LOCUS HUMFXIIIA 3816 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human placental FXIIIa mRNA, complete cds.
ACCESSION M14354
VERSION M14354.1
KEYWORDS factor XIIIa; fibrinoligase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3816)
AUTHORS Grundmann,U., Amann,E., Zettlmeissl,G. and Kupper,H.A.
TITLE Characterization of cDNA coding for human factor XIIIa
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (21), 8024-8028 (1986)
PUBMED 2877457
COMMENT Original source text: Human placenta, cDNA to mRNA, clones
lambda-gt10-[11,12,20].
Computer-readable sequence of [1] kindly provided by U.Grundmann
(27-JAN-1987).
FEATURES Location/Qualifiers
source 1..3816
/db_xref="H-InvDB:HIT000194332"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="6p25-p24"
gene 1..3816
/gene="F13A1"
mRNA <1..3816
/gene="F13A1"
/product="FXIIIa mRNA"
CDS 85..2283
/gene="F13A1"
/note="clotting factor XIIIa precursor (EC 2.3.2.13)"
/codon_start=1
/protein_id="AAA52488.1"
/db_xref="GDB:G00-120-614"
/translation="MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQE
FLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDLSRPYDPRRDLFRV
EYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRM
YVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEV
NDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVL
VGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPAR
IVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGG
WQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGT
HVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLN
TEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPK
AEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQK
STVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKETLRNVWVHLDGPGVTRPMKKMFR
EIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM"
mat_peptide 88..2280
/gene="F13A1"
/product="clotting factor XIIIa"
BASE COUNT 1086 a 866 c 897 g 967 t
ORIGIN 196 bp upstream of SmaI site; chromosome 6p24-p21.3.
1 gaggaagtcc ccgaggcgca cagagcaagc ccacgcgagg gcacctctgg aggggagcgc
61 ctgcaggacc ttgtaaagtc aaaaatgtca gaaacttcca ggaccgcctt tggaggcaga
121 agagcagttc cacccaataa ctctaatgca gcggaagatg acctgcccac agtggagctt
181 cagggcgtgg tgccccgggg cgtcaacctg caagagtttc ttaatgtcac gagcgttcac
241 ctgttcaagg agagatggga cactaacaag gtggaccacc acactgacaa gtatgaaaac
301 aacaagctga ttgtccgcag agggcagtct ttctatgtgc agattgacct cagtcgtcca
361 tatgacccca gaagggatct cttcagggtg gaatacgtca ttggtcgcta cccacaggag
421 aacaagggaa cctacatccc agtgcctata gtctcagagt tacaaagtgg aaagtggggg
481 gccaagattg tcatgagaga ggacaggtct gtgcggctgt ccatccagtc ttcccccaaa
541 tgtattgtgg ggaaattccg catgtatgtt gctgtctgga ctccctatgg cgtacttcga
601 accagtcgaa acccagaaac agacacgtac attctcttca atccttggtg tgaagatgat
661 gctgtgtatc tggacaatga gaaagaaaga gaagagtatg tcctgaatga catcggggta
721 attttttatg gagaggtcaa tgacatcaag accagaagct ggagctatgg tcagtttgaa
781 gatggcatcc tggacacttg cctgtatgtg atggacagag cacaaatgga cctctctgga
841 agagggaatc ccatcaaagt cagccgtgtg gggtctgcaa tggtgaatgc caaagatgac
901 gaaggtgtcc tcgttggatc ctgggacaat atctatgcct atggcgtccc cccatcggcc
961 tggactggaa gcgttgacat tctattggaa taccggagct ctgagaatcc agtccggtat
1021 ggccaatgct gggtttttgc tggtgtcttt aacacatttt tacgatgcct tggaatacca
1081 gcaagaattg ttaccaatta tttctctgcc catgataatg atgccaattt gcaaatggac
1141 atcttcctgg aagaagatgg gaacgtgaat tccaaactca ccaaggattc agtgtggaac
1201 taccactgct ggaatgaagc atggatgaca aggcctgacc ttcctgttgg atttggaggc
1261 tggcaagctg tggacagcac cccccaggaa aatagcgatg gcatgtatcg gtgtggcccc
1321 gcctcggttc aagccatcaa gcacggccat gtctgcttcc aatttgatgc accttttgtt
1381 tttgcagagg tcaacagcga cctcatttac attacagcta agaaagatgg cactcatgtg
1441 gtggaaaatg tggatgccac ccacattggg aaattaattg tgaccaaaca aattggagga
1501 gatggcatga tggatattac tgatacttac aaattccaag aaggtcaaga agaagagaga
1561 ttggccctag aaactgccct gatgtacgga gctaaaaagc ccctcaacac agaaggtgtc
1621 atgaaatcaa ggtccaacgt tgacatggac tttgaagtgg aaaatgctgt gctgggaaaa
1681 gacttcaagc tctccatcac cttccggaac aacagccaca accgttacac catcacagct
1741 tatctctcag ccaacatcac cttctacacc ggggtcccga aggcagagtt caagaaggag
1801 acgttcgacg tgacgctgga gcccttgtcc ttcaagaaag aggcggtgct gatccaagcc
1861 ggcgagtaca tgggtcagct gctggaacaa gcgtccctgc acttctttgt cacagctcgc
1921 atcaatgaga ccagggatgt tctggccaag caaaagtcca ccgtgctaac catccctgag
1981 atcatcatca aggtccgtgg cactcaggta gttggttctg acatgactgt gacagttcag
2041 tttaccaatc ctttaaaaga aaccctgcga aatgtctggg tacacctgga tggtcctgga
2101 gtaacaagac caatgaagaa gatgttccgt gaaatccggc ccaactccac cgtgcagtgg
2161 gaagaagtgt gccggccctg ggtctctggg catcggaagc tgatagccag catgagcagt
2221 gactccctga gacatgtgta tggcgagctg gacgtgcaga ttcaaagacg accttccatg
2281 tgaatgcaca ggaagctgag atgaaccctg gcatttggcc tcttgtagtc ttggctaagg
2341 aaattctaac gcaaaaatag ctcttgcttt gacttaggtg tgaagaccca gacaggactg
2401 cagagggccc cagagtggag atcccacata tttcaaaaac atacttttcc aaacccaggc
2461 tattcggcaa ggaagttagt ttttaatctc tccaccttcc aaagagtgct aagcattagc
2521 tttaattaag ctctcatagc tcataagagt aacagtcatc atttatcatc acaaatggct
2581 acatctccaa atatcagtgg gctctcttac cagggagatt tgctcaatac ctggcctcat
2641 ttaaaacaag acttcagatt ccccactcag ccttttggga ataatagcac atgatttggg
2701 ctctagaatt ccagtcccct ttctcggggt caggttctac cctccatgtg agaatatttt
2761 tcccaggact agagcacaac ataattttta tttttggcaa agccagaaaa agatctttca
2821 ttttgcacct gcagccaagc aaatgcctgc caaattttag atttaccttg ttagaagagg
2881 tggccccata ttaacaaatt gcatttgtgg gaaacttaac cacctacaag gagataagaa
2941 agcaggtgca acactcaagt ctattgaata atgtagtttt gtgatgcatt ttatagaatg
3001 tgtcacactg tggcctgatc agcaggagcc aatatccctt actttaaccc tttctgggat
3061 gcaatactag gaagtaaagt gaagaattta tctctttagt tagtgattat atttcaccca
3121 tctctcagga atcatctcct ttgcagaatg atgcaggttc aggtcccctt tcagagatat
3181 aataagccca acaagttgaa gaagctggcg gatctagtga ccagatatat agaaggactg
3241 cagccactga ttctctcttg tccttcacat caccattttg agacctcagc ttggcactca
3301 ggtgctgaag ggtaatatgg actcagcctt gcaaatagcc agtgctagtt ctgacccaac
3361 cacagaggat gctgacatca tttgtattat gttccaaggc tactacagag aaggctgcct
3421 gctatgtatt tgcaaggctg atttatggtc agaatttccc tctgatatgt ctagggtgtg
3481 atttaggtca gtagactgtg attcttagca aaaaatgaac agtgataagt atactggggg
3541 caaaatcaga atggaatgct ctggtctata taaccacatt tctgagcctt tgagactgtt
3601 cctgagcctt cagcactaac ctatgagggt gagctggtcc cctctatata tacatcatac
3661 ttaactttac taagtaatct cacagcattt gccaagtctc ccaatatcca attttaaaat
3721 gaaatgcatt ttgctagaca gttaaactgg cttaacttag tatattatta ttaattacaa
3781 tgtaatagaa gcttaaaata aagttaaact gattat
//