LOCUS       HUMFVA                  6893 bp    mRNA    linear   HUM 08-AUG-1995
DEFINITION  Human coagulation factor V mRNA, complete cds.
ACCESSION   M14335 M17785
VERSION     M14335.1
KEYWORDS    coagulation factor V; factor V; glycoprotein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 3636 to 6893)
  AUTHORS   Kane,W.H. and Davie,E.W.
  TITLE     Cloning of a cDNA coding for human factor V, a blood coagulation
            factor homologous to factor VIII and ceruloplasmin
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (18), 6800-6804 (1986)
   PUBMED   3092220
REFERENCE   2  (bases 1 to 4876)
  AUTHORS   Kane,W.H., Ichinose,A., Hagen,F.S. and Davie,E.W.
  TITLE     Cloning of cDNAs coding for the heavy chain region and connecting
            region of human factor V, a blood coagulation factor with four
            types of internal repeats
  JOURNAL   Biochemistry 26 (20), 6508-6514 (1987)
   PUBMED   2827731
COMMENT     Original source text: Human liver (normal hepatocyte and HepG-2
            cells), cDNA to mRNA, clones HV3.37, HV0.85, HV1.66 and HV2.97.
            Draft entry and computer-readable sequence [1] kindly submitted by
            W.H.Kane, 13-JUN-1988.
FEATURES             Location/Qualifiers
     source          1..6893
                     /db_xref="H-InvDB:HIT000194331"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="1q21-q25"
     gene            1..6893
                     /gene="F5"
     CDS             77..6751
                     /gene="F5"
                     /note="factor V precusor"
                     /codon_start=1
                     /protein_id="AAB59532.1"
                     /db_xref="GDB:G00-119-896"
                     /translation="MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWS
                     YRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHF
                     KNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGP
                     THDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVF
                     DESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVL
                     EQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTR
                     NLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYK
                     KVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGV
                     TFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSD
                     VDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKF
                     CENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTI
                     HFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDV
                     KCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFR
                     NSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAP
                     SHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGE
                     FRSQEHAKRKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQD
                     TGSPSRMRPWEDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWL
                     ISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTR
                     KKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPS
                     MDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSH
                     RSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNL
                     SPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPEL
                     SQTNLSPALGQMPLSPDLSHTTISLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMP
                     ISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPE
                     LSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQV
                     TLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPS
                     SPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKT
                     DVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIP
                     EDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPY
                     SLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACR
                     AWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPVDMREFVLLFMTFDEKKSWYY
                     EKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVV
                     HFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPF
                     LIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFA
                     SKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVM
                     YFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMEN
                     GKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKK
                     ITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKN
                     FFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY"
     sig_peptide     77..160
                     /gene="F5"
                     /note="factor V signal peptide"
     mat_peptide     161..6748
                     /gene="F5"
                     /product="factor V"
     variation       3723..4024
                     /gene="F5"
                     /note="ccctt in clone HV2.97 [1]"
                     /replace="ccctt"
BASE COUNT         2090 a         1700 c         1423 g         1680 t
ORIGIN      270 bp upstream of AccI site; chromosome 1q21-q25.
        1 ctccgggctg tcccagctcg gcaagcgctg cccaggtcct ggggtggtgg cagccagcgg
       61 gagcaggaaa ggaagcatgt tcccaggctg cccacgcctc tgggtcctgg tggtcttggg
      121 caccagctgg gtaggctggg ggagccaagg gacagaagcg gcacagctaa ggcagttcta
      181 cgtggctgct cagggcatca gttggagcta ccgacctgag cccacaaact caagtttgaa
      241 tctttctgta acttccttta agaaaattgt ctacagagag tatgaaccat attttaagaa
      301 agaaaaacca caatctacca tttcaggact tcttgggcct actttatatg ctgaagtcgg
      361 agacatcata aaagttcact ttaaaaataa ggcagataag cccttgagca tccatcctca
      421 aggaattagg tacagtaaat tatcagaagg tgcttcttac cttgaccaca cattccctgc
      481 agagaagatg gacgacgctg tggctccagg ccgagaatac acctatgaat ggagtatcag
      541 tgaggacagt ggacccaccc atgatgaccc tccatgcctc acacacatct attactccca
      601 tgaaaatctg atcgaggatt tcaactctgg gctgattggg cccctgctta tctgtaaaaa
      661 agggacccta actgagggtg ggacacagaa gacgtttgac aagcaaatcg tgctactatt
      721 tgctgtgttt gatgaaagca agagctggag ccagtcatca tccctaatgt acacagtcaa
      781 tggatatgtg aatgggacaa tgccagatat aacagtttgt gcccatgacc acatcagctg
      841 gcatctgctg ggaatgagct cggggccaga attattctcc attcatttca acggccaggt
      901 cctggagcag aaccatcata aggtctcagc catcaccctt gtcagtgcta catccactac
      961 cgcaaatatg actgtgggcc cagagggaaa gtggatcata tcttctctca ccccaaaaca
     1021 tttgcaagct gggatgcagg cttacattga cattaaaaac tgcccaaaga aaaccaggaa
     1081 tcttaagaaa ataactcgtg agcagaggcg gcacatgaag aggtgggaat acttcattgc
     1141 tgcagaggaa gtcatttggg actatgcacc tgtaatacca gcgaatatgg acaaaaaata
     1201 caggtctcag catttggata atttctcaaa ccaaattgga aaacattata agaaagttat
     1261 gtacacacag tacgaagatg agtccttcac caaacataca gtgaatccca atatgaaaga
     1321 agatgggatt ttgggtccta ttatcagagc ccaggtcaga gacacactca aaatcgtgtt
     1381 caaaaatatg gccagccgcc cctatagcat ttaccctcat ggagtgacct tctcgcctta
     1441 tgaagatgaa gtcaactctt ctttcacctc aggcaggaac aacaccatga tcagagcagt
     1501 tcaaccaggg gaaacctata cttataagtg gaacatctta gagtttgatg aacccacaga
     1561 aaatgatgcc cagtgcttaa caagaccata ctacagtgac gtggacatca tgagagacat
     1621 cgcctctggg ctaataggac tacttctaat ctgtaagagc agatccctgg acaggcgagg
     1681 aatacagagg gcagcagaca tcgaacagca ggctgtgttt gctgtgtttg atgagaacaa
     1741 aagctggtac cttgaggaca acatcaacaa gttttgtgaa aatcctgatg aggtgaaacg
     1801 tgatgacccc aagttttatg aatcaaacat catgagcact atcaatggct atgtgcctga
     1861 gagcataact actcttggat tctgctttga tgacactgtc cagtggcact tctgtagtgt
     1921 ggggacccag aatgaaattt tgaccatcca cttcactggg cactcattca tctatggaaa
     1981 gaggcatgag gacaccttga ccctcttccc catgcgtgga gaatctgtga cggtcacaat
     2041 ggataatgtt ggaacttgga tgttaacttc catgaattct agtccaagaa gcaaaaagct
     2101 gaggctgaaa ttcagggatg ttaaatgtat cccagatgat gatgaagact catatgagat
     2161 ttttgaacct ccagaatcta cagtcatggc tacacggaaa atgcatgatc gtttagaacc
     2221 tgaagatgaa gagagtgatg ctgactatga ttaccagaac agactggctg cagcattagg
     2281 aattaggtca ttccgaaact catcattgaa ccaggaagaa gaagagttca atcttactgc
     2341 cctagctctg gagaatggca ctgaattcgt ttcttcgaac acagatataa ttgttggttc
     2401 aaattattct tccccaagta atattagtaa gttcactgtc aataaccttg cagaacctca
     2461 gaaagcccct tctcaccaac aagccaccac agctggttcc ccactgagac acctcattgg
     2521 caagaactca gttctcaatt cttccacagc agagcattcc agcccatatt ctgaagaccc
     2581 tatagaggat cctctacagc cagatgtcac agggatacgt ctactttcac ttggtgctgg
     2641 agaattcaga agtcaagaac atgctaagcg taagggaccc aaggtagaaa gagatcaagc
     2701 agcaaagcac aggttctcct ggatgaaatt actagcacat aaagttggga gacacctaag
     2761 ccaagacact ggttctcctt ccggaatgag gccctgggag gaccttccta gccaagacac
     2821 tggttctcct tccagaatga ggccctggga ggaccctcct agtgatctgt tactcttaaa
     2881 acaaagtaac tcatctaaga ttttggttgg gagatggcat ttggcttctg agaaaggtag
     2941 ctatgaaata atccaagata ctgatgaaga cacagctgtt aacaattggc tgatcagccc
     3001 ccagaatgcc tcacgtgctt ggggagaaag cacccctctt gccaacaagc ctggaaagca
     3061 gagtggccac ccaaagtttc ctagagttag acataaatct ctacaagtaa gacaggatgg
     3121 aggaaagagt agactgaaga aaagccagtt tctcattaag acacgaaaaa agaaaaaaga
     3181 gaagcacaca caccatgctc ctttatctcc gaggaccttt caccctctaa gaagtgaagc
     3241 ctacaacaca ttttcagaaa gaagacttaa gcattcgttg gtgcttcata aatccaatga
     3301 aacatctctt cccacagacc tcaatcagac attgccctct atggattttg gctggatagc
     3361 ctcacttcct gaccataatc agaattcctc aaatgacact ggtcaggcaa gctgtcctcc
     3421 aggtctttat cagacagtgc ccccagagga acactatcaa acattcccca ttcaagaccc
     3481 tgatcaaatg cactctactt cagaccccag tcacagatcc tcttctccag agctcagtga
     3541 aatgcttgag tatgaccgaa gtcacaagtc cttccccaca gatataagtc aaatgtcccc
     3601 ttcctcagaa catgaagtct ggcagacagt catctctcca gacctcagcc aggtgaccct
     3661 ctctccagaa ctcagccaga caaacctctc tccagacctc agccacacga ctctctctcc
     3721 agaactcatt cagagaaacc tttccccagc cctcggtcag atgcccattt ctccagacct
     3781 cagccataca accctttctc cagacctcag ccatacaacc ctttctttag acctcagcca
     3841 gacaaacctc tctccagaac tcagtcagac aaacctttct ccagccctcg gtcagatgcc
     3901 cctttctcca gacctcagcc atacaaccat ttctctagac ttcagccaga caaacctctc
     3961 tccagaactc agccatatga ctctctctcc agaactcagt cagacaaacc tttccccagc
     4021 cctcggtcag atgcccattt ctccagacct cagccataca accctttctc tagacttcag
     4081 ccagacaaac ctctctccag aactcagtca aacaaacctt tccccagccc tcggtcagat
     4141 gcccctttct ccagacccca gccatacaac cctttctcta gacctcagcc agacaaacct
     4201 ctctccagaa ctcagtcaga caaacctttc cccagacctc agtgagatgc ccctctttgc
     4261 agatctcagt caaattcccc ttaccccaga cctcgaccag atgacacttt ctccagacct
     4321 tggtgagaca gatctttccc caaactttgg tcagatgtcc ctttccccag acctcagcca
     4381 ggtgactctc tctccagaca tcagtgacac cacccttctc ccggatctca gccagatatc
     4441 acctcctcca gaccttgatc agatattcta cccttctgaa tctagtcagt cattgcttct
     4501 tcaagaattt aatgagtctt ttccttatcc agaccttggt cagatgccat ctccttcatc
     4561 tcctactctc aatgatactt ttctatcaaa ggaatttaat ccactggtta tagtgggcct
     4621 cagtaaagat ggtacagatt acattgagat cattccaaag gaagaggtcc agagcagtga
     4681 agatgactat gctgaaattg attatgtgcc ctatgatgac ccctacaaaa ctgatgttag
     4741 gacaaacatc aactcctcca gagatcctga caacattgca gcatggtacc tccgcagcaa
     4801 caatggaaac agaagaaatt attacattgc tgctgaagaa atatcctggg attattcaga
     4861 atttgtacaa agggaaacag atattgaaga ctctgatgat attccagaag ataccacata
     4921 taagaaagta gtttttcgaa agtacctcga cagcactttt accaaacgtg atcctcgagg
     4981 ggagtatgaa gagcatctcg gaattcttgg tcctattatc agagctgaag tggatgatgt
     5041 tatccaagtt cgttttaaaa atttagcatc cagaccgtat tctctacatg cccatggact
     5101 ttcctatgaa aaatcatcag agggaaagac ttatgaagat gactctcctg aatggtttaa
     5161 ggaagataat gctgttcagc caaatagcag ttatacctac gtatggcatg ccactgagcg
     5221 atcagggcca gaaagtcctg gctctgcctg tcgggcttgg gcctactact cagctgtgaa
     5281 cccagaaaaa gatattcact caggcttgat aggtcccctc ctaatctgcc aaaaaggaat
     5341 actacataag gacagcaaca tgcctgtgga catgagagaa tttgtcttac tatttatgac
     5401 ctttgatgaa aagaagagct ggtactatga aaagaagtcc cgaagttctt ggagactcac
     5461 atcctcagaa atgaaaaaat cccatgagtt tcacgccatt aatgggatga tctacagctt
     5521 gcctggcctg aaaatgtatg agcaagagtg ggtgaggtta cacctgctga acataggcgg
     5581 ctcccaagac attcacgtgg ttcactttca cggccagacc ttgctggaaa atggcaataa
     5641 acagcaccag ttaggggtct ggccccttct gcctggttca tttaaaactc ttgaaatgaa
     5701 ggcatcaaaa cctggctggt ggctcctaaa cacagaggtt ggagaaaacc agagagcagg
     5761 gatgcaaacg ccatttctta tcatggacag agactgtagg atgccaatgg gactaagcac
     5821 tggtatcata tctgattcac agatcaaggc ttcagagttt ctgggttact gggagcccag
     5881 attagcaaga ttaaacaatg gtggatctta taatgcttgg agtgtagaaa aacttgcagc
     5941 agaatttgcc tctaaacctt ggatccaggt ggacatgcaa aaggaagtca taatcacagg
     6001 gatccagacc caaggtgcca aacactacct gaagtcctgc tataccacag agttctatgt
     6061 agcttacagt tccaaccaga tcaactggca gatcttcaaa gggaacagca caaggaatgt
     6121 gatgtatttt aatggcaatt cagatgcctc tacaataaaa gagaatcagt ttgacccacc
     6181 tattgtggct agatatatta ggatctctcc aactcgagcc tataacagac ctacccttcg
     6241 attggaactg caaggttgtg aggtaaatgg atgttccaca cccctgggta tggaaaatgg
     6301 aaagatagaa aacaagcaaa tcacagcttc ttcgtttaag aaatcttggt ggggagatta
     6361 ctgggaaccc ttccgtgccc gtctgaatgc ccagggacgt gtgaatgcct ggcaagccaa
     6421 ggcaaacaac aataagcagt ggctagaaat tgatctactc aagatcaaga agataacggc
     6481 aattataaca cagggctgca agtctctgtc ctctgaaatg tatgtaaaga gctataccat
     6541 ccactacagt gagcagggag tggaatggaa accatacagg ctgaaatcct ccatggtgga
     6601 caagattttt gaaggaaata ctaataccaa aggacatgtg aagaactttt tcaacccccc
     6661 aatcatttcc aggtttatcc gtgtcattcc taaaacatgg aatcaaagta ttgcacttcg
     6721 cctggaactc tttggctgtg atatttacta gaattgaaca ttcaaaaacc cctggaagag
     6781 actctttaag acctcaaacc atttagaatg ggcaatgtat tttacgctgt gttaaatgtt
     6841 aacagttttc cactatttct ctttcttttc tattagtgaa taaaatttta tac
//