LOCUS       HUMELAP2A                914 bp    mRNA    linear   HUM 07-NOV-1994
DEFINITION  Human pancreatic elastase IIA mRNA, complete cds.
ACCESSION   M16652
VERSION     M16652.1
KEYWORDS    elastase; pancreatic elastase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Kawashima,I., Tani,T., Shimoda,K. and Takiguchi,Y.
  TITLE     Characterization of pancreatic elastase II cDNAs: two elastase II
            mRNAs are expressed in human pancreas
  JOURNAL   DNA 6 (2), 163-172 (1987)
   PUBMED   3646943
COMMENT     Original source text: Human pancreas, cDNA to mRNA, clone pH2E2.
            Draft entry and clean copy of sequence in [1] kindly provided by
            I.Kawashima, 25-AUG-1987.
            An activation peptide is located at positions 75 to 110.
FEATURES             Location/Qualifiers
     source          1..914
                     /db_xref="H-InvDB:HIT000194468"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="12"
     gene            1..914
                     /gene="ELA1"
     mRNA            1..914
                     /gene="ELA1"
                     /product="pancreatic elastase IIA mRNA"
     CDS             27..836
                     /gene="ELA1"
                     /note="pancreatic elastase IIA zymogen"
                     /codon_start=1
                     /protein_id="AAA52380.1"
                     /db_xref="GDB:G00-119-866"
                     /translation="MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQV
                     SLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSV
                     SKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGW
                     GRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGG
                     PLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN"
     sig_peptide     27..74
                     /gene="ELA1"
                     /note="pancreatic elastase IIA signal peptide"
     mat_peptide     111..833
                     /gene="ELA1"
                     /product="pancreatic elastase IIA mature peptide"
BASE COUNT          198 a          276 c          253 g          187 t
ORIGIN      142 bp upstream of PvuII site.
        1 ttttacagaa ctcccacgga cacaccatga taaggacgct gctgctgtcc actttggtgg
       61 ctggagccct cagttgtggg gaccccactt acccacctta tgtgactagg gtggttggcg
      121 gtgaagaagc gaggcccaac agctggccct ggcaggtctc cctgcagtac agctccaatg
      181 gcaagtggta ccacacctgc ggagggtccc tgatagccaa cagctgggtc ctgacggctg
      241 cccactgcat cagctcctcc aggacctacc gcgtggggct gggccggcac aacctctacg
      301 ttgcggagtc cggctcgctg gcagtcagtg tctctaagat tgtggtgcac aaggactgga
      361 actccaacca aatctccaaa gggaacgaca ttgccctgct caaactggct aaccccgtct
      421 ccctcaccga caagatccag ctggcctgcc tccctcctgc cggcaccatt ctacccaaca
      481 actacccctg ctacgtcacg ggctggggaa ggctgcagac caacggggct gttcctgatg
      541 tcctgcagca gggccggttg ctggttgtgg actatgccac ctgctccagc tctgcctggt
      601 ggggcagcag cgtgaaaacc agtatgatct gtgctggggg tgatggcgtg atctccagct
      661 gcaacggaga ctctggcggg ccactgaact gtcaggcgtc tgacggccgg tggcaggtgc
      721 acggcatcgt cagcttcggg tctcgcctcg gctgcaacta ctaccacaag ccctccgtct
      781 tcacgcgggt ctccaattac atcgactgga tcaattcggt gattgcaaat aactaaccaa
      841 aagaagtccc tgggactgtt tcagacttgg aaaggtcaca gaaggaaaat aatataataa
      901 agtgacaact atgc
//