LOCUS HUMFVA 6893 bp mRNA linear HUM 08-AUG-1995 DEFINITION Human coagulation factor V mRNA, complete cds. ACCESSION M14335 M17785 VERSION M14335.1 KEYWORDS coagulation factor V; factor V; glycoprotein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 3636 to 6893) AUTHORS Kane,W.H. and Davie,E.W. TITLE Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (18), 6800-6804 (1986) PUBMED 3092220 REFERENCE 2 (bases 1 to 4876) AUTHORS Kane,W.H., Ichinose,A., Hagen,F.S. and Davie,E.W. TITLE Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats JOURNAL Biochemistry 26 (20), 6508-6514 (1987) PUBMED 2827731 COMMENT Original source text: Human liver (normal hepatocyte and HepG-2 cells), cDNA to mRNA, clones HV3.37, HV0.85, HV1.66 and HV2.97. Draft entry and computer-readable sequence [1] kindly submitted by W.H.Kane, 13-JUN-1988. FEATURES Location/Qualifiers source 1..6893 /db_xref="H-InvDB:HIT000194331" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="1q21-q25" gene 1..6893 /gene="F5" CDS 77..6751 /gene="F5" /note="factor V precusor" /codon_start=1 /protein_id="AAB59532.1" /db_xref="GDB:G00-119-896" /translation="MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWS YRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHF KNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGP THDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVF DESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVL EQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTR NLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYK KVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGV TFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSD VDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKF CENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTI HFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDV KCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFR NSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAP SHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGE FRSQEHAKRKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQD TGSPSRMRPWEDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWL ISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTR KKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPS MDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSH RSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNL SPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPEL SQTNLSPALGQMPLSPDLSHTTISLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMP ISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPE LSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQV TLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPS SPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKT DVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIP EDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPY SLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACR AWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPVDMREFVLLFMTFDEKKSWYY EKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVV HFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPF LIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFA SKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVM YFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMEN GKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKK ITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKN FFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY" sig_peptide 77..160 /gene="F5" /note="factor V signal peptide" mat_peptide 161..6748 /gene="F5" /product="factor V" variation 3723..4024 /gene="F5" /note="ccctt in clone HV2.97 [1]" /replace="ccctt" BASE COUNT 2090 a 1700 c 1423 g 1680 t ORIGIN 270 bp upstream of AccI site; chromosome 1q21-q25. 1 ctccgggctg tcccagctcg gcaagcgctg cccaggtcct ggggtggtgg cagccagcgg 61 gagcaggaaa ggaagcatgt tcccaggctg cccacgcctc tgggtcctgg tggtcttggg 121 caccagctgg gtaggctggg ggagccaagg gacagaagcg gcacagctaa ggcagttcta 181 cgtggctgct cagggcatca gttggagcta ccgacctgag cccacaaact caagtttgaa 241 tctttctgta acttccttta agaaaattgt ctacagagag tatgaaccat attttaagaa 301 agaaaaacca caatctacca tttcaggact tcttgggcct actttatatg ctgaagtcgg 361 agacatcata aaagttcact ttaaaaataa ggcagataag cccttgagca tccatcctca 421 aggaattagg tacagtaaat tatcagaagg tgcttcttac cttgaccaca cattccctgc 481 agagaagatg gacgacgctg tggctccagg ccgagaatac acctatgaat ggagtatcag 541 tgaggacagt ggacccaccc atgatgaccc tccatgcctc acacacatct attactccca 601 tgaaaatctg atcgaggatt tcaactctgg gctgattggg cccctgctta tctgtaaaaa 661 agggacccta actgagggtg ggacacagaa gacgtttgac aagcaaatcg tgctactatt 721 tgctgtgttt gatgaaagca agagctggag ccagtcatca tccctaatgt acacagtcaa 781 tggatatgtg aatgggacaa tgccagatat aacagtttgt gcccatgacc acatcagctg 841 gcatctgctg ggaatgagct cggggccaga attattctcc attcatttca acggccaggt 901 cctggagcag aaccatcata aggtctcagc catcaccctt gtcagtgcta catccactac 961 cgcaaatatg actgtgggcc cagagggaaa gtggatcata tcttctctca ccccaaaaca 1021 tttgcaagct gggatgcagg cttacattga cattaaaaac tgcccaaaga aaaccaggaa 1081 tcttaagaaa ataactcgtg agcagaggcg gcacatgaag aggtgggaat acttcattgc 1141 tgcagaggaa gtcatttggg actatgcacc tgtaatacca gcgaatatgg acaaaaaata 1201 caggtctcag catttggata atttctcaaa ccaaattgga aaacattata agaaagttat 1261 gtacacacag tacgaagatg agtccttcac caaacataca gtgaatccca atatgaaaga 1321 agatgggatt ttgggtccta ttatcagagc ccaggtcaga gacacactca aaatcgtgtt 1381 caaaaatatg gccagccgcc cctatagcat ttaccctcat ggagtgacct tctcgcctta 1441 tgaagatgaa gtcaactctt ctttcacctc aggcaggaac aacaccatga tcagagcagt 1501 tcaaccaggg gaaacctata cttataagtg gaacatctta gagtttgatg aacccacaga 1561 aaatgatgcc cagtgcttaa caagaccata ctacagtgac gtggacatca tgagagacat 1621 cgcctctggg ctaataggac tacttctaat ctgtaagagc agatccctgg acaggcgagg 1681 aatacagagg gcagcagaca tcgaacagca ggctgtgttt gctgtgtttg atgagaacaa 1741 aagctggtac cttgaggaca acatcaacaa gttttgtgaa aatcctgatg aggtgaaacg 1801 tgatgacccc aagttttatg aatcaaacat catgagcact atcaatggct atgtgcctga 1861 gagcataact actcttggat tctgctttga tgacactgtc cagtggcact tctgtagtgt 1921 ggggacccag aatgaaattt tgaccatcca cttcactggg cactcattca tctatggaaa 1981 gaggcatgag gacaccttga ccctcttccc catgcgtgga gaatctgtga cggtcacaat 2041 ggataatgtt ggaacttgga tgttaacttc catgaattct agtccaagaa gcaaaaagct 2101 gaggctgaaa ttcagggatg ttaaatgtat cccagatgat gatgaagact catatgagat 2161 ttttgaacct ccagaatcta cagtcatggc tacacggaaa atgcatgatc gtttagaacc 2221 tgaagatgaa gagagtgatg ctgactatga ttaccagaac agactggctg cagcattagg 2281 aattaggtca ttccgaaact catcattgaa ccaggaagaa gaagagttca atcttactgc 2341 cctagctctg gagaatggca ctgaattcgt ttcttcgaac acagatataa ttgttggttc 2401 aaattattct tccccaagta atattagtaa gttcactgtc aataaccttg cagaacctca 2461 gaaagcccct tctcaccaac aagccaccac agctggttcc ccactgagac acctcattgg 2521 caagaactca gttctcaatt cttccacagc agagcattcc agcccatatt ctgaagaccc 2581 tatagaggat cctctacagc cagatgtcac agggatacgt ctactttcac ttggtgctgg 2641 agaattcaga agtcaagaac atgctaagcg taagggaccc aaggtagaaa gagatcaagc 2701 agcaaagcac aggttctcct ggatgaaatt actagcacat aaagttggga gacacctaag 2761 ccaagacact ggttctcctt ccggaatgag gccctgggag gaccttccta gccaagacac 2821 tggttctcct tccagaatga ggccctggga ggaccctcct agtgatctgt tactcttaaa 2881 acaaagtaac tcatctaaga ttttggttgg gagatggcat ttggcttctg agaaaggtag 2941 ctatgaaata atccaagata ctgatgaaga cacagctgtt aacaattggc tgatcagccc 3001 ccagaatgcc tcacgtgctt ggggagaaag cacccctctt gccaacaagc ctggaaagca 3061 gagtggccac ccaaagtttc ctagagttag acataaatct ctacaagtaa gacaggatgg 3121 aggaaagagt agactgaaga aaagccagtt tctcattaag acacgaaaaa agaaaaaaga 3181 gaagcacaca caccatgctc ctttatctcc gaggaccttt caccctctaa gaagtgaagc 3241 ctacaacaca ttttcagaaa gaagacttaa gcattcgttg gtgcttcata aatccaatga 3301 aacatctctt cccacagacc tcaatcagac attgccctct atggattttg gctggatagc 3361 ctcacttcct gaccataatc agaattcctc aaatgacact ggtcaggcaa gctgtcctcc 3421 aggtctttat cagacagtgc ccccagagga acactatcaa acattcccca ttcaagaccc 3481 tgatcaaatg cactctactt cagaccccag tcacagatcc tcttctccag agctcagtga 3541 aatgcttgag tatgaccgaa gtcacaagtc cttccccaca gatataagtc aaatgtcccc 3601 ttcctcagaa catgaagtct ggcagacagt catctctcca gacctcagcc aggtgaccct 3661 ctctccagaa ctcagccaga caaacctctc tccagacctc agccacacga ctctctctcc 3721 agaactcatt cagagaaacc tttccccagc cctcggtcag atgcccattt ctccagacct 3781 cagccataca accctttctc cagacctcag ccatacaacc ctttctttag acctcagcca 3841 gacaaacctc tctccagaac tcagtcagac aaacctttct ccagccctcg gtcagatgcc 3901 cctttctcca gacctcagcc atacaaccat ttctctagac ttcagccaga caaacctctc 3961 tccagaactc agccatatga ctctctctcc agaactcagt cagacaaacc tttccccagc 4021 cctcggtcag atgcccattt ctccagacct cagccataca accctttctc tagacttcag 4081 ccagacaaac ctctctccag aactcagtca aacaaacctt tccccagccc tcggtcagat 4141 gcccctttct ccagacccca gccatacaac cctttctcta gacctcagcc agacaaacct 4201 ctctccagaa ctcagtcaga caaacctttc cccagacctc agtgagatgc ccctctttgc 4261 agatctcagt caaattcccc ttaccccaga cctcgaccag atgacacttt ctccagacct 4321 tggtgagaca gatctttccc caaactttgg tcagatgtcc ctttccccag acctcagcca 4381 ggtgactctc tctccagaca tcagtgacac cacccttctc ccggatctca gccagatatc 4441 acctcctcca gaccttgatc agatattcta cccttctgaa tctagtcagt cattgcttct 4501 tcaagaattt aatgagtctt ttccttatcc agaccttggt cagatgccat ctccttcatc 4561 tcctactctc aatgatactt ttctatcaaa ggaatttaat ccactggtta tagtgggcct 4621 cagtaaagat ggtacagatt acattgagat cattccaaag gaagaggtcc agagcagtga 4681 agatgactat gctgaaattg attatgtgcc ctatgatgac ccctacaaaa ctgatgttag 4741 gacaaacatc aactcctcca gagatcctga caacattgca gcatggtacc tccgcagcaa 4801 caatggaaac agaagaaatt attacattgc tgctgaagaa atatcctggg attattcaga 4861 atttgtacaa agggaaacag atattgaaga ctctgatgat attccagaag ataccacata 4921 taagaaagta gtttttcgaa agtacctcga cagcactttt accaaacgtg atcctcgagg 4981 ggagtatgaa gagcatctcg gaattcttgg tcctattatc agagctgaag tggatgatgt 5041 tatccaagtt cgttttaaaa atttagcatc cagaccgtat tctctacatg cccatggact 5101 ttcctatgaa aaatcatcag agggaaagac ttatgaagat gactctcctg aatggtttaa 5161 ggaagataat gctgttcagc caaatagcag ttatacctac gtatggcatg ccactgagcg 5221 atcagggcca gaaagtcctg gctctgcctg tcgggcttgg gcctactact cagctgtgaa 5281 cccagaaaaa gatattcact caggcttgat aggtcccctc ctaatctgcc aaaaaggaat 5341 actacataag gacagcaaca tgcctgtgga catgagagaa tttgtcttac tatttatgac 5401 ctttgatgaa aagaagagct ggtactatga aaagaagtcc cgaagttctt ggagactcac 5461 atcctcagaa atgaaaaaat cccatgagtt tcacgccatt aatgggatga tctacagctt 5521 gcctggcctg aaaatgtatg agcaagagtg ggtgaggtta cacctgctga acataggcgg 5581 ctcccaagac attcacgtgg ttcactttca cggccagacc ttgctggaaa atggcaataa 5641 acagcaccag ttaggggtct ggccccttct gcctggttca tttaaaactc ttgaaatgaa 5701 ggcatcaaaa cctggctggt ggctcctaaa cacagaggtt ggagaaaacc agagagcagg 5761 gatgcaaacg ccatttctta tcatggacag agactgtagg atgccaatgg gactaagcac 5821 tggtatcata tctgattcac agatcaaggc ttcagagttt ctgggttact gggagcccag 5881 attagcaaga ttaaacaatg gtggatctta taatgcttgg agtgtagaaa aacttgcagc 5941 agaatttgcc tctaaacctt ggatccaggt ggacatgcaa aaggaagtca taatcacagg 6001 gatccagacc caaggtgcca aacactacct gaagtcctgc tataccacag agttctatgt 6061 agcttacagt tccaaccaga tcaactggca gatcttcaaa gggaacagca caaggaatgt 6121 gatgtatttt aatggcaatt cagatgcctc tacaataaaa gagaatcagt ttgacccacc 6181 tattgtggct agatatatta ggatctctcc aactcgagcc tataacagac ctacccttcg 6241 attggaactg caaggttgtg aggtaaatgg atgttccaca cccctgggta tggaaaatgg 6301 aaagatagaa aacaagcaaa tcacagcttc ttcgtttaag aaatcttggt ggggagatta 6361 ctgggaaccc ttccgtgccc gtctgaatgc ccagggacgt gtgaatgcct ggcaagccaa 6421 ggcaaacaac aataagcagt ggctagaaat tgatctactc aagatcaaga agataacggc 6481 aattataaca cagggctgca agtctctgtc ctctgaaatg tatgtaaaga gctataccat 6541 ccactacagt gagcagggag tggaatggaa accatacagg ctgaaatcct ccatggtgga 6601 caagattttt gaaggaaata ctaataccaa aggacatgtg aagaactttt tcaacccccc 6661 aatcatttcc aggtttatcc gtgtcattcc taaaacatgg aatcaaagta ttgcacttcg 6721 cctggaactc tttggctgtg atatttacta gaattgaaca ttcaaaaacc cctggaagag 6781 actctttaag acctcaaacc atttagaatg ggcaatgtat tttacgctgt gttaaatgtt 6841 aacagttttc cactatttct ctttcttttc tattagtgaa taaaatttta tac //