LOCUS       HUMRBSY79                480 bp    mRNA    linear   HUM 22-SEP-2008
DEFINITION  Human mutated retinoblastoma susceptibility (RB) mRNA, complete
            cds.
ACCESSION   M19701 J03809
VERSION     M19701.1
KEYWORDS    retinoblastoma susceptibility.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Lee,E.Y., Bookstein,R., Young,L.J., Lin,C.J., Rosenfeld,M.G. and
            Lee,W.H.
  TITLE     Molecular mechanism of retinoblastoma gene inactivation in
            retinoblastoma cell line Y79
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (16), 6017-6021 (1988)
   PUBMED   3413073
COMMENT     Draft entry and computer-readable sequence kindly provided by
            E.Y.-H.P.Lee, 15-JUL-1988 The deletion spans exons 2-6 of the
            normal gene.
FEATURES             Location/Qualifiers
     source          1..480
                     /db_xref="H-InvDB:HIT000194695"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="13q14.2"
     gene            1..480
                     /gene="RB1"
     CDS             139..300
                     /gene="RB1"
                     /codon_start=1
                     /product="mutated retinoblastoma protein"
                     /protein_id="AAA60259.1"
                     /db_xref="GDB:G00-118-734"
                     /translation="MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPL
                     VRGSITNGR"
     misc_recomb     275..276
                     /gene="RB1"
BASE COUNT          111 a          151 c          125 g           93 t
ORIGIN      
        1 ttccggtttt tctcagggga cgttgaaatt atttttgtaa cgggagtcgg gagaggacgg
       61 ggcgtgcccc gcgtgcgcgc gcgtcgtcct ccccggcgct cctccacagc tcgctggctc
      121 ccgccgcgga aaggcgtcat gccgcccaaa accccccgaa aaacggccgc caccgccgcc
      181 gctgccgccg cggaaccccc ggcaccgccg ccgccgcccc ctcctgagga ggacccagag
      241 caggacagcg gcccggagga cctgcctctc gtcaggggaa gtattacaaa tggaagatga
      301 tctggtgatt tcatttcagt taatgctatg tgtccttgac tattttatta aactctcacc
      361 tcccatgttg ctcaaagaac catataaaac agctgttata cccattaatg gttcacctcg
      421 aacacccagg cgaggtcaga acaggagtgc acggatagca aaacaactag aaaatgatac
//