LOCUS HUMP45C17 8549 bp DNA linear HUM 27-APR-1993
DEFINITION Human P450XVIIA-1 (steroid 17-alpha-hydroxylase/17,20 lyase) gene,
complete cds.
ACCESSION M19489
VERSION M19489.1
KEYWORDS cytochrome; cytochrome P450; cytochrome p.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8549)
AUTHORS Picado-Leonard,J. and Miller,W.L.
TITLE Cloning and sequence of the human gene for P450c17 (steroid 17
alpha-hydroxylase/17,20 lyase): similarity with the gene for
P450c21
JOURNAL DNA 6 (5), 439-448 (1987)
PUBMED 3500022
COMMENT Original source text: Human DNA, Maniatis library (Lawn, et al.),
clones lambda-hM171 and lambda-hM17-2.
Clean copy of sequence [1] kindly provided by W.L.Miller,
08-DEC-1988.
FEATURES Location/Qualifiers
source 1..8549
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="10"
repeat_region 1446..1517
/note="Alu repeat"
prim_transcript 1779..8437
/note="P450c17 mRNA and introns"
CDS join(1839..2135,3804..3942,4176..4405,5068..5154,
5849..6064,6297..6466,7364..7467,7986..8269)
/gene="CYP17"
/note="cytochrome P450c17"
/codon_start=1
/protein_id="AAA36405.1"
/translation="MWELVALLLLTLAYLFWPKRRWPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL
DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV
PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
"
gene join(1839..2135,3804..3942,4176..4405,5068..5154,
5849..6064,6297..6466,7364..7467,7986..8268)
/gene="CYP17"
gene 1839..2135
/gene="CYP1A1"
exon <1839..2135
/gene="CYP1A1"
/note="cytochrome P450c17, (EC 1.14.99.9)"
/number=1
intron 2136..3803
/note="cytochrome P450c17, intron A"
repeat_region 2722..2927
/note="Alu repeat"
exon 3804..3942
/gene="CYP17"
/number=2
intron 3943..4175
/note="cytochrome P450c17, intron B"
exon 4176..4405
/gene="CYP17"
/number=3
intron 4406..5067
/note="cytochrome P450c17, intron C"
exon 5068..5154
/gene="CYP17"
/number=4
intron 5155..5848
/note="cytochrome P450c17, intron D"
repeat_region 5406..5598
/note="Alu repeat"
exon 5849..6064
/gene="CYP17"
/number=5
intron 6065..6296
/note="cytochrome P450c17, intron E"
exon 6297..6466
/gene="CYP17"
/number=6
intron 6467..7363
/note="cytochrome P450c17, intron F"
repeat_region 6696..6907
/note="Alu repeat"
exon 7364..7467
/gene="CYP17"
/number=7
intron 7468..7985
/note="cytochrome P450c17, intron G"
exon 7986..>8269
/note="cytochrome P450c17"
/number=8
BASE COUNT 2057 a 2306 c 2027 g 2159 t
ORIGIN 265 bp upstream of HincII site; chromosome 15q22-q24.
1 gagcaagcct tcatcccgac ggcacactta tataaaaaag aaagggagag atgtatgcgg
61 gaagtcaggg acctgaatga agggactgct ggagccatgg cagaggaaca taaattgtga
121 agatttcatt taatatggac atttatcagt tcccaaataa tacttttata atttcttatg
181 cctgtcttta ctttaatctc ttaatcctgt tatctttgta agctgaggat gtttgtcact
241 tcaggaccac tgtgataatt gtgttaactg tacaaattga ttgtaagaca tgtgtttgaa
301 caatatgaaa ttagtgcacc ttgaaaaaga acacaataag agcaattttt agggaacaag
361 ggaaaacaac cataaggtct gactgcctgc agggtcgggc agaaagagcc atattttcct
421 tcttgagaga ggctataaat ggacatgcaa gtagggaaga tatcactaaa ttcttttcct
481 agcaaggagt attattatta ataccctggg aaaggaatgc attcctgggg ggaggtctat
541 aaacagccgc tctgggaatg tctatcttgt gcagttgaga taaggactga gatacgccct
601 ggtctcctgc agtaccctca ggcttactag ggtggggaaa aactccgccc tggtaaattt
661 gtggtcagac cggttctctg ctgtcgaagg gtgtttgctg ttgtttaagg tgtttatcaa
721 gacagtatgt gcaccgctga acatagaccc tcatctgtag ttctgctttt gccctttgcc
781 ttgtgatctt tgttggaccc ttatcagtgg ttctgctttt gccctttgcc ttgtgatctt
841 tgttggaccc ttatcggtag ttctgctttt tgccctttgt cctttccctc agaagcatgt
901 gatctttgtt agacacttat tagtagttct gcttttcgcc ctttgaagca tgtgatcttt
961 gtaccctact ctccctgttc ttacaccccc tccccttttt gaaaccctta ataaaaactt
1021 gctggtttga ggctcaggtg ggtatcacag tcctaccgat atgtgatgcc acccccggcg
1081 gcccagctgt aaaattcctc tctttatact gtctctcttt atttctcagc cggctgacac
1141 ttatagaaag aacctacgtt gaaatattgg gggtgggttc ccccagtacg ctagtcctgc
1201 tgatgagcaa agaaggtgtt gatggcattt tgatcaacaa gaaatgttat gaaacggcct
1261 cccacctctg gcattcctag tactgaccta tctctccctt cccttccacc gctccccaca
1321 gcccttccac cgctccccac agcttagcac ccctttcgtt cccatacaca tgtacatttt
1381 tattttgggg accattaacc cgacagccct tatcgctgcc aaaaccacat gggctggagg
1441 gccagggctg catggacagt cacaccactg cacaccagcc tggtgatgga gcaagactct
1501 gaaaaaaaaa aaaagaagca taaaagacct ttaacagtcc ctgctacttg tgaccctcct
1561 gaatctgtca tctgtccagt gattttgatt ttgcagcatg gaaagttcca agccttgact
1621 cctgagccca gataccattc gcactctgga gtcattcaag catggggagc tcaggcctgg
1681 ctgggctcca ggagaatctt tcttccacaa ggcaagagat aacacaaaag tcaaggtgaa
1741 gatcagggta gccctttaaa aggcctcctt gtgccctaga gttgccacag ctcttctact
1801 ccactgctgt ctatcttgcc tgccggcacc cagccaccat gtgggagctc gtggctctct
1861 tgctgcttac cctagcttat ttgttttggc ccaagagaag gtggcctggt gccaagtacc
1921 ccaagagcct cctgtccctg cccctggtgg gcagcctgcc attcctcccc agacatggcc
1981 atatgcataa caacttcttc aagctgcaga aaaaatatgg ccccatctat tctgttcgta
2041 tgggcaccaa gactacagtg attgtcggcc accaccagct ggccaaggag gtgcttatta
2101 agaagggcaa ggacttctct gggcggcctc aaatggtaag tggtgcccat ctcctccctg
2161 cccccttcac caccccctgg gattggttca ggtcttcaga ccatgcctag aatggggctt
2221 ccagctccaa caacctgtat ttcttcccaa aagtagacta gtgggatgat gtgaagggag
2281 tgaaccttca gacccccacc cagcctctaa attaggcagg ttgaattaaa ggaatgtctc
2341 ctctaccagg ctgcccagga ggtgggatgg gaggaccaca gtggtctgag gggtcaagga
2401 atcctcactc cactcctctc tctgagccta gacttctcta atggactgag aaggtgcatg
2461 tacagcactt agcctagcac ccagcacagt aagtgccctt atacagccag gattcatgtt
2521 acttttcatg gaaaatgggg gcagtgacta ctgtcctcca tgaaagctgc tggggagaat
2581 tagcctagct attgcaggct gggattgctg ctttcctggt gctatttcca gctactcagg
2641 ctcacagggg cagttttcta caatgacatt tcagggttgc tgatgagcct cccactcagc
2701 agggccccca gcctctcagc attttttttt tttttttttt tttttgagac agagtctctc
2761 tctgtcgccc agcctggagt gcagtggcca atctcagctc actgcaacct ctgcctcccg
2821 ggtcaagtga ttctcctgcc tcagactcct gagtacctgg gactacagga gcatgccacc
2881 atgcccgcta attttttgta tttttagtag agatggtgtt tcaccatgtt agccaggatg
2941 gtctcgatct cctgacctcg tgatcctccc accttagcct cccaaagtgc taggattata
3001 ggcgtaagcc actgtgccct gccagcctct cagctttgat caagccaagg gttggtttat
3061 tttttcttgg accaatcagc caggtctgct gaccaactac ctagctccca cctctgctgg
3121 cttcctcccg ggggcagaga agatggagaa ggctagtcat gtggatcttc agggtcagga
3181 aatggaaaag ggaggctttg gacccttttg ctttgggggg cacctctaga agaagcgctc
3241 gcccaagtcc agactgggta gacaaacatc tgcactctcc aaatgtgggc ttgtggctgg
3301 gtatgcaggc ttgcaatgga agggtaaacc tgagtgaggt gagctgtgcc tttagctcag
3361 ctaagggctc agggaaaagc agagatctgt gcagtcctca gcctctacaa gctcacctgc
3421 tccctaccct ctggacaggc atagtttaga gagtttatcc catccagagt tgccttcctg
3481 tggtcagaaa ctgatgagca aaaagaagcc agagggcacc ctgtcagcga aaagaacccc
3541 aatgctgctg cattctaatt aagggttctt tctttctcct tgatctactg tatttctgaa
3601 ggaattggga gtaggaggcc ttagggtctg tcctaccaag tccttgcagt catggtggag
3661 tgcagtgggg ctgtgcccac atgggagtca gcatgccagg tacctccctt ctcctccagg
3721 aaggaaagca gggaccagag gtgtaagggc aagagtgggg tggatgggtg tgagattcct
3781 acagccttgc ctgctctcta aaggcaactc tagacatcgc gtccaacaac cgtaagggta
3841 tcgccttcgc tgactctggc gcacactggc agctgcatcg aaggctggcg atggccacct
3901 ttgccctgtt caaggatggc gatcagaagc tggagaagat cagtgagtgc caggctggcc
3961 cctggggctg gggctggatc ccacaggagc tgctggaggg agaggagggt tgggcagggg
4021 taaggggtta ggactagagc gcaatgcagc cttttcttgg ctactgctgc catctagtgg
4081 catctgctat ctgtcccccg ctcctgaggc aactggtaca gagagggggt aagggtgctg
4141 attcatttcc accctcatgc cccctctccc ttcagtttgt caggaaatca gtacattgtg
4201 tgatatgctg gccacccaca acggacagtc catagacatc tcctttcctg tcttcgtggc
4261 ggtaaccaat gtcatctcct tgatctgctt caatacctcc tacaagaatg gggaccctga
4321 gttgaatgtc atacagaatt acaatgaagg catcatagac aacctgagca aagacagcct
4381 ggtggaccta gtcccctggt tgaaggtgag atgctgccag ccctgccttc aggttctagt
4441 agaccctgac attgtcccca atcttccttc ctttttactt ccctgctcca gccgcaatga
4501 cccatctttt tcctgattac ctccgccacc tctacctcct ctgccactta aaacctttgc
4561 catttctctg cagagataag atttagcctt ttaattatgc accttagtac tccagataat
4621 gaccttcatt tcttttccaa ttaccatgtg ccagtactaa gcattctata cgcattcatc
4681 gctgaattcc tttggaagta ggttttatta tccccattgt gcaggtgaga agcaggctta
4741 gcggggttaa ggagcttgtc tgagccttca ggtcatcgtc tctctcactc ctaagggctg
4801 gacacatagc agagtcagcg cttgatgttt gattgaatgg ggaaggagag gtggagacca
4861 cgccctcctc ccttgtttag aattgtcttc gtcgtcatga taaacccgtt ctgtgtcccc
4921 atcttgcctt ccattctggc tgaaggtcag gggtggagta ggaacttcca gagacagaaa
4981 agctaagatc cgcctccagg agagactctg gcagctggag aagcaaaatg gaagaagggt
5041 ggatttaaca tttcttttta tttccagatt ttccccaaca aaaccctgga aaaattaaag
5101 agccatgtta aaatacgaaa tgatctgctg aataaaatac ttgaaaatta caaggtaggt
5161 gatagagcag aagagaatat gagttaggct aaaaggaatc acaagagcag ggtggagtcc
5221 attctacaca ctgtagaagc ttcaaaacca agcagagaac ctggcacata gtaggtgtac
5281 aataaaaact gacttaaggg ctgggcgcgg tggctcatgc tgtaatccca acactttgga
5341 ggccgaggtg ggcagatcac ctgaggttgg gaggttcgag accagcctga ccaacatgga
5401 gaaactctgt ctctactaaa aatacaaaat tagccgggca cggtggcgca tgcctataat
5461 cccagctaat ttcgggaggc tgaggcagga gactcacttg aacccgagaa gcagaggttg
5521 cagtgagctg agatcatgcc attgcactcc agcctgggca ttgcaccaag attctgtctc
5581 aaaaaaaaaa aaaaaaaact gactcaagga gttgggatcg aaaagtgagg aactgaagag
5641 gatcctagaa gagacctaac ctctccacca atttaaaaag ggcccggggc tgcctcctac
5701 ctccacacgt tcgtaggtcc tgcccagact tgctctactt ccaagtggaa ggagccttgt
5761 tatctctagt cagggacaga agtatggcag gagtgtcaca gatggggctc cttccttatt
5821 aatgtctccc aaacctcacc caacccagga gaaattccgg agtgactcta tcaccaacat
5881 gctggacaca ctgatgcaag ccaagatgaa ctcagataat ggcaatgctg gcccagatca
5941 agattcagag ctgctttcag ataaccacat tctcaccacc ataggggaca tctttggggc
6001 tggcgtggag accaccacct ctgtggttaa atggaccctg gccttcctgc tgcacaatcc
6061 tcaggtgtgc ttccccctca ttgatcctag accccagcca gcccaatctc tgggctccag
6121 agaaagggag agccaattct ctcaggcttt ctgtgcagga agactaggcc ccagagccac
6181 tactgggaag ggactggaca ggctcttctc gatcgtcaca gttggattat tctctaagcc
6241 cttgcctctc ctgggcttac acacactagt cacctccaac ctactctggt cttcaggtga
6301 agaagaagct ctacgaggag attgaccaga atgtgggttt cagccgcaca ccaactatca
6361 gtgaccgtaa ccgtctcctc ctgctggagg ccaccatccg agaggtgctt cgcctcaggc
6421 ccgtggcccc tatgctcatc ccccacaagg ccaacgttga ctccaggtgt gcctgccctc
6481 ccagtgacat ctagccccat gatgcattca ctgcttgcca gcccacctgg ctccccctac
6541 ccccgcccct gctggccaac ctaaagtcag tcaaccatca actactaaaa atcatcctgc
6601 cggctgggca ctggctcaca cctgtcatcc caacactttg ggaggtgagg cgggtggatc
6661 atgaggtcag gggttcaaga ccagcctgac caattatggt tgaaaccccc gtctcttact
6721 taaaatacaa aaaattagcc atgcatcgtg gcgctgtcct gtagtcccag ctactcagga
6781 ggctgaggca ggagaatcac ttgaaccaag gcggcggagg ttgcagtgag ccaagattgc
6841 accactgcac tccagcctgg gtgacagagc gggactctgt ctcaaaataa ataattaatt
6901 aattaaatat aaaaatcatc ctgcccccag ccccgtggct ccatatctct accacctaca
6961 gacacgcatt gactcatcca cagatctgcc tgacttccca gaggagcttc ctgctgccct
7021 cagagacatg tggtctggga tgaaaggctg ggagctccat gttccaacca gctgcagcac
7081 gcacataaca tgcgctgcag ctccaaacac acacccacat acactgccag acaccaaagt
7141 ccacagacac aggtgttcag acagaagcgc ctgttaggag ggaagggatg gagaagggct
7201 ggatttaggt ttgatctggc agaagctgag gaaaacatga gtgagtggga atgagggagt
7261 aaagggcatt ttcctcacgg cggaagaatg agggggcatg aggctgagca aggaagggag
7321 tacgaagtcc cagacccact tttcctcttc cactctggag cagcatcggt gagtttgctg
7381 tggacaaggg cacagaagtt atcatcaatc tgtgggcgct gcatcacaat gagaaggagt
7441 ggcaccagcc ggatcagttc atgcctggtg agtctgtcct gtcctgcgcc ctgggccaca
7501 cagcgagcct ggactctgct ccaaccaccc cagtacccct tcacctctgc aaagcttccg
7561 ctagaaagct cttggctcca actataccga cctgttgacg ccctcatcct gccatagact
7621 tacccaaact cttcacagct gggtttccca cgctcttctt ccaaccaact gcaaattcac
7681 cctccaagaa gccctctact cctctgtctg ccattaagtc tgtcccttct cccctcggat
7741 ggtgctattt tcataggtta attccacctc ttttccatcc ttcctgaata tttcatttcc
7801 tctgtgtcgt taagggctac ctgaaagcag ggctgtatct ctccccaggc gggttcccca
7861 taataaggct acatcctcag atcagggttc cctgggaggg ccatgtctcc ccctcaacca
7921 gggcagaacc atgcctctcc tccctcctgc cctaacccct ggctgatgcc actccttgcc
7981 agcagagcgt ttcttgaatc cagcggggac ccagctcatc tcaccgtcag taagctattt
8041 gcccttcgga gcaggacctc gctcctgtat aggtgagatc ctggcccgcc aggagctctt
8101 cctcatcatg gcctggctgc tgcagaggtt cgacctggag gtgccagatg atgggcagct
8161 gccctccctg gaaggcatcc ccaaggtggt ctttctgatc gactctttca aagtgaagat
8221 caaggtgcgc caggcctgga gggaagccca ggctgagggt agcacctaaa ggctgtaact
8281 cacagcccct gtccacccta tgtggcccca caacacagat ttagagatac aaccccccac
8341 ccttctccgc cattcttccc tactcccaac ccactctgcc ttctttttca gcttgtggca
8401 atgccagtga tgtgcataaa cagttttttt tttttccata aggtccctga gtagttcatt
8461 tatgtattca tttgctcact cattctttca acaccgattt tattgagcac ctactatgtg
8521 ccattctctt tctcaggaca ctcgagctc
//