LOCUS HUMAPOBB 13993 bp mRNA linear HUM 22-JUL-1996 DEFINITION Human apolipoprotein B-100 mRNA, complete cds. ACCESSION M14162 VERSION M14162.1 KEYWORDS apolipoprotein B100. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (sites) AUTHORS Law,S.W., Grant,S.M., Higuchi,K., Hospattankar,A., Lackner,K., Lee,N. and Brewer,H.B. Jr. TITLE Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (21), 8142-8146 (1986) PUBMED 3464946 REFERENCE 2 (sites) AUTHORS Soria,L.F., Ludwig,E.H., Clarke,H.R., Vega,G.L., Grundy,S.M. and McCarthy,B.J. TITLE Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (2), 587-591 (1989) PUBMED 2563166 COMMENT Original source text: Homo sapiens (clone: lambda-MDB-[1-4], pMDB[5-10].) liver cDNA to mRNA. Draft entry and clean copy sequence for [1] kindly provided by S.W.Law, 22-JAN-1987. The mutation at position 10580 results in the substitution of a glutamine for an arginine. This causes hypercholesterolemia because of a defective low density lipoprotein [2]. FEATURES Location/Qualifiers source 1..13993 /db_xref="H-InvDB:HIT000194303" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="2p24-p23" /clone="lambda-MDB-[1-4], pMDB[5-10]." /tissue_type="liver" gene 1..13993 /gene="APOB" mRNA <1..13993 /gene="APOB" /product="apoB mRNA" CDS 1..13692 /gene="APOB" /note="apolipoprotein B-100 precursor" /codon_start=1 /protein_id="AAB04636.1" /db_xref="GDB:G00-119-686" /translation="MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDAT RFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEV YGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGI ISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPI RTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYKNKY GMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKK LTISEQNIQRANLFNKLVTELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCST HILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVN NYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKS SILKCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLM RSPSQADINKIVQILPWEQNEQVKNFVASHIANILNSEELDIQDLKKLVKEALKESQL PTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLIFDPNNYLPKESMLKTTLTAFGF ASADLIEIGLEGKGFEPTLEAPFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGY TKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRILGEELGFASLHDLRLLGKL LLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAP GAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAH VALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENRQSWSVCKQVFPG LNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATYELQREDRALV DTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKT SYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKL LLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDYPKSL HMYANRLLDHRVPQTDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFN LQNMGLPDSHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPA LHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNT STDHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIK FSHVEKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSS FYAKGTYGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQS GIIKNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLR FFSLLSGSLNSHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLE NELNAELGLSGASMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNI FNFKVSQEGLKLSNDMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTV NLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAI SSAALSASYKADTVAKVQGVEFSHGLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVM APFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRK SISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLAD LTLLDSPIKVPLLLSEPININDALEMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFF ETLQEYFERNRQTIIVVLENVQRNLKHINIDQFVRKYRAALGKLPQQANDYLNSFNWE RQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYMIQFDQYIKDSYD LHDLKIAIANIIDEIIEKLKSLDEHYHTRVNLVKTIHDLHLFIENIDFNKSGSSTASW IQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLLDQLGTTIS FERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLMDKLVEL AHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNKFLDM LIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEALKLFLEETKATVAVY LESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLSL VGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGT MPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILN TFHIPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDIYLRDLKVEDIPLARITLPDFR LPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFT LDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKINPLALKESV KFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSN TKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWASPRFSDEGTHES QISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVL TAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRF PLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGIN GEANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQ YKKNKHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYK AEKSHDELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSIIGSDVRV PSYTLILPSLELPVLHVPRNLKLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITL NTNAELFNQSDIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEG SHNSTVSLTTKNMEVSVAKTTKPEIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNS SMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSK STRSSVKLQGTSKIDDIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGE HTSKATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIH SGSFQSQVELSNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGR RQHLRVSTAFVYTKNPNGYSFSIPVKVLADKFIIPGLKLNDLNSVLVMPTFHVPFTDL QVPSCKLDFREIQIYKKLRTSSFALTLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEIT VPESQLTVSQFTLPKSVSDGIAALDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVP AGIVIPSFQALTARFEVDSPVYNATWSASLKNKADYVETVLDSTCSSTVQFLEYELNV LGTHKIEDGTLASKTKGTLAHRDFSAEYEEDGKYEGLQEWEGKAHLNIKSPAFTDLHL RYQKDKKGISTSAASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKTELRVR ESDEETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKL RRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGTYQEWKDKAQNLYQELLTQEGQA SFQGLKDNVFDGLVRVTQKFHMKVKKLIDSLIDFLNFPRFQFPGKPGIYTREELCTMF MREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKHKLIDVISMYRELLKDLSK EAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEMKFTYLINYIQDEINTI FNDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQYIMALREEYFDPSIV GWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQEYL SILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQDFSDQLSDYY EKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELTIIL" sig_peptide 1..81 /gene="APOB" /note="apolipoprotein B-100 signal peptide" mat_peptide 82..13689 /gene="APOB" /product="apolipoprotein B-100" variation 10580 /gene="APOB" /note="g in wt; a in defective low density lipoprotein [2]" BASE COUNT 4352 a 3191 c 2860 g 3590 t ORIGIN 392 bp upstream of SacI site. 1 atggacccgc cgaggcccgc gctgctggcg ctgctggcgc tgcctgcgct gctgctgctg 61 ctgctggcgg gcgccagggc cgaagaggaa atgctggaaa atgtcagcct ggtctgtcca 121 aaagatgcga cccgattcaa gcacctccgg aagtacacat acaactatga ggctgagagt 181 tccagtggag tccctgggac tgctgattca agaagtgcca ccaggatcaa ctgcaaggtt 241 gagctggagg ttccccagct ctgcagcttc atcctgaaga ccagccagtg caccctgaaa 301 gaggtgtatg gcttcaaccc tgagggcaaa gccttgctga agaaaaccaa gaactctgag 361 gagtttgctg cagccatgtc caggtatgag ctcaagctgg ccattccaga agggaagcag 421 gttttccttt acccggagaa agatgaacct acttacatcc tgaacatcaa gaggggcatc 481 atttctgccc tcctggttcc cccagagaca gaagaagcca agcaagtgtt gtttctggat 541 accgtgtatg gaaactgctc cactcacttt accgtcaaga cgaggaaggg caatgtggca 601 acagaaatat ccactgaaag agacctgggg cagtgtgatc gcttcaagcc catccgcaca 661 ggcatcagcc cacttgctct catcaaaggc atgacccgcc ccttgtcaac tctgatcagc 721 agcagccagt cctgtcagta cacactggac gctaagagga agcatgtggc agaagccatc 781 tgcaaggagc aacacctctt cctgcctttc tcctacaaga ataagtatgg gatggtagca 841 caagtgacac agactttgaa acttgaagac acaccaaaga tcaacagccg cttctttggt 901 gaaggtacta agaagatggg cctcgcattt gagagcacca aatccacatc acctccaaag 961 caggccgaag ctgttttgaa gactctccag gaactgaaaa aactaaccat ctctgagcaa 1021 aatatccaga gagctaatct cttcaataag ctggttactg agctgagagg cctcagtgat 1081 gaagcagtca catctctctt gccacagctg attgaggtgt ccagccccat cactttacaa 1141 gccttggttc agtgtggaca gcctcagtgc tccactcaca tcctccagtg gctgaaacgt 1201 gtgcatgcca acccccttct gatagatgtg gtcacctacc tggtggccct gatccccgag 1261 ccctcagcac agcagctgcg agagatcttc aacatggcga gggatcagcg cagccgagcc 1321 accttgtatg cgctgagcca cgcggtcaac aactatcata agacaaaccc tacagggacc 1381 caggagctgc tggacattgc taattacctg atggaacaga ttcaagatga ctgcactggg 1441 gatgaagatt acacctattt gattctgcgg gtcattggaa atatgggcca aaccatggag 1501 cagttaactc cagaactcaa gtcttcaatc ctgaaatgtg tccaaagtac aaagccatca 1561 ctgatgatcc agaaagctgc catccaggct ctgcggaaaa tggagcctaa agacaaggac 1621 caggaggttc ttcttcagac tttccttgat gatgcttctc cgggagataa gcgactggct 1681 gcctatctta tgttgatgag gagtccttca caggcagata ttaacaaaat tgtccaaatt 1741 ctaccatggg aacagaatga gcaagtgaag aactttgtgg cttcccatat tgccaatatc 1801 ttgaactcag aagaattgga tatccaagat ctgaaaaagt tagtgaaaga agctctgaaa 1861 gaatctcaac ttccaactgt catggacttc agaaaattct ctcggaacta tcaactctac 1921 aaatctgttt ctcttccatc acttgaccca gcctcagcca aaatagaagg gaatcttata 1981 tttgatccaa ataactacct tcctaaagaa agcatgctga aaactaccct cactgccttt 2041 ggatttgctt cagctgacct catcgagatt ggcttggaag gaaaaggctt tgagccaaca 2101 ttggaggctc cttttgggaa gcaaggattt ttcccagaca gtgtcaacaa agctttgtac 2161 tgggttaatg gtcaagttcc tgatggtgtc tctaaggtct tagtggacca ctttggctat 2221 accaaagatg ataaacatga gcaggatatg gtaaatggaa taatgctcag tgttgagaag 2281 ctgattaaag atttgaaatc caaagaagtc ccggaagcca gagcctacct ccgcatcttg 2341 ggagaggagc ttggttttgc cagtctccat gacctccgac tcctgggaaa gctgcttctg 2401 atgggtgccc gcactctgca ggggatcccc cagatgattg gagaggtcat caggaagggc 2461 tcaaagaatg acttttttct tcactacatc ttcatggaga atgcctttga actccccact 2521 ggagctggat tacagttgca aatatcttca tctggagtca ttgctcccgg agccaaggct 2581 ggagtaaaac tggaagtagc caacatgcag gctgaactgg tggcaaaacc ctccgtgtct 2641 gtggagtttg tgacaaatat gggcatcatc attccggact tcgctaggag tggggtccag 2701 atgaacacca acttcttcca cgagtcgggt ctggaggctc atgttgccct aaaagctggg 2761 aagctgaagt ttatcattcc ttccccaaag agaccagtca agctgctcag tggaggcaac 2821 acattacatt tggtctctac caccaaaacg gaggtcatcc cacctctcat tgagaacagg 2881 cagtcctggt cagtttgcaa gcaagtcttt cctggcctga attactgcac ctcaggcgct 2941 tactccaacg ccagctccac agactccgcc tcctactatc cgctgaccgg ggacaccaga 3001 ttagagctgg aactgaggcc tacaggagag attgagcagt attctgtcag cgcaacctat 3061 gagctccaga gagaggacag agccttggtg gataccctga agtttgtaac tcaagcagaa 3121 ggcgcgaagc agactgaggc taccatgaca ttcaaatata atcggcagag tatgaccttg 3181 tccagtgaag tccaaattcc ggattttgat gttgacctcg gaacaatcct cagagttaat 3241 gatgaatcta ctgagggcaa aacgtcttac agactcaccc tggacattca gaacaagaaa 3301 attactgagg tcgccctcat gggccaccta agttgtgaca caaaggaaga aagaaaaatc 3361 aagggtgtta tttccatacc ccgtttgcaa gcagaagcca gaagtgagat cctcgcccac 3421 tggtcgcctg ccaaactgct tctccaaatg gactcatctg ctacagctta tggctccaca 3481 gtttccaaga gggtggcatg gcattatgat gaagagaaga ttgaatttga atggaacaca 3541 ggcaccaatg tagataccaa aaaaatgact tccaatttcc ctgtggatct ctccgattat 3601 cctaagagct tgcatatgta tgctaataga ctcctggatc acagagtccc tcaaacagac 3661 atgactttcc ggcacgtggg ttccaaatta atagttgcaa tgagctcatg gcttcagaag 3721 gcatctggga gtcttcctta tacccagact ttgcaagacc acctcaatag cctgaaggag 3781 ttcaacctcc agaacatggg attgccagac tcccacatcc cagaaaacct cttcttaaaa 3841 agcgatggcc gcgtcaaata taccttgaac aagaacagtt tgaaaattga gattcctttg 3901 ccttttggtg gcaaatcctc cagagatcta aagatgttag agactgttag gacaccagcc 3961 ctccacttca agtctgtggg attccatctg ccatctcgag agttccaagt ccctactttt 4021 accattccca agttgtatca actgcaagtg cctctcctgg gtgttctaga cctctccacg 4081 aatgtctaca gcaacttgta caactggtcc gcctcctaca gtggtggcaa caccagcaca 4141 gaccatttca gccttcgggc tcgttaccac atgaaggctg actctgtggt tgacctgctt 4201 tcctacaatg tgcaaggatc tggagaaaca acatatgacc acaagaatac gttcacacta 4261 tcatgtgatg ggtctctacg ccacaaattt ctagattcga atatcaaatt cagtcatgta 4321 gaaaaacttg gaaacaaccc agtctcaaaa ggtttactaa tattcgatgc atctagttcc 4381 tggggaccac agatgtctgc ttcagttcat ttggactcca aaaagaaaca gcatttgttt 4441 gtcaaagaag tcaagattga tgggcagttc agagtctctt cgttctatgc taaaggcaca 4501 tatggcctgt cttgtcagag ggatcctaac actggccggc tcaatggaga gtccaacctg 4561 aggtttaact cctcctacct ccaaggcacc aaccagataa caggaagata tgaagatgga 4621 accctctccc tcacctccac ctctgatctg caaagtggca tcattaaaaa tactgcttcc 4681 ctaaagtatg agaactacga gctgacttta aaatctgaca ccaatgggaa gtataagaac 4741 tttgccactt ctaacaagat ggatatgacc ttctctaagc aaaatgcact gctgcgttct 4801 gaatatcagg ctgattacga gtcattgagg ttcttcagcc tgctttctgg atcactaaat 4861 tcccatggtc ttgagttaaa tgctgacatc ttaggcactg acaaaattaa tagtggtgct 4921 cacaaggcga cactaaggat tggccaagat ggaatatcta ccagtgcaac gaccaacttg 4981 aagtgtagtc tcctggtgct ggagaatgag ctgaatgcag agcttggcct ctctggggca 5041 tctatgaaat taacaacaaa tggccgcttc agggaacaca atgcaaaatt cagtctggat 5101 gggaaagccg ccctcacaga gctatcactg ggaagtgctt atcaggccat gattctgggt 5161 gtcgacagca aaaacatttt caacttcaag gtcagtcaag aaggacttaa gctctcaaat 5221 gacatgatgg gctcatatgc tgaaatgaaa tttgaccaca caaacagtct gaacattgca 5281 ggcttatcac tggacttctc ttcaaaactt gacaacattt acagctctga caagttttat 5341 aagcaaactg ttaatttaca gctacagccc tattctctgg taactacttt aaacagtgac 5401 ctgaaataca atgctctgga tctcaccaac aatgggaaac tacggctaga acccctgaag 5461 ctgcatgtgg ctggtaacct aaaaggagcc taccaaaata atgaaataaa acacatctat 5521 gccatctctt ctgctgcctt atcagcaagc tataaagcag acactgttgc taaggttcag 5581 ggtgtggagt ttagccatgg gctcaacaca gacatcgctg ggctggcttc agccattgac 5641 atgagcacaa actataattc agactcactg catttcagca atgtcttccg ttctgtaatg 5701 gccccgttta ccatgaccat cgatgcacat acaaatggca atgggaaact cgctctctgg 5761 ggagaacata ctgggcagct gtatagcaaa ttcctgttga aagcagaacc tctggcattt 5821 actttctctc atgattacaa aggctccaca agtcatcatc tcgtgtctag gaaaagcatc 5881 agtgcagctc ttgaacacaa agtcagtgcc ctgcttactc cagctgagca gacaggcacc 5941 tggaaactca agacccaatt taacaacaat gaatacagcc aggacttgga tgcttacaac 6001 actaaagata aaattggcgt ggagcttact ggacgaactc tggctgacct aactctacta 6061 gactccccaa ttaaagtgcc acttttactc agtgagccca tcaatatcaa tgatgcttta 6121 gagatgagag atgccgttga gaagccccaa gaatttacaa ttgttgcttt tgtaaagtat 6181 gataaaaacc aagatgttca ctccattaac ctcccatttt ttgagacctt gcaagaatat 6241 tttgagagga atcgacaaac cattatagtt gtactggaaa acgtacagag aaacctgaag 6301 cacatcaata ttgatcaatt tgtaagaaaa tacagagcag ccctgggaaa actcccacag 6361 caagctaatg attatctgaa ttcattcaat tgggagagac aagtttcaca tgccaaggag 6421 aaactgactg ctctcacaaa aaagtataga attacagaaa atgatataca aattgcatta 6481 gatgatgcca aaatcaactt taatgaaaaa ctatctcaac tgcagacata tatgatacaa 6541 tttgatcagt atattaaaga tagttatgat ttacatgatt tgaaaatagc tattgctaat 6601 attattgatg aaatcattga aaaattaaaa agtcttgatg agcactatca tacccgtgta 6661 aatttagtaa aaacaatcca tgatctacat ttgtttattg aaaatattga ttttaacaaa 6721 agtggaagta gtactgcatc ctggattcaa aatgtggata ctaagtacca aatcagaatc 6781 cagatacaag aaaaactgca gcagcttaag agacacatac agaatataga catccagcac 6841 ctagctggaa agttaaaaca acacattgag gctattgatg ttagagtgct tttagatcaa 6901 ttgggaacta caatttcatt tgaaagaata aatgatgttc ttgagcatgt caaacacttt 6961 gttataaatc ttattgggga ttttgaagta gctgagaaaa tcaatgcctt cagagccaaa 7021 gtccatgagt taatcgagag gtatgaagta gaccaacaaa tccaggtttt aatggataaa 7081 ttagtagagt tggcccacca atacaagttg aaggagacta ttcagaagct aagcaatgtc 7141 ctacaacaag ttaagataaa agattacttt gagaaattgg ttggatttat tgatgatgct 7201 gtcaagaagc ttaatgaatt atcttttaaa acattcattg aagatgttaa caaattcctt 7261 gacatgttga taaagaaatt aaagtcattt gattaccacc agtttgtaga tgaaaccaat 7321 gacaaaatcc gtgaggtgac tcagagactc aatggtgaaa ttcaggctct ggaactacca 7381 caaaaagctg aagcattaaa actgttttta gaggaaacca aggccacagt tgcagtgtat 7441 ctggaaagcc tacaggacac caaaataacc ttaatcatca attggttaca ggaggcttta 7501 agttcagcat ctttggctca catgaaggcc aaattccgag agactctaga agatacacga 7561 gaccgaatgt atcaaatgga cattcagcag gaacttcaac gatacctgtc tctggtaggc 7621 caggtttata gcacacttgt cacctacatt tctgattggt ggactcttgc tgctaagaac 7681 cttactgact ttgcagagca atattctatc caagattggg ctaaacgtat gaaagcattg 7741 gtagagcaag ggttcactgt tcctgaaatc aagaccatcc ttgggaccat gcctgccttt 7801 gaagtcagtc ttcaggctct tcagaaagct accttccaga cacctgattt tatagtcccc 7861 ctaacagatt tgaggattcc atcagttcag ataaacttca aagacttaaa aaatataaaa 7921 atcccatcca ggttttccac accagaattt accatcctta acaccttcca cattccttcc 7981 tttacaattg actttgtaga aatgaaagta aagatcatca gaaccattga ccagatgctg 8041 aacagtgagc tgcagtggcc cgttccagat atatatctca gggatctgaa ggtggaggac 8101 attcctctag cgagaatcac cctgccagac ttccgtttac cagaaatcgc aattccagaa 8161 ttcataatcc caactctcaa ccttaatgat tttcaagttc ctgaccttca cataccagaa 8221 ttccagcttc cccacatctc acacacaatt gaagtaccta cttttggcaa gctatacagt 8281 attctgaaaa tccaatctcc tcttttcaca ttagatgcaa atgctgacat agggaatgga 8341 accacctcag caaacgaagc aggtatcgca gcttccatca ctgccaaagg agagtccaaa 8401 ttagaagttc tcaattttga ttttcaagca aatgcacaac tctcaaaccc taagattaat 8461 ccgctggctc tgaaggagtc agtgaagttc tccagcaagt acctgagaac ggagcatggg 8521 agtgaaatgc tgttttttgg aaatgctatt gagggaaaat caaacacagt ggcaagttta 8581 cacacagaaa aaaatacact ggagcttagt aatggagtga ttgtcaagat aaacaatcag 8641 cttaccctgg atagcaacac taaatacttc cacaaattga acatccccaa actggacttc 8701 tctagtcagg ctgacctgcg caacgagatc aagacactgt tgaaagctgg ccacatagca 8761 tggacttctt ctggaaaagg gtcatggaaa tgggcctcgc ccagattctc agatgaggga 8821 acacatgaat cacaaattag tttcaccata gaaggacccc tcacttcctt tggactgtcc 8881 aataagatca atagcaaaca cctaagagta aaccaaaact tggtttatga atctggctcc 8941 ctcaactttt ctaaacttga aattcaatca caagtcgatt cccagcatgt gggccacagt 9001 gttctaactg ctaaaggcat ggcactgttt ggagaaggga aggcagagtt tactgggagg 9061 catgatgctc atttaaatgg aaaggttatt ggaactttga aaaattctct tttcttttca 9121 gcccagccat ttgagatcac ggcatccaca aacaatgaag ggaatttgaa agttcgtttt 9181 ccattaaggt taacagggaa gatagacttc ctgaataact atgcactgtt tctgagtccc 9241 agtgcccagc aagcaagttg gcaagtaagt gctaggttca atcagtataa gtacaaccaa 9301 aatttctctg ctggaaacaa cgagaacatt atggaggccc atgtaggaat aaatggagaa 9361 gcaaatctgg atttcttaaa cattccttta acaattcctg aaatgcgtct accttacaca 9421 ataatcacaa ctcctccact gaaagatttc tctctatggg aaaaaacagg cttgaaggaa 9481 ttcttgaaaa cgacaaagca atcatttgat ttaagtgtaa aagctcagta taagaaaaac 9541 aaacacaggc attccatcac aaatcctttg gctgtgcttt gtgagtttat cagtcagagc 9601 atcaaatcct ttgacaggca ttttgaaaaa aacagaaaca atgcattaga ttttgtcacc 9661 aaatcctata atgaaacaaa aattaagttt gataagtaca aagctgaaaa atctcacgac 9721 gagctcccca ggacctttca aattcctgga tacactgttc cagttgtcaa tgttgaagtg 9781 tctccattca ccatagagat gtcggcattc ggctatgtgt tcccaaaagc agtcagcatg 9841 cctagtttct ccatcatagg ttctgacgtc cgtgtgcctt catacacatt aatcctgcca 9901 tcattagagc tgccagtcct tcatgtccct agaaatctca agctttctct tccagatttc 9961 aaggaattgt gtaccataag ccatattttt attcctgcca tgggcaatat tacctatgat 10021 ttctccttta aatcaagtgt catcacactg aataccaatg ctgaactttt taaccagtca 10081 gatattgttg ctcatctcct ttcttcatct tcatctgtca ttgatgcact gcagtacaaa 10141 ttagagggca ccacaagatt gacaagaaaa aggggattga agttagccac agctctgtct 10201 ctgagcaaca aatttgtgga gggtagtcat aacagtactg tgagcttaac cacgaaaaat 10261 atggaagtgt cagtggcaaa aaccacaaaa ccggaaattc caattttgag aatgaatttc 10321 aagcaagaac ttaatggaaa taccaagtca aaacctactg tctcttcctc catggaattt 10381 aagtatgatt tcaattcttc aatgctgtac tctaccgcta aaggagcagt tgaccacaag 10441 cttagcttgg aaagcctcac ctcttacttt tccattgagt catctaccaa aggagatgtc 10501 aagggttcgg ttctttctcg ggaatattca ggaactattg ctagtgaggc caacacttac 10561 ttgaattcca agagcacacg gtcttcagtg aagctgcagg gcacttccaa aattgatgat 10621 atctggaacc ttgaagtaaa agaaaatttt gctggagaag ccacactcca acgcatatat 10681 tccctctggg agcacagtac gaaaaaccac ttacagctag agggcctctt tttcaccaac 10741 ggagaacata caagcaaagc caccctggaa ctctctccat ggcaaatgtc agctcttgtt 10801 caggtccatg caagtcagcc cagttccttc catgatttcc ctgaccttgg ccaggaagtg 10861 gccctgaatg ctaacactaa gaaccagaag atcagatgga aaaatgaagt ccggattcat 10921 tctgggtctt tccagagcca ggtcgagctt tccaatgacc aagaaaaggc acaccttgac 10981 attgcaggat ccttagaagg acacctaagg ttcctcaaaa atatcatcct accagtctat 11041 gacaagagct tatgggattt cctaaagctg gatgtcacca ccagcattgg taggagacag 11101 catcttcgtg tttcaactgc ctttgtgtac accaaaaacc ccaatggcta ttcattctcc 11161 atccctgtaa aagttttggc tgataaattc attattcctg ggctgaaact aaatgatcta 11221 aattcagttc ttgtcatgcc tacgttccat gtcccattta cagatcttca ggttccatcg 11281 tgcaaacttg acttcagaga aatacaaatc tataagaagc tgagaacttc atcatttgcc 11341 ctcaccctac caacactccc cgaggtaaaa ttccctgaag ttgatgtgtt aacaaaatat 11401 tctcaaccag aagactcctt gattcccttt tttgagataa ccgtgcctga atctcagtta 11461 actgtgtccc agttcacgct tccaaaaagt gtttcagatg gcattgctgc tttggatcta 11521 aatgcagtag ccaacaagat cgcagacttt gagttgccca ccatcatcgt gcctgagcag 11581 accattgaga ttccctccat taagttctct gtacctgctg gaattgtcat tccttccttt 11641 caagcactga ctgcacgctt tgaggtagac tctcccgtgt ataatgccac ttggagtgcc 11701 agtttgaaaa acaaagcaga ttatgttgaa acagtcctgg attccacatg cagctcaacc 11761 gtacagttcc tagaatatga actaaatgtt ttgggaacac acaaaatcga agatggtacg 11821 ttagcctcta agactaaagg aacacttgca caccgtgact tcagtgcaga atatgaagaa 11881 gatggcaaat atgaaggact tcaggaatgg gaaggaaaag cgcacctcaa tatcaaaagc 11941 ccagcgttca ccgatctcca tctgcgctac cagaaagaca agaaaggcat ctccacctca 12001 gcagcctccc cagccgtagg caccgtgggc atggatatgg atgaagatga cgacttttct 12061 aaatggaact tctactacag ccctcagtcc tctccagata aaaaactcac catattcaaa 12121 actgagttga gggtccggga atctgatgag gaaactcaga tcaaagttaa ttgggaagaa 12181 gaggcagctt ctggcttgct aacctctctg aaagacaacg tgcccaaggc cacaggggtc 12241 ctttatgatt atgtcaacaa gtaccactgg gaacacacag ggctcaccct gagagaagtg 12301 tcttcaaagc tgagaagaaa tctgcagaac aatgctgagt gggtttatca aggggccatt 12361 aggcaaattg atgatatcga cgtgaggttc cagaaagcag ccagtggcac cactgggacc 12421 taccaagagt ggaaggacaa ggcccagaat ctgtaccagg aactgttgac tcaggaaggc 12481 caagccagtt tccagggact caaggataac gtgtttgatg gcttggtacg agttactcaa 12541 aaattccata tgaaagtcaa gaagctgatt gactcactca ttgattttct gaacttcccc 12601 agattccagt ttccggggaa acctgggata tacactaggg aggaactttg cactatgttc 12661 atgagggagg tagggacggt actgtcccag gtatattcga aagtccataa tggttcagaa 12721 atactgtttt cctatttcca agacctagtg attacacttc ctttcgagtt aaggaaacat 12781 aaactaatag atgtaatctc gatgtatagg gaactgttga aagatttatc aaaagaagcc 12841 caagaggtat ttaaagccat tcagtctctc aagaccacag aggtgctacg taatcttcag 12901 gaccttttac aattcatttt ccaactaata gaagataaca ttaaacagct gaaagagatg 12961 aaatttactt atcttattaa ttatatccaa gatgagatca acacaatctt caatgattat 13021 atcccatatg tttttaaatt gttgaaagaa aacctatgcc ttaatcttca taagttcaat 13081 gaatttattc aaaacgagct tcaggaagct tctcaagagt tacagcagat ccatcaatac 13141 attatggccc ttcgtgaaga atattttgat ccaagtatag ttggctggac agtgaaatat 13201 tatgaacttg aagaaaagat agtcagtctg atcaagaacc tgttagttgc tcttaaggac 13261 ttccattctg aatatattgt cagtgcctct aactttactt cccaactctc aagtcaagtt 13321 gagcaatttc tgcacagaaa tattcaggaa tatcttagca tccttaccga tccagatgga 13381 aaagggaaag agaagattgc agagctttct gccactgctc aggaaataat taaaagccag 13441 gccattgcga cgaagaaaat aatttctgat taccaccagc agtttagata taaactgcaa 13501 gatttttcag accaactctc tgattactat gaaaaattta ttgctgaatc caaaagattg 13561 attgacctgt ccattcaaaa ctaccacaca tttctgatat acatcacgga gttactgaaa 13621 aagctgcaat caaccacagt catgaacccc tacatgaagc ttgctccagg agaacttact 13681 atcatcctct aattttttta aaagaaatct tcatttattc ttcttttcca attgaacttt 13741 cacatagcac agaaaaaatt caaactgcct atattgataa aaccatacag tgagccagcc 13801 ttgcagtagg cagtagacta taagcagaag cacatatgaa ctggacctgc accaaagctg 13861 gcaccagggc tcggaaggtc tctgaactca gaaggatggc attttttgca agttaaagaa 13921 aatcaggatc tgagttattt tgctaaactt gggggaggag gaacaaataa atggagtctt 13981 tattgtgtat cat //