LOCUS       AH003180                7931 bp    DNA     linear   HUM 10-JUN-2016
DEFINITION  Homo sapiens clone Lambda-HGK[1,2] KLK2 gene, complete sequence;
            glandular kallikrein precursor, gene, complete cds; and KLK1 gene,
            complete sequence.
ACCESSION   AH003180 M18156 M18157
VERSION     AH003180.2
KEYWORDS    kallikrein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7931)
  AUTHORS   Schedlich,L.J., Bennetts,B.H. and Morris,B.J.
  TITLE     Primary structure of a human glandular kallikrein gene
  JOURNAL   DNA 6 (5), 429-437 (1987)
   PUBMED   2824146
COMMENT     On or before Jun 10, 2016 this sequence version replaced M18156.1,
            M18157.1, AH003180.1.
FEATURES             Location/Qualifiers
     source          1..7931
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="19q13.3"
                     /clone="Lambda-HGK[1,2]"
                     /tissue_type="liver"
                     /dev_stage="fetal"
     gene            1..1692
                     /gene="KLK2"
     misc_feature    1..1692
                     /gene="KLK2"
                     /note="G00-120-119"
     gap             1693..1792
                     /estimated_length=unknown
     prim_transcript 2286..>7432
                     /note="KAL mRNA and introns"
     CDS             join(2315..2360,3567..3726,5316..5602,5716..5852,
                     7246..7401)
                     /note="glandular kallikrein precursor"
                     /codon_start=1
                     /protein_id="AAA74454.1"
                     /translation="MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYS
                     HGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYN
                     MSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSI
                     EPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLV
                     CNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAANP"
     sig_peptide     join(2315..2360,3567..3568)
                     /note="glandular kallikrein signal peptide"
     sig_peptide     join(2360,3567..3592)
                     /note="glandular kallikrein signal peptide"
     mat_peptide     join(3593..3726,5316)
                     /product="glandular kallikrein"
     mat_peptide     join(3725..3726,5316..5602,5716..5717)
                     /product="glandular kallikrein"
     mat_peptide     join(5602,5716..5852)
                     /product="glandular kallikrein"
     mat_peptide     7246..7398
                     /product="glandular kallikrein"
     gene            2315..2360
                     /gene="KLK1"
     exon            <2315..2360
                     /gene="KLK1"
                     /note="glandular kallikrein precursor; G00-120-118"
                     /number=1
     intron          2361..3566
                     /note="KAL intron A"
     exon            3567..3726
                     /number=2
     intron          3727..5315
                     /note="KAL intron B"
     exon            5316..5602
                     /number=3
     intron          5603..5715
                     /note="KAL intron C"
     exon            5716..5852
                     /number=4
     intron          5853..7245
                     /note="KAL intron D"
     exon            7246..>7401
                     /note="glandular kallikrein precursor"
                     /number=5
BASE COUNT         1630 a         2153 c         2069 g         1979 t
ORIGIN      883 bp upstream of BamHI site.
        1 gagtttgggg attggcaatt taaaggtggt ttgggatggc atggctttgg gatggaaata
       61 ggtttgtttt tatgttggct gggaagggtg tggggattga attggggatg aagtaggttt
      121 agttttggag atagaataca tggagctggc tattgcatgc gaggatgtgc attagtttgg
      181 tttgatcttt aaataaagga ggctattagg gttgtcttga attagattaa gttgtgttgg
      241 gttgatgggt tgggcttgtg ggtgatgtgg ttggattggg ctgtgttaaa ttggtttggg
      301 tcaggttttg gttgaggtta tcatggggat gaggatatgc ttgggacatg gattcaggtg
      361 gttctcattc aagctgaggc aaatttcctt tcagacggtc attccaggga acgagtggtt
      421 gtgtggggga aatcaggcca ctggctgtga atatccctct atcctggtct tgaattgtga
      481 ttatctatgt ccattctgtc tccttcactg tacttggaat tgatctggtc attcagctgg
      541 aaatggggga agattttgtc aaattcttga gacacagctg ggtctggatc agcgtaagcc
      601 ttccttctgg ttttattgaa cagatgaaat cacatttttt ttttcaaaat cacagaaatc
      661 ttatagagtt aacagtggac tcttataata agagttaaca ccaggactct tattcttgat
      721 tcttttctga gacaccaaaa tgagatttct caatgccacc ctaattcttt tttttttttt
      781 tttttttttt gagacacagt ctgggtcttt tgctctgtca ctcaggctgg agcgcagtgg
      841 tgtgatcata gctcactgaa cccttgacct cctggactta agggatcctc ctgcttcagc
      901 ctcctgagta gatggggcta caggtgcttg ccaccacacc tggctaatta aatttttttt
      961 ttttttttgt agagaaaggg tctcactttg ttgccctggc tgatcttgaa cttctgactt
     1021 caagtgattc ttcagccttg gactcccaaa gcactgggat tgctggcatg agccactcac
     1081 cgtgcctggc ttgcagctta atcttggagt gtataaacct ggctcctgat agctagacat
     1141 ttcagtgaga aggaggcatt ggattttgca tgaggacaat tctgacctag gagggcaggt
     1201 caacaggaat ccccgctgta cctgtacgtt gtacaggcat ggagaatgag gagtgaggag
     1261 gccgtaccgg aaccccatat tgtttagtgg acattggatt ttgaaataat agggaacttg
     1321 gtctgggaga gtcatatttc tggattggac aatatgtggt atcacaaggt tttatgatga
     1381 gggagaaatg tatgtgggga accattttct gagtgtggaa gtgcaagaat cagagagtag
     1441 ctgaatgcca acgcttctat ttcaggaaca tggtaagttg gaggtccagc tctcgggctc
     1501 agacgggtat agggaccagg aagtctcaca atccgatcat tctgatattt cagggcatat
     1561 taggtttggg gtgcaaagga agtacttggg acttaggcac atgagacttt gtattgaaaa
     1621 tcaatgattg gggctggccg tggtgctcac gcctgtaatc tcatcacttt gggagaccga
     1681 agtgggagga tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngctggatg
     1801 tggtggtgca tgcttgtggt ctcagctatc ctggaggctg agacaggaga atcggttgag
     1861 tctgggagtt caaggctaca gggagctgcg atcacgccgc tgcactccag cctgggaaac
     1921 agagtgagac tgtctcagaa tttttttaaa aaagaatcag tgatcatccc aacccctgtt
     1981 gctgttcatc ctgagcctgc cttctctggc tttgttccct agatcacatc tccatgatcc
     2041 ataggccctg cccaatctga cctcacaccg tgggaatgcc tccagactga tctagtatgt
     2101 gtggaacagc aagtgctggc tctccctccc cttccacagc tctgggtgtg ggagggggtt
     2161 gtccagcctc cagcagcatg gggagggcct tggtcagcat ctaggtgcca acagggcaag
     2221 ggcggggtcc tggagaatga aggctttata gggctcctca gggaggcccc ccagccccaa
     2281 actgcaccac ctggccgtgg acacctgtgt cagcatgtgg gacctggttc tctccatcgc
     2341 cttgtctgtg gggtgcactg gtgagattgg ggggataaag gaaggggggc gggttctgac
     2401 tcttatgctg aagccctttt cctcccaccc agtgccccag cctcgtccct tcagcccaca
     2461 gttcagccca gacaatgtgc ccctgactct tccacattgc aatagtcctc atgcccacac
     2521 taggtccccg ctccctccca cttacctcag acctttctct ccattgccca gccaaatccc
     2581 tgctcccagc tgctttacta aagagcaagt tcctaggcat ctctgtgttt ctctttatgg
     2641 ggttcaaaac ctttcaagga cctctctcca tgccactggt tccttggacc ctatcactgg
     2701 gctgcctcct gagcccctca gtcctaccac agtctactga cttttcccat tcagctgtga
     2761 gcattcaacc ctgtcccctg gaccttgaca cctggctccc caaccctgtc ccaggaaacc
     2821 cagattccac cagacacttc cttcttcccc cccgaggcta tctggcctga gacaacaaat
     2881 gctgcctccc accctgagtc tggcactggg actttcagaa ctcctccttc cctgactctt
     2941 tgccccagac ccgtcattca atggctagct ttttccatgg gaagaagaac aacgagcacc
     3001 cccaaccaca acggccagtt ctctgattcc ctaaatccgc acccttttca aaacctcaaa
     3061 aacaaaacaa aacaaaacaa agcaagaaac aactcaggca aaacttgttg cttaaccttg
     3121 gacatggtaa accatccaaa accttcctct cccagcaact aaacctctcc actgggcact
     3181 taacctttgg tttcttggaa cctcttaatc tcttagaacc cacagctgcc accacatgcc
     3241 cttctcccaa tgtaagaccc caaatcactc caaatgaccc aacccccaac ccatgcctcc
     3301 ttcagatatt tcccatgtcc cctactctga tctctggggt cagctccgtt ctcgagagca
     3361 tgaagcctcc cgacctggtc cagccaccaa cccgctaacg cagggaatag ctacagaatt
     3421 gccagccctc ccaggacccc ttgcttgtgt cctggactcc cagtcctggt cctctgcccc
     3481 catgtctctt caaacccaca gctcagctcc ctcccctatc caattctttt gggtctgatc
     3541 cccctgaccc agcaccccct ccgcaggtgc cgtgcccctc atccagtctc ggattgtggg
     3601 aggctgggag tgtgagaagc attcccaacc ctggcaggtg gctgtgtaca gtcatggatg
     3661 ggcacactgt gggggtgtcc tggtgcaccc ccagtgggtg ctcacagctg cccattgcct
     3721 aaagaagtaa gtaggaccct gggatctggg gagggaatgg ctgtgtccca caggaataac
     3781 agcgggatgc ttcccccagg gtcacttctc aggtgaggct tcagactaaa ggagagaggg
     3841 aaggtcctgg cccaggtcgc acccggaggc agagctgggg ctggaccact ctccccatgg
     3901 ctgcctgggt ttctctctgt gtctgatctc gctgtgtctc ttggtatctg gctctggttg
     3961 tgtctgtatg actgtgtttt ggtctctatg tccctctctc ttttctgtct ccctgtgtct
     4021 gtgtctcccc cgtctctgtc tctgggtctc tctgtggcca tctctgtcac cgtgtgtctc
     4081 accctgcatc tctttgcctg tctttctctc tgggtctctg cctcagccct tcctcatcac
     4141 tactgaacac accccgtgag gtgggtgggg agcacccaga aaaaggaagg actttaagct
     4201 caatgtgtgt gcatgtgagg gggtgcctgt cattgcacag cactctctgc aggacatccc
     4261 tccaccctgg ggagacacag ggagggctgg tttcagctgt agctgggtgc acagttgagg
     4321 agggaggaag gagaagggga aacaagaaag gaggggaagg tggccgggca cggtggccca
     4381 cgcctgtaat cccagcactt tgggaggccg aggtgggtgg atcatctgag gtcaggagtt
     4441 tgaaaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaataca aaaagtagcc
     4501 aggcgtggtg ctgcgcgcct gtaatccaat tactagggag gctgaggcag gagaatcgct
     4561 tgaacccggg aggcagaggt tgcagtgagc cgagatcgtg ccactgcact ccagcctggg
     4621 tgacagagca agactccatc tcagaaaaaa caaacaaaca aacaaacaac aaaaaaaatc
     4681 gaaaggaggg gaagggagct ggagagagaa agggggacat ggccctgagc tgtgggccgg
     4741 gccacccgcc actacagagc cctcactcca gccccagctg caggtgagcc accctcatgc
     4801 ctctcctcct ccccctgcta ctccacactc ctcagatgcc cccgtggcct ccctcctttt
     4861 tctctcccac actgtatcac ccctggcttc ctctctgctg tttctccttc tctctctgac
     4921 ttcccgcatc cttttctcat ttgtctattt ctcactccct tcctggttct gttctttctc
     4981 ccttcctctt ccccatgtct atttcttgct gtctctgtct cttctttgct catcctaatt
     5041 ctcactgttc tcccttctgt ttttgtcatt cctctgccat tttatgctct ctcttttcca
     5101 cttcgtttct ttcagtttct gtctctgcct ctcacatgat cacactcctg ttttctaact
     5161 cactgtctgt atttcaccac gactatatct ccccgacccc tgtgcttttc tcactgtttc
     5221 tttttcttcc ctttggagtc tcccttatcc tcccctgccc catctacctt tccccatttt
     5281 ctctctcctc atgcatccac ccccttcctc cccaggaata gccaggtctg gctgggtcgg
     5341 cacaacctgt ttgagcctga agacacaggc cagagggtcc ctgtcagcca cagcttccca
     5401 cacccgctct acaatatgag ccttctgaag catcaaagcc ttagaccaga tgaagactcc
     5461 agccatgacc tcatgctgct ccgcctgtca gagcctgcca agatcacaga tgttgtgaag
     5521 gtcctgggcc tgcccaccca ggagccagca ctggggacca cctgctacgc ctcaggctgg
     5581 ggcagcatcg aaccagagga gtgtacgcct gggccagatg gtgtagctgg gagcccagat
     5641 gcctgggtct gagggaagtg gggccaaaga accaggtggg gtccggccac agcccagttt
     5701 ttctctgacc catagtcttg cgccccagga gtcttcagtg tgtgagcctc catctcctgt
     5761 ccaatgacat gtgtgctaga gcttactctg agaaggtgac agagttcatg ttgtgtgctg
     5821 ggctctggac aggtggtaaa gacacttgtg gggtgagtca tccctactcc caacatctgg
     5881 aggggaaagg tgagtgaaga ccctaattct gggctgcaat ctgaaagcta accagacatc
     5941 tgcctcccct gctccccagc tatagccacg ccccctcccc atgcctcatc tgccgccctc
     6001 cttccccctt ccctgactcc ctcaacacaa gaggtgattc tcacagcata attcacccat
     6061 tcctgtgttg agcacatgct tactgggcac tgctacgtga ccagcattgc cgtagaccct
     6121 gggaagcagc agtgaacagg tagagagcag cctctccctc ctgcagcccc catgctggtg
     6181 aggggcactg gcaggaacag tggacccaac atggaaatgc tggagggtgt caggaagtga
     6241 tcgggctctg gggcagggag gaggggtggg gagtgtcact gggaggggac atcctgcaga
     6301 aggtaggagt gagcaaacac ccgctgcagg ggaggggaga gccctgcggc acctggggga
     6361 gcagagggag cagcacctgc ccaggcctgg gaggaggggc cgggagggcg tgaggaggag
     6421 cgagggggct gcatggctgg agtgagggat caggggcagg gcgcgagatg gcctcacaca
     6481 gggaagagag ggcccctcct gcagggcctc acctgggcca caggaggaca ctgcttttcc
     6541 tctgaggagt caggagctgt ggatggtgct ggacagaaga aggacagggc ctggctcagg
     6601 tgtccagagg ctgtcgctgg cttccctttg ggatcagact gcagggaggg agggcggcag
     6661 ggttgtgggg ggagtgacga tgaggatgac ctgggggtgg ctccaggcct tgcccctgcc
     6721 tgggccctca cccagcctcc ctcacagtct cctggccctc cagtctctcc cctccactcc
     6781 atcctccatc tggcctcagt gggtcattct gatcactgaa ctgaccatac ccagccctgc
     6841 ccacggccct ccatggctcc ccaatgccct ggagagggga catctagtca gagagtagtc
     6901 ctgaagaggt ggcctctgcg atgtgcctgt gggggcagca acctgcagat ggtcccggcc
     6961 ctcatcctgc tgacctgtct gcagggatgt cctcctggac cttgcccctg tgcaggagct
     7021 ggaccctgaa gtcccctccc cataggccaa gactggagcc ttgttccctc tgttggactc
     7081 cctgcccata ttcttgtggg agtgggttct ggagacattt ctgtctgttc ctgagagctg
     7141 ggaattgctc tcagtcatct gcctgcgcgg ttctgagaga tggagttgcc taggcagtta
     7201 ttggggccaa tctttctcac tgtgtctctc ctcctttacc cttagggtga ttctgggggt
     7261 ccacttgtct gtaatggggt gcttcaaggt atcacatcat ggggccctga gccatgtgcc
     7321 ctgcctgaaa agcctgctgt gtacaccaag gtggtgcatt accggaagtg gatcaaggac
     7381 accatcgcag ccaacccctg agtgcccctg tcccacccct acctctagta aatttaagtc
     7441 cacctcacgt tctggcatca cttggccttt ctggatgctg gacacctgaa gcttggaact
     7501 cacctggccg aagctcgagc ctcctgagtc ctactgacct gtgctttctg gtgtggagtc
     7561 cagggctgct aggaaaagga atgggcagac acaggtgtat gccaatgttt ctgaaatggg
     7621 tataatttcg tcctctcctt cggaacactg gctgtctctg aagacttctc gctcagtttc
     7681 agtgaggaca cacacaaaga cgtgggtgac catgttgttt gtggggtgca gagatgggag
     7741 gggtggggcc cacctggaag agtggacagt gacacaaggt ggacactctc tacagatcac
     7801 tgaggataag ctggagccac aatgcatgag gcacacacac agcaaggatg acgctgtaaa
     7861 catagcccac gctgtcctgg gggcactggg aagcctagat aaggccgtga gcagaaagaa
     7921 ggggaggatc c
//