LOCUS HUMFXIIIB 3821 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human factor XIII subunit a mRNA, 3' end.
ACCESSION M14539
VERSION M14539.1
KEYWORDS factor XIII; fibrin; fibrinoligase; glycoprotein; plasma
transglutaminase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3821)
AUTHORS Ichinose,A., Hendrickson,L.E., Fujikawa,K. and Davie,E.W.
TITLE Amino acid sequence of the a subunit of human factor XIII
JOURNAL Biochemistry 25 (22), 6900-6906 (1986)
PUBMED 3026437
COMMENT Original source text: Human placenta, cDNA to mRNA, clones
lambda-HFXIIIa[2.14,3.82].
Draft entry and computer-readable sequence for [1] kindly provided
by A.Ichinose, 23-FEB-1987. The mature factor XIII is cleaved by
thrombin at a point between positions 201 and 202 to produce active
factor XIII-a.
FEATURES Location/Qualifiers
source 1..3821
/db_xref="H-InvDB:HIT000194340"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="6p25-p24"
gene 1..3821
/gene="F13A1"
CDS <1..2286
/gene="F13A1"
/note="factor XIII precursor"
/codon_start=1
/protein_id="AAA52489.1"
/db_xref="GDB:G00-120-614"
/translation="REEVPEAHRASPREGTSGGERLQDLVKSKMSETSRTAFGGRRAV
PPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENN
KLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKW
GAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWC
EDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQ
MDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRS
SENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNS
KLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHG
HVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDIT
DTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLS
ITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEY
MGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTIQF
TNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMS
SDSLRHVYGELDVQIQRRPSM"
sig_peptide <1..90
/gene="F13A1"
/note="factor XIII signal peptide"
mat_peptide 91..2283
/gene="F13A1"
/product="factor XIII"
BASE COUNT 1089 a 867 c 899 g 966 t
ORIGIN 199 bp upstream of SmaI site.
1 cgggaggaag tccccgaggc gcacagagca agcccacgcg agggcacctc tggaggggag
61 cgcctgcagg accttgtaaa gtcaaaaatg tcagaaactt ccaggaccgc ctttggaggc
121 agaagagcag ttccacccaa taactctaat gcagcggaag atgacctgcc cacagtggag
181 cttcagggcg tggtgccccg gggcgtcaac ctgcaagagt ttcttaatgt cacgagcgtt
241 cacctgttca aggagagatg ggacactaac aaggtggacc accacactga caagtatgaa
301 aacaacaagc tgattgtccg cagagggcag tctttctatg tgcagattga cttcagtcgt
361 ccatatgacc ccagaaggga tctcttcagg gtggaatacg tcattggtcg ctacccacag
421 gagaacaagg gaacctacat cccagtgcct atagtctcag agttacaaag tggaaagtgg
481 ggggccaaga ttgtcatgag agaggacagg tctgtgcggc tgtccatcca gtcttccccc
541 aaatgtattg tggggaaatt ccgcatgtat gttgctgtct ggactcccta tggcgtactt
601 cgaaccagtc gaaacccaga aacagacacg tacattctct tcaatccttg gtgtgaagat
661 gatgctgtgt atctggacaa tgagaaagaa agagaagagt atgtcctgaa tgacatcggg
721 gtaatttttt atggagaggt caatgacatc aagaccagaa gctggagcta tggtcagttt
781 gaagatggca tcctggacac ttgcctgtat gtgatggaca gagcacaaat ggacctctct
841 ggaagaggga atcccatcaa agtcagccgt gtggggtctg caatggtgaa tgccaaagat
901 gacgaaggtg tcctcgttgg atcctgggac aatatctatg cctatggcgt ccccccatcg
961 gcctggactg gaagcgttga cattctattg gaataccgga gctctgagaa tccagtccgg
1021 tatggccaat gctgggtttt tgctggtgtc tttaacacat ttttacgatg ccttggaata
1081 ccagcaagaa ttgttaccaa ttatttctct gcccatgata atgatgccaa tttgcaaatg
1141 gacatcttcc tggaagaaga tgggaacgtg aattccaaac tcaccaagga ttcagtgtgg
1201 aactaccact gctggaatga agcatggatg acaaggcctg accttcctgt tggatttgga
1261 ggctggcaag ctgtggacag caccccccag gaaaatagcg atggcatgta tcggtgtggc
1321 cccgcctcgg ttcaagccat caagcacggc catgtctgct tccaatttga tgcacctttt
1381 gtttttgcag aggtcaacag cgacctcatt tacattacag ctaagaaaga tggcactcat
1441 gtggtggaaa atgtggatgc cacccacatt gggaaattaa ttgtgaccaa acaaattgga
1501 ggagatggca tgatggatat tactgatact tacaaattcc aagaaggtca agaagaagag
1561 agattggccc tagaaactgc cctgatgtac ggagctaaaa agcccctcaa cacagaaggt
1621 gtcatgaaat caaggtccaa cgttgacatg gactttgaag tggaaaatgc tgtgctggga
1681 aaagacttca agctctccat caccttccgg aacaacagcc acaaccgtta caccatcaca
1741 gcttatctct cagccaacat caccttctac accggggtcc cgaaggcaga attcaagaag
1801 gagacgttcg acgtgacgct ggagcccttg tccttcaaga aagaggcggt gctgatccaa
1861 gccggcgagt acatgggtca gctgctggaa caagcgtccc tgcacttctt tgtcacagct
1921 cgcatcaatg agaccaggga tgttctggcc aagcaaaagt ccaccgtgct aaccatccct
1981 gagatcatca tcaaggtccg tggcactcag gtagttggtt ctgacatgac tgtgacaatt
2041 cagtttacca atcctttaaa agaaaccctg cgaaatgtct gggtacacct ggatggtcct
2101 ggagtaacaa gaccaatgaa gaagatgttc cgtgaaatcc ggcccaactc caccgtgcag
2161 tgggaagaag tgtgccggcc ctgggtctct gggcatcgga agctgatagc cagcatgagc
2221 agtgactccc tgagacatgt gtatggcgag ctggacgtgc agattcaaag acgaccttcc
2281 atgtgaatgc acaggaagct gagatgaacc ctggcatttg gcctcttgta gtcttggcta
2341 aggaaattct aacgcaaaaa tagctcttgc tttgacttag gtgtgaagac ccagacagga
2401 ctgcagaggg ccccagagtg gagatcccac atatttcaaa aacatgcttt tccaaaccca
2461 ggctattcgg caaggaagtt agtttttaat ctctccacct tccaaagagt gctaagcatt
2521 agctttaatt aagctctcat agctcataag agtaacagtc atcatttatc atcacaaatg
2581 gctacatctc caaatatcag tgggctctct taccagggag atttgctcaa tacctggcct
2641 catttaaaac aagacttcag attccccact cagccttttg ggaataatag cacatgattt
2701 gggctctaga attccagtcc cctttctcgg ggtcaggttc taccctccat gtgagaatat
2761 ttttcccagg actagagcac aacataattt ttatttttgg caaagccaga aaaagatctt
2821 tcattttgca cctgcagcca agcaaatgcc tgccaaattt tagatttacc ttgttagaag
2881 aggtggcccc atattaacaa attgcatttg tgggaaactt aaccacctac aaggagataa
2941 gaaagcaggt gcaacactca agtctattga ataatgtagt tttgtgatgc attttataga
3001 atgtgtcaca ctgtggcctg atcagcagga gccaatatcc cttactttaa ccctttctgg
3061 gatgcaatac taggaagtaa agtggaagaa tttatctctt tagttagtga ttatatttca
3121 cccatctctc aggaatcatc tcctttgcag aatgatgcag gttcaggtcc cctttcagag
3181 atataataag cccaacaagt tgaagaagct ggcggatcta gtgaccagat atatagaagg
3241 actgcagcca ctgattctct cttgtccttc acatcaccca tgttgagacc tcagcttggc
3301 actcaggtgc tgaagggtaa tatggactca gccttgcaaa tagccagtgc tagttctgac
3361 ccaaccacag aggatgctga catcatttgt attatgttcc aaggctacta cagagaaggc
3421 tgcctgctat gtatttgcaa ggctgattta tggtcagaat ttccctctga taagtctagg
3481 gtgtgattta ggtcagtaga ctgtgattct tagcaaaaaa tgaacagtga taagtatact
3541 gggggcaaaa tcagaatgga atgctctggt ctatataacc acatttctaa gcctttgaga
3601 ctgttcctga gccttcagca ctaacctatg agggtgagct ggtcccctct atatatacat
3661 catacttaac tttactaagt aatctcacag catttgccaa gtctcccaat atccaatttt
3721 aaaatgaaat gcattttgct agacagttaa actggcttaa cttagtatat tattattaat
3781 tacaatgtaa tagaagctta aaataaagtt aaactgatta t
//