LOCUS HUMMPO 3215 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human myeloperoxidase mRNA, complete cds.
ACCESSION M19507 M17709
VERSION M19507.1
KEYWORDS myeloperoxidase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1939 to 3208)
AUTHORS Yamada,M., Hur,S.J., Hashinaka,K., Tsuneoka,K., Saeki,T.,
Nishio,C., Sakiyama,F. and Tsunasawa,S.
TITLE Isolation and characterization of a cDNA coding for human
myeloperoxidase
JOURNAL Arch. Biochem. Biophys. 255 (1), 147-155 (1987)
PUBMED 2884926
REFERENCE 2 (bases 1 to 3215)
AUTHORS Yamada,M.
JOURNAL Unpublished
REFERENCE 3 (bases 58 to 3215)
AUTHORS Hashinaka,K., Nishio,C., Hur,S.J., Sakiyama,F., Tsunasawa,S. and
Yamada,M.
TITLE Multiple species of myeloperoxidase messenger RNAs produced by
alternative splicing and differential polyadenylation
JOURNAL Biochemistry 27 (16), 5906-5914 (1988)
PUBMED 2903767
COMMENT Original source text: Human promyelocytic leukemia cell line HL-60,
cDNA to mRNA, clone pMP1 [1], clone lambda-MP-H17 [3],[2].
Draft entry and printed copy of sequence for [1] kindly provided by
M.Yamada, 23-NOV-1987 and for [3] 11-MAY-1988.
FEATURES Location/Qualifiers
source 1..3215
/db_xref="H-InvDB:HIT000194690"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="17q21.3-q23"
/cell_line="HL-60"
/tissue_type="promyelocytic leukemia"
gene 1..3215
/gene="MPO"
mRNA <1..3215
/gene="MPO"
/note="G00-120-192"
mRNA <1..3208
/gene="MPO"
/note="G00-120-192"
mRNA <1..2597
/gene="MPO"
/note="G00-120-192"
mRNA <1..2594
/gene="MPO"
/note="G00-120-192"
mRNA <1..2590
/gene="MPO"
/note="G00-120-192"
CDS 178..2415
/gene="MPO"
/EC_number="1.11.1.7"
/codon_start=1
/product="myeloperoxidase"
/protein_id="AAA59863.1"
/db_xref="GDB:G00-120-192"
/translation="MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQ
PSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYF
KQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAY
QDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVK
RNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFV
TGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALT
SFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNR
SARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIV
GAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPF
MFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD
EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNL
KLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN
EGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLAS
WREAS"
mat_peptide 670..993
/gene="MPO"
/product="myeloperoxidase light chain"
/note="G00-120-192"
mat_peptide 1012..2409
/gene="MPO"
/product="myeloperoxidase heavy chain"
/note="G00-120-192"
BASE COUNT 652 a 949 c 933 g 681 t
ORIGIN 54 bp upstream of PvuII site; chromosome 17q21-q23.
1 gacaatatca ggtgagctgt ggaggtgggg tccttggaag ctggatgaca gcagctggca
61 aggggataag agagcagtga gcccctccct caaggaggtc tggctttatc catagacagg
121 gccctctgag gtggggctga ggtacaaagg gggattgagc agcccaggag aagagagatg
181 ggggttccct tcttctcttc tctcagatgc atggtggact taggaccttg ctgggctggg
241 ggtctcactg cagagatgaa gctgcttctg gccctagcag ggctcctggc cattctggcc
301 acgccccagc cctctgaagg tgctgctcca gctgtcctgg gggaggtgga cacctcgttg
361 gtgctgagct ccatggagga ggccaagcag ctggtggaca aggcctacaa ggagcggcgg
421 gaaagcatca agcagcggct tcgcagcggc tcagccagcc ccatggaact cctatcctac
481 ttcaagcagc cggtggcagc caccaggacg gcggtgaggg ccgctgacta cctgcacgtg
541 gctctagacc tgctggagag gaagctgcgg tccctgtggc gaaggccatt caatgtcact
601 gatgtgctga cgcccgccca gctgaatgtg ttgtccaagt caagcggctg cgcctaccag
661 gacgtggggg tgacttgccc ggagcaggac aaataccgca ccatcaccgg gatgtgcaac
721 aacagacgca gccccacgct gggggcctcc aaccgtgcct ttgtgcgctg gctgccggcg
781 gagtatgagg acggcttctc tcttccctac ggctggacgc ccggggtcaa gcgcaacggc
841 ttcccggtgg ctctggctcg cgcggtctcc aacgagatcg tgcgcttccc cactgatcag
901 ctgactccgg accaggagcg ctcactcatg ttcatgcaat ggggccagct gttggaccac
961 gacctcgact tcacccctga gccggccgcc cgggcctcct tcgtcactgg cgtcaactgc
1021 gagaccagct gcgttcagca gccgccctgc ttcccgctca agatcccgcc caatgacccc
1081 cgcatcaaga accaagccga ctgcatcccg ttcttccgct cctgcccggc ttgccccggg
1141 agcaacatca ccatccgcaa ccagatcaac gcgctcactt ccttcgtgga cgccagcatg
1201 gtgtacggca gcgaggagcc cctggccagg aacctgcgca acatgtccaa ccagctgggg
1261 ctgctggccg tcaaccagcg cttccaagac aacggccggg ccctgctgcc ctttgacaac
1321 ctgcacgatg acccctgtct cctcaccaac cgctcagcgc gcatcccctg cttcctggca
1381 ggggacaccc gttccagtga gatgcccgag ctcacctcca tgcacaccct cttacttcgg
1441 gagcacaacc ggctggccac agagctcaag agcctgaacc ctaggtggga tggggagagg
1501 ctctaccagg aagcccggaa gatcgtgggg gccatggtcc agatcatcac ttaccgggac
1561 tacctgcccc tggtgctggg gccaacggcc atgaggaagt acctgcccac gtaccgttcc
1621 tacaatgact cagtggaccc acgcatcgcc aacgtcttca ccaatgcctt ccgctacggc
1681 cacaccctca tccaaccctt catgttccgc ctggacaatc ggtaccagcc catggaaccc
1741 aacccccgtg tccccctcag cagggtcttt tttgcctcct ggagggtcgt gctggaaggt
1801 ggcattgacc ccatcctccg gggcctcatg gccacccctg ccaagctgaa tcgtcagaac
1861 caaattgcag tggatgagat ccgggagcga ttgtttgagc aggtcatgag gattgggctg
1921 gacctgcctg ctctgaacat gcagcgcagc agggaccacg gcctcccagg atacaatgcc
1981 tggaggcgct tctgtgggct cccgcagcct gaaactgtgg gccagctggg cacggtgctg
2041 aggaacctga aattggcgag gaaactgatg gagcagtatg gcacgcccaa caacatcgac
2101 atctggatgg gcggcgtgtc cgagcctctg aagcgcaaag gccgcgtggg cccactcctc
2161 gcctgcatca tcggtaccca gttcaggaag ctccgggatg gtgatcggtt ttggtgggag
2221 aacgagggtg tgttcagcat gcagcagcga caggccctgg cccagatctc attgccccgg
2281 atcatctgcg acaacacagg catcaccacc gtgtctaaga acaacatctt catgtccaac
2341 tcatatcccc gggactttgt caactgcagt acacttcctg cattgaacct ggcttcctgg
2401 agggaagcct cctagaggcc aggtaagggg gtgcagcagt gaggggtata tctgggctgg
2461 ccagttggaa ccacggagat ctccttgccc tagatgagcc cagccctgtt ctgggtgcag
2521 ctgagaaaat gagtgactag acgttcattt gtgtgctcat gtatgtgcga agtatataaa
2581 ttggcttttc atgcgtgtgt gttgtctgaa catggggagt gtttcatggg ttatgtgtat
2641 gtgccattta tgtgagtgtg tgtttgtgct gatgagaata ctgagtatgt ggaaggcagc
2701 agagcggact ggtgaggagc acagctcagg aactagactg cctgggttcc aatcctggct
2761 ctgtggcttg ctagctatgt gaccttgagc aaattaccct ccttaaacaa gagttttctt
2821 ccttgtaaat tacatctgtc atggtttctt ggagggccca cttgtatcct ctggttcttc
2881 atttattgag cacctactac atgcaaggca ctgtactagg cgtgagaagc atatagaggc
2941 aagaaagaga taccaagatg ccatctgtgt cctggttagc agagctggac cagtggtgcc
3001 ttggagggat aagccagctg cagctgggct gtgtggttga cttatgggcc cagccagcca
3061 ggctcaggcc atggctcccc tttttcttcc tcaccctgat ttcttgctta ttcactgaag
3121 ttctcctgaa gaggaactgg gcctgttgcc ctttctgtac catttatttg ctcccaatgt
3181 ttatgataat aaaggcaccg ctgatgggga cctcc
//