LOCUS       HUMC8AS                 2397 bp    mRNA    linear   HUM 07-NOV-1994
DEFINITION  Human complement protein C8 alpha subunit mRNA, complete cds.
ACCESSION   M16974
VERSION     M16974.1
KEYWORDS    complement C8; complement C8-alpha; serum protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2397)
  AUTHORS   Rao,A.G., Howard,O.M., Ng,S.C., Whitehead,A.S., Colten,H.R. and
            Sodetz,J.M.
  TITLE     Complementary DNA and derived amino acid sequence of the alpha
            subunit of human complement protein C8: evidence for the existence
            of a separate alpha subunit messenger RNA
  JOURNAL   Biochemistry 26 (12), 3556-3564 (1987)
   PUBMED   2820471
REFERENCE   2  (bases 1 to 2394)
  AUTHORS   Sodetz,J.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-1988) J.M. Sodetz, Department of Chemistry and
            Biochemistry, University of South Columbia, SC 29208, USA
REFERENCE   3  (bases 1 to 2394)
  AUTHORS   Sodetz,J.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-FEB-1993) J.M. Sodetz, Department of Chemistry and
            Biochemistry, University of South Columbia, SC 29208, USA
COMMENT     Original source text: Human cDNA to mRNA.
            [1] [2] are revised by [3].
FEATURES             Location/Qualifiers
     source          1..2397
                     /db_xref="H-InvDB:HIT000194505"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="1p32"
                     /map="360 bp upstream of PstI site; chromosome
                     1p36.2-p22.1"
                     /clone="A1 and B1"
                     /tissue_type="liver"
     gene            1..2397
                     /gene="C8A"
     mRNA            1..2397
                     /gene="C8A"
                     /product="C8 mRNA"
     CDS             138..1892
                     /gene="C8A"
                     /note="complement protein C8 alpha subunit precursor"
                     /codon_start=1
                     /protein_id="AAA52200.1"
                     /db_xref="GDB:G00-119-735"
                     /translation="MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNW
                     SEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQC
                     KETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILT
                     QEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFE
                     ALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFL
                     NELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFI
                     NDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKINVGG
                     GLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTITYRSWGRSL
                     KYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVP
                     ILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRAGIQERRRECDNPA
                     PQNGGASCPGRKVQTQAC"
     sig_peptide     138..227
                     /gene="C8A"
                     /note="complement protein C8 alpha subunit signal peptide"
     mat_peptide     228..1889
                     /gene="C8A"
                     /product="complement protein C8 alpha subunit"
BASE COUNT          684 a          504 c          605 g          604 t
ORIGIN      
        1 tttttttttt catcctactt tgttttattg ggcgttgatt gttacaggtc ccagcctgta
       61 gacatctttt actccaattt cctgaataga tagctttatt ccttcaaggt aatatagtgc
      121 ggtggcttct ggctgagatg tttgctgttg ttttcttcat cttgtctttg atgacttgtc
      181 agcctggggt aactgcacag gagaaggtga accagagagt aagacgggca gctacacccg
      241 cagcagttac ctgccagctg agcaactggt cagagtggac agattgcttt ccgtgccagg
      301 acaaaaagta ccgacaccgg agcctcttgc agccaaacaa gtttggggga accatctgca
      361 gtggtgacat ctgggatcaa gccagctgct ccagttctac aacttgtgta aggcaagcac
      421 agtgtggaca ggatttccag tgtaaggaga caggtcgctg cctgaaacgc caccttgtgt
      481 gtaatggaga ccaggactgc cttgatggct ctgatgagga cgactgtgaa gatgtcaggg
      541 ccattgacga agactgcagc cagtatgaac caattccagg atcacagaag gcagccttgg
      601 ggtacaatat cctgacccag gaagatgctc agagtgtgta cgatgccagt tattatgggg
      661 gccagtgtga gacggtatac aatggggaat ggagggagct tcgatatgac tccacctgtg
      721 aacgtctcta ctatggagat gatgagaaat actttcggaa accctacaac tttctgaagt
      781 accactttga agccctggca gatactggaa tctcctcaga gttttatgat aatgcaaatg
      841 accttctttc caaagttaaa aaagacaagt ctgactcatt tggagtgacc atcggcatag
      901 gcccagccgg cagcccttta ttggtgggtg taggtgtatc ccactcacaa gacacttcat
      961 tcttgaacga attaaacaag tataatgaga agaaattcat tttcacaaga atcttcacaa
     1021 aggtgcagac tgcacatttt aagatgagga aggatgacat tatgctggat gaaggaatgc
     1081 tgcagtcatt aatggagctt ccagatcagt acaattatgg catgtatgcc aagttcatca
     1141 atgactatgg cacccattac atcacatctg gatccatggg tggcatttat gaatatatcc
     1201 tggtgattga caaagcaaaa atggaatccc ttggtattac cagcagagat atcacgacat
     1261 gttttggagg ctccttgggc attcaatatg aagacaaaat aaatgttggt ggaggtttat
     1321 caggagacca ttgtaaaaaa tttggaggtg gcaaaactga aagggccagg aaggccatgg
     1381 ctgtggaaga cattatttct cgggtgcgag gtggcagttc tggctggagc ggtggcttgg
     1441 cacagaacag gagcaccatt acataccgtt cctgggggag gtcattaaag tataatcctg
     1501 ttgttatcga ttttgagatg cagcctatcc acgaggtgct gcggcacaca agcctggggc
     1561 ctctggaggc caagcgccag aacctgcgcc gcgccttgga ccagtatctg atggaattca
     1621 atgcctgccg atgtgggcct tgcttcaaca atggggtgcc catcctcgag ggcaccagct
     1681 gcaggtgcca gtgccgcctg ggtagcttgg gtgctgcctg tgagcaaaca cagacagaag
     1741 gagccaaagc agatgggagc tggagttgct ggagctcctg gtctgtatgc agagcaggca
     1801 tccaggaaag gagaagagag tgtgacaatc cagcacctca gaatggaggg gcctcgtgtc
     1861 cagggcggaa agtacagacg caggcttgct gagggcctct ggacacaggc tggaccagat
     1921 gctgtggatg tcgacccctg cactgactat tggataaaga cttctttcaa ctaagagaag
     1981 atgcaaatca gcacactttt ttctttgttc tgccagcttc caggcctaag actaggtttt
     2041 gctgtctaca gccaactatt ctattagtta caaaactcaa tcattttatt cagcaactgg
     2101 atgttgactg ttaactagaa gctctgtcct acttacagca ctttggatca tcaaaaaaat
     2161 aaagtaaaat agaaaactga gaaaactcaa tccatgacca gggagaactt acaggatgtt
     2221 agagacaaaa caagcagaca cctgaaacaa tcaacgccca ataaaacaaa gtaggatgaa
     2281 aattctctta gttctttgat aacaatttgt tcactcatag aaacattatt aattggtagg
     2341 gtaagcagac actctgaaac aatgagaaaa atactaaaaa ttgacttgag ttatttc
//