LOCUS AH003180 7931 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens clone Lambda-HGK[1,2] KLK2 gene, complete sequence; glandular kallikrein precursor, gene, complete cds; and KLK1 gene, complete sequence. ACCESSION AH003180 M18156 M18157 VERSION AH003180.2 KEYWORDS kallikrein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7931) AUTHORS Schedlich,L.J., Bennetts,B.H. and Morris,B.J. TITLE Primary structure of a human glandular kallikrein gene JOURNAL DNA 6 (5), 429-437 (1987) PUBMED 2824146 COMMENT On or before Jun 10, 2016 this sequence version replaced M18156.1, M18157.1, AH003180.1. FEATURES Location/Qualifiers source 1..7931 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="19q13.3" /clone="Lambda-HGK[1,2]" /tissue_type="liver" /dev_stage="fetal" gene 1..1692 /gene="KLK2" misc_feature 1..1692 /gene="KLK2" /note="G00-120-119" gap 1693..1792 /estimated_length=unknown prim_transcript 2286..>7432 /note="KAL mRNA and introns" CDS join(2315..2360,3567..3726,5316..5602,5716..5852, 7246..7401) /note="glandular kallikrein precursor" /codon_start=1 /protein_id="AAA74454.1" /translation="MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYS HGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYN MSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSI EPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLV CNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAANP" sig_peptide join(2315..2360,3567..3568) /note="glandular kallikrein signal peptide" sig_peptide join(2360,3567..3592) /note="glandular kallikrein signal peptide" mat_peptide join(3593..3726,5316) /product="glandular kallikrein" mat_peptide join(3725..3726,5316..5602,5716..5717) /product="glandular kallikrein" mat_peptide join(5602,5716..5852) /product="glandular kallikrein" mat_peptide 7246..7398 /product="glandular kallikrein" gene 2315..2360 /gene="KLK1" exon <2315..2360 /gene="KLK1" /note="glandular kallikrein precursor; G00-120-118" /number=1 intron 2361..3566 /note="KAL intron A" exon 3567..3726 /number=2 intron 3727..5315 /note="KAL intron B" exon 5316..5602 /number=3 intron 5603..5715 /note="KAL intron C" exon 5716..5852 /number=4 intron 5853..7245 /note="KAL intron D" exon 7246..>7401 /note="glandular kallikrein precursor" /number=5 BASE COUNT 1630 a 2153 c 2069 g 1979 t ORIGIN 883 bp upstream of BamHI site. 1 gagtttgggg attggcaatt taaaggtggt ttgggatggc atggctttgg gatggaaata 61 ggtttgtttt tatgttggct gggaagggtg tggggattga attggggatg aagtaggttt 121 agttttggag atagaataca tggagctggc tattgcatgc gaggatgtgc attagtttgg 181 tttgatcttt aaataaagga ggctattagg gttgtcttga attagattaa gttgtgttgg 241 gttgatgggt tgggcttgtg ggtgatgtgg ttggattggg ctgtgttaaa ttggtttggg 301 tcaggttttg gttgaggtta tcatggggat gaggatatgc ttgggacatg gattcaggtg 361 gttctcattc aagctgaggc aaatttcctt tcagacggtc attccaggga acgagtggtt 421 gtgtggggga aatcaggcca ctggctgtga atatccctct atcctggtct tgaattgtga 481 ttatctatgt ccattctgtc tccttcactg tacttggaat tgatctggtc attcagctgg 541 aaatggggga agattttgtc aaattcttga gacacagctg ggtctggatc agcgtaagcc 601 ttccttctgg ttttattgaa cagatgaaat cacatttttt ttttcaaaat cacagaaatc 661 ttatagagtt aacagtggac tcttataata agagttaaca ccaggactct tattcttgat 721 tcttttctga gacaccaaaa tgagatttct caatgccacc ctaattcttt tttttttttt 781 tttttttttt gagacacagt ctgggtcttt tgctctgtca ctcaggctgg agcgcagtgg 841 tgtgatcata gctcactgaa cccttgacct cctggactta agggatcctc ctgcttcagc 901 ctcctgagta gatggggcta caggtgcttg ccaccacacc tggctaatta aatttttttt 961 ttttttttgt agagaaaggg tctcactttg ttgccctggc tgatcttgaa cttctgactt 1021 caagtgattc ttcagccttg gactcccaaa gcactgggat tgctggcatg agccactcac 1081 cgtgcctggc ttgcagctta atcttggagt gtataaacct ggctcctgat agctagacat 1141 ttcagtgaga aggaggcatt ggattttgca tgaggacaat tctgacctag gagggcaggt 1201 caacaggaat ccccgctgta cctgtacgtt gtacaggcat ggagaatgag gagtgaggag 1261 gccgtaccgg aaccccatat tgtttagtgg acattggatt ttgaaataat agggaacttg 1321 gtctgggaga gtcatatttc tggattggac aatatgtggt atcacaaggt tttatgatga 1381 gggagaaatg tatgtgggga accattttct gagtgtggaa gtgcaagaat cagagagtag 1441 ctgaatgcca acgcttctat ttcaggaaca tggtaagttg gaggtccagc tctcgggctc 1501 agacgggtat agggaccagg aagtctcaca atccgatcat tctgatattt cagggcatat 1561 taggtttggg gtgcaaagga agtacttggg acttaggcac atgagacttt gtattgaaaa 1621 tcaatgattg gggctggccg tggtgctcac gcctgtaatc tcatcacttt gggagaccga 1681 agtgggagga tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngctggatg 1801 tggtggtgca tgcttgtggt ctcagctatc ctggaggctg agacaggaga atcggttgag 1861 tctgggagtt caaggctaca gggagctgcg atcacgccgc tgcactccag cctgggaaac 1921 agagtgagac tgtctcagaa tttttttaaa aaagaatcag tgatcatccc aacccctgtt 1981 gctgttcatc ctgagcctgc cttctctggc tttgttccct agatcacatc tccatgatcc 2041 ataggccctg cccaatctga cctcacaccg tgggaatgcc tccagactga tctagtatgt 2101 gtggaacagc aagtgctggc tctccctccc cttccacagc tctgggtgtg ggagggggtt 2161 gtccagcctc cagcagcatg gggagggcct tggtcagcat ctaggtgcca acagggcaag 2221 ggcggggtcc tggagaatga aggctttata gggctcctca gggaggcccc ccagccccaa 2281 actgcaccac ctggccgtgg acacctgtgt cagcatgtgg gacctggttc tctccatcgc 2341 cttgtctgtg gggtgcactg gtgagattgg ggggataaag gaaggggggc gggttctgac 2401 tcttatgctg aagccctttt cctcccaccc agtgccccag cctcgtccct tcagcccaca 2461 gttcagccca gacaatgtgc ccctgactct tccacattgc aatagtcctc atgcccacac 2521 taggtccccg ctccctccca cttacctcag acctttctct ccattgccca gccaaatccc 2581 tgctcccagc tgctttacta aagagcaagt tcctaggcat ctctgtgttt ctctttatgg 2641 ggttcaaaac ctttcaagga cctctctcca tgccactggt tccttggacc ctatcactgg 2701 gctgcctcct gagcccctca gtcctaccac agtctactga cttttcccat tcagctgtga 2761 gcattcaacc ctgtcccctg gaccttgaca cctggctccc caaccctgtc ccaggaaacc 2821 cagattccac cagacacttc cttcttcccc cccgaggcta tctggcctga gacaacaaat 2881 gctgcctccc accctgagtc tggcactggg actttcagaa ctcctccttc cctgactctt 2941 tgccccagac ccgtcattca atggctagct ttttccatgg gaagaagaac aacgagcacc 3001 cccaaccaca acggccagtt ctctgattcc ctaaatccgc acccttttca aaacctcaaa 3061 aacaaaacaa aacaaaacaa agcaagaaac aactcaggca aaacttgttg cttaaccttg 3121 gacatggtaa accatccaaa accttcctct cccagcaact aaacctctcc actgggcact 3181 taacctttgg tttcttggaa cctcttaatc tcttagaacc cacagctgcc accacatgcc 3241 cttctcccaa tgtaagaccc caaatcactc caaatgaccc aacccccaac ccatgcctcc 3301 ttcagatatt tcccatgtcc cctactctga tctctggggt cagctccgtt ctcgagagca 3361 tgaagcctcc cgacctggtc cagccaccaa cccgctaacg cagggaatag ctacagaatt 3421 gccagccctc ccaggacccc ttgcttgtgt cctggactcc cagtcctggt cctctgcccc 3481 catgtctctt caaacccaca gctcagctcc ctcccctatc caattctttt gggtctgatc 3541 cccctgaccc agcaccccct ccgcaggtgc cgtgcccctc atccagtctc ggattgtggg 3601 aggctgggag tgtgagaagc attcccaacc ctggcaggtg gctgtgtaca gtcatggatg 3661 ggcacactgt gggggtgtcc tggtgcaccc ccagtgggtg ctcacagctg cccattgcct 3721 aaagaagtaa gtaggaccct gggatctggg gagggaatgg ctgtgtccca caggaataac 3781 agcgggatgc ttcccccagg gtcacttctc aggtgaggct tcagactaaa ggagagaggg 3841 aaggtcctgg cccaggtcgc acccggaggc agagctgggg ctggaccact ctccccatgg 3901 ctgcctgggt ttctctctgt gtctgatctc gctgtgtctc ttggtatctg gctctggttg 3961 tgtctgtatg actgtgtttt ggtctctatg tccctctctc ttttctgtct ccctgtgtct 4021 gtgtctcccc cgtctctgtc tctgggtctc tctgtggcca tctctgtcac cgtgtgtctc 4081 accctgcatc tctttgcctg tctttctctc tgggtctctg cctcagccct tcctcatcac 4141 tactgaacac accccgtgag gtgggtgggg agcacccaga aaaaggaagg actttaagct 4201 caatgtgtgt gcatgtgagg gggtgcctgt cattgcacag cactctctgc aggacatccc 4261 tccaccctgg ggagacacag ggagggctgg tttcagctgt agctgggtgc acagttgagg 4321 agggaggaag gagaagggga aacaagaaag gaggggaagg tggccgggca cggtggccca 4381 cgcctgtaat cccagcactt tgggaggccg aggtgggtgg atcatctgag gtcaggagtt 4441 tgaaaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaataca aaaagtagcc 4501 aggcgtggtg ctgcgcgcct gtaatccaat tactagggag gctgaggcag gagaatcgct 4561 tgaacccggg aggcagaggt tgcagtgagc cgagatcgtg ccactgcact ccagcctggg 4621 tgacagagca agactccatc tcagaaaaaa caaacaaaca aacaaacaac aaaaaaaatc 4681 gaaaggaggg gaagggagct ggagagagaa agggggacat ggccctgagc tgtgggccgg 4741 gccacccgcc actacagagc cctcactcca gccccagctg caggtgagcc accctcatgc 4801 ctctcctcct ccccctgcta ctccacactc ctcagatgcc cccgtggcct ccctcctttt 4861 tctctcccac actgtatcac ccctggcttc ctctctgctg tttctccttc tctctctgac 4921 ttcccgcatc cttttctcat ttgtctattt ctcactccct tcctggttct gttctttctc 4981 ccttcctctt ccccatgtct atttcttgct gtctctgtct cttctttgct catcctaatt 5041 ctcactgttc tcccttctgt ttttgtcatt cctctgccat tttatgctct ctcttttcca 5101 cttcgtttct ttcagtttct gtctctgcct ctcacatgat cacactcctg ttttctaact 5161 cactgtctgt atttcaccac gactatatct ccccgacccc tgtgcttttc tcactgtttc 5221 tttttcttcc ctttggagtc tcccttatcc tcccctgccc catctacctt tccccatttt 5281 ctctctcctc atgcatccac ccccttcctc cccaggaata gccaggtctg gctgggtcgg 5341 cacaacctgt ttgagcctga agacacaggc cagagggtcc ctgtcagcca cagcttccca 5401 cacccgctct acaatatgag ccttctgaag catcaaagcc ttagaccaga tgaagactcc 5461 agccatgacc tcatgctgct ccgcctgtca gagcctgcca agatcacaga tgttgtgaag 5521 gtcctgggcc tgcccaccca ggagccagca ctggggacca cctgctacgc ctcaggctgg 5581 ggcagcatcg aaccagagga gtgtacgcct gggccagatg gtgtagctgg gagcccagat 5641 gcctgggtct gagggaagtg gggccaaaga accaggtggg gtccggccac agcccagttt 5701 ttctctgacc catagtcttg cgccccagga gtcttcagtg tgtgagcctc catctcctgt 5761 ccaatgacat gtgtgctaga gcttactctg agaaggtgac agagttcatg ttgtgtgctg 5821 ggctctggac aggtggtaaa gacacttgtg gggtgagtca tccctactcc caacatctgg 5881 aggggaaagg tgagtgaaga ccctaattct gggctgcaat ctgaaagcta accagacatc 5941 tgcctcccct gctccccagc tatagccacg ccccctcccc atgcctcatc tgccgccctc 6001 cttccccctt ccctgactcc ctcaacacaa gaggtgattc tcacagcata attcacccat 6061 tcctgtgttg agcacatgct tactgggcac tgctacgtga ccagcattgc cgtagaccct 6121 gggaagcagc agtgaacagg tagagagcag cctctccctc ctgcagcccc catgctggtg 6181 aggggcactg gcaggaacag tggacccaac atggaaatgc tggagggtgt caggaagtga 6241 tcgggctctg gggcagggag gaggggtggg gagtgtcact gggaggggac atcctgcaga 6301 aggtaggagt gagcaaacac ccgctgcagg ggaggggaga gccctgcggc acctggggga 6361 gcagagggag cagcacctgc ccaggcctgg gaggaggggc cgggagggcg tgaggaggag 6421 cgagggggct gcatggctgg agtgagggat caggggcagg gcgcgagatg gcctcacaca 6481 gggaagagag ggcccctcct gcagggcctc acctgggcca caggaggaca ctgcttttcc 6541 tctgaggagt caggagctgt ggatggtgct ggacagaaga aggacagggc ctggctcagg 6601 tgtccagagg ctgtcgctgg cttccctttg ggatcagact gcagggaggg agggcggcag 6661 ggttgtgggg ggagtgacga tgaggatgac ctgggggtgg ctccaggcct tgcccctgcc 6721 tgggccctca cccagcctcc ctcacagtct cctggccctc cagtctctcc cctccactcc 6781 atcctccatc tggcctcagt gggtcattct gatcactgaa ctgaccatac ccagccctgc 6841 ccacggccct ccatggctcc ccaatgccct ggagagggga catctagtca gagagtagtc 6901 ctgaagaggt ggcctctgcg atgtgcctgt gggggcagca acctgcagat ggtcccggcc 6961 ctcatcctgc tgacctgtct gcagggatgt cctcctggac cttgcccctg tgcaggagct 7021 ggaccctgaa gtcccctccc cataggccaa gactggagcc ttgttccctc tgttggactc 7081 cctgcccata ttcttgtggg agtgggttct ggagacattt ctgtctgttc ctgagagctg 7141 ggaattgctc tcagtcatct gcctgcgcgg ttctgagaga tggagttgcc taggcagtta 7201 ttggggccaa tctttctcac tgtgtctctc ctcctttacc cttagggtga ttctgggggt 7261 ccacttgtct gtaatggggt gcttcaaggt atcacatcat ggggccctga gccatgtgcc 7321 ctgcctgaaa agcctgctgt gtacaccaag gtggtgcatt accggaagtg gatcaaggac 7381 accatcgcag ccaacccctg agtgcccctg tcccacccct acctctagta aatttaagtc 7441 cacctcacgt tctggcatca cttggccttt ctggatgctg gacacctgaa gcttggaact 7501 cacctggccg aagctcgagc ctcctgagtc ctactgacct gtgctttctg gtgtggagtc 7561 cagggctgct aggaaaagga atgggcagac acaggtgtat gccaatgttt ctgaaatggg 7621 tataatttcg tcctctcctt cggaacactg gctgtctctg aagacttctc gctcagtttc 7681 agtgaggaca cacacaaaga cgtgggtgac catgttgttt gtggggtgca gagatgggag 7741 gggtggggcc cacctggaag agtggacagt gacacaaggt ggacactctc tacagatcac 7801 tgaggataag ctggagccac aatgcatgag gcacacacac agcaaggatg acgctgtaaa 7861 catagcccac gctgtcctgg gggcactggg aagcctagat aaggccgtga gcagaaagaa 7921 ggggaggatc c //