LOCUS HUMC8BS 1995 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human complement protein C8 beta subunit mRNA, complete cds.
ACCESSION M16973
VERSION M16973.1
KEYWORDS complement C8; complement C8 beta; serum protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 28 to 1995)
AUTHORS Howard,O.M., Rao,A.G. and Sodetz,J.M.
TITLE Complementary DNA and derived amino acid sequence of the beta
subunit of human complement protein C8: identification of a close
structural and ancestral relationship to the alpha subunit and C9
JOURNAL Biochemistry 26 (12), 3565-3570 (1987)
PUBMED 2820472
REFERENCE 2 (bases 1 to 1995)
AUTHORS Sodetz,J.M.
JOURNAL Unpublished
COMMENT Original source text: Human liver, cDNA to mRNA.
[2] revises [1].
Draft entry and computer-readable sequence for [2] kindly provided
by J.M.Sodetz, 14-JUN-1988.
FEATURES Location/Qualifiers
source 1..1995
/db_xref="H-InvDB:HIT000194504"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p32"
gene 1..1995
/gene="C8B"
mRNA <1..1995
/gene="C8B"
/product="C8 mRNA"
CDS 28..1803
/gene="C8B"
/note="complement protein C8 beta subunit precursor"
/codon_start=1
/protein_id="AAA51862.1"
/db_xref="GDB:G00-119-736"
/translation="MKNSRTWAWRAPVELFLLCAALGCLSLPGSRGERPHSFGSNAVN
KSFAKSRQMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNF
SDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYK
KCQHEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVES
YTPQTQGKYEFILKEYESYSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGK
HYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYR
DLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEV
YVSLGVSVGKCRGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADLMQ
EWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPC
QGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQR
QCNNPPPQNGGSPCSGPASETLDCS"
sig_peptide 28..189
/gene="C8B"
/note="complement protein C8 beta subunit signal peptide"
mat_peptide 190..1800
/gene="C8B"
/product="complement protein C8"
BASE COUNT 567 a 441 c 516 g 471 t
ORIGIN 33 bp upstream of EcoRI site; chromosome 1p36.2-p22.1.
1 ctgtggcatc tcctgtcaca ttgggaaatg aagaattcca ggacatgggc ttggagggcg
61 ccggtggagc tatttcttct ctgtgctgcc ctgggctgtc tcagtttgcc tggctccaga
121 ggtgaaaggc cacattcctt tgggtcaaat gcagtcaaca agagctttgc taagagcaga
181 cagatgcgga gtgtggatgt taccctgatg cccattgatt gtgagctgtc tagttggtcc
241 tcttggacca catgtgaccc ctgtcagaag aaaaggtaca ggtatgccta cttgctccag
301 ccctctcagt tccatgggga accgtgcaac ttctctgaca aggaagtcga agactgtgtt
361 accaacagac catgcggaag tcaagtgcga tgtgaaggct ttgtgtgtgc acagacagga
421 aggtgtgtaa accgcagact tctttgcaat ggggacaatg actgtggaga ccagtcagat
481 gaagcaaact gtagaaggat ttataaaaaa tgtcagcatg aaatggacca atactgggga
541 attggcagtc tggccagtgg gataaatttg ttcacaaaca gttttgaggg cccagttctt
601 gatcacaggt attatgcagg tggatgctcc ccgcattaca tcctgaacac gaggtttagg
661 aagccctaca atgtggaaag ctacacgcca cagacccaag gcaaatacga attcatatta
721 aaagagtatg aatcatactc agattttgaa cgcaatgtca cagagaaaat ggcaagcaag
781 tctggtttca gttttggttt taaaatacct ggaatatttg aacttggcat cagtagtcaa
841 agtgatcgag gcaaacacta tattaggaga accaaacgat tctctcatac taaaagcgta
901 tttctgcatg cacgctctga ccttgaagta gcacattaca agctgaaacc cagaagcctc
961 atgctccatt acgagttcct tcagagagtt aagcggctgc ccctggagta cagctacggg
1021 gaatacagag atctcttccg tgattttggg acccactaca tcacagaggc tgtgcttggg
1081 ggcatttatg aatacaccct cgttatgaac aaagaggcca tggagagagg agattatact
1141 cttaacaacg tccatgcctg tgccaaaaat gattttaaaa ttggtggtgc cattgaagag
1201 gtctacgtca gtctgggtgt gtctgtaggc aaatgcagag gtattctgaa tgaaataaaa
1261 gacagaaaca agagggacac catggtggag gacttggtgg tcctggtacg aggaggggca
1321 agtgagcaca tcaccaccct ggcataccag gagctgccga cggcggacct gatgcaggag
1381 tggggagacg ctgtgcagta caacccagcc atcatcaaag ttaaggtgga gcctctgtat
1441 gaactagtga cagccacaga ttttgcctat tccagcacag tgaggcagaa catgaagcag
1501 gcactggagg agttccagaa ggaagttagt tcctgccact gtgctccctg ccaaggaaat
1561 ggagtccctg tcctgaaagg atcacgctgt gactgcatct gtcctgttgg atcccaaggc
1621 ctagcctgtg aggtctccta tcggaagaat acccccattg atgggaagtg gaattgctgg
1681 tcaaattggt cttcatgctc tggaagacgt aagacaagac aaaggcagtg taacaatcca
1741 cctcctcaaa atgggggtag cccctgttca ggccctgctt cagaaacact tgactgctcc
1801 tagcagatga tacagcagtg ggctacatac aatgagagcc ctgagccctc aagaactcac
1861 gccagctcag ccctacacca gtttccacct ggagttcatg caagggcaaa aggcagtgcc
1921 atgcaagctg tttaaaataa agatgttacc ttgtaaaatg caagttgatt taaataaata
1981 ctgagttaaa ggctt
//