LOCUS HUMMCR 5749 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human mineralocorticoid receptor mRNA (hMR), complete cds.
ACCESSION M16801
VERSION M16801.1
KEYWORDS mineralocorticoid receptor; steroid receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5749)
AUTHORS Arriza,J.L., Weinberger,C., Cerelli,G., Glaser,T.M., Handelin,B.L.,
Housman,D.E. and Evans,R.M.
TITLE Cloning of human mineralocorticoid receptor complementary DNA:
structural and functional kinship with the glucocorticoid receptor
JOURNAL Science 237 (4812), 268-275 (1987)
PUBMED 3037703
COMMENT Original source text: Human kidney cDNA to mRNA, clones
lambda-hk[10,2].
Draft entry and clean copy of sequence [1] kindly provided by
J.L.Arriza, (25-AUG-1987).
FEATURES Location/Qualifiers
source 1..5749
/db_xref="H-InvDB:HIT000194482"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q31"
gene 1..5749
/gene="MLR"
mRNA 1..5749
/gene="MLR"
/product="mineralocorticoid receptor mRNA"
CDS 217..3171
/gene="MLR"
/note="mineralocorticoid receptor"
/codon_start=1
/protein_id="AAA59571.1"
/db_xref="GDB:G00-120-188"
/translation="METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYME
IVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVA
ESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTP
LRSFMSDSGSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTA
SFGSFPVHSPITQGTPLTCSPNAENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPP
SHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSIC
SPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQL
NIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPF
PFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASI
PSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDL
SSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCK
VFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLK
GIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVM
VLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQ
ITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQIS
LQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNS
GQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVE
SGNAKPLYFHRK"
BASE COUNT 1627 a 1268 c 1255 g 1599 t
ORIGIN 73 bp upstream of AvaI site; chromosome 4.
1 cgcgggagcc aacttcaggc tgctcagagg aagcccgtgc agtcagtcac ctgggtgcaa
61 gagcgttgct gcctcgggct ctcccgctgc agggagagcg gcactcgctg gcctggatgt
121 ggttggattt aggggggctc cgcagcaggg gtttcgtggc ggtggcaagc gctgcaacag
181 gtagacggcg agagacggac cccggccgag gcagggatgg agaccaaagg ctaccacagt
241 ctccctgaag gtctagatat ggaaagacgg tggggtcaag tttctcaggc tgtggagcgt
301 tcttccctgg gacctacaga gaggaccgat gagaataact acatggagat tgtcaacgta
361 agctgtgttt ccggtgctat tccaaacaac agtactcaag gaagcagcaa agaaaaacaa
421 gaactactcc cttgccttca gcaagacaat aatcggcctg ggattttaac atctgatatt
481 aaaactgagc tggaatctaa ggaactttca gcaactgtag ctgagtccat gggtttatat
541 atggattctg taagagatgc tgactattcc tatgagcagc agaaccaaca aggaagcatg
601 agtccagcta agatttatca gaatgttgaa cagctggtga aattttacaa aggaaatggc
661 catcgtcctt ccactctaag ttgtgtgaac acgcccttga gatcatttat gtctgactct
721 gggagctccg tgaatggtgg cgtcatgcgc gccattgtta aaagccctat catgtgtcat
781 gagaaaagcc cgtctgtttg cagccctctg aacatgacat cttcggtttg cagccctgct
841 ggaatcaact ctgtgtcctc caccacagcc agctttggca gttttccagt gcacagccca
901 atcacccagg gaactcctct gacatgctcc cctaatgctg aaaatcgagg ctccaggtcg
961 cacagccctg cacatgctag caatgtgggc tctcctctct caagtccgtt aagtagcatg
1021 aaatcctcaa tttccagccc tccaagtcac tgcagtgtaa aatctccagt ctccagtccc
1081 aataatgtca ctctgagatc ctctgtgtct agccctgcaa atattaacaa ctcaaggtgc
1141 tctgtttcca gcccttcgaa cactaataac agatccacgc tttccagtcc ggcagccagt
1201 actgtgggat ctatctgtag ccctgtaaac aatgccttca gctacactgc ttctggcacc
1261 tctgctggat ccagtacatt gcgggatgtg gttcccagtc cagacacgca ggagaaaggt
1321 gctcaagagg tcccttttcc taagactgag gaagtagaga gtgccatctc aaatggtgtg
1381 actggccagc ttaatattgt ccagtacata aaaccagaac cagatggagc ttttagcagc
1441 tcatgtctag gaggaaatag caaaataaat tcggattctt cattctcagt accaataaag
1501 caagaatcaa ccaagcattc atgttcaggc acctctttta aagggaatcc aacagtaaac
1561 ccgtttccat ttatggatgg ctcgtatttt tcctttatgg atgataaaga ctattattcc
1621 ctatcaggaa ttttaggacc acctgtgccc ggctttgatg gtaactgtga aggcagcgga
1681 ttcccagtgg gtattaaaca agaaccagat gacgggagct attacccaga ggccagcatc
1741 ccttcctctg ctattgttgg ggtgaattca ggtggacagt ccttccacta caggattggt
1801 gctcaaggta caatatcttt atcacgatcg gctagagacc aatctttcca acacctgagt
1861 tcctttcctc ctgtcaatac tttagtggag tcatggaaat cacacggcga cctgtcgtct
1921 agaagaagtg atgggtatcc ggtcttagaa tacattccag aaaatgtatc aagctctact
1981 ttacgaagtg tttctactgg atcttcaaga ccttcaaaaa tatgtttggt gtgtggggat
2041 gaggcttcag gatgccatta tggggtagtc acctgtggca gctgcaaagt tttcttcaaa
2101 agagcagtgg aagggcaaca caactattta tgtgctggaa gaaatgattg catcattgat
2161 aagattcgac gaaagaattg tcctgcttgc agacttcaga aatgtcttca agctggaatg
2221 aatttaggag cacgaaagtc aaagaagttg ggaaagttaa aagggattca cgaggagcag
2281 ccacagcagc agcagccccc acccccaccc ccacccccgc aaagcccaga ggaagggaca
2341 acgtacatcg ctcctgcaaa agaaccctcg gtcaacacag cactggttcc tcagctctcc
2401 acaatctcac gagcgctcac accttccccc gttatggtcc ttgaaaacat tgaacctgaa
2461 attgtatatg caggctatga cagctcaaaa ccagatacag ccgaaaatct gctctccacg
2521 ctcaaccgct tagcaggcaa acagatgatc caagtcgtga agtgggcaaa ggtacttcca
2581 ggatttaaaa acttgcctct tgaggaccaa attaccctaa tccagtattc ttggatgtgt
2641 ctatcatcat ttgccttgag ctggagatcg tacaaacata cgaacagcca atttctctat
2701 tttgcaccag acctagtctt taatgaagag aagatgcatc agtctgccat gtatgaacta
2761 tgccagggga tgcaccaaat cagccttcag ttcgttcgac tgcagctcac ctttgaagaa
2821 tacaccatca tgaaagtttt gctgctacta agcacaattc caaaggatgg cctcaaaagc
2881 caggctgcat ttgaagaaat gaggacaaat tacatcaaag aactgaggaa gatggtaact
2941 aagtgtccca acaattctgg gcagagctgg cagaggttct accaactgac caagctgctg
3001 gactccatgc atgacctggt gagcgacctg ctggaattct gcttctacac cttccgagag
3061 tcccatgcgc tgaaggtaga gttccccgca atgctggtgg agatcatcag cgaccagctg
3121 cccaaggtgg agtcggggaa cgccaagccg ctctacttcc accggaagtg actgcccgct
3181 gcccagaaga actttgcctt aagtttccct gtgttgttcc acacccagaa ggacccaaga
3241 aaacctgttt ttaacatgtg atggttgatt cacacttgtt caacagtttc tcaagtttaa
3301 agtcatgtca gaggtttgga gccgggaaag ctgtttttcc gtggatttgg cgagaccaga
3361 gcagtctgaa ggattcccca cctccaatcc cccagcgctt agaaacatgt tcctgttcct
3421 cgggatgaaa agccatatct agtcaataac tctgattttg atattttcac agatggaaga
3481 agttttaact atgccgtgta gtttctggta tcgttcgctt gttttaaaag ggttcaagga
3541 ctaacgaacg ttttaaagct tacccttggt ttgcacataa aacgtatagt caatatgggg
3601 cattaatatt cttttgttat taaaaaaaca caaaaaaata ataaaaaaat atatacagat
3661 tcctgttgtg taataacaga actcgtggcg tggggcagca gctgcctctg agccctcgct
3721 cgtccacggt cttctgcatc actggtatac acactcgtta gcgtccattt cttatttaat
3781 tagaatggat aagatgatgt taaatgcctt ggtttgattt ctagtatcta ttgtgttggc
3841 tttacaaata attttttgca gtcttttgct gtgctgtaca ttactgtatg tataaattat
3901 gaaggacctg aaataaggta taaggatctt ttgtaaatga gacacataca aaaaaaatct
3961 ttaatggtta ataggatgaa tgggaaagta tttttgaaag aattctattt tgctggagac
4021 tatttaagta ctatctttgt ctaaacaagg taattttttt ttgtaaagtg caatgtcctg
4081 catgcataat gaaccgttta cagtgtattt aagaaaggga aagctgtgcc ttttttagct
4141 tcatatctaa tttaccatta ttttacagtc tctgttgtaa ataaccacac tgaaacctct
4201 tcggttgtct tgaaaccttt ctactttttc tgtacttttt gttttgttct tggtctcccg
4261 cttggggcat ttgtgggact ccagcacgtt ttctggcttc tgcttcatcc tgctccatcg
4321 gggaatgaca cactgcggtg tctgcagctc ctggaaggtg tcatttgaca acacatgtgg
4381 gagaggaggt ccttggagtg ctgcagcttt gggaaagcct gcctcgtttc ccttttcctc
4441 tagaagcaga accagctcta cgagagtgag actgggaact tgatggctca gagagcatct
4501 tttcctccca ttttagaaaa tcagattttc tcctgtggga aaaaaaaatt ccatgcactc
4561 tctctctgtt aaagatcagc tattcccttc tgatcttgga aagaggttct gcactcctgg
4621 aaccggtcac aggaacgcac agatcatggc aggatgcgct gggacggccc atcttggcaa
4681 ggttcagtct gaatggcatg gagaccggga gatagagggg ttttagattt ttaaaaggta
4741 ggttttaaaa ataagtttta tacataaaca gttttggaga aaaattacag atcatataag
4801 caagacagtg gcactaaaat gtttaattca ttaatctgtt tgtttggcac tgatgcaatg
4861 tatggctttt ctcttgcccc aaatcacaaa catatgtatc tttggggaaa ctaacaatat
4921 gattgcacta aataaactac tttgaataga ggccaaatta atcttttaaa aatgatgata
4981 atcatcaggt ttactcagtg aaatcatatt aattattttc caaaatctaa aagctgtagc
5041 tggagaagcc catggccacg aggaagcagc aattaattag atcaacactt ttctccaggg
5101 ttcaccatgc aggcaacatt accttgtctt tcaaaagaca cctgccttag tgcaagggga
5161 aacctgtgaa agctgcactc agagggagga gtctttctta cataatttgc aatttcagga
5221 atttaattta taggcagatc tttaaataca gtcaacttac ggtgcacagt aatatgaaag
5281 ccacactttg aaggtaataa atacacagca tgcagactgg gagttgctag caaacaaatg
5341 gcttacttac aaaagcagct tttagttcag acttagtttt tataaaatga gaattctgac
5401 ttacttaacc aggtttggga tggagatggt ctgcatcagc tttttgtatt aacaaagtta
5461 ctggctcttt gtgtgtctcc aggtaacttt gcttgattaa acagcaaagc catattctaa
5521 attcactgtt gaatgcctgt cccagtccaa attgtctgtc tgctcttatt tttgtaccat
5581 attgctctta aaaatcttgg tttggtacag ttcataattc accaaaaagt tcatataatt
5641 taaagaaaca ctaaattagt ttaaaatgaa gcaatttata tctttatgca aaaacatatg
5701 tctgtctttg caaaggactg taagcagatt acaataaatc ctttacttt
//