LOCUS HUMANTCE 3036 bp DNA linear HUM 08-AUG-1995
DEFINITION Human carcinoembryonic antigen gene, complete cds.
ACCESSION M17303
VERSION M17303.1
KEYWORDS carcinoembryonic antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3036)
AUTHORS Beauchemin,N.
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2541)
AUTHORS Beauchemin,N., Benchimol,S., Cournoyer,D., Fuks,A. and
Stanners,C.P.
TITLE Isolation and characterization of full-length functional cDNA
clones for human carcinoembryonic antigen
JOURNAL Mol. Cell. Biol. 7 (9), 3221-3230 (1987)
PUBMED 3670312
COMMENT Original source text: Human colonic adenocarcinoma cell line Ls180,
cDNA to mRNA, and DNA.
Draft entry and computer-readable sequence for [2],[1] kindly
provided by N.Beauchemin, 23-NOV-1987.
[1] revises [2].
FEATURES Location/Qualifiers
source 1..3036
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="19q13.2"
mRNA 1..2541
/product="CEA mRNA"
variation 58
/note="a in one clone; t in another"
/replace="t"
gene 97..2205
/gene="CEA"
CDS 97..2205
/gene="CEA"
/note="carcinoembryonic antigen precursor"
/codon_start=1
/protein_id="AAB59513.1"
/db_xref="GDB:G00-119-054"
/translation="MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFN
VAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY
PNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK
DAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ
NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT
FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP
VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYE
CGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWL
IDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSN
NSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDA
RAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ
YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPG
LSAGATVGIMIGVLVGVALI"
sig_peptide 97..198
/gene="CEA"
/note="carcinoembryonic antigen signal peptide"
mat_peptide 199..2202
/gene="CEA"
/product="carcinoembryonic antigen"
repeat_region 2330..2560
/note="Alu repeat"
BASE COUNT 860 a 853 c 614 g 709 t
ORIGIN 477 bp upstream of BglII site; chromosome 19.
1 cgaccagcag accagacagt cacagcagcc ttgacaaaac gttcctggaa ctcaagcact
61 tctccacaga ggaggacaga gcagacagca gagaccatgg agtctccctc ggcccctccc
121 cacagatggt gcatcccctg gcagaggctc ctgctcacag cctcacttct aaccttctgg
181 aacccgccca ccactgccaa gctcactatt gaatccacgc cgttcaatgt cgcagagggg
241 aaggaggtgc ttctacttgt ccacaatctg ccccagcatc tttttggcta cagctggtac
301 aaaggtgaaa gagtggatgg caaccgtcaa attataggat atgtaatagg aactcaacaa
361 gctaccccag ggcccgcata cagtggtcga gagataatat accccaatgc atccctgctg
421 atccagaaca tcatccagaa tgacacagga ttctacaccc tacacgtcat aaagtcagat
481 cttgtgaatg aagaagcaac tggccagttc cgggtatacc cggagctgcc caagccctcc
541 atctccagca acaactccaa acccgtggag gacaaggatg ctgtggcctt cacctgtgaa
601 cctgagactc aggacgcaac ctacctgtgg tgggtaaaca atcagagcct cccggtcagt
661 cccaggctgc agctgtccaa tggcaacagg accctcactc tattcaatgt cacaagaaat
721 gacacagcaa gctacaaatg tgaaacccag aacccagtga gtgccaggcg cagtgattca
781 gtcatcctga atgtcctcta tggcccggat gcccccacca tttcccctct aaacacatct
841 tacagatcag gggaaaatct gaacctctcc tgccatgcag cctctaaccc acctgcacag
901 tactcttggt ttgtcaatgg gactttccag caatccaccc aagagctctt tatccccaac
961 atcactgtga ataatagtgg atcctatacg tgccaagccc ataactcaga cactggcctc
1021 aataggacca cagtcacgac gatcacagtc tatgcagagc cacccaaacc cttcatcacc
1081 agcaacaact ccaaccccgt ggaggatgag gatgctgtag ccttaacctg tgaacctgag
1141 attcagaaca caacctacct gtggtgggta aataatcaga gcctcccggt cagtcccagg
1201 ctgcagctgt ccaatgacaa caggaccctc actctactca gtgtcacaag gaatgatgta
1261 ggaccctatg agtgtggaat ccagaacgaa ttaagtgttg accacagcga cccagtcatc
1321 ctgaatgtcc tctatggccc agacgacccc accatttccc cctcatacac ctattaccgt
1381 ccaggggtga acctcagcct ctcctgccat gcagcctcta acccacctgc acagtattct
1441 tggctgattg atgggaacat ccagcaacac acacaagagc tctttatctc caacatcact
1501 gagaagaaca gcggactcta tacctgccag gccaataact cagccagtgg ccacagcagg
1561 actacagtca agacaatcac agtctctgcg gagctgccca agccctccat ctccagcaac
1621 aactccaaac ccgtggagga caaggatgct gtggccttca cctgtgaacc tgaggctcag
1681 aacacaacct acctgtggtg ggtaaatggt cagagcctcc cagtcagtcc caggctgcag
1741 ctgtccaatg gcaacaggac cctcactcta ttcaatgtca caagaaatga cgcaagagcc
1801 tatgtatgtg gaatccagaa ctcagtgagt gcaaaccgca gtgacccagt caccctggat
1861 gtcctctatg ggccggacac ccccatcatt tcccccccag actcgtctta cctttcggga
1921 gcgaacctca acctctcctg ccactcggcc tctaacccat ccccgcagta ttcttggcgt
1981 atcaatggga taccgcagca acacacacaa gttctcttta tcgccaaaat cacgccaaat
2041 aataacggga cctatgcctg ttttgtctct aacttggcta ctggccgcaa taattccata
2101 gtcaagagca tcacagtctc tgcatctgga acttctcctg gtctctcagc tggggccact
2161 gtcggcatca tgattggagt gctggttggg gttgctctga tatagcagcc ctggtgtagt
2221 ttcttcattt caggaagact gacagttgtt ttgcttcttc cttaaagcat ttgcaacagc
2281 tacagtctaa aattgcttct ttaccaagga tatttacaga aaagactctg accagagatc
2341 gagaccatcc tagccaacat cgtgaaaccc catctctact aaaaatacaa aaatgagctg
2401 ggcttggtgg cgcgcacctg tagtcccagt tactcgggag gctgaggcag gagaatcgct
2461 tgaacccggg aggtggagat tgcagtgagc ccagatcgca ccactgcact ccagtctggc
2521 aacagagcaa gactccatct caaaaagaaa agaaaagaag actctgacct gtactcttga
2581 atacaagttt ctgataccac tgcactgtct gagaatttcc aaaactttaa tgaactaact
2641 gacagcttca tgaaactgtc caccaagatc aagcagagaa aataattaat ttcatgggac
2701 taaatgaact aatgaggata atattttcat aattttttat ttgaaatttt gctgattctt
2761 taaatgtctt gtttcccaga tttcaggaaa ctttttttct tttaagctat ccacagctta
2821 cagcaatttg ataaaatata cttttgtgaa caaaaattga gacatttaca ttttctccct
2881 atgtggtcgc tccagacttg ggaaactatt catgaatatt tatattgtat ggtaatatag
2941 ttattgcaca agttcaataa aaatctgctc tttgtatgac agaatacatt tgaaaacatt
3001 ggttatatta ccaagacttt gactagaatg tcgtat
//