LOCUS HUMVTNR 5717 bp mRNA linear HUM 03-AUG-1993 DEFINITION Human cell adhesion protein (vitronectin) receptor alpha subunit mRNA, complete cds. ACCESSION M14648 J02826 M18365 VERSION M14648.1 KEYWORDS cell adhesion protein receptor; glycoprotein; vitronectin receptor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1276 to 5717) AUTHORS Suzuki,S., Argraves,W.S., Pytela,R., Arai,H., Krusius,T., Pierschbacher,M.D. and Ruoslahti,E. TITLE cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (22), 8614-8618 (1986) PUBMED 2430295 REFERENCE 2 (bases 20 to 1343) AUTHORS Fitzgerald,L.A., Poncz,M., Steiner,B., Rall,S.C. Jr., Bennett,J.S. and Phillips,D.R. TITLE Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb JOURNAL Biochemistry 26 (25), 8158-8165 (1987) PUBMED 2450560 REFERENCE 3 (bases 1 to 5717) AUTHORS Suzuki,S., Argraves,W.S., Arai,H., Languino,L.R., Pierschbacher,M.D. and Ruoslahti,E. TITLE Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs JOURNAL J. Biol. Chem. 262 (29), 14080-14085 (1987) PUBMED 2443500 COMMENT Original source text: Human fibroblast cell line IMR-90, cDNA to mRNA, clones lambda-VNR[10,11]; clones lambda VRN[21,26] [3]; HUVE, cDNA to mRNA (see comment). Complete source information: Human fibroblast cell line IMR-90, cDNA to mRNA, clones lambda-VNR[10,11] [1]; clones lambda VRN[21,26] [3]; HUVE, cDNA to mRNA [2]. FEATURES Location/Qualifiers source 1..5717 /db_xref="H-InvDB:HIT000194350" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 42..3188 /note="vitronectin alpha subunit precursor" /codon_start=1 /protein_id="AAA36808.1" /translation="MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGP EGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEF DATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFL QDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQV AEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRA ARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRG SDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAA PYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYP DLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFC LKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCE ELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILL DCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQAD FIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTS VKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHIFLPIPNWEHKENPET EEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDM EINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVC QVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDIT NSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEE QEREQLQPHENGEGNSET" sig_peptide 42..131 /note="vitronectin alpha subunit signal peptide" mat_peptide 132..2711 /product="vitronectin alpha subunit heavy chain" mat_peptide 2712..3185 /product="vitronectin alpha subunit light chain" BASE COUNT 1704 a 1025 c 1149 g 1839 t ORIGIN Unreported. 1 ggctaccgct cccggcttgg cgtcccgcgc gcacttcggc gatggctttt ccgccgcggc 61 gacggctgcg cctcggtccc cgcggcctcc cgcttcttct ctcgggactc ctgctacctc 121 tgtgccgcgc cttcaaccta gacgtggaca gtcctgccga gtactctggc cccgagggaa 181 gttacttcgg cttcgccgtg gatttcttcg tgcccagcgc gtcttcccgg atgtttcttc 241 tcgtgggagc tcccaaagca aacaccaccc agcctgggat tgtggaagga gggcaggtcc 301 tcaaatgtga ctggtcttct acccgccggt gccagccaat tgaatttgat gcaacaggca 361 atagagatta tgccaaggat gatccattgg aatttaagtc ccatcagtgg tttggagcat 421 ctgtgaggtc gaaacaggat aaaattttgg cctgtgcccc attgtaccat tggagaactg 481 agatgaaaca ggagcgagag cctgttggaa catgctttct tcaagatgga acaaagactg 541 ttgagtatgc tccatgtaga tcacaagata ttgatgctga tggacaggga ttttgtcaag 601 gaggattcag cattgatttt actaaagctg acagagtact tcttggtggt cctggtagct 661 tttattggca aggtcagctt atttcggatc aagtggcaga aatcgtatct aaatacgacc 721 ccaatgttta cagcatcaag tataataacc aattagcaac tcggactgca caagctattt 781 ttgatgacag ctatttgggt tattctgtgg ctgtcggaga tttcaatggt gatggcatag 841 atgactttgt ttcaggagtt ccaagagcag caaggacttt gggaatggtt tatatttatg 901 atgggaagaa catgtcctcc ttatacaatt ttactggcga gcagatggct gcatatttcg 961 gattttctgt agctgccact gacattaatg gagatgatta tgcagatgtg tttattggag 1021 cacctctctt catggatcgt ggctctgatg gcaaactcca agaggtgggg caggtctcag 1081 tgtctctaca gagagcttca ggagacttcc agacgacaaa gctgaatgga tttgaggtct 1141 ttgcacggtt tggcagtgcc atagctcctt tgggagatct ggaccaggat ggtttcaatg 1201 atattgcaat tgctgctcca tatgggggtg aagataaaaa aggaattgtt tatatcttca 1261 atggaagatc aacaggcttg aacgcagtcc catctcaaat ccttgaaggg cagtgggctg 1321 ctcgaagcat gccaccaagc tttggctatt caatgaaagg agccacagat atagacaaaa 1381 atggatatcc agacttaatt gtaggagctt ttggtgtaga tcgagctatc ttatacaggg 1441 ccagaccagt tatcactgta aatgctggtc ttgaagtgta ccctagcatt ttaaatcaag 1501 acaataaaac ctgctcactg cctggaacag ctctcaaagt ttcctgtttt aatgttaggt 1561 tctgcttaaa ggcagatggc aaaggagtac ttcccaggaa acttaatttc caggtggaac 1621 ttcttttgga taaactcaag caaaagggag caattcgacg agcactgttt ctctacagca 1681 ggtccccaag tcactccaag aacatgacta tttcaagggg gggactgatg cagtgtgagg 1741 aattgatagc gtatctgcgg gatgaatctg aatttagaga caaactcact ccaattacta 1801 tttttatgga atatcggttg gattatagaa cagctgctga tacaacaggc ttgcaaccca 1861 ttcttaacca gttcacgcct gctaacatta gtcgacaggc tcacattcta cttgactgtg 1921 gtgaagacaa tgtctgtaaa cccaagctgg aagtttctgt agatagtgat caaaagaaga 1981 tctatattgg ggatgacaac cctctgacat tgattgttaa ggctcagaat caaggagaag 2041 gtgcctacga agctgagctc atcgtttcca ttccactgca ggctgatttc atcggggttg 2101 tccgaaacaa tgaagcctta gcaagacttt cctgtgcatt taagacagaa aaccaaactc 2161 gccaggtggt atgtgacctt ggaaacccaa tgaaggctgg aactcaactc ttagctggtc 2221 ttcgtttcag tgtgcaccag cagtcagaga tggatacttc tgtgaaattt gacttacaaa 2281 tccaaagctc aaatctattt gacaaagtaa gcccagttgt atctcacaaa gttgatcttg 2341 ctgttttagc tgcagttgag ataagaggag tctcgagtcc tgatcatatc tttcttccga 2401 ttccaaactg ggagcacaag gagaaccctg agactgaaga agatgttggg ccagttgttc 2461 agcacatcta tgagctgaga aacaatggtc caagttcatt cagcaaggca atgctccatc 2521 ttcagtggcc ttacaaatat aataataaca ctctgttgta tatccttcat tatgatattg 2581 atggaccaat gaactgcact tcagatatgg agatcaaccc tttgagaatt aagatctcat 2641 ctttgcaaac aactgaaaag aatgacacgg ttgccgggca aggtgagcgg gaccatctca 2701 tcactaagcg ggatcttgcc ctcagtgaag gagatattca cactttgggt tgtggagttg 2761 ctcagtgctt gaagattgtc tgccaagttg ggagattaga cagaggaaag agtgcaatct 2821 tgtacgtaaa gtcattactg tggactgaga cttttatgaa taaagaaaat cagaatcatt 2881 cctattctct gaagtcgtct gcttcattta atgtcataga gtttccttat aagaatcttc 2941 caattgagga tatcaccaac tccacattgg ttaccactaa tgtcacctgg ggcattcagc 3001 cagcgcccat gcctgtgcct gtgtgggtga tcattttagc agttctagca ggattgttgc 3061 tactggctgt tttggtattt gtaatgtaca ggatgggctt ttttaaacgg gtccggccac 3121 ctcaagaaga acaagaaagg gagcagcttc aacctcatga aaatggtgaa ggaaactcag 3181 aaacttaact gcagttttta agttatgcta catcttgacc cactagaatt agcaacttta 3241 ttatagattt aaactttctt catgaggagt aaaaatccaa ggctttactg ctgatagtgc 3301 taattggcat taaccacaaa atgagaatta tatttgtcaa ccttctcctt ataaataagt 3361 tcagacatac atttaataac atagggtgac ttgtgttttt aggtatttaa ataataaaat 3421 ttcaagggat agtttttatt caatgtatat aagacaggta gtgcctgatt tactacttta 3481 tataaaatag tacctccttc agttactgtt tctgatttaa tgtacggaac tttatttgtt 3541 gttgttgttg ttgttgttgt tgttgtttta aagcagtcca aatttggacc ttagcaatca 3601 tgtcttttgt ataggtactt aatgttaata catattacac tacagtttac ttttcagaat 3661 actaaagact ttataactgc atgaacttgg atttttttaa tcactcatat ggtagaattt 3721 tataaacaca tacatgatac catccaaatt cttgctttta ataacaaagg tacaatattt 3781 tgttttagta tgaaaatctg gtagatccta ttacacttct gtttatatta aatccacaat 3841 attttattac atttttaact tgtataaatt ttaggtcaaa tccttcaagc caacctatac 3901 taaaaattag ttccataatc acaaatggct cttttgtgta attgtttaat ttcacctgaa 3961 tatcataatg cttaaagcca tatggagttg gaaattattt ccaaagcata tttattccat 4021 tgttttagtc tggctattta cagtataaaa aaagcatttt attaaaatac tgtgtagttc 4081 tttgagatag ttgcttatgc atatagtaag tattacattc ttagagtaga gcagagtttt 4141 tagttagtat taatttattt tcctccattc atgtactttt ccttatattt ccaaaactgt 4201 tactgagaat gggtcaagat cagtgagaaa tctttacagt tgacaggaac ctggacccct 4261 taccccaact ttatgagtaa tgcttggaat aaaaaactct taaggcaact cactgattta 4321 cttctagcaa tagcatgatg ttacaggaat attacctctg tttaagcaag gtaatgtgta 4381 aaatcagtct cggctgtcag aataacttct aaaaggtatt tttataagca gttcaagtta 4441 ctgaaaacct tttaaacctt tctgaagttc gttagtataa attacttttc taggattatt 4501 aataaaagcc acataggtgg caagttgtag ttttatatgg ctctgtagag tggtgaacct 4561 tctagaggaa tatatgattt attcacagtt cctcaaggcc tggggatgat gatcagttat 4621 acctattttt gtgcaattac atcatgttgt acattagaaa tggagagttt aatagctctt 4681 taactgctgt cctcattagg taatgataaa tatttccctt aaataattga ctattttgct 4741 gtgttttaaa aatgattgaa atttatcttg ccatatctca taatttcatg cacaagttga 4801 ctgagctaat cttgagaata tattcgtaaa ataggagcac atttagttga ggtatacaag 4861 gtaggactct agacaaaacc ttctatttta gctttagtga atttcaaaag taatgggtct 4921 tggagtatag atttttatta gtagcttgaa agagcttaat catatgcagt aagtattttt 4981 attaccaata aatttaaaat tttttaagaa aaatattttt atcctagggc caagtgttgc 5041 ctgccaccaa tcagtaagtt agtctataac aaattttacc ctaacagttt taccacctag 5101 caacagtcat ttctgaaaat atgttggata gaaagtcact ctttggcaaa agtgttagaa 5161 tttgcttttg tgccatctat tccttttatg gcatctatct tgaaagtaat cttgtattgg 5221 agattgaaag atgctgtaat ttagaaatta acatgatatc ttaaattacc tttatgaaat 5281 atagttttgt ataatagcat agattttcct tcaaaaaatg aacatttata tatctacaaa 5341 aatatggaga agagcaattt gaaagcctac tttctgaaga aaatggtggg attttttttt 5401 atcatgatta aatatcaaaa aattgcccta tgaaaacttt aaatctctaa aacatttgaa 5461 atactaccat atttgtgatt tattgagaat aaaaatccat tttgaaatgt aaaattttta 5521 tgatctgatt cagttttaag aaaacatgaa tgaactagaa gatattaaaa acatttgaca 5581 ttggtaagaa atattgatac tgatattgat ttttatatag gtatttattt cagaattgat 5641 attttgagaa aaatacatgt gagtcatttt ttctgtttct cttttctctt aacgattatc 5701 actgtaattc tgaatct //