LOCUS HUMNGFR 3386 bp mRNA linear HUM 11-AUG-1995
DEFINITION Human nerve growth factor receptor mRNA, complete cds.
ACCESSION M14764
VERSION M14764.1
KEYWORDS nerve growth factor receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3386)
AUTHORS Johnson,D., Lanahan,A., Buck,C.R., Sehgal,A., Morgan,C., Mercer,E.,
Bothwell,M. and Chao,M.
TITLE Expression and structure of the human NGF receptor
JOURNAL Cell 47 (4), 545-554 (1986)
PUBMED 3022937
COMMENT Original source text: Homo sapiens (clone: E1.) melanoma cDNA to
mRNA.
Draft entry and clean copy sequence for [1] kindly provided by
M.Bothwell, 28-APR-1987.
FEATURES Location/Qualifiers
source 1..3386
/db_xref="H-InvDB:HIT000194363"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="17q21-q22"
/clone="E1."
/cell_line="A875"
/tissue_type="melanoma"
gene 1..3386
/gene="NGFR"
mRNA <1..3386
/gene="NGFR"
/note="G00-120-234"
CDS 114..1397
/gene="NGFR"
/codon_start=1
/product="nerve growth factor receptor"
/protein_id="AAB59544.1"
/db_xref="GDB:G00-120-234"
/translation="MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECC
KACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEA
DDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANH
VDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAP
PEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWN
SCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGG
LYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWAT
QDSATLDALLAALRRIQRADLVESLCSESTATSPV"
sig_peptide 114..197
/gene="NGFR"
/note="G00-120-234"
mat_peptide 198..1394
/gene="NGFR"
/product="nerve growth factor receptor"
/note="G00-120-234"
variation 1105
/gene="NGFR"
/note="g sometimes t"
/replace="t"
BASE COUNT 656 a 1104 c 1030 g 596 t
ORIGIN 5 bp upstream of SacII site; 17q21-q22.
1 gccgcggcca gctccggcgg gcaggggggg cgctggagcg cagcgcagcg cagccccatc
61 agtccgcaaa gcggaccgag ctggaagtcg agcgctgccg cgggaggcgg gcgatggggg
121 caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg cttctggggg
181 tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac agcggtgagt
241 gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc aaccagaccg
301 tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg accgagccgt
361 gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc gtggaggccg
421 acgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact gggcgctgcg
481 aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag gacaagcaga
541 acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac cacgtggacc
601 cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag tgcacacgct
661 gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc acacccccag
721 agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca gaacaagacc
781 tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc cagcccgtgg
841 tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg gctgctgtgg
901 ttgtgggcct tgtggcctac atagccttca agaggtggaa cagctgcaag cagaacaagc
961 aaggagccaa cagccggcca gtgaaccaga cgcccccacc agagggagaa aaactccaca
1021 gcgacagtgg catctccgtg gacagccaga gcctgcatga ccagcagccc cacacgcaga
1081 cagcctcggg ccaggccctc aagggtgacg gaggcctcta cagcagcctg cccccagcca
1141 agcgggagga ggtggagaag cttctcaacg gctctgcggg ggacacctgg cggcacctgg
1201 cgggcgagct gggctaccag cccgagcaca tagactcctt tacccatgag gcctgccccg
1261 ttcgcgccct gcttgcaagc tgggccaccc aggacagcgc cacactggac gccctcctgg
1321 ccgccctgcg ccgcatccag cgagccgacc tcgtggagag tctgtgcagt gagtccactg
1381 ccacatcccc ggtgtgagcc caaccgggga gcccccgccc cgccccacat tccgacaacc
1441 gatgctccag ccaacccctg tggagcccgc acccccaccc tttggggggg gcccgcctgg
1501 cagaactgag ctcctctggg caggacctca gagtccaggc cccaaaacca cagccctgtc
1561 agtgcagccc gtgtggcccc ttcacttctg accacacttc ctgtccagag agagaagtgc
1621 ccctgctgcc tccccaaccc tgcccctgcc ccgtcaccat ctcaggccac ctgccccctt
1681 ctcccacact gctaggtggg ccagcccctc ccaccacagc aggtgtcata tatggggggc
1741 caacaccagg gatggtacta gggggaagtg acaaggcccc agagactcag agggaggaat
1801 cgaggaacca gagccatgga ctctacactg tgaacttggg gaacaagggt ggcatcccag
1861 tggcctcaac cctccctcag cccctcttgc cccccacccc agcctaagat gaagaggatc
1921 ggaggcttgt cagagctggg aggggttttc gaagctcagc ccacccccct cattttggat
1981 ataggtcagt gaggcccagg gagaggccat gattcgccca aagccagaca gcaacgggga
2041 ggccaagtgc aggctggcac cgccttctct aaatgagggg cctcaggttt gcctgagggc
2101 gaggggaggg tggcaggtga ccttctggga aatggcttga agccaagtca gctttgcctt
2161 ccacgctgtc tccagacccc caccccttcc ccactgcctg cccacccgtg gagatgggat
2221 gcttgcctag ggcctggtcc atgatggagt caggtttggg gttcgtggaa agggtgctgc
2281 ttccctctgc ctgtccctct caggcatgcc tgtgtgacat cagtggcatg gctccagtct
2341 gctgccctcc atcccgacat ggacccggag ctaacactgg cccctagaat cagcctaggg
2401 gtcagggacc aaggacccct caccttgcaa cacacagaca cacgcacaca cacacacagg
2461 aggagaaatc tcacttttct ccatgagttt tttctcttgg gctgagactg gatactgccc
2521 ggggcagctg ccagagaagc atcggaggga attgaggtct gctcggccgt cttcactcgc
2581 ccccgggttt ggcgggccaa ggactgccga ccgaggctgg agctggcgtc tgtcttcaag
2641 ggcttacacg tggaggaatg ctcccccatc ctccccttcc ctgcaaacat ggggttggct
2701 gggcccagaa ggttgcgatg aagaaaagcg ggccagtgtg ggaatgcggc aagaaggaat
2761 tgacttcgac tgtgacctgt ggggatttct cccagctcta gacaaccctg caaaggactg
2821 ttttttcctg agcttggcca gaagggggcc atgaggcctc agtggacttt ccaccccctc
2881 cctggcctgt tctgttttgc ctgaagttgg agtgagtgtg gctcccctct atttagcatg
2941 acaagcccca ggcaggctgt gcgctgacaa ccaccgctcc ccagcccagg gttcccccag
3001 ccctgtggaa gggactagga gcactgtagt aaatggcaat tctttgacct caacctgtga
3061 tgaggggagg aaactcacct gctggcccct cacctgggca cctggggagt gggacagagt
3121 ctgggtgtat ttattttcct ccccagcagg tggggagggg gtttggtggc ttgcaagtat
3181 gttttagcat gtgtttggtt ctggggcccc tttttactcc ccttgagctg agatggaacc
3241 cttttggccc ccagctgggg gccatgagct ccagaccccc agcaaccctc ctatcacctc
3301 ccctccttgc ctcctgtgta atcatttctt gggccctcct gaaacttaca cacaaaacgt
3361 taagtgatga acattaaata gcaaag
//