LOCUS HUMFAV 6909 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human coagulation factor V mRNA, complete cds.
ACCESSION M16967
VERSION M16967.1
KEYWORDS blood coagulation factor; factor V.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6909)
AUTHORS Jenny,R.J., Pittman,D.D., Toole,J.J., Kriz,R.W., Aldape,R.A.,
Hewick,R.M., Kaufman,R.J. and Mann,K.G.
TITLE Complete cDNA and derived amino acid sequence of human factor V
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (14), 4846-4850 (1987)
PUBMED 3110773
COMMENT Original source text: Human fetal liver, cDNA to mRNA, clones V401
and V402.
FEATURES Location/Qualifiers
source 1..6909
/db_xref="H-InvDB:HIT000194503"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1q21-q25"
gene 1..6909
/gene="F5"
CDS 91..6765
/gene="F5"
/note="coagulation factor V precursor"
/codon_start=1
/protein_id="AAA52424.1"
/db_xref="GDB:G00-119-896"
/translation="MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWS
YRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHF
KNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGP
THDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVF
DESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVL
EQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTR
NLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYK
KVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGV
TFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSD
VDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKF
CENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTI
HFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDV
KCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFR
NSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAP
SHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGE
FRSQEHAKRKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQD
TGSPSRMRPWEDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWL
ISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTR
KKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPS
MDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSH
RSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNL
SPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPEL
SQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMP
ISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPE
LSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQV
TLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPS
SPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKT
DVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIP
EDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPY
SLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACR
AWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPVDMREFVLLFMTFDEKKSWYY
EKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVV
HFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPF
LIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFA
SKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVM
YFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMEN
GKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKK
ITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKN
FFNPPIISRFIRVIPKTWNQSITLRLELFGCDIY"
sig_peptide 91..174
/gene="F5"
/note="coagulation factor V signal peptide"
mat_peptide 2302..4809
/gene="F5"
/product="coagulation factor Va (alt.)"
mat_peptide 3229..4809
/gene="F5"
/product="coagulation factor Va' (alt.)"
BASE COUNT 2096 a 1701 c 1430 g 1682 t
ORIGIN 1 bp upstream of EcoRI site; chromosome 1q21-q25.
1 gaattccgca gcccggagtg tggttagcag ctcggcaagc gctgcccagg tcctggggtg
61 gtggcagcca gcgggagcag gaaaggaagc atgttcccag gctgcccacg cctctgggtc
121 ctggtggtct tgggcaccag ctgggtaggc tgggggagcc aagggacaga agcggcacag
181 ctaaggcagt tctacgtggc tgctcagggc atcagttgga gctaccgacc tgagcccaca
241 aactcaagtt tgaatctttc tgtaacttcc tttaagaaaa ttgtctacag agagtatgaa
301 ccatatttta agaaagaaaa accacaatct accatttcag gacttcttgg gcctacttta
361 tatgctgaag tcggagacat cataaaagtt cactttaaaa ataaggcaga taagcccttg
421 agcatccatc ctcaaggaat taggtacagt aaattatcag aaggtgcttc ttaccttgac
481 cacacattcc ctgcggagaa gatggacgac gctgtggctc caggccgaga atacacctat
541 gaatggagta tcagtgagga cagtggaccc acccatgatg accctccatg cctcacacac
601 atctattact cccatgaaaa tctgatcgag gatttcaact cggggctgat tgggcccctg
661 cttatctgta aaaaagggac cctaactgag ggtgggacac agaagacgtt tgacaagcaa
721 atcgtgctac tatttgctgt gtttgatgaa agcaagagct ggagccagtc atcatcccta
781 atgtacacag tcaatggata tgtgaatggg acaatgccag atataacagt ttgtgcccat
841 gaccacatca gctggcatct gctgggaatg agctcggggc cagaattatt ctccattcat
901 ttcaacggcc aggtcctgga gcagaaccat cataaggtct cagccatcac ccttgtcagt
961 gctacatcca ctaccgcaaa tatgactgtg ggcccagagg gaaagtggat catatcttct
1021 ctcaccccaa aacatttgca agctgggatg caggcttaca ttgacattaa aaactgccca
1081 aagaaaacca ggaatcttaa gaaaataact cgtgagcaga ggcggcacat gaagaggtgg
1141 gaatacttca ttgctgcaga ggaagtcatt tgggactatg cacctgtaat accagcgaat
1201 atggacaaaa aatacaggtc tcagcatttg gataatttct caaaccaaat tggaaaacat
1261 tataagaaag ttatgtacac acagtacgaa gatgagtcct tcaccaaaca tacagtgaat
1321 cccaatatga aagaagatgg gattttgggt cctattatca gagcccaggt cagagacaca
1381 ctcaaaatcg tgttcaaaaa tatggccagc cgcccctata gcatttaccc tcatggagtg
1441 accttctcgc cttatgaaga tgaagtcaac tcttctttca cctcaggcag gaacaacacc
1501 atgatcagag cagttcaacc aggggaaacc tatacttata agtggaacat cttagagttt
1561 gatgaaccca cagaaaatga tgcccagtgc ttaacaagac catactacag tgacgtggac
1621 atcatgagag acatcgcctc tgggctaata ggactacttc taatctgtaa gagcagatcc
1681 ctggacaggc gaggaataca gagggcagca gacatcgaac agcaggctgt gtttgctgtg
1741 tttgatgaga acaaaagctg gtaccttgag gacaacatca acaagttttg tgaaaatcct
1801 gatgaggtga aacgtgatga ccccaagttt tatgaatcaa acatcatgag cactatcaat
1861 ggctatgtgc ctgagagcat aactactctt ggattctgct ttgatgacac tgtccagtgg
1921 cacttctgta gtgtggggac ccagaatgaa attttgacca tccacttcac tgggcactca
1981 ttcatctatg gaaagaggca tgaggacacc ttgaccctct tccccatgcg tggagaatct
2041 gtgacggtca caatggataa tgttggaact tggatgttaa cttccatgaa ttctagtcca
2101 agaagcaaaa agctgaggct gaaattcagg gatgttaaat gtatcccaga tgatgatgaa
2161 gactcatatg agatttttga acctccagaa tctacagtca tggctacacg gaaaatgcat
2221 gatcgtttag aacctgaaga tgaagagagt gatgctgact atgattacca gaacagactg
2281 gctgcagcat taggaattag gtcattccga aactcatcat tgaaccagga agaagaagag
2341 ttcaatctta ctgccctagc tctggagaat ggcactgaat tcgtttcttc gaacacagat
2401 ataattgttg gttcaaatta ttcttcccca agtaatatta gtaagttcac tgtcaataac
2461 cttgcagaac ctcagaaagc cccttctcac caacaagcca ccacagctgg ttccccactg
2521 agacacctca ttggcaagaa ctcagttctc aattcttcca cagcagagca ttccagccca
2581 tattctgaag accctataga ggatcctcta cagccagatg tcacagggat acgtctactt
2641 tcacttggtg ctggagaatt cagaagtcaa gaacatgcta agcgtaaggg acccaaggta
2701 gaaagagatc aagcagcaaa gcacaggttc tcctggatga aattactagc acataaagtt
2761 gggagacacc taagccaaga cactggttct ccttccggaa tgaggccctg ggaggacctt
2821 cctagccaag acactggttc tccttccaga atgaggccct gggaggaccc tcctagtgat
2881 ctgttactct taaaacaaag taactcatct aagattttgg ttgggagatg gcatttggct
2941 tctgagaaag gtagctatga aataatccaa gatactgatg aagacacagc tgttaacaat
3001 tggctgatca gcccccagaa tgcctcacgt gcttggggag aaagcacccc tcttgccaac
3061 aagcctggaa agcagagtgg ccacccaaag tttcctagag ttagacataa atctctacaa
3121 gtaagacagg atggaggaaa gagtagactg aagaaaagcc agtttctcat taagacacga
3181 aaaaagaaaa aagagaagca cacacaccat gctcctttat ctccgaggac ctttcaccct
3241 ctaagaagtg aagcctacaa cacattttca gaaagaagac ttaagcattc gttggtgctt
3301 cataaatcca atgaaacatc tcttcccaca gacctcaatc agacattgcc ctctatggat
3361 tttggctgga tagcctcact tcctgaccat aatcagaatt cctcaaatga cactggtcag
3421 gcaagctgtc ctccaggtct ttatcagaca gtgcccccag aggaacacta tcaaacattc
3481 cccattcaag accctgatca aatgcactct acttcagacc ccagtcacag atcctcttct
3541 ccagagctca gtgaaatgct tgagtatgac cgaagtcaca agtccttccc cacagatata
3601 agtcaaatgt ccccttcctc agaacatgaa gtctggcaga cagtcatctc tccagacctc
3661 agccaggtga ccctctctcc agaactcagc cagacaaacc tctctccaga cctcagccac
3721 acgactctct ctccagaact cattcagaga aacctttccc cagccctcgg tcagatgccc
3781 atttctccag acctcagcca tacaaccctt tctccagacc tcagccatac aaccctttct
3841 ttagacctca gccagacaaa cctctctcca gaactcagtc agacaaacct ttccccagcc
3901 ctcggtcaga tgcccctttc tccagacctc agccatacaa ccctttctct agacttcagc
3961 cagacaaacc tctctccaga actcagccat atgactctct ctccagaact cagtcagaca
4021 aacctttccc cagcccttgg tcagatgccc atttctccag acctcagcca tacaaccctt
4081 tctctagact tcagccagac aaacctctct ccagaactca gtcaaacaaa cctttcccca
4141 gccctcggtc agatgcccct ttctccagac cccagccata caaccctttc tctagacctc
4201 agccagacaa acctctctcc agaactcagt cagacaaacc tttccccaga cctcagtgag
4261 atgcccctct ttgcagatct cagtcaaatt ccccttaccc cagacctcga ccagatgaca
4321 ctttctccag accttggtga gacagatctt tccccaaact ttggtcagat gtccctttcc
4381 ccagacctca gccaggtgac tctctctcca gacatcagtg acaccaccct tctcccggat
4441 ctcagccaga tatcacctcc tccagacctt gatcagatat tctacccttc tgaatctagt
4501 cagtcattgc ttcttcaaga atttaatgag tcttttcctt atccagacct tggtcagatg
4561 ccatctcctt catctcctac tctcaatgat acttttctat caaaggaatt taatccactg
4621 gttatagtgg gcctcagtaa agatggtaca gattacattg agatcattcc aaaggaagag
4681 gtccagagca gtgaagatga ctatgctgaa attgattatg tgccctatga tgacccctac
4741 aaaactgatg ttaggacaaa catcaactcc tccagagatc ctgacaacat tgcagcatgg
4801 tacctccgca gcaacaatgg aaacagaaga aattattaca ttgctgctga agaaatatcc
4861 tgggattatt cagaatttgt acaaagggaa acagatattg aagactctga tgatattcca
4921 gaagatacca catataagaa agtagttttt cgaaagtacc tcgacagcac ttttaccaaa
4981 cgtgatcctc gaggggagta tgaagagcat ctcggaattc ttggtcctat tatcagagct
5041 gaagtggatg atgttatcca agttcgtttt aaaaatttag catccagacc gtattctcta
5101 catgcccatg gactttccta tgaaaaatca tcagagggaa agacttatga agatgactct
5161 cctgaatggt ttaaggaaga taatgctgtt cagccaaata gcagttatac ctacgtatgg
5221 catgccactg agcgatcagg gccagaaagt cctggctctg cctgtcgggc ttgggcctac
5281 tactcagctg tgaacccaga aaaagatatt cactcaggct tgataggtcc cctcctaatc
5341 tgccaaaaag gaatactaca taaggacagc aacatgcctg tggacatgag agaatttgtc
5401 ttactattta tgacctttga tgaaaagaag agctggtact atgaaaagaa gtcccgaagt
5461 tcttggagac tcacatcctc agaaatgaaa aaatcccatg agtttcacgc cattaatggg
5521 atgatctaca gcttgcctgg cctgaaaatg tatgagcaag agtgggtgag gttacacctg
5581 ctgaacatag gcggctccca agacattcac gtggttcact ttcacggcca gaccttgctg
5641 gaaaatggca ataaacagca ccagttaggg gtctggcccc ttctgcctgg ttcatttaaa
5701 actcttgaaa tgaaggcatc aaaacctggc tggtggctcc taaacacaga ggttggagaa
5761 aaccagagag cagggatgca aacgccattt cttatcatgg acagagactg taggatgcca
5821 atgggactaa gcactggtat catatctgat tcacagatca aggcttcaga gtttctgggt
5881 tactgggagc ccagattagc aagattaaac aatggtggat cttataatgc ttggagtgta
5941 gaaaaacttg cagcagaatt tgcctctaaa ccttggatcc aggtggacat gcaaaaggaa
6001 gtcataatca cagggatcca gacccaaggt gccaaacact acctgaagtc ctgctatacc
6061 acagagttct atgtagctta cagttccaac cagatcaact ggcagatctt caaagggaac
6121 agcacaagga atgtgatgta ttttaatggc aattcagatg cctctacaat aaaagagaat
6181 cagtttgacc cacctattgt ggctagatat attaggatct ctccaactcg agcctataac
6241 agacctaccc ttcgattgga actgcaaggt tgtgaggtaa atggatgttc cacacccctg
6301 ggtatggaaa atggaaagat agaaaacaag caaatcacag cttcttcgtt taagaaatct
6361 tggtggggag attactggga acccttccgt gcccgtctga atgcccaggg acgtgtgaat
6421 gcctggcaag ccaaggcaaa caacaataag cagtggctag aaattgatct actcaagatc
6481 aagaagataa cggcaattat aacacagggc tgcaagtctc tgtcctctga aatgtatgta
6541 aagagctata ccatccacta cagtgagcag ggagtggaat ggaaaccata caggctgaaa
6601 tcctccatgg tggacaagat ttttgaagga aatactaata ccaaaggaca tgtgaagaac
6661 tttttcaacc ccccaatcat ttccaggttt atccgtgtca ttcctaaaac atggaatcaa
6721 agtattacac ttcgcctgga actctttggc tgtgatattt actagaattg aacattcaaa
6781 aacccctgga agagactctt taagacctca aaccatttag aatgggcaat gtattttacg
6841 ctgtgttaaa tgttaacagt tttccactat ttctctttct tttctattag tgaataaaat
6901 tttatacaa
//