LOCUS HUMTHX 1921 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human tyrosine hydroxylase type 4 mRNA, complete cds.
ACCESSION M17589
VERSION M17589.1
KEYWORDS tyrosine hydroxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1921)
AUTHORS Nagatsu,T.
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 282)
AUTHORS Kaneda,N., Kobayashi,K., Ichinose,H., Kishi,F., Nakazawa,A.,
Kurosawa,Y., Fujita,K. and Nagatsu,T.
TITLE Isolation of a novel cDNA clone for human tyrosine hydroxylase:
alternative RNA splicing produces four kinds of mRNA from a single
gene
JOURNAL Biochem. Biophys. Res. Commun. 146 (3), 971-975 (1987)
PUBMED 2887169
COMMENT Original source text: Human (adult) pheochromocytoma, cDNA to mRNA,
clone hTH 502 (type 4).
Draft entry and computer-readable sequence for [2] kindly provided
by T.Nagatsu, 12/23/87.
FEATURES Location/Qualifiers
source 1..1921
/db_xref="H-InvDB:HIT000194552"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="11p15.5"
gene 1..1921
/gene="TH"
CDS 10..1596
/gene="TH"
/note="tyrosine hydroxylase type 4 (EC 1.14.16.2)"
/codon_start=1
/protein_id="AAA61179.1"
/translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGS
PWPGTAAPAASYTPTPRSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAV
AFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLE
YFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDL
DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYAT
HACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASL
AFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDE
EIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAV
QPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRR
SLEGVQDELDTLAHALSAIG"
BASE COUNT 332 a 657 c 598 g 334 t
ORIGIN 119 bp upstream of SmaI site; chromosome 11p15.5.
1 cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt ccgcagggcc
61 gtgtctgagc tggacgccaa gcaggcagag gccatcatgg taagagggca gggcgccccg
121 gggcccagcc tcacaggctc tccgtggcct ggaactgcag ccccagctgc atcctacacc
181 cccaccccaa ggtccccgcg gttcattggg cgcaggcaga gcctcatcga ggacgcccgc
241 aaggagcggg aggcggcggt ggcagcagcg gccgctgcag tcccctcgga gcccggggac
301 cccctggagg ctgtggcctt tgaggagaag gaggggaagg ccgtgctaaa cctgctcttc
361 tccccgaggg ccaccaagcc ctcggcgctg tcccgagctg tgaaggtgtt tgagacgttt
421 gaagccaaaa tccaccatct agagacccgg cccgcccaga ggccgcgagc tgggggcccc
481 cacctggagt acttcgtgcg cctcgaggtg cgccgagggg acctggccgc cctgctcagt
541 ggtgtgcgcc aggtgtcaga ggacgtgcgc agccccgcgg ggcccaaggt cccctggttc
601 ccaagaaaag tgtcagagct ggacaagtgt catcacctgg tcaccaagtt cgaccctgac
661 ctggacttgg accacccggg cttctcggac caggtgtacc gccagcgcag gaagctgatt
721 gctgagatcg ccttccagta caggcacggc gacccgattc cccgtgtgga gtacaccgcc
781 gaggagattg ccacctggaa ggaggtctac accacgctga agggcctcta cgccacgcac
841 gcctgcgggg agcacctgga ggcctttgct ttgctggagc gcttcagcgg ctaccgggaa
901 gacaatatcc cccagctgga ggacgtctcc cgcttcctga aggagcgcac gggcttccag
961 ctgcggcctg tggccggcct gctgtccgcc cgggacttcc tggccagcct ggccttccgc
1021 gtgttccagt gcacccagta tatccgccac gcgtcctcgc ccatgcactc ccctgagccg
1081 gactgctgcc acgagctgct ggggcacgtg cccatgctgg ccgaccgcac cttcgcgcag
1141 ttctcgcagg acattggcct ggcgtccctg ggggcctcgg atgaggaaat tgagaagctg
1201 tccacgctgt catggttcac ggtggagttc gggctgtgta agcagaacgg ggaggtgaag
1261 gcctatggtg ccgggctgct gtcctcctac ggggagctcc tgcactgcct gtctgaggag
1321 cctgagattc gggccttcga ccctgaggct gcggccgtgc agccctacca agaccagacg
1381 taccagtcag tctacttcgt gtctgagagc ttcagtgacg ccaaggacaa gctcaggagc
1441 tatgcctcac gcatccagcg ccccttctcc gtgaagttcg acccgtacac gctggccatc
1501 gacgtgctgg acagccccca ggccgtgcgg cgctccctgg agggtgtcca ggatgagctg
1561 gacacccttg cccatgcgct gagtgccatt ggctaggtgc acggcgtccc tgagggccct
1621 tcccaacctc ccctggtcct gcactgtccc ggagctcagg ccctggtgag gggctgggtc
1681 ccgggtgccc cccatgccct ccctgctgcc aggctcccac tgcccctgca cctgcttctc
1741 agcgcaacag ctgtgtgtgc ccgtggtgag gttgtgctgc ctgtggtgag gtcctgtcct
1801 ggctcccagg gtcctggggg ctgctgcact gccctccgcc cttccctgac actgtctgct
1861 gccccaatca ccgtcacaat aaaagaaact gtggtctcta aaaaaaaaaa aaaaaaaaaa
1921 a
//