LOCUS HUMSTS 6520 bp mRNA linear HUM 13-JAN-1995
DEFINITION Human steroid sulfatase (STS) mRNA, complete cds.
ACCESSION M16505
VERSION M16505.1
KEYWORDS steroid sulfatase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2429)
AUTHORS Yen,P.H., Allen,E., Marsh,B., Mohandas,T., Wang,N., Taggart,R.T.
and Shapiro,L.J.
TITLE Cloning and expression of steroid sulfatase cDNA and the frequent
occurrence of deletions in STS deficiency: implications for X-Y
interchange
JOURNAL Cell 49 (4), 443-454 (1987)
PUBMED 3032454
REFERENCE 2 (bases 2430 to 6520)
AUTHORS Yen,P.H.
JOURNAL Unpublished
COMMENT Original source text: Human placenta, cDNA to mRNA, clones M13mp18
and M13mp19.
There is a steroid sulfatase (STS) pseudogene on Yq.
FEATURES Location/Qualifiers
source 1..6520
/db_xref="H-InvDB:HIT000194456"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xp22.32"
gene 1..6520
/gene="STS"
mRNA <1..2429
/gene="STS"
/product="steroid sulfatase mRNA"
CDS 221..1972
/gene="STS"
/note="steroid sulfatase precursor (EC 3.1.6.2)"
/codon_start=1
/protein_id="AAA60596.1"
/db_xref="GDB:G00-120-393"
/translation="MPLRKMKIPFLLLFFLWEAESHEASRPNIILVMADDLGIGDPGC
YGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVF
LFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFY
GISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFS
LLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNT
ETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLAND
TLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQ
KIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYL
NAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKD
PRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPST
GLSCQCDREKQDKRLSR"
sig_peptide 221..286
/gene="STS"
/note="steroid sulfatase signal peptide"
mat_peptide 287..1969
/gene="STS"
/product="steroid sulfatase"
BASE COUNT 1881 a 1440 c 1363 g 1835 t
ORIGIN Chromosome Xp22.32.
1 acagtgctgt tggccaagcc tccagcagct gacgggaccc agctgtagtg aggttgcagt
61 gattgagtag gattggcctg cttcaaagca gaggtttctc atgggaatat gcttattaaa
121 ctcccactgg tgcagaaacc atgaacagag gatgaacaag tgaagttgca atctcctcca
181 tcacagctca gttccccaac aacaggatca caagctggag atgcctttaa ggaagatgaa
241 gatccctttc ctcctactgt tctttctgtg ggaagccgag agccacgaag catcaaggcc
301 gaacatcatc ctggtgatgg ctgacgacct cggcattgga gatcctgggt gctatgggaa
361 caaaactatc aggactccca atatcgaccg gttggccagt gggggagtga aactcactca
421 gcacctggca gcatcaccgc tgtgcacacc aagcagggca gccttcatga ctggccggta
481 ccctgtccga tcaggaatgg catcttggtc ccgcactgga gttttcctct tcacagcctc
541 ttcgggagga cttcccaccg atgagattac ctttgctaag cttctgaagg atcaaggtta
601 ttcaacagca ctgataggga aatggcacct tgggatgagc tgtcacagca agactgactt
661 ctgtcaccac cctttacatc acggcttcaa ttatttctat gggatctctt tgaccaatct
721 gagagactgc aagcccggag agggcagtgt cttcaccacg ggcttcaaga ggctggtctt
781 cctccccctg cagatcgtcg gggtcaccct ccttaccctt gctgcactca attgtctggg
841 gctactccac gtgcctctag gcgttttttt cagccttctc ttcctagcag ccctaatcct
901 gacccttttc ttgggcttcc ttcattactt ccggcccctg aactgcttca tgatgaggaa
961 ctacgagatc attcagcagc ccatgtccta tgacaatctc acccagaggc taacggtgga
1021 ggcggcccag ttcatacagc ggaacactga gactccgttc ctgcttgtct tgtcctacct
1081 ccacgtgcac acagccctgt tctccagcaa agactttgct ggcaaaagtc aacacggagt
1141 ctacggggat gctgttgagg aaatggactg gagtgtgggg cagatcttga accttctgga
1201 tgagctgaga ttggctaatg ataccctcat ctacttcaca tcggaccagg gagcacatgt
1261 agaagaagtg tcttccaaag gagaaattca tggcggaagt aatgggatct ataaaggagg
1321 aaaagcaaac aactgggaag gaggtatccg ggttccaggc atccttcgtt ggcccagggt
1381 gatacaggct ggccagaaga ttgatgagcc cactagcaac atggacatat ttcctacagt
1441 agccaagctg gctggagctc ccttgcctga ggacaggatc attgatggac gtgatctgat
1501 gcccctgctt gaaggaaaaa gccaacgctc cgatcatgag tttctcttcc attactgcaa
1561 cgcctactta aatgctgtgc gctggcaccc tcagaacagc acatccatct ggaaggcctt
1621 tttcttcacc cccaacttca accccgtggg ttccaacgga tgctttgcca cacacgtgtg
1681 cttctgtttc gggagttatg tcacccatca cgacccacct ttactctttg atatttccaa
1741 agatcccaga gagagaaacc cacttactcc agcatccgag ccccggtttt atgaaatcct
1801 caaagtcatg caggaagctg cggacagaca cacccagacc ctgccagagg tgcccgatca
1861 gttttcatgg aacaactttc tttggaagcc ctggcttcag ctgtgctgtc cttccaccgg
1921 cctgtcttgc cagtgtgata gagaaaaaca ggataagaga ctgagccgct agcagcgcct
1981 ggggaccaga cagacgcatg tggcaaagct caccatcttc actacaaaca cgcctgagag
2041 tggcactggg gaaacataac tccatctaca ccttggattt ggactgattc tccattttat
2101 cacctgaagg cttgggccag agctcaacag ctactcaact ggaggggtga gggggataag
2161 gtctgtagta tacagacagg aagatggtag gtttatgcct tctgtggcca gagtcttgga
2221 ctcatggaaa tagaatgaat agaggggcat tcacaaggca caccagtgca agcagatgac
2281 aaaaaggtgc agaaggcaat cttaaaacag aaaggtgcag gaggtacctt aactcacccc
2341 tcagcaaata cctatgtcaa cagtataagt taccatttac tctataatct gcagtgatgc
2401 aataaccagc ataataaaaa ggcaatcaca taaaaaagag tttagtcgtc taaacataag
2461 taactttaag gtgaatgaaa gatcttcttt aggaataata gatgatggta agttccactn
2521 tggttattgg aaggcaagtc attattattg gtattagtta aaacacatat caaatgcttg
2581 ctcttcatca tatatatagt tatgcataca tacacacaca cacatacagt atattctttc
2641 ctcaaaaggg ttaagatgtc taaaataggg acctagaagc ttaacactat ttaagtaaat
2701 acagtagaag ctcacaaata gatttctttg cacaatgatt ttttgcaaaa ttttacagta
2761 ataataatcc caaggcaaat ctctcctgaa ctgctttcca ttccataatt tgtagtataa
2821 ttcttggatt ccactgtttt ctttggggaa tggaagttct gaattaaaag cccactgtgg
2881 agatgctgtg gttcatggaa tctcttccag tgtaattcag aatcatggcc tagaaagtct
2941 ctgatatttg gaggggaaca aaaatcactc acaagcaatc catgatctat acacataagc
3001 ataatttcct ttagttctag ttagtcatca gagaacagtc atgtatgcaa gttttgtgac
3061 tgagaaattt ctgtgcttcc aatccacaat gagatgcatg attttgtttt catcccattt
3121 cccccaagcc cctgtaaatc agggaaaatg cgcaactgat cgcctaggag agggcctcgt
3181 agtggcacag ctggagatag tttcaaagtc taaaccacca gcccatcctg aggaaagcct
3241 cctatggaat gtaaagtgca atcatttctt cagatataag actttcccca acaatgtgat
3301 tggattcctt tatgctcaaa atcgagagaa gctgccatcc acctgcttat gcatttatct
3361 cttttgtgga cttgtctgac caccttctat ttgcccagag tttgctcaat tccaagacag
3421 tgcccatgaa tgggacacct gtaatgtaac ccacacagcg gtttgcagag aatgttagcc
3481 atgacttggg ctttgtaaag ttggctataa tttctctatc cctacccaca accctgggaa
3541 gttggagcaa gaggggcata ctattgggct gggaggattt gacagcattt ccccagttgc
3601 cctttaagtt cttctatttc aaacgttaat tttgcttctc tttctaaaaa aaaaaaaaaa
3661 aaagaaagag aagaaagaag tgattcctac ccctacctcc agagttgttg aaagctgaaa
3721 agcatacaag attcttcctt ttaacttgga tttctcgttc cagaaattgt gggataatct
3781 gtattcttgc tttagaaaac aattcttaga gagggtacta gcttactgat gatgtgttag
3841 gattgctact gatgctgtca tgtggaaact atttaaaggc actattataa atttatccta
3901 taagatgaca atgtttactc aaagtctaac atattcaatg caagtaagac tttctgaaaa
3961 cacttgatga tgtggaaatg ctgcaggacc taaataactt gaagagcctt tatagattat
4021 atgaatgcct atttgtgtct agaaccagtt atttaacctg taaaatgtca atagcaaatg
4081 aaggatgaag tatatctcta gatgcaaata cattgagttt aaaagtgcct caaaataatt
4141 gagatcacat ttcaggacat ttggaaatca ggtcgatttg tggtaactgt agtcatctta
4201 aatttcaaac catttaccat ctgaaagttt tgatttgaat gtaaaacagg aaattggaat
4261 tcctttgtcc aggagaaacc tcacaaacct tctttaaggc atagttttgt tgtttgtttg
4321 cttgtttgtt gcaggctgta aggcatggct gcttgtttac aaagcatctc attcatatta
4381 cctgtggagt tgcatatcca aaccttagtg agttttgaag ctttaagcaa attcttttaa
4441 aaaattcttg tatttctagc attactagat attaaaagtt aagcaaatag attaatgacg
4501 tatacatagg catcatttca caaggtcagt aatgctgcag gaaaagcaaa attgcaatct
4561 acgtatctat ggtactaagg aagtcctgtt ttcaaaaatg gaagcccact tctcagattt
4621 ttctgaaggg catacaatga aaagtgaagg ggaaacacac acacacaaaa aaaacaagta
4681 tttggcttgt cacaggaatc tgattgcatt aagtgaagga ttatttagaa tatgttaatg
4741 caaagctaaa ataaaatttt ccttggcaat taaaaatgct gtgcgctaat accctgcttt
4801 ctatcgtgac tcaattcaac aatgtgggga atgtttacta catttccaac ttgatgtcaa
4861 gcaatgggga atacaagttc cagttctgca aagattcgtc aactttctta gctcaagaga
4921 gaggctgaga aatgcagaga agaataagac ataaaatagc tccgacctcc atgatccgag
4981 agtgggaaaa ggcccgatta ttacccataa ggcacactct ctaaggcctt ttaaggggcc
5041 tacaaaaatg ttttatttta taatcagaag aaaaggaaat gaacattggg gattgaaaat
5101 catattggta tttgcaccaa catagtcata aaatagtatg ttaatatgtt tttactttat
5161 atatttatat attaaaatat atttaatatg ttttgccttt gtggcccatg aaagtcttac
5221 tgggccctgg ggaaggtatc ctaccctggt gaagcagctg ctttgctcta caaatacctg
5281 gggcagaaat ttgatttgaa aagtattatt ctctcttctc tttgtttcaa ctggattcct
5341 ttggaaaacc aaactagtat cagaacaaac cccgaaacag taagaaattg gagtgagaag
5401 ggcatggtat tgggactagg atcggctctc attcgatcga gctattctct taaaatgaca
5461 aaaagtgtcc ataaagaggc tgctggagag tgcgtggcca tagggagccg acatgcccgg
5521 gaggaaaggt gttgattaca tggatacttc taaaagctaa agccttgttg ccttctcttt
5581 aatgcctaga gaatgggatg tgtgatgcaa atgctcaaaa cctcttaaat catagctgtc
5641 tgacctctac ggacctcaca tccatctgag gcttcatgga caaagattct ccacttggcc
5701 aaactttagc caagctcctc aaccttctcc caggcccaat ctgggcactt ccttgtaaaa
5761 tctagttttg gcaagaagtc tattaggtca gtttagcaag aacacctaac ccccccatat
5821 ctgttcaacc tcagtatctg atcaggctcc tcagcctcca ccatccccca ggtgatgtct
5881 ggtcaactgg cctaccttca gctagaatcc tgttaggtcg gtttagatga atgctccctg
5941 atatttcctc ttggtaatct tccatccact gcccatgacc ctgttccctg tctataaatc
6001 cccagttttc catggtatat tcagagctga gtccagtctc tctcccctac tacaagtccc
6061 cattgctgtg gtccccgtac ctgtcatgat ggtcctaaat aaagtcttac tgtgctttaa
6121 taggtagcat tgaaaaattt ttttctttga catcattcat gacaacatga aacctattgg
6181 gacagcatga ctgtgcaggg tctttagagc tcagctttct gaggccctga gcattcttgg
6241 ttttccgaca tcgtgaacct gttctgtgtt gcaagatatc actcaagcca gtgttgctta
6301 ataccatctc tttgtgtaat agatctgaat aaagtaattg taatacacca atattttact
6361 ttgttgagta ttattttaat gggagccttt ccaatgaagg aaacatcagc tttccttgtt
6421 agaatgcaag cagcttaaaa actacccatg tctttctgga aaggaaacat tgccatgtaa
6481 ctatgtatca gttttctaag aacttcatgg gccttccata
//