aaggacaaat
721 ttgcaaaggc caaagtgttg ggtgccactg aatgcatcaa ccctcaagac tacaagaaac
781 ccatccagga agtgctaaag gaaatgactg atggaggtgt ggatttttcg tttgaagtca
841 tcggtcggct tgacaccatg atggcttccc tgttatgttg tcatgaggca tgtggcacaa
901 gcgtcatcgt aggggtacct cctgcttccc agaacctctc aataaaccct atgctgctac
961 tgactggacg cacctggaag ggggctgttt atggtggctt taagagtaaa gaaggtatcc
1021 caaaacttgt ggctgatttt atggctaaga agttttcact ggatgcgtta ataacccatg
1081 ttttaccttt tgaaaaaata aatgaaggat ttgacctgct tcactctggg aaaagtatcc
1141 gtaccgtcct gacgttttga ggcaatagag atgccttccc ctgtagcagt cttcagcctc
1201 ctctacccta cgagatctgg agcaacagct aggaaatatc attaattcag ctcttcagag
1261 atgttatcaa taaattacac atgggggctt tccaaagaaa tggaaattga tgggaaatta
1321 tttttcagga aaatttaaaa ttcaagtgag aagtaaataa agtgttgaac atcagctggg
1381 gaattgaagc caacaaacct tccttcttaa ccattctact gtgtcacctt tgccattgag
1441 gaaaaatatt cctgtgactt cttgcatttt tggtatcttc ataatcttta gtcatcgaat
1501 cccagtggag gggacccttt tacttgccct gaacatacac atgctgggcc attgtgattg
1561 aagtcttcta actctgtctc agttttcact gtcgacattt tcctttttct aataaaaatg
1621 taccaaatcc ctggggtaaa agctagggta aggtaaagga tagactcaca tttacaagta
1681 gtgaaggtcc aagagttcta aatacaggaa atttcttagg aactcaaata aaatgcccca
1741 cattttacta cagtaaatgg cagtgttttt atgactttta tactatttct ttatggtcga
1801 tatacaattg attttttaaa ataatagcag atttcttgct tcatatgaca aagcctcaat
1861 tactaattgt aaaaactgaa ctattcccag aatcatgttc aaaaaatctg taatttttgc
1921 tgatcgaaag tgcttcattg actaaacagt attagtttgt ggctataaat gattatttag
1981 atgatgactg aaaatgtgta taaagtaatt aaaagtaata tggtggcttt aagtgtagag
2041 atgggatggc aaatgctgtg aatgcagaat gtaaaattgg taactaagaa atggcacaaa
2101 caccttaagc aatatatttt cctagtagat atatatatac acatacatat atacacatat
2161 acaaatgtat atttttgcaa aattgttttc aatctagaac ttttctatta actaccatgt
2221 cttaaaatca agtctataat cctagcatta gtttaatatt ttgaatatgt aaacacctgt
2281 gttaatgctt tgttaatgct tttcccactc tcatttgtta atgctttccc actctcggga
2341 aggatttgca ttttgagctt tatctctaaa tgtgacatgc aaagattatt cctggtaaag
2401 gaggtagctg tctcc
//