LOCUS HUMCTSB 2002 bp mRNA linear HUM 01-NOV-1994
DEFINITION Human cathepsin B proteinase mRNA, complete cds.
ACCESSION M14221
VERSION M14221.1
KEYWORDS cathepsin B; proteinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2002)
AUTHORS Chan,S.J., San Segundo,B., McCormick,M.B. and Steiner,D.F.
TITLE Nucleotide and predicted amino acid sequences of cloned human and
mouse preprocathepsin B cDNAs
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (20), 7721-7725 (1986)
PUBMED 3463996
COMMENT Original source text: Human kidney, cDNA to mRNA, clone
lambda-hCB79.
FEATURES Location/Qualifiers
source 1..2002
/db_xref="H-InvDB:HIT000194314"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="8p22"
gene 1..2002
/gene="CTSB"
mRNA 195..2002
/gene="CTSB"
/product="preprocathepsin B mRNA"
CDS 195..1214
/gene="CTSB"
/note="preprocathepsin B"
/codon_start=1
/protein_id="AAA52129.1"
/db_xref="GDB:G00-119-087"
/translation="MWQLWASLCCLLVLANARSRPSFHPVSDELVNYVNKRNTTWQAG
HNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQ
GSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWN
FWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPT
YKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMG
GHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQ
YWEKI"
BASE COUNT 460 a 553 c 550 g 439 t
ORIGIN Chromosome 8p22; EcoRI site.
1 aattccgcgg caaccgctcc ggcaacgcca accgctccgc tgcgcgcagg ctgggctgca
61 ggctctcggc tgcagcgctg ggctggtgtg cagtggtgcg accacggctc acggcagcct
121 cagccaccca gatgtaagcg atctggttcc cacctcagcc ttccgagtag tggatctagg
181 atctggcttc caacatgtgg cagctctggg cctccctctg ctgcctgctg gtgttggcca
241 atgcccggag caggccctct ttccatcccg tgtcggatga gctggtcaac tatgtcaaca
301 aacggaatac cacgtggcag gccgggcaca acttctacaa cgtggacatg agctacttga
361 agaggctatg tggtaccttc ctgggtgggc ccaagccacc ccagagagtt atgtttaccg
421 aggacctgaa gctgcctgca agcttcgatg cacgggaaca atggccacag tgtcccacca
481 tcaaagagat cagagaccag ggctcctgtg gctcctgctg ggccttcggg gctgtggaag
541 ccatctctga ccgcatctgc atccacacca atgcgcacgt cagcgtggag gtgtcggcgg
601 aggacctgct cacctgctgt ggcagcatgt gtggggacgg ctgtaatggt ggctatcctg
661 ctgaagcttg gaacttctgg acaagaaaag gcctggtttc tggtggcctc tatgaatccc
721 atgtagggtg cagaccgtac tccatccctc cctgtgagca ccacgtcaac ggctcccggc
781 ccccatgcac gggggaggga gataccccca agtgtagcaa gatctgtgag cctggctaca
841 gcccgaccta caaacaggac aagcactacg gatacaattc ctacagcgtc tccaatagcg
901 agaaggacat catggccgag atctacaaaa acggccccgt ggagggagct ttctctgtgt
961 attcggactt cctgctctac aagtcaggag tgtaccaaca cgtcaccgga gagatgatgg
1021 gtggccatgc catccgcatc ctgggctggg gagtggagaa tggcacaccc tactggctgg
1081 ttgccaactc ctggaacact gactggggtg acaatggctt ctttaaaata ctcagaggac
1141 aggatcactg cggaatcgaa tcagaagtgg tggctggaat tccacgcacc gatcagtact
1201 gggaaaagat ctaatctgcc gtgggcctgt cgtgccagtc ctgggggcga gatcggggta
1261 gaaagtcatt ttattcttta agttcacgta agatacaagt ttcaggcagg gtctgaagga
1321 ctggattggc caaagtcctc caaggagacc aagtcctggc tacatcccag cctgtggtta
1381 cagtgcagac aggccatgtg agccaccgct gccagcacag agcgtccttc cccctgtaga
1441 ctagtgccgt gggagtacct gctgcccagc tgctgtggcc ccctccgtga tccatccatc
1501 tccagggagc aagacagaga cgcaggatgg aaagcggagt tcctaacagg atgaaagttc
1561 ccccatcagt tcccccagta cctccaagca agtagctttc cacatttgtc acagaaatca
1621 gaggagagat ggtgttggga gccctttgga gaacgccagt ctccaggtcc ccctgcatct
1681 atcgagtttg caatgtcaca acctctctga tcttgtgctc agcatgattc tttaatagaa
1741 gttttatttt tcgtgcactc tgctaatcat gtgggtgagc cagtggaaca gcgggagcct
1801 gtgctggttt gcagattgcc tcctaatgac gcggctcaaa aggaaaccaa gtggtcagga
1861 gttgtttctg acccactgat ctctactacc acaaggaaaa tagtttagga gaaaccagct
1921 tttactgttt ttgaaaaatt acagcttcac cctgtcaagt taacaaggaa tgcctgtgcc
1981 aataaaaggt ttctccaact tg
//