LOCUS HUMGLYPL 2828 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human liver glycogen phosphorylase mRNA, complete cds.
ACCESSION M14636
VERSION M14636.1
KEYWORDS glycogen phosphorylase; phosphorylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2828)
AUTHORS Newgard,C.B., Nakano,K., Hwang,P.K. and Fletterick,R.J.
TITLE Sequence analysis of the cDNA encoding human liver glycogen
phosphorylase reveals tissue-specific codon usage
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (21), 8132-8136 (1986)
PUBMED 2877458
COMMENT Original source text: Human liver, cDNA to mRNA (library of
A.DiLella and S.Woo), clones HL-[1-10] and (library of J.-H.Ou),
clone HL-11.
There is a polyadenylation signal sequence at positions 2806 to
2811.
FEATURES Location/Qualifiers
source 1..2828
/db_xref="H-InvDB:HIT000194349"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="14q11.2-q24.3"
gene 1..2828
/gene="PYGL"
CDS 114..2657
/gene="PYGL"
/note="glycogen phosphorylase (EC 2.4.1.1)"
/codon_start=1
/protein_id="AAA52577.1"
/db_xref="GDB:G00-120-328"
/translation="MGEPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDR
NVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKREYYLSLEFYMGRTLQNTMIN
LGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
RYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWID
TQVVLALPYDTPEPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENI
SRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGQGTVFDAFPDQV
AIQLNDTHPRIAIPELMRIFVDIEKLPWSKAWELNQKTFAYTNHTVLPEALERWPVDL
VEKLLPRHLEIIYEINQKHLDRIVALFPKDVDPLRRMSLIEEEGSKRINMAHLCIVGS
HAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKI
GEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDV
QVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLI
TSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKF
MLNGALTIGTMDGANVEMAEEAGEENLFIFGMSIDDVAALDKKGYEAKEYYEALPELK
LVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAW
NTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN"
BASE COUNT 800 a 673 c 709 g 646 t
ORIGIN 699 bp upstream of EcoRI site.
1 gttgaaagct cctggcgcgg cggggcggac tccacccctg cccggcagcc cagcgcctcc
61 ggccgcactt ccagctctct gcgcagcccg ccgcgcagcc cgccgcccca gccatgggcg
121 aaccgctgac agaccaggag aagcggcggc agatcagcat ccgcggcatc gtgggcgtgg
181 agaacgtggc agagctgaag aagagtttca accggcacct gcacttcacg ctggtcaagg
241 accgcaacgt ggccaccacc cgcgactact acttcgcgct ggcgcacacg gtgcgggacc
301 acctggtggg gcgctggatc cgcacgcagc agcactacta cgacaagtgc cccaagaggg
361 aatattacct ctctctggaa ttttacatgg gccgaacatt acagaacacc atgatcaacc
421 tcggtctgca aaatgcctgt gatgaggcca tttaccagct tggattggat atagaagagt
481 tagaagaaat tgaagaagat gctggacttg gcaatggtgg tcttgggaga cttgctgcct
541 gcttcttgga ttccatggca accctgggac ttgcagccta tggatacggc attcggtatg
601 aatatgggat tttcaatcag aagatccgag atggatggca ggtagaagaa gcagatgatt
661 ggctcagata tggaaaccct tgggagaagt cccgcccaga attcatgctg cctgtgcact
721 tctatggaaa agtagaacac accaacaccg ggaccaagtg gattgacact caagtggtcc
781 tggctctgcc atatgacacc cccgagcccg gctacatgaa taacactgtc aacaccatgc
841 gcctctggtc tgctcgggca ccaaatgact ttaacctcag agactttaat gttggagact
901 acattcaggc tgtgctggac cgaaacctgg ccgagaacat ctcccgggtc ctctatccca
961 atgacaattt ttttgaaggg aaggagctaa gattgaagca ggaatacttt gtggtggctg
1021 caaccttgca agatatcatc cgccgtttca aagcctccaa gtttggctcc acccgtggtc
1081 aaggaactgt gtttgatgcc ttcccggatc aggtggccat ccagctgaat gatactcacc
1141 ctcgcatcgc gatccctgag ctgatgagga tttttgtgga tattgaaaaa ctgccctggt
1201 ccaaggcatg ggagctcaac cagaagacct tcgcctacac caaccacaca gtgctcccgg
1261 aagccctgga gcgctggccc gtggacctgg tggagaagct gctccctcga catttggaaa
1321 tcatttatga gataaatcag aagcatttag atagaattgt ggccttgttt cctaaagatg
1381 tggaccctct gagaaggatg tctctgatag aagaggaagg aagcaaaagg atcaacatgg
1441 cccatctctg cattgtcggt tcccatgctg tgaatggcgt ggctaaaatc cactcagaca
1501 tcgtgaagac taaagtattc aaggacttca gtgagctaga acctgacaag tttcagaata
1561 aaaccaatgg gatcactcca aggcgctggc tcctactctg caacccagga cttgcagagc
1621 tcatagcaga gaaaattgga gaagactatg tgaaagacct gagccagctg acgaagctcc
1681 acagcttcct gggtgatgat gtcttcctcc gggaactcgc caaggtgaag caggagaata
1741 agctgaagtt ttctcagttc ctggagacgg agtacaaagt gaagatcaac ccatcctcca
1801 tgtttgatgt ccaggtgaag aggatacatg agtacaagcg acagctcttg aactgtctgc
1861 atgtgatcac gatgtacaac cgcattaaga aagaccctaa gaagttattc gtgccaagga
1921 cagttatcat tggtggtaaa gctgccccag gatatcacat ggccaaaatg atcataaagc
1981 tgatcacttc agtggcagat gtggtgaaca atgaccctat ggttggaagc aagttgaaag
2041 tcatcttctt ggagaactac agagtatctc ttgctgaaaa agtcattcca gccacagatc
2101 tgtcagagca gatttccact gcaggcaccg aagcctcggg gacaggcaat atgaagttca
2161 tgctaaatgg ggccctaact atcgggacca tggatggggc caatgtggaa atggcagaag
2221 aagctgggga agagaacctg ttcatctttg gcatgagcat agatgatgtg gctgctttgg
2281 acaagaaagg gtacgaggca aaagaatact atgaggcact tccagagctg aagctggtca
2341 ttgatcaaat tgacaatggc tttttttctc ccaagcagcc tgacctcttc aaagatatca
2401 tcaacatgct attttatcat gacaggttta aagtctttgc agactacgaa gcctatgtca
2461 agtgtcaaga taaagtgagt cagctgtaca tgaatccaaa ggcctggaac acaatggtac
2521 tcaaaaacat agctgcctcg gggaaattct ccagtgaccg aacaattaaa gaatatgccc
2581 aaaacatctg gaacgtggaa ccttcagatc taaagatttc tctatccaat gaatctaaca
2641 aagtcaatgg aaattgaact ctacaatgtc tctagaaaac atagcttctt actgaacttg
2701 aacattttta caacattcac tggtttttgt tttgttagct aataatctat aatagttgag
2761 tatctctggg aatggggagg gaaattatat gtaatagagc ttaaaaataa agtgtcaatt
2821 tccaagga
//