LOCUS HUMGDHL 3051 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human glutamate dehydrogenase (GDH) mRNA, complete cds.
ACCESSION M20867
VERSION M20867.1
KEYWORDS glutamate dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3051)
AUTHORS Amuro,N.
JOURNAL Unpublished
REFERENCE 2 (bases 28 to 3051)
AUTHORS Amuro,N., Yamaura,M., Goto,Y. and Okazaki,T.
TITLE Molecular cloning and nucleotide sequence of the cDNA for human
liver glutamate dehydrogenase precursor
JOURNAL Biochem. Biophys. Res. Commun. 152 (3), 1395-1400 (1988)
PUBMED 3377777
COMMENT Original source text: Human (female, adult) liver, cDNA to mRNA,
clones lambda-[GDHh1,GDHn61,HF71].
Draft entry and sequence [2] kindly provided by N.Amuro,
30-NOV-1988.
FEATURES Location/Qualifiers
source 1..3051
/db_xref="H-InvDB:HIT000194758"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="10q21.1-q24.3"
gene 1..3051
/gene="GLUD1"
CDS 98..1774
/gene="GLUD1"
/note="glutamate dehydrogenase precursor (EC 1.4.1.3.)"
/codon_start=1
/protein_id="AAA52526.1"
/db_xref="GDB:G00-119-994"
/translation="MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPG
LALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRV
RGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDE
VKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPG
IDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGV
FHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESD
GSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSN
APRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVS
YGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHS
GLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT"
sig_peptide 98..256
/gene="GLUD1"
/note="glutamate dehydrogenase signal peptide"
mat_peptide 257..1771
/gene="GLUD1"
/product="glutamate dehydrogenase"
BASE COUNT 826 a 686 c 726 g 813 t
ORIGIN 107 bp upstream of SmaI site; chromosome 10q23-q24.
1 gggcaacccg cgcgggaccc ttcctcccta gtcgcgggga gtctgagaaa gcgcgcctgt
61 ttcgcgacca tcacgcacct cccctccgct tgtggccatg taccgctacc tgggcgaagc
121 gctgttgctg tcccgggccg ggcccgctgc cctgggctcg gcgtccgccg actcggccgc
181 gttgctgggc tgggcccggg gacagcccgc cgccgccccg cagccggggc tggcattggc
241 cgcccggcgc cactacagcg aggcggtggc cgaccgcgag gacgacccca acttcttcaa
301 gatggtggag ggcttcttcg atcgcggcgc cagcatcgtg gaggacaagc tggtggagga
361 cctgaggacc cgggagagcg aggagcagaa gcggaaccgg gtgcgcggca tcctgcggat
421 catcaagccc tgcaaccatg tgctgagtct ctccttcccc atccggcgcg acgacggctc
481 ctgggaggtc atcgaaggct accgggccca gcacagccag caccgcacgc cctgcaaggg
541 aggtatccgt tacagcactg atgtgagtgt agatgaagta aaagctttgg cttctctgat
601 gacatacaag tgtgcagtgg ttgatgtgcc gtttgggggt gctaaagctg gtgttaagat
661 caatcccaag aactatactg ataatgaatt ggaaaagatc acaaggaggt tcaccatgga
721 gctagcaaaa aagggcttta ttggtcctgg cattgatgtg cctgctccag acatgagcac
781 aggtgagcgg gagatgtcct ggatcgctga tacctatgcc agcaccatag ggcactatga
841 tattaatgca cacgcctgtg ttactggtaa acccatcagc caagggggaa tccatggacg
901 catctctgct actggccgtg gtgtcttcca tgggattgaa aatttcatca atgaagcttc
961 ttacatgagc attttaggaa tgacaccagg gtttggagat aaaacatttg ttgttcaggg
1021 atttggtaat gtgggcctac actctatgag atatttacat cgttttggtg ctaaatgtat
1081 tgctgttggt gagtctgatg ggagtatatg gaatccagat ggtattgacc caaaggaact
1141 ggaagacttc aaattgcaac atgggtccat tctgggcttc cccaaggcaa agccctatga
1201 aggaagcatc ttggaggccg actgtgacat actgatccca gctgccagtg agaagcagtt
1261 gaccaaatcc aacgcaccca gagtcaaagc caagatcatt gctgaaggtg ccaatgggcc
1321 aacaactcca gaagctgaca agatcttcct ggagagaaac attatggtta ttccagatct
1381 ctacttgaat gctggaggag tgacagtatc ttactttgag tggctgaaga atctaaatca
1441 tgtcagctat ggccgtttga ccttcaaata tgaaagggat tctaactacc acttgctcat
1501 gtctgttcaa gagagtttag aaagaaaatt tggaaagcat ggtggaacta ttcccattgt
1561 acccacggca gagttccaag acaggatatc gggtgcatct gagaaagaca tcgtgcactc
1621 tggcttggca tacacaatgg agcgttctgc caggcaaatt atgcgcacag ccatgaagta
1681 taacctggga ttggacctga gaacagctgc ctatgttaat gccattgaga aagtcttcaa
1741 agtgtacaat gaagctggtg tgaccttcac atagatggat catggctgac ttcctcacta
1801 tcctcttcac atgtaacttc tgcagaccta tcacaagttt acatgtaacc acagaaatcc
1861 ctttctctcc tgactcatta ataatggata ccattctcaa caagtcaatc caagtcagcc
1921 cgttaaggag aaagaaatta aggttagcgg atcatgtaca agctgagtgt gaaagtagaa
1981 atcacctaca ccagagagcc attttggtat tttgccttta aataaaaagc ctcctttatc
2041 tggctgtgca gccttgctct gtggcttttc ccaacacaat cagtgctagt gctggggagg
2101 aacagtcaag agcagtcagt tgcttgctta ttttttctgg atgagtctgg gacacactgt
2161 aactttaaca catttaagaa gtaggtgtgt ggccttttca gaaggtggca tggtcctcaa
2221 gtgagttctt agtattttat atcagcaaaa taattcaatt ttgcaggttg caaacaaata
2281 taaaacctgt ttctgtttat gaatattatt cttttagaat agaataagta catgctgctg
2341 taataaaatt gcctttaatc acttaacaag cctaaccttg actcaaacag tgaatgccta
2401 tagaaataat aaatgaaaaa aactagtatt tttatatcat aaaacaatgt catttatagc
2461 ttatcattca tgtattgtcc agcagacatt aaaagccctg tggataatta agttatcttc
2521 atacctgcaa aatggtggag gctattttca ttaaaactgt cagaatttgc ttaccataat
2581 tatgatacag tccaaagaat gcagtcactt tttatcatgt taactaattg ttctcttttg
2641 aagatctatg gttgactaat taaacaataa ttcaagtaga gtgtcccaga aaaaaaccac
2701 ttgggctccc tgtttggagt ctggctggct ctgagcattg ccaatggccc ctactcacct
2761 gactttgtat cctctccttt tagaggcttt gcattctgca cccagcttca ctaacagtgg
2821 gctgaaaaca tccttgggtt gagtgtttca tttgggagtt atttggccag ggccttttga
2881 acagtagtgt ccccatgaag tgctagataa tatatgtgta agagtcagct tttttttttt
2941 tttttaactc taacaccctt cagaaatttc taactacttt gtaactgcat ggcttaacct
3001 ggtgataaaa gcagttatta aaagtctacg ttttccaaaa aaaaaaaaaa a
//