LOCUS HUMALPPA 2599 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human placental alkaline phosphatase type 1 mRNA.
ACCESSION M14169
VERSION M14169.1
KEYWORDS Alu repeat; alkaline phosphatase; phosphatase; placental alkaline
phosphatase; repeat region.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2599)
AUTHORS Henthorn,P.S., Knoll,B.J., Raducha,M., Rothblum,K.N., Slaughter,C.,
Weiss,M., Lafferty,M.A., Fischer,T. and Harris,H.
TITLE Products of two common alleles at the locus for human placental
alkaline phosphatase differ by seven amino acids
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (15), 5597-5601 (1986)
PUBMED 3461452
COMMENT Original source text: Human term placenta, cDNA to mRNA.
Draft entry and clean copy sequence for [1] kindly provided by
P.S.Henthorn, 27-JAN-1987. [1] believes that positions 1-11 are a
cloning artefact and are not present in normal mRNA.
FEATURES Location/Qualifiers
source 1..2599
/db_xref="H-InvDB:HIT000194304"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="2q37"
gene 1..2599
/gene="ALPP"
mRNA <1..2599
/gene="ALPP"
/product="ALP1 mRNA"
CDS <1..1557
/gene="ALPP"
/note="preplacental alkaline phosphatase type 1 (EC
3.1.3.1)"
/codon_start=1
/protein_id="AAA51708.1"
/db_xref="GDB:G00-119-672"
/translation="ACLEGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIF
LGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATAT
AYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHAS
PAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTP
DPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEP
GDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALT
ETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKA
YTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQ
AHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGT
LLLLETATAP"
sig_peptide <1..15
/gene="ALPP"
/note="placental alkaline phosphatase type 1 signal
peptide"
mat_peptide 16..1554
/gene="ALPP"
/product="placental alkaline phosphatase type 1"
repeat_region 2368..>2599
/gene="ALPP"
/note="Alu repeat"
BASE COUNT 535 a 855 c 763 g 446 t
ORIGIN Chromosome 2q37; 2112 bp upstream of ApaI site.
1 gcatgtctgg agggcatcat cccagttgag gaggagaacc cggacttctg gaaccgcgag
61 gcagccgagg ccctgggtgc cgccaagaag ctgcagcctg cacagacagc cgccaagaac
121 ctcatcatct tcctgggcga tgggatgggg gtgtctacgg tgacagctgc caggatccta
181 aaagggcaga agaaggacaa actggggcct gagatacccc tggccatgga ccgcttccca
241 tatgtggctc tgtccaagac atacaatgta gacaaacatg tgccagacag tggagccaca
301 gccacggcct acctgtgcgg ggtcaagggc aacttccaga ccattggctt gagtgcagcc
361 gcccgcttta accagtgcaa cacgacacgc ggcaacgagg tcatctccgt gatgaatcgg
421 gccaagaaag cagggaagtc agtgggagtg gtaaccacca cacgagtgca gcacgcctcg
481 ccagccggca cctacgccca cacggtgaac cgcaactggt actcggacgc cgacgtgcct
541 gcctccgccc gccaggaggg gtgccaggac atcgctacgc agctcatctc caacatggac
601 attgacgtga tcctaggtgg aggccgaaag tacatgtttc gcatgggaac cccagaccct
661 gagtacccag atgactacag ccaaggtggg accaggctgg acgggaagaa tctggtgcag
721 gaatggctgg cgaagcgcca gggtgcccgg tatgtgtgga accgcactga gctcatgcag
781 gcttccctgg acccgtctgt gacccatctc atgggtctct ttgagcctgg agacatgaaa
841 tacgagatcc accgagactc cacactggac ccctccctga tggagatgac agaggctgcc
901 ctgcgcctgc tgagcaggaa cccccgcggc ttcttcctct tcgtggaggg tggtcgcatc
961 gaccatggtc atcatgaaag cagggcttac cgggcactga ctgagacgat catgttcgac
1021 gacgccattg agagggcggg ccagctcacc agcgaggagg acacgctgag cctcgtcact
1081 gccgaccact cccacgtctt ctccttcgga ggctaccccc tgcgagggag ctccatcttc
1141 gggctggccc ctggcaaggc ccgggacagg aaggcctaca cggtcctcct atacggaaac
1201 ggtccaggct atgtgctcaa ggacggcgcc cggccggatg ttaccgagag cgagagcggg
1261 agccccgagt atcggcagca gtcagcagtg cccctggacg aagagaccca cgcaggcgag
1321 gacgtggcgg tgttcgcgcg cggcccgcag gcgcacctgg ttcacggcgt gcaggagcag
1381 accttcatag cgcacgtcat ggccttcgcc gcctgcctgg agccctacac cgcctgcgac
1441 ctggcgcccc ccgccggcac caccgacgcc gcgcacccgg ggcggtccgt ggtccccgcg
1501 ttgcttcctc tgctggccgg gaccctgctg ctgctggaga cggccactgc tccctgagtg
1561 tcccgtccct ggggctcctg cttccccatc ccggagttct cctgctcccc acctcctgtc
1621 gtcctgcctg gcctccagcc cgagtcgtca tccccggagt ccctatacag aggtcctgcc
1681 atggaacctt cccctccccg tgcgctctgg ggactgagcc catgacacca aacctgcccc
1741 ttggctgctc tcggactccc taccccaacc ccagggactg caggttgtgc cctgtggctg
1801 cctgcacccc aggaaaggag ggggctcagg ccatccagcc accacctaca gcccagtggg
1861 taccaggcag gctcccttcc tggggaaaag aagcacccag accccgcgcc ccgctgatct
1921 ttgcttcagt ccttgaatca cctgtgggac ttgaggactc gggatcttca ggacgcctgg
1981 agaagggtgg tttcctgcca ccctgctggc caaggaggct cctggggtgg ggatcaccag
2041 ggggattttg acacagcctt cggctgcccc ccactaagct aattccacac ccctgtaccc
2101 ccccaggggg ccctctgcct catggcaaag gcttgcccca aatctcaact tctcagacgt
2161 tccatacccc cacatgccaa tttcagcacc caactgagat ccgaggagct cctgggaagc
2221 cctgggtgca ggacactggt cgagagccaa aggtccctcc ccagacatct ggacactggg
2281 catagatttc tcaagaagga agactcccct gcctccccag ggcctctgct ctcctgggag
2341 acaaagcaat aataaaagga agtgtttgta atcccagcac tttgggaggc cgaggtgggc
2401 ggatcacgag gtcaggagat ggagaccatc ctggctaaca cggtgaaacc ccttatctat
2461 gcgcctgtag tcccagctac ccaggaggct gaagcaggat aatcgcttga acccgggcgg
2521 cggagattgc agtgagccga ggtcatgcca ctgcactgca gcctgggcga cagagcgaga
2581 ttctgcctca aaaataaac
//