LOCUS HUMLPL 3549 bp mRNA linear HUM 08-AUG-1995
DEFINITION Human lipoprotein lipase mRNA, complete cds.
ACCESSION M15856
VERSION M15856.1
KEYWORDS lipoprotein lipase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3549)
AUTHORS Wion,K.L., Kirchgessner,T.G., Lusis,A.J., Schotz,M.C. and Lawn,R.M.
TITLE Human lipoprotein lipase complementary DNA sequence
JOURNAL Science 235 (4796), 1638-1641 (1987)
PUBMED 3823907
COMMENT Original source text: Human adipose tissue, cDNA to mRNA, clones
LPL[35,37,46].
Draft entry and clean copy sequence for [1] kindly provided by
R.Lawn, 18-MAY-1987.
Several mRNAs ended at around position 2416.
FEATURES Location/Qualifiers
source 1..3549
/db_xref="H-InvDB:HIT000194421"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="8p22"
gene 1..3549
/gene="LPL"
mRNA <1..3549
/gene="LPL"
/note="LPL mRNA (alt.); G00-120-700"
mRNA <1..3154
/gene="LPL"
/note="LPL mRNA (alt.); G00-120-700"
CDS 175..1602
/gene="LPL"
/note="lipoprotein lipase precursor"
/codon_start=1
/protein_id="AAB59536.1"
/db_xref="GDB:G00-120-700"
/translation="MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALR
TPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKR
EPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSL
GAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPG
RSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFI
DSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRS
QMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFL
IYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKV
SHLQKGKAPAVFVKCHDKSLNKKSG"
sig_peptide 175..255
/gene="LPL"
/note="lipoprotein lipase signal peptide; G00-120-700"
mat_peptide 256..1599
/gene="LPL"
/product="lipoprotein lipase; G00-120-700"
variation 1611
/gene="LPL"
/note="g can be a; G00-120-700"
/replace="a"
variation 2743
/gene="LPL"
/note="t can be c; G00-120-700"
/replace="c"
variation 2851
/gene="LPL"
/note="a can be g; G00-120-700"
/replace="g"
BASE COUNT 1020 a 739 c 806 g 984 t
ORIGIN Unreported.
1 cccctcttcc tcctcctcaa gggaaagctg cccacttcta gctgccctgc catccccttt
61 aaagggcgac ttgctcagcg ccaaaccgcg gctccagccc tctccagcct ccggctcagc
121 cggctcatca gtcggtccgc gccttgcagc tcctccagag ggacgcgccc cgagatggag
181 agcaaagccc tgctcgtgct gactctggcc gtgtggctcc agagtctgac cgcctcccgc
241 ggaggggtgg ccgccgccga ccaaagaaga gattttatcg acatcgaaag taaatttgcc
301 ctaaggaccc ctgaagacac agctgaggac acttgccacc tcattcccgg agtagcagag
361 tccgtggcta cctgtcattt caatcacagc agcaaaacct tcatggtgat ccatggctgg
421 acggtaacag gaatgtatga gagttgggtg ccaaaacttg tggccgccct gtacaagaga
481 gaaccagact ccaatgtcat tgtggtggac tggctgtcac gggctcagga gcattaccca
541 gtgtccgcgg gctacaccaa actggtggga caggatgtgg cccggtttat caactggatg
601 gaggaggagt ttaactaccc tctggacaat gtccatctct tgggatacag ccttggagcc
661 catgctgctg gcattgcagg aagtctgacc aataagaaag tcaacagaat tactggcctc
721 gatccagctg gacctaactt tgagtatgca gaagccccga gtcgtctttc tcctgatgat
781 gcagattttg tagacgtctt acacacattc accagagggt cccctggtcg aagcattgga
841 atccagaaac cagttgggca tgttgacatt tacccgaatg gaggtacttt tcagccagga
901 tgtaacattg gagaagctat ccgcgtgatt gcagagagag gacttggaga tgtggaccag
961 ctagtgaagt gctcccacga gcgctccatt catctcttca tcgactctct gttgaatgaa
1021 gaaaatccaa gtaaggccta caggtgcagt tccaaggaag cctttgagaa agggctctgc
1081 ttgagttgta gaaagaaccg ctgcaacaat ctgggctatg agatcaataa agtcagagcc
1141 aaaagaagca gcaaaatgta cctgaagact cgttctcaga tgccctacaa agtcttccat
1201 taccaagtaa agattcattt ttctgggact gagagtgaaa cccataccaa tcaggccttt
1261 gagatttctc tgtatggcac cgtggccgag agtgagaaca tcccattcac tctgcctgaa
1321 gtttccacaa ataagaccta ctccttccta atttacacag aggtagatat tggagaacta
1381 ctcatgttga agctcaaatg gaagagtgat tcatacttta gctggtcaga ctggtggagc
1441 agtcccggct tcgccattca gaagatcaga gtaaaagcag gagagactca gaaaaaggtg
1501 atcttctgtt ctagggagaa agtgtctcat ttgcagaaag gaaaggcacc tgcggtattt
1561 gtgaaatgcc atgacaagtc tctgaataag aagtcaggct gaaactgggc gaatctacag
1621 aacaaagaac ggcatgtgaa ttctgtgaag aatgaagtgg aggaagtaac ttttacaaaa
1681 catacccagt gtttggggtg tttcaaaagt ggattttcct gaatattaat cccagcccta
1741 cccttgttag ttattttagg agacagtctc aagcactaaa aagtggctaa ttcaatttat
1801 ggggtatagt ggccaaatag cacatcctcc aacgttaaaa gacagtggat catgaaaagt
1861 gctgttttgt cctttgagaa agaaataatt gtttgagcgc agagtaaaat aaggctcctt
1921 catgtggcgt attgggccat agcctataat tggttagaac ctcctatttt aattggaatt
1981 ctggatcttt cggactgagg ccttctcaaa ctttactcta agtctccaag aatacagaaa
2041 atgcttttcc gcggcacgaa tcagactcat ctacacagca gtatgaatga tgttttagaa
2101 tgattccctc ttgctattgg aatgtggtcc agacgtcaac caggaacatg taacttggag
2161 agggacgaag aaagggtctg ataaacacag aggttttaaa cagtccctac cattggcctg
2221 catcatgaca aagttacaaa ttcaaggaga tataaaatct agatcaatta attcttaata
2281 ggctttatcg tttattgctt aatccctctc tcccccttct tttttgtctc aagattatat
2341 tataataatg ttctctgggt aggtgttgaa aatgagcctg taatcctcag ctgacacata
2401 atttgaatgg tgcagaaaaa aaaaagatac cgtaatttta ttattagatt ctccaaatga
2461 ttttcatcaa tttaaaatca ttcaatatct gacagttact cttcagtttt aggcttacct
2521 tggtcatgct tcagttgtac ttccagtgcg tctcttttgt tcctggcttt gacatgaaaa
2581 gataggtttg agttcaaatt ttgcattgtg tgagcttcta cagattttag acaaggaccg
2641 tttttactaa gtaaaagggt ggagaggttc ctggggtgga ttcctaagca gtgcttgtaa
2701 accatcgcgt gcaatgagcc agatggagta ccatgagggt tgttatttgt tgtttttaac
2761 aactaatcaa gagtgagtga acaactattt ataaactaga tctcctattt ttcagaatgc
2821 tcttctacgt ataaatatga aatgataaag atgtcaaata tctcagaggc tatagctggg
2881 aacccgactg tgaaagtatg tgatatctga acacatacta gaaagctctg catgtgtgtt
2941 gtccttcagc ataattcgga agggaaaaca gtcgatcaag ggatgtattg gaacatgtcg
3001 gagtagaaat tgttcctgat gtgccagaac ttcgaccctt tctctgagag agatgatcgt
3061 gcctataaat agtaggacca atgttgtgat taacatcatc aggcttggaa tgaattctct
3121 ctaaaaataa aatgatgtat gatttgttgt tggcatcccc tttattaatt cattaaattt
3181 ctggatttgg gttgtgaccc agggtgcatt aacttaaaag attcactaaa gcagcacata
3241 gcactgggaa ctctggctcc gaaaaacttt gttatatata tcaaggatgt tctggcttta
3301 cattttattt attagctgta aatacatgtg tggatgtgta aatggagctt gtacatattg
3361 gaaaggtcat tgtggctatc tgcatttata aatgtgtggt gctaactgta tgtgtcttta
3421 tcagtgatgg tctcacagag ccaactcact cttatgaaat gggctttaac aaaacaagaa
3481 agaaacgtac ttaactgtgt gaagaaatgg aatcagcttt taataaaatt gacaacattt
3541 tattaccac
//