LOCUS HUMPOLP 3640 bp mRNA linear HUM 08-JAN-1995
DEFINITION Human poly(ADP-ribose) polymerase mRNA, complete cds.
ACCESSION M18112
VERSION M18112.1
KEYWORDS polymerase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3640)
AUTHORS Uchida,K., Morita,T., Sato,T., Ogura,T., Yamashita,R., Noguchi,S.,
Suzuki,H., Nyunoya,H., Miwa,M. and Sugimura,T.
TITLE Nucleotide sequence of a full-length cDNA for human fibroblast
poly(ADP-ribose) polymerase
JOURNAL Biochem. Biophys. Res. Commun. 148 (2), 617-622 (1987)
PUBMED 3120710
COMMENT Original source text: Human SV40 transformed fibroblast, cDNA to
mRNA, clone pPAP.
Draft entry and computer readable sequence for [1] kindly provided
by K.Uchida, 02-MAR-1988.
FEATURES Location/Qualifiers
source 1..3640
/db_xref="H-InvDB:HIT000194617"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1q41-q42"
gene 1..3640
/gene="PPOL"
mRNA <1..3640
/gene="PPOL"
/product="POLP mRNA"
CDS 140..3184
/gene="PPOL"
/note="poly(ADP-ribose) polymerase"
/codon_start=1
/protein_id="AAA60137.1"
/db_xref="GDB:G00-119-508"
/translation="MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMF
DGKVPHWYHFSCFWKVGHSIRHPDVQVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGI
GSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHP
GCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDE
VAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGE
SAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
TPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSN
MKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSK
GQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
NSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGN
AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESM
KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLI
PHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
TDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHN
RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGD
PIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLG
TGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
BASE COUNT 999 a 833 c 1008 g 800 t
ORIGIN Chromosome 1p11-qter.
1 aatctatcag gaacgcgtgc gtcgcgtgtt cgtgcggctc tggccgctca gctcggctgg
61 gtgagcgcac gcgagcgcag cggcagcgtg tttctaggtc gtgcgtcggg cttccggagc
121 tttgcggcag ctagggagga tggcggagtc ttcggataag ctctatcgag tcgagtacgc
181 caagagcggg cgcgcctctt gcaagaaatg cagcgagagc atccccaagg actcgctccg
241 gatggccatc atggtgcagt cgcccatgtt tgatggaaaa gtcccacact ggtaccactt
301 ctcctgcttc tggaaggtgg gccactccat ccggcaccct gacgttcagg tggatgggtt
361 ctctgagctt cggtgggatg accagcagaa agtcaagaag acagcggaag ctggaggagt
421 gacaggcaaa ggccaggatg gaattggtag caaggcagag aagactctgg gtgactttgc
481 agcagagtat gccaagtcca acagaagtac gtgcaagggg tgtatggaga agatagaaaa
541 gggccaggtg cgcctgtcca agaagatggt ggacccggag aagccacagc taggcatgat
601 tgaccgctgg taccatccag gctgctttgt caagaacagg gaggagctgg gtttccggcc
661 cgagtacagt gcgagtcagc tcaagggctt cagcctcctt gctacagagg ataaagaagc
721 cctgaagaag cagctcccag gagtcaagag tgaaggaaag agaaaaggcg atgaggtgga
781 tggagtggat gaagtggcga agaagaaatc taaaaaagaa aaagacaagg atagtaagct
841 tgaaaaagcc ctaaaggctc agaacgacct gatctggaac atcaaggacg agctaaagaa
901 agtgtgttca actaatgacc tgaaggagct actcatcttc aacaagcagc aagtgccttc
961 tggggagtcg gcgatcttgg accgagtagc tgatggcatg gtgttcggtg ccctccttcc
1021 ctgcgaggaa tgctcgggtc agctggtctt caagagcgat gcctattact gcactgggga
1081 cgtcactgcc tggaccaagt gtatggtcaa gacacagaca cccaaccgga aggagtgggt
1141 aaccccaaag gaattccgag aaatctctta cctcaagaaa ttgaaggtta aaaagcagga
1201 ccgtatattc cccccagaaa ccagcgcctc cgtggcggcc acgcctccgc cctccacagc
1261 ctcggctcct gctgctgtga actcctctgc ttcagcagat aagccattat ccaacatgaa
1321 gatcctgact ctcgggaagc tgtcccggaa caaggatgaa gtgaaggcca tgattgagaa
1381 actcgggggg aagttgacgg ggacggccaa caaggcttcc ctgtgcatca gcaccaaaaa
1441 ggaggtggaa aagatgaata agaagatgga ggaagtaaag gaagccaaca tccgagttgt
1501 gtctgaggac ttcctccagg acgtctccgc ctccaccaag agccttcagg agttgttctt
1561 agcgcacatc ttgtcccctt ggggggcaga ggtgaaggca gagcctgttg aagttgtggc
1621 cccaagaggg aagtcagggg ctgcgctctc caaaaaaagc aagggccagg tcaaggagga
1681 aggtatcaac aaatctgaaa agagaatgaa attaactctt aaaggaggag cagctgtgga
1741 tcctgattct ggactggaac actctgcgca tgtcctggag aaaggtggga aggtcttcag
1801 tgccaccctt ggcctggtgg acatcgttaa aggaaccaac tcctactaca agctgcagct
1861 tctggaggac gacaaggaaa acaggtattg gatattcagg tcctggggcc gtgtgggtac
1921 ggtgatcggt agcaacaaac tggaacagat gccgtccaag gaggatgcca ttgagcactt
1981 catgaaatta tatgaagaaa aaaccgggaa cgcttggcac tccaaaaatt tcacgaagta
2041 tcccaaaaag ttctaccccc tggagattga ctatggccag gatgaagagg cagtgaagaa
2101 gctgacagta aatcctggca ccaagtccaa gctccccaag ccagttcagg acctcatcaa
2161 gatgatcttt gatgtggaaa gtatgaagaa agccatggtg gagtatgaga tcgaccttca
2221 gaagatgccc ttggggaagc tgagcaaaag gcagatccag gccgcatact ccatcctcag
2281 tgaggtccag caggcggtgt ctcagggcag cagcgactct cagatcctgg atctctcaaa
2341 tcgcttttac accctgatcc cccacgactt tgggatgaag aagcctccgc tcctgaacaa
2401 tgcagacagt gtgcaggcca aggtggaaat gcttgacaac ctgctggaca tcgaggtggc
2461 ctacagtctg ctcaggggag ggtctgatga tagcagcaag gatcccatcg atgtcaacta
2521 tgagaagctc aaaactgaca ttaaggtggt tgacagagat tctgaagaag ccgagatcat
2581 caggaagtat gttaagaaca ctcatgcaac cacacacaat gcgtatgact tggaagtcat
2641 cgatatcttt aagatagagc gtgaaggcga atgccagcgt tacaagccct ttaagcagct
2701 tcataaccga agattgctgt ggcacgggtc caggaccacc aactttgctg ggatcctgtc
2761 ccagggtctt cggatagccc cgcctgaagc gcccgtgaca ggctacatgt ttggtaaagg
2821 gatctatttc gctgacatgg tctccaagag tgccaactac tgccatacgt ctcagggaga
2881 cccaataggc ttaatcctgt tgggagaagt tgcccttgga aacatgtatg aactgaagca
2941 cgcttcacat atcagcaagt tacccaaggg caagcacagt gtcaaaggtt tgggcaaaac
3001 tacccctgat ccttcagcta acattagtct ggatggtgta gacgttcctc ttgggaccgg
3061 gatttcatct ggtgtgaatg acacctctct actatataac gagtacattg tctatgatat
3121 tgctcaggta aatctgaagt atctgctgaa actgaaattc aattttaaga cctccctgtg
3181 gtaattggga gaggtagccg agtcacaccc ggtggctctg gtatgaattc acccgaagcg
3241 cttctgcacc aactcacctg gccgctaagt tgctgatggg tagtacctgt actaaaccac
3301 ctcagaaagg attttacaga aacgtgttaa aggttttctc taacttctca agtcccttgt
3361 tttgtgttgt gtctgtgggg aggggttgtt ttggggttgt ttttgttttt tcttgccagg
3421 tagataaaac tgacatagag aaaaggctgg agagagattc tgttgcatag actagtccta
3481 tggaaaaaac caagcttcgt tagaatgtct gccttactgg tttccccagg gaaggaaaaa
3541 tacacttcca cccttttttc taagtgttcg tctttagttt tgattttgga aagatgttaa
3601 gcatttattt ttagttaaaa ataaaaacta atttcatact
//