LOCUS HUMTKR 3370 bp mRNA linear HUM 03-AUG-1993
DEFINITION Human tyrosine kinase receptor (eph) mRNA, complete cds.
ACCESSION M18391
VERSION M18391.1
KEYWORDS tyrosine kinase receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3370)
AUTHORS Hirai,H., Maru,Y., Hagiwara,K., Nishida,J. and Takaku,F.
TITLE A novel putative tyrosine kinase receptor encoded by the eph gene
JOURNAL Science 238 (4834), 1717-1720 (1987)
PUBMED 2825356
COMMENT Original source text: Human hepatocellular carcinoma cell line
ETL-1, cDNA to mRNA, clone CL-70.
FEATURES Location/Qualifiers
source 1..3370
/db_xref="H-InvDB:HIT000194631"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 94..3048
/note="tyrosine kinase receptor precursor (put.);
putative"
/codon_start=1
/protein_id="AAA36747.1"
/translation="MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLL
DPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFT
VRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLA
SGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTL
PGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEA
CVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPS
APRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHF
SPGARALTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSG
LSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQP
DTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGIL
VFRSRRAQRQRQQRHVTAPPMWIERTSCAEALCGTSRHTRTLHREPWTLPGGWSNFPS
RELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREA
TIMGQFSHPHILHLEGVVTKRKPIMIITEFMENAALDAFLREREDQLVPGQLVAMLQG
IASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPI
RWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPP
VDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRVTLRLPS
LSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQ
KRILCSIQGFKD"
sig_peptide 94..162
/note="tyrosine kinase receptor signal peptide (put.);
putative"
mat_peptide 163..3045
/product="tyrosine kinase receptor (put.); putative"
BASE COUNT 689 a 1002 c 1005 g 674 t
ORIGIN 1053 bp upstream of SstI site.
1 gcccccgccc ggcccgcccc gctctcctag tcccttgcaa cctggcgctg catccgggcc
61 actgtcccag gtcccaggtc ccggcccgga gctatggagc ggcgctggcc cctggggcta
121 gggctggtgc tgctgctctg cgccccgctg cccccggggg cgcgcgccaa ggaagttact
181 ctgatggaca caagcaaggc acagggagag ctgggctggc tgctggatcc cccaaaagat
241 gggtggagtg aacagcaaca gatactgaat gggacacccc tctacatgta ccaggactgc
301 ccaatgcaag gacgcagaga cactgaccac tggcttcgct ccaattggat ctaccgcggg
361 gaggaggctt cccgcgtcca cgtggagctg cagttcaccg tgcgggactg caagagtttc
421 cctgggggag ccgggcctct gggctgcaag gagaccttca accttctgta catggagagt
481 gaccaggatg tgggcattca gctccgacgg cccttgttcc agaaggtaac cacggtggct
541 gcagaccaga gcttcaccat tcgagacctt gcgtctggct ccgtgaagct gaatgtggag
601 cgctgctctc tgggccgcct gacccgccgt ggcctctacc tcgctttcca caacccgggt
661 gcctgtgtgg ccctggtgtc tgtccgggtc ttctaccagc gctgtcctga gaccctgaat
721 ggcttggccc aattcccaga cactctgcct ggccccgctg ggttggtgga agtggcgggc
781 acctgcttgc cccacgcgcg ggccagcccc aggccctcag gtgcaccccg catgcactgc
841 agccctgatg gcgagtggct ggtgcctgta ggacggtgcc actgtgagcc tggctatgag
901 gaaggtggca gtggcgaagc atgtgttgcc tgccctagcg gctcctaccg gatggacatg
961 gacacacccc attgtctcac gtgcccccag cagagcactg ctgagtctga gggggccacc
1021 atctgtacct gtgagagcgg ccattacaga gctcccgggg agggccccca ggtggcatgc
1081 acaggtcccc cctcggcccc ccgaaacctg agcttctctg cctcagggac tcagctctcc
1141 ctgcgttggg aacccccagc agatacgggg ggacgccagg atgtcagata cagtgtgagg
1201 tgttcccagt gtcagggcac agcacaggac ggggggccct gccagccctg tggggtgggc
1261 gtgcacttct cgccgggggc ccgggcgctc accacacctg cagtgcatgt caatggcctt
1321 gaaccttatg ccaactacac ctttaatgtg gaagcccaaa atggagtgtc agggctgggc
1381 agctctggcc atgccagcac ctcagtcagc atcagcatgg ggcatgcaga gtcactgtca
1441 ggcctgtctc tgagactggt gaagaaagaa ccgaggcaac tagagctgac ctgggcgggg
1501 tcccggcccc gaagccctgg ggcgaacctg acctatgagc tgcacgtgct gaaccaggat
1561 gaagaacggt accagatggt tctagaaccc agggtcttgc tgacagagct gcagcctgac
1621 accacataca tcgtcagagt ccgaatgctg accccactgg gtcctggccc tttctcccct
1681 gatcatgagt ttcggaccag cccaccagtg tccaggggcc tgactggagg agagattgta
1741 gccgtcatct ttgggctgct gcttggtgca gccttgctgc ttgggattct cgttttccgg
1801 tccaggagag cccagcggca gaggcagcag aggcacgtga ccgcgccacc gatgtggatc
1861 gagaggacaa gctgtgctga agccttatgt ggtacctcca ggcatacgag gaccctgcac
1921 agggagcctt ggactttacc cggaggctgg tctaattttc cttcccggga gcttgatcca
1981 gcgtggctga tggtggacac tgtcatagga gaaggagagt ttggggaagt gtatcgaggg
2041 accctcaggc tccccagcca ggactgcaag actgtggcca ttaagacctt aaaagacaca
2101 tccccaggtg gccagtggtg gaacttcctt cgagaggcaa ctatcatggg ccagtttagc
2161 cacccgcata ttctgcatct ggaaggcgtc gtcacaaagc gaaagccgat catgatcatc
2221 acagaattta tggagaatgc agccctggat gccttcctga gggagcggga ggaccagctg
2281 gtccctgggc agctagtggc catgctgcag ggcatagcat ctggcatgaa ctacctcagt
2341 aatcacaatt atgtccaccg ggacctggct gccagaaaca tcttggtgaa tcaaaacctg
2401 tgctgcaagg tgtctgactt tggcctgact cgcctcctgg atgactttga tggcacatac
2461 gaaacccagg gaggaaagat ccctatccgt tggacagccc ctgaagccat tgcccatcgg
2521 atcttcacca cagccagcga tgtgtggagc tttgggattg tgatgtggga ggtgctgagc
2581 tttggggaca agccttatgg ggagatgagc aatcaggagg ttatgaagag cattgaggat
2641 gggtaccggt tgccccctcc tgtggactgc cctgcccctc tgtatgagct catgaagaac
2701 tgctgggcat atgaccgtgc ccgccggcca cacttccaga agcttcaggc acatctggag
2761 caactgcttg ccaaccccca ctccctgcgg accattgcca actttgaccc cagggtgact
2821 cttcgcctgc ccagcctgag tggctcagat gggatcccgt atcgaaccgt ctctgagtgg
2881 ctcgagtcca tacgcatgaa acgctacatc ctgcacttcc actcggctgg gctggacacc
2941 atggagtgtg tgctggagct gaccgctgag gacctgacgc agatgggaat cacactgccc
3001 gggcaccaga agcgcattct ttgcagtatt cagggattca aggactgatc cctcctctca
3061 ccccatgccc aatcagggtg caaggagcaa ggacggggcc aaggtcgctc atggtcactc
3121 cctgcgcccc ttcccacaac ctgccagact aggctatcgg tgctgcttct gcccgcttta
3181 aggagaaccc tgctctgcac cccagaaaac ctctttgttt taaaagggag gtgggggtag
3241 aagtaaaagg atgatcatgg gagggagctc aggggttaat atatatacat acatacacat
3301 atatatattg ttgtaaataa acaggaaatg attttctgcc tccatcccac ccatcagggc
3361 tgcaggcact
//