LOCUS       HUMVTNR                 5717 bp    mRNA    linear   HUM 03-AUG-1993
DEFINITION  Human cell adhesion protein (vitronectin) receptor alpha subunit
            mRNA, complete cds.
ACCESSION   M14648 J02826 M18365
VERSION     M14648.1
KEYWORDS    cell adhesion protein receptor; glycoprotein; vitronectin receptor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1276 to 5717)
  AUTHORS   Suzuki,S., Argraves,W.S., Pytela,R., Arai,H., Krusius,T.,
            Pierschbacher,M.D. and Ruoslahti,E.
  TITLE     cDNA and amino acid sequences of the cell adhesion protein receptor
            recognizing vitronectin reveal a transmembrane domain and
            homologies with other adhesion protein receptors
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (22), 8614-8618 (1986)
   PUBMED   2430295
REFERENCE   2  (bases 20 to 1343)
  AUTHORS   Fitzgerald,L.A., Poncz,M., Steiner,B., Rall,S.C. Jr., Bennett,J.S.
            and Phillips,D.R.
  TITLE     Comparison of cDNA-derived protein sequences of the human
            fibronectin and vitronectin receptor alpha-subunits and platelet
            glycoprotein IIb
  JOURNAL   Biochemistry 26 (25), 8158-8165 (1987)
   PUBMED   2450560
REFERENCE   3  (bases 1 to 5717)
  AUTHORS   Suzuki,S., Argraves,W.S., Arai,H., Languino,L.R.,
            Pierschbacher,M.D. and Ruoslahti,E.
  TITLE     Amino acid sequence of the vitronectin receptor alpha subunit and
            comparative expression of adhesion receptor mRNAs
  JOURNAL   J. Biol. Chem. 262 (29), 14080-14085 (1987)
   PUBMED   2443500
COMMENT     Original source text: Human fibroblast cell line IMR-90, cDNA to
            mRNA, clones lambda-VNR[10,11]; clones lambda VRN[21,26] [3]; HUVE,
            cDNA to mRNA (see comment).
            Complete source information:
            Human fibroblast cell line IMR-90, cDNA to mRNA, clones
            lambda-VNR[10,11] [1]; clones lambda VRN[21,26] [3]; HUVE, cDNA to
            mRNA [2].
FEATURES             Location/Qualifiers
     source          1..5717
                     /db_xref="H-InvDB:HIT000194350"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             42..3188
                     /note="vitronectin alpha subunit precursor"
                     /codon_start=1
                     /protein_id="AAA36808.1"
                     /translation="MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGP
                     EGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEF
                     DATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFL
                     QDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQV
                     AEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRA
                     ARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRG
                     SDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAA
                     PYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYP
                     DLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFC
                     LKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCE
                     ELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILL
                     DCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQAD
                     FIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTS
                     VKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHIFLPIPNWEHKENPET
                     EEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDM
                     EINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVC
                     QVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDIT
                     NSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEE
                     QEREQLQPHENGEGNSET"
     sig_peptide     42..131
                     /note="vitronectin alpha subunit signal peptide"
     mat_peptide     132..2711
                     /product="vitronectin alpha subunit heavy chain"
     mat_peptide     2712..3185
                     /product="vitronectin alpha subunit light chain"
BASE COUNT         1704 a         1025 c         1149 g         1839 t
ORIGIN      Unreported.
        1 ggctaccgct cccggcttgg cgtcccgcgc gcacttcggc gatggctttt ccgccgcggc
       61 gacggctgcg cctcggtccc cgcggcctcc cgcttcttct ctcgggactc ctgctacctc
      121 tgtgccgcgc cttcaaccta gacgtggaca gtcctgccga gtactctggc cccgagggaa
      181 gttacttcgg cttcgccgtg gatttcttcg tgcccagcgc gtcttcccgg atgtttcttc
      241 tcgtgggagc tcccaaagca aacaccaccc agcctgggat tgtggaagga gggcaggtcc
      301 tcaaatgtga ctggtcttct acccgccggt gccagccaat tgaatttgat gcaacaggca
      361 atagagatta tgccaaggat gatccattgg aatttaagtc ccatcagtgg tttggagcat
      421 ctgtgaggtc gaaacaggat aaaattttgg cctgtgcccc attgtaccat tggagaactg
      481 agatgaaaca ggagcgagag cctgttggaa catgctttct tcaagatgga acaaagactg
      541 ttgagtatgc tccatgtaga tcacaagata ttgatgctga tggacaggga ttttgtcaag
      601 gaggattcag cattgatttt actaaagctg acagagtact tcttggtggt cctggtagct
      661 tttattggca aggtcagctt atttcggatc aagtggcaga aatcgtatct aaatacgacc
      721 ccaatgttta cagcatcaag tataataacc aattagcaac tcggactgca caagctattt
      781 ttgatgacag ctatttgggt tattctgtgg ctgtcggaga tttcaatggt gatggcatag
      841 atgactttgt ttcaggagtt ccaagagcag caaggacttt gggaatggtt tatatttatg
      901 atgggaagaa catgtcctcc ttatacaatt ttactggcga gcagatggct gcatatttcg
      961 gattttctgt agctgccact gacattaatg gagatgatta tgcagatgtg tttattggag
     1021 cacctctctt catggatcgt ggctctgatg gcaaactcca agaggtgggg caggtctcag
     1081 tgtctctaca gagagcttca ggagacttcc agacgacaaa gctgaatgga tttgaggtct
     1141 ttgcacggtt tggcagtgcc atagctcctt tgggagatct ggaccaggat ggtttcaatg
     1201 atattgcaat tgctgctcca tatgggggtg aagataaaaa aggaattgtt tatatcttca
     1261 atggaagatc aacaggcttg aacgcagtcc catctcaaat ccttgaaggg cagtgggctg
     1321 ctcgaagcat gccaccaagc tttggctatt caatgaaagg agccacagat atagacaaaa
     1381 atggatatcc agacttaatt gtaggagctt ttggtgtaga tcgagctatc ttatacaggg
     1441 ccagaccagt tatcactgta aatgctggtc ttgaagtgta ccctagcatt ttaaatcaag
     1501 acaataaaac ctgctcactg cctggaacag ctctcaaagt ttcctgtttt aatgttaggt
     1561 tctgcttaaa ggcagatggc aaaggagtac ttcccaggaa acttaatttc caggtggaac
     1621 ttcttttgga taaactcaag caaaagggag caattcgacg agcactgttt ctctacagca
     1681 ggtccccaag tcactccaag aacatgacta tttcaagggg gggactgatg cagtgtgagg
     1741 aattgatagc gtatctgcgg gatgaatctg aatttagaga caaactcact ccaattacta
     1801 tttttatgga atatcggttg gattatagaa cagctgctga tacaacaggc ttgcaaccca
     1861 ttcttaacca gttcacgcct gctaacatta gtcgacaggc tcacattcta cttgactgtg
     1921 gtgaagacaa tgtctgtaaa cccaagctgg aagtttctgt agatagtgat caaaagaaga
     1981 tctatattgg ggatgacaac cctctgacat tgattgttaa ggctcagaat caaggagaag
     2041 gtgcctacga agctgagctc atcgtttcca ttccactgca ggctgatttc atcggggttg
     2101 tccgaaacaa tgaagcctta gcaagacttt cctgtgcatt taagacagaa aaccaaactc
     2161 gccaggtggt atgtgacctt ggaaacccaa tgaaggctgg aactcaactc ttagctggtc
     2221 ttcgtttcag tgtgcaccag cagtcagaga tggatacttc tgtgaaattt gacttacaaa
     2281 tccaaagctc aaatctattt gacaaagtaa gcccagttgt atctcacaaa gttgatcttg
     2341 ctgttttagc tgcagttgag ataagaggag tctcgagtcc tgatcatatc tttcttccga
     2401 ttccaaactg ggagcacaag gagaaccctg agactgaaga agatgttggg ccagttgttc
     2461 agcacatcta tgagctgaga aacaatggtc caagttcatt cagcaaggca atgctccatc
     2521 ttcagtggcc ttacaaatat aataataaca ctctgttgta tatccttcat tatgatattg
     2581 atggaccaat gaactgcact tcagatatgg agatcaaccc tttgagaatt aagatctcat
     2641 ctttgcaaac aactgaaaag aatgacacgg ttgccgggca aggtgagcgg gaccatctca
     2701 tcactaagcg ggatcttgcc ctcagtgaag gagatattca cactttgggt tgtggagttg
     2761 ctcagtgctt gaagattgtc tgccaagttg ggagattaga cagaggaaag agtgcaatct
     2821 tgtacgtaaa gtcattactg tggactgaga cttttatgaa taaagaaaat cagaatcatt
     2881 cctattctct gaagtcgtct gcttcattta atgtcataga gtttccttat aagaatcttc
     2941 caattgagga tatcaccaac tccacattgg ttaccactaa tgtcacctgg ggcattcagc
     3001 cagcgcccat gcctgtgcct gtgtgggtga tcattttagc agttctagca ggattgttgc
     3061 tactggctgt tttggtattt gtaatgtaca ggatgggctt ttttaaacgg gtccggccac
     3121 ctcaagaaga acaagaaagg gagcagcttc aacctcatga aaatggtgaa ggaaactcag
     3181 aaacttaact gcagttttta agttatgcta catcttgacc cactagaatt agcaacttta
     3241 ttatagattt aaactttctt catgaggagt aaaaatccaa ggctttactg ctgatagtgc
     3301 taattggcat taaccacaaa atgagaatta tatttgtcaa ccttctcctt ataaataagt
     3361 tcagacatac atttaataac atagggtgac ttgtgttttt aggtatttaa ataataaaat
     3421 ttcaagggat agtttttatt caatgtatat aagacaggta gtgcctgatt tactacttta
     3481 tataaaatag tacctccttc agttactgtt tctgatttaa tgtacggaac tttatttgtt
     3541 gttgttgttg ttgttgttgt tgttgtttta aagcagtcca aatttggacc ttagcaatca
     3601 tgtcttttgt ataggtactt aatgttaata catattacac tacagtttac ttttcagaat
     3661 actaaagact ttataactgc atgaacttgg atttttttaa tcactcatat ggtagaattt
     3721 tataaacaca tacatgatac catccaaatt cttgctttta ataacaaagg tacaatattt
     3781 tgttttagta tgaaaatctg gtagatccta ttacacttct gtttatatta aatccacaat
     3841 attttattac atttttaact tgtataaatt ttaggtcaaa tccttcaagc caacctatac
     3901 taaaaattag ttccataatc acaaatggct cttttgtgta attgtttaat ttcacctgaa
     3961 tatcataatg cttaaagcca tatggagttg gaaattattt ccaaagcata tttattccat
     4021 tgttttagtc tggctattta cagtataaaa aaagcatttt attaaaatac tgtgtagttc
     4081 tttgagatag ttgcttatgc atatagtaag tattacattc ttagagtaga gcagagtttt
     4141 tagttagtat taatttattt tcctccattc atgtactttt ccttatattt ccaaaactgt
     4201 tactgagaat gggtcaagat cagtgagaaa tctttacagt tgacaggaac ctggacccct
     4261 taccccaact ttatgagtaa tgcttggaat aaaaaactct taaggcaact cactgattta
     4321 cttctagcaa tagcatgatg ttacaggaat attacctctg tttaagcaag gtaatgtgta
     4381 aaatcagtct cggctgtcag aataacttct aaaaggtatt tttataagca gttcaagtta
     4441 ctgaaaacct tttaaacctt tctgaagttc gttagtataa attacttttc taggattatt
     4501 aataaaagcc acataggtgg caagttgtag ttttatatgg ctctgtagag tggtgaacct
     4561 tctagaggaa tatatgattt attcacagtt cctcaaggcc tggggatgat gatcagttat
     4621 acctattttt gtgcaattac atcatgttgt acattagaaa tggagagttt aatagctctt
     4681 taactgctgt cctcattagg taatgataaa tatttccctt aaataattga ctattttgct
     4741 gtgttttaaa aatgattgaa atttatcttg ccatatctca taatttcatg cacaagttga
     4801 ctgagctaat cttgagaata tattcgtaaa ataggagcac atttagttga ggtatacaag
     4861 gtaggactct agacaaaacc ttctatttta gctttagtga atttcaaaag taatgggtct
     4921 tggagtatag atttttatta gtagcttgaa agagcttaat catatgcagt aagtattttt
     4981 attaccaata aatttaaaat tttttaagaa aaatattttt atcctagggc caagtgttgc
     5041 ctgccaccaa tcagtaagtt agtctataac aaattttacc ctaacagttt taccacctag
     5101 caacagtcat ttctgaaaat atgttggata gaaagtcact ctttggcaaa agtgttagaa
     5161 tttgcttttg tgccatctat tccttttatg gcatctatct tgaaagtaat cttgtattgg
     5221 agattgaaag atgctgtaat ttagaaatta acatgatatc ttaaattacc tttatgaaat
     5281 atagttttgt ataatagcat agattttcct tcaaaaaatg aacatttata tatctacaaa
     5341 aatatggaga agagcaattt gaaagcctac tttctgaaga aaatggtggg attttttttt
     5401 atcatgatta aatatcaaaa aattgcccta tgaaaacttt aaatctctaa aacatttgaa
     5461 atactaccat atttgtgatt tattgagaat aaaaatccat tttgaaatgt aaaattttta
     5521 tgatctgatt cagttttaag aaaacatgaa tgaactagaa gatattaaaa acatttgaca
     5581 ttggtaagaa atattgatac tgatattgat ttttatatag gtatttattt cagaattgat
     5641 attttgagaa aaatacatgt gagtcatttt ttctgtttct cttttctctt aacgattatc
     5701 actgtaattc tgaatct
//