LOCUS HUMPAI 2876 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human plasminogen activator inhibitor-1 (PAI-1) mRNA, complete cds.
ACCESSION M16006
VERSION M16006.1
KEYWORDS glycoprotein; plasminogen activator inhibitor; plasminogen
activator inhibitor 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 8 to 2876)
AUTHORS Ginsburg,D., Zeheb,R., Yang,A.Y., Rafferty,U.M., Andreasen,P.A.,
Nielsen,L., Dano,K., Lebo,R.V. and Gelehrter,T.D.
TITLE cDNA cloning of human plasminogen activator-inhibitor from
endothelial cells
JOURNAL J. Clin. Invest. 78 (6), 1673-1680 (1986)
PUBMED 3097076
REFERENCE 2 (bases 1 to 7)
AUTHORS Ginsburg,D.
JOURNAL Unpublished
COMMENT Original source text: Human umbilical vein endothelial cell
(HU-VEC), cDNA to mRNA, clone PAI-B4.
Draft entry and computer-readable copy of [1] kindly provided by,
D.Ginsburg, 23-JUN-1987.
FEATURES Location/Qualifiers
source 1..2876
/db_xref="H-InvDB:HIT000194431"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="7q21.3-q22.1"
gene 1..2876
/gene="PAI1"
CDS 76..1284
/gene="PAI1"
/note="plasminogen activator inhibitor-1"
/codon_start=1
/protein_id="AAA60003.1"
/translation="MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQ
QVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLY
KELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIIN
DWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGS
TVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNI
LSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSD
QEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGT
VLFMGQVMEP"
sig_peptide 76..144
/gene="PAI1"
/note="plasminogen activator inhibitor-1 leader peptide"
mat_peptide 145..1281
/gene="PAI1"
/product="plasminogen activator inhibitor-1 mature
peptide"
BASE COUNT 706 a 793 c 726 g 651 t
ORIGIN 1 bp upstream of EcoRI site; chromosome 7.
1 gaattcctgc agctcagcag ccgccgccag agcaggacga accgccaatc gcaaggcacc
61 tctgagaact tcaggatgca gatgtctcca gccctcacct gcctagtcct gggcctggcc
121 cttgtctttg gtgaagggtc tgctgtgcac catcccccat cctacgtggc ccacctggcc
181 tcagacttcg gggtgagggt gtttcagcag gtggcgcagg cctccaagga ccgcaacgtg
241 gttttctcac cctatggggt ggcctcggtg ttggccatgc tccagctgac aacaggagga
301 gaaacccagc agcagattca agcagctatg ggattcaaga ttgatgacaa gggcatggcc
361 cccgccctcc ggcatctgta caaggagctc atggggccat ggaacaagga tgagatcagc
421 accacagacg cgatcttcgt ccagcgggat ctgaagctgg tccagggctt catgccccac
481 ttcttcaggc tgttccggag cacggtcaag caagtggact tttcagaggt ggagagagcc
541 agattcatca tcaatgactg ggtgaagaca cacacaaaag gtatgatcag caacttgctt
601 gggaaaggag ccgtggacca gctgacacgg ctggtgctgg tgaatgccct ctacttcaac
661 ggccagtgga agactccctt ccccgactcc agcacccacc gccgcctctt ccacaaatca
721 gacggcagca ctgtctctgt gcccatgatg gctcagacca acaagttcaa ctatactgag
781 ttcaccacgc ccgatggcca ttactacgac atcctggaac tgccctacca cggggacacc
841 ctcagcatgt tcattgctgc cccttatgaa aaagaggtgc ctctctctgc cctcaccaac
901 attctgagtg cccagctcat cagccactgg aaaggcaaca tgaccaggct gccccgcctc
961 ctggttctgc ccaagttctc cctggagact gaagtcgacc tcaggaagcc cctagagaac
1021 ctgggaatga ccgacatgtt cagacagttt caggctgact tcacgagtct ttcagaccaa
1081 gagcctctcc acgtcgcgca ggcgctgcag aaagtgaaga tcgaggtgaa cgagagtggc
1141 acggtggcct cctcatccac agctgtcata gtctcagccc gcatggcccc cgaggagatc
1201 atcatggaca gacccttcct ctttgtggtc cggcacaacc ccacaggaac agtccttttc
1261 atgggccaag tgatggaacc ctgaccctgg ggaaagacgc cttcatctgg gacaaaactg
1321 gagatgcatc gggaaagaag aaactccgaa gaaaagaatt ttagtgttaa tgactctttc
1381 tgaaggaaga gaagacattt gccttttgtt aaaagatggt aaaccagatc tgtctccaag
1441 accttggcct ctccttggag gacctttagg tcaaactccc tagtctccac ctgagaccct
1501 gggagagaag tttgaagcac aactccctta aggtctccaa accagacggt gacgcctgcg
1561 ggaccatctg gggcacctgc ttccacccgt ctctctgccc actcgggtct gcagacctgg
1621 ttcccactga ggccctttgc aggatggaac tacggggctt acaggagctt ttgtgtgcct
1681 ggtagaaact atttctgttc cagtcacatt gccatcactc ttgtactgcc tgccaccgcg
1741 gaggaggctg gtgacaggcc aaaggccagt ggaagaaaca ccctttcatc tcagagtcca
1801 ctgtggcact ggccacccct ccccagtaca ggggtgctgc aggtggcaga gtgaatgtcc
1861 cccatcatgt ggcccaactc tcctggcctg gccatctccc tccccagaaa cagtgtgcat
1921 gggttatttt ggagtgtagg tgacttgttt actcattgaa gcagatttct gcttcctttt
1981 atttttatag gaatagagga agaaatgtca gatgcgtgcc cagctcttca ccccccaatc
2041 tcttggtggg gaggggtgta cctaaatatt tatcatatcc ttgcccttga gtgcttgtta
2101 gagagaaaga gaactactaa ggaaaataat attatttaaa ctcgctccta gtgtttcttt
2161 gtggtctgtg tcaccgtatc tcaggaagtc cagccacttg actggcacac acccctccgg
2221 acatccagcg tgacggagcc cacactgcca ccttgtggcc gcctgagacc ctcgcgcccc
2281 ccgcgccccc cgcgcccctc tttttcccct tgatggaaat tgaccataca atttcatcct
2341 ccttcagggg atcaaaagga cggagtgggg ggacagagac tcagatgagg acagagtggt
2401 ttccaatgtg ttcaatagat ttaggagcag aaatgcaagg ggctgcatga cctaccagga
2461 cagaactttc cccaattaca gggtgactca cagccgcatt ggtgactcac ttcaatgtgt
2521 catttccggc tgctgtgtgt gagcagtgga cacgtgaggg gggggtgggt gagagagaca
2581 ggcagctcgg attcaactac cttagataat atttctgaaa acctaccagc cagagggtag
2641 ggcacaaaga tggatgtaat gcactttggg aggccaaggc gggaggattg cttgagccca
2701 ggagttcaag accagcctgg gcaacatacc aagacccccg tctctttaaa aatatatata
2761 ttttaaatat acttaaatat atatttctaa tatctttaaa tatatatata tattttaaag
2821 accaatttat gggagaattg cacacagatg tgaaatgaat gtaatctaat agaagc
//