LOCUS HUMCYPAX 1829 bp mRNA linear HUM 27-APR-1993
DEFINITION Human cytochrome P-450 1 functional form mRNA, complete cds.
ACCESSION M17397 J03472
VERSION M17397.1
KEYWORDS alternative splicing; cytochrome P450.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1829)
AUTHORS Okino,S.T., Quattrochi,L.C., Pendurthi,U.R., McBride,O.W. and
Tukey,R.H.
TITLE Characterization of multiple human cytochrome P-450 1 cDNAs. The
chromosomal localization of the gene and evidence for alternate RNA
splicing
JOURNAL J. Biol. Chem. 262 (33), 16072-16079 (1987)
PUBMED 3500169
COMMENT Original source text: Human liver, cDNA to mRNA, clone HP1-1.
Draft entry and computer-readable sequence for [1] kindly provided
by R.Tukey, 02-OCT-1987.
The two mRNAs encoding citochrome P-450 1 were derived from the
same gene by alternative splicing. The other one is to
be found under accession M17398.
A polyadenylation signal is located at positions 1801-1806.
FEATURES Location/Qualifiers
source 1..1829
/db_xref="H-InvDB:HIT000194539"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 2..1474
/note="cytochrome P-450 1"
/codon_start=1
/protein_id="AAA35739.1"
/translation="MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQ
IDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPI
SQRITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTK
ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN
FPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKD
NQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRH
RSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLT
SVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLT
TILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV"
BASE COUNT 533 a 407 c 361 g 528 t
ORIGIN 337 bp upstream of XmnI site; chromosome 10.
1 aatggaacct tttgtggtcc tggtgctgtg tctctctttt atgcttctct tttcactctg
61 gagacagagc tgtaggagaa ggaagctccc tcctggcccc actcctcttc ctattattgg
121 aaatatgcta cagatagatg ttaaggacat ctgcaaatct ttcaccaatt tctcaaaagt
181 ctatggtcct gtgttcaccg tgtattttgg catgaatccc atagtggtgt ttcatggata
241 tgaggcagtg aaggaagccc tgattgataa tggagaggag ttttctggaa gaggcaattc
301 cccaatatct caaagaatta ctaaaggact tggaatcatt tccagcaatg gaaagagatg
361 gaaggagatc cggcgtttct ccctcacaaa cttgcggaat tttgggatgg ggaagaggag
421 cattgaggac cgtgttcaag aggaagctca ctgccttgtg gaggagttga gaaaaaccaa
481 ggcttcaccc tgtgatccca ctttcatcct gggctgtgct ccctgcaatg tgatctgctc
541 cgttgttttc cagaaacgat ttgattataa agatcagaat tttctcaccc tgatgaaaag
601 attcaatgaa aacttcagga ttctgaactc cccatggatc caggtctgca ataatttccc
661 tctactcatt gattgtttcc caggaactca caacaaagtg cttaaaaatg ttgctcttac
721 acgaagttac attagggaga aagtaaaaga acaccaagca tcactggatg ttaacaatcc
781 tcgggacttt atggattgct tcctgatcaa aatggagcag gaaaaggaca accaaaagtc
841 agaattcaat attgaaaact tggttggcac tgtagctgat ctatttgttg ctggaacaga
901 gacaacaagc accactctga gatatggact cctgctcctg ctgaagcacc cagaggtcac
961 agctaaagtc caggaagaga ttgatcatgt aattggcaga cacaggagcc cctgcatgca
1021 ggataggagc cacatgcctt acactgatgc tgtagtgcac gagatccaga gatacagtga
1081 ccttgtcccc accggtgtgc cccatgcagt gaccactgat actaagttca gaaactacct
1141 catccccaag ggcacaacca taatggcatt actgacttcc gtgctacatg atgacaaaga
1201 atttcctaat ccaaatatct ttgaccctgg ccactttcta gataagaatg gcaactttaa
1261 gaaaagtgac tacttcatgc ctttctcagc aggaaaacga atttgtgcag gagaaggact
1321 tgcccgcatg gagctatttt tatttctaac cacaatttta cagaacttta acctgaaatc
1381 tgttgatgat ttaaagaacc tcaatactac tgcagttacc aaagggattg tttctctgcc
1441 accctcatac cagatctgct tcatccctgt ctgaagaatg ctagcccatc tggctgctga
1501 tctgctatca cctgcaactc tttttttatc aaggacattc ccactattat gtcttctctg
1561 acctctcatc aaatcttccc attcactcaa tatcccataa gcatccaaac tccattaagg
1621 agagttgttc aggtcactgc acaaatatat ctgcaattat tcatactctg taacacttgt
1681 attaattgct gcatatgcta atacttttct aatgctgact ttttaatatg ttatcactgt
1741 aaaacacaga aaagtgatta atgaatgata atttagtcca tttcttttgt gaatgtgcta
1801 aataaaaagt gttattaatt gctggttca
//