LOCUS HUMTCBJC 4913 bp DNA linear HUM 13-JAN-1995
DEFINITION Human T-cell receptor germline beta-chain D1.1 and J1.1 to J1.6
genes.
ACCESSION M14158
VERSION M14158.1
KEYWORDS D-region; J-region; T-cell receptor; T-cell receptor beta-chain;
germline.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4913)
AUTHORS Toyonaga,B., Yoshikai,Y., Vadasz,V., Chin,B. and Mak,T.W.
TITLE Organization and sequences of the diversity, joining, and constant
region genes of the human T-cell receptor beta chain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (24), 8624-8628 (1985)
PUBMED 3866244
COMMENT Original source text: Human (library T.Maniatis) DNA.
Draft entry and printed copy of the sequence in [1] kindly provided
by B.Toyonaga, 08-JUL-1986.
FEATURES Location/Qualifiers
source 1..4913
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="7q35"
iDNA <1..>4913
/note="V-D intervening DNA (3' end +/- 1 bp)"
gene 82..93
/gene="TCRB"
CDS 82..93
/gene="TCRB"
/note="T-cell receptor beta-chain D1.1"
/codon_start=1
/protein_id="AAA60667.1"
/db_xref="GDB:G00-120-405"
/translation="GTGG"
iDNA 94..2858
/note="D-J1.6 intervening DNA (5' end +/- 1 bp)"
iDNA 94..2367
/note="D-J1.5 intervening DNA (5' end +/- 1 bp)"
iDNA 94..2094
/note="D-J1.4 intervening DNA (5' end +/- 1 bp)"
iDNA 94..1498
/note="D-J1.3 intervening DNA (5' end +/- 1 bp)"
iDNA 94..885
/note="D-J1.2 intervening DNA (5' end +/- 1 bp)"
iDNA 94..748
/note="D-J1.1 intervening DNA (5' end +/- 1 bp)"
CDS 749..796
/note="T-cell receptor beta-chain J1.1"
/codon_start=3
/protein_id="AAA60668.1"
/translation="NTEAFFGQGTRLTVV"
intron 797..>4913
/note="J1.1-C intron"
CDS 886..933
/note="T-cell receptor beta-chain J1.2"
/codon_start=3
/protein_id="AAA60669.1"
/translation="NYGYTFGSGTRLTVV"
intron 934..>4913
/note="J1.2-C intron"
CDS <1499..1548
/note="T-cell receptor beta-chain J1.3"
/codon_start=3
/protein_id="AAA60670.1"
/translation="LETPYILEREVGSLL"
intron 1549..>4913
/note="J1.3-C intron"
CDS 2095..2145
/note="T-cell receptor beta-chain J1.4"
/codon_start=3
/protein_id="AAA60671.1"
/translation="TNEKLFFGSGTQLSVL"
intron 2146..>4913
/note="J1.4-C intron"
CDS 2368..2417
/note="T-cell receptor beta-chain J1.5"
/codon_start=2
/protein_id="AAA60672.1"
/translation="SNQPQHFGDGTRLSIL"
intron 2418..>4913
/note="J1.5-C intron"
CDS 2859..2911
/note="T-cell receptor beta-chain J1.6"
/codon_start=2
/protein_id="AAA60673.1"
/translation="SYNSPLHFGNGTRLTVT"
intron 2912..>4913
/note="J1.6-C intron"
BASE COUNT 1104 a 1206 c 1278 g 1325 t
ORIGIN 278 bp upstream of HindIII site.
1 cagctgctct ggtggtctct cccaggctct gggggcggac ccatgggagg ggctgttttt
61 gtacaaagct gtaacattgt ggggacaggg ggccacaatg attcaactct acgggaaacc
121 tttacaaaaa cctctctggc ggtcccaact cccagagtcc tcttctttcc tcctgggtca
181 caggtcttaa tgcaatttgg ttcagaatgc ctctgcctca ctcctgatca catgtcagac
241 caagactgtg gacaaggaca ggcccagatg agaactaaag cttcccaggc agagagaggt
301 cagacataag aagactgcct caggaacctc acaagtggag gactcaggga gggtcccaat
361 ccccaaaaat tgagacaaag tcaggtggaa ggttcatcgg aggtgaccag ctctccagag
421 gactcgggaa gaagtcaggg gtatctatag atggagtcac aggttctggg cccctgccat
481 cctctgcagg ccatgcactt tccctttcga tggaccctca cagagggagc atctgaatgg
541 ggcatccttt gaaaaaggaa cctaggaccc tgtggatgga ctctgtcatt ctccatggtc
601 ctaaaaagca aaagtcaaag tgttcttctg tgtaataccc ataaagcaca ggaggagatt
661 tcttagctca ctgtcctcca tcctagccag ggccctctcc cctctctatg ccttcaatgt
721 gattttcacc ttgacccctg tcactgtgtg aacactgaag ctttctttgg acaaggcacc
781 agactcacag ttgtaggtaa gacatttttc aggttctttt gcagatccgt cacagggaaa
841 agtgggtcca cagtgtccct tttagagtgg ctatattctt atgtgctaac tatggctaca
901 ccttcggttc ggggaccagg ttaaccgttg taggtaaggc tgggggtctc taggaggggt
961 gcgatgaggg aggactctgt cctgggaaat gtcaaagaga acagagatcc cagctcccgg
1021 agccagactg agggagacgt catgtcatgt cccgggattg agttcagggg aggctccctg
1081 tgagggcgaa tccacccagg cttcccagag gctctgagca gtcacagctg agcccagggt
1141 gatggggcag aagagggaag gggagggggc ctctcctcat agttccctga gatagcccag
1201 agaaagcccg gtgggtaatg aatgagccac aacacctctc catctatctg cttcactgac
1261 agaggttctc tgtagattct tcgtatattc ctgtgctgga ttttatagga ggccactctg
1321 tgtctctttt tgtcacctgc ctgagtcttg ggcaagctct ggaagggaac acagagtact
1381 ggaagcagag ctgctgtccc tgtgagggaa gagttcccat gaactcccaa cctctgcctg
1441 aatcccagct gtgctcagca gagactgggg ggttttgaag tggccctggg aggctgtgct
1501 ctggaaacac catatatttt ggagagggaa gttggctcac tgttgtaggt gagtaagtca
1561 aggctggaca gctgggaact tgcaaaaagg ggctggaatc cagacggagc ctttgtctct
1621 agtgcttagg tgaaagtgta tttttgtcag gaaggcctat gaggcagatg aggaggggat
1681 agcctccctc tcctctccac tattttgtag actgcctgtg ccaagttagg ttcccctact
1741 gagagatggg tagactcagc ttggaagggg tcaccttgaa catctcctgt ctccttgaag
1801 ggtgccggtc cacggccatg acagataaaa gagcctctga ccttaccacc acggtcctac
1861 cgtttctctc cctcacacag aaaggagaag gtcacagaag agggaacttg ggggatcaca
1921 cggggcctaa ttggtctgct gaccaccgca ttttgggttg taccattgtc tacccctcta
1981 cccaccaggg ttaaaattct actaaggaac aggagaggac ctggcaggtg gacttgggga
2041 ggcaggagtg gaaggcagca ggtcgcggtt ttccttccag tctttaatgt tgtgcaacta
2101 atgaaaaact gttttttggc agtggaaccc agctctctgt cttgggtatg taaaagactt
2161 ctttcgggat agtgtatcat aaggtcggag ttccaggagg accccttgcg ggagggcaga
2221 aactgagaac acagccaaga aaagctcata aaatgtgggt cagtggagtg tgtggtgggg
2281 ccccaagagt tctgtgtgta agcagcttct ggaaggaagg gcccacacca gctcctctgg
2341 ggtttgccac actcatgatg cactgtgtag caatcagccc cagcattttg gtgatgggac
2401 tcgactctcc atcctaggta agttggcaga atcagggtgg tatggccatt gtcccttgaa
2461 ggcagagttc tctgcttctc ctcccggtgc tggtgaggca gattgagtaa aatctcttac
2521 cccatggggt aagagctgtg cctgtgcctg cgttcccttt ggtgtgtctt ggttgactcc
2581 tctatttctc ttctctaagt cttcagtcca taatctgcct cctcactccc ttcttggctc
2641 atcctccctc ttatgtgcat ggctctgcct ctcctaagcc tcttcctctt gcgccttatg
2701 ctgcacagta tgcttaggcc tttttcctaa cagaatccct ttggtccaga gccatgaatc
2761 caggcagaga aaggcagcca tcctgctgtc agggagctaa gacttgccct ctgactggag
2821 atcgccgggt gggttttatc taagcctctg cagctgtgct cctataattc acccctccac
2881 tttgggaatg ggaccaggct cactgtgaca ggtatggggg ctccactctt gactcggggg
2941 tgcctgggtt tgactgcaat gatcagttgc tgggaaggga attgagtgta agaacggagg
3001 tcagggtcac cccttcttac ctggagcact gtgccctctc ctcccctccc tggagctctt
3061 ccagcttgtt gctctgctgt gttgcctgca gttcctcagc tgtagagctc cttgcttagt
3121 cttcagggct gtgtgtttct ttgctcttct tttcattgtt ttctgggact cttctcatct
3181 ctactttctt agtggatgta ttgttttact ttcccttttt taaattgcat cttctccatt
3241 ttttccttcc cattctaact ccacttctgc attgttgact ccttttggtg actagctctg
3301 tcttctatgt taagattctc cccactgcca gcctccagca cagaactctg ctcatgtctt
3361 catctccctc cttctttctt tctctaccag tcttagaaga tgcatctatg tcttcctgag
3421 gtagtttgaa ggttcatgag ccaggcatga ccaggttggg gagacaggtg gtttcagggt
3481 tgctcttgag gcctgagggc agaagtccct gtcacagcat tgggcgagct gcagggagtc
3541 tctgaggtgc ctgtgtttgg caggtgtttg ggagataggt ctgaagagag tgttacaact
3601 ggaaactgac attatcttag caacagataa ggtataaaga agacaaaatg ggtaggagac
3661 tctattttct ttttttctga gacggtgtct agctctattg cccaggctgg agtgcagtgg
3721 cacgatctcg gctcactgca acctccgcct cctgggtttg agcgattctc ctcccttggc
3781 ctcccgagta gctgggatta caggtgcctg ccaccaaacc cagctacttt ttgcattttt
3841 agtagagata gggtttcact gtgttagccg ggctgttctc aaactcctga cctcgtgatc
3901 cgcctgcctt gggcctcccg agtagctggg attacaggtg cctgccacca aacccagcta
3961 gctttttgca ttttttagta gagatagggt ttcactgtgt tagccgggct gttctcaaat
4021 ctcctgacct cgtgatccgc ctgccttggc ctcccaaagt gctgggatta caaatgtgag
4081 ccactgcacc cagccaagac tccattctct taagcctcag aatctatgct agaacaatag
4141 ggtaaaggcc ccaccaggaa gccctagtac aaccttcccc atgctgggga ggaagcagac
4201 aggcggtgga gcggggttgg gatgggatga ggtctaggat ggagacatag acaagggtgg
4261 aggaatggga ctcatagggt ctaccaaagt ttaggggctt gggcagacat tagtgtaggt
4321 ggggacacac accaagacgt tgagtggaaa gtacaaatca ccagattcaa aggcctgggt
4381 tcaaggggct gtggtggggg aggtgtgcaa tttgaaaagc aacttaagct gcctcctctc
4441 taagacatag aaacagaaga gactaactta tatgaaaatc ctttgtaaag gattttgtaa
4501 aggactcaac ttgtggtgac aatccttttc attcctgttg tttatgatca ctaggtcaca
4561 gggtttgcct ttttccaaac ctgcatctca attttcccat caaaaacatt tcccaaattt
4621 ggataaagaa cccatatcta gacttgccac atttctgcac caaaagctca ctctcatggt
4681 tggaacagag ccaagcaaag ggcacagtaa attgtggttt cttccactcc tcatgtgtct
4741 tcagatgaaa tcattctttc caataatccc agaaattctt tctctcctct ctcaagcatg
4801 tgaaaaggtc cagagctctg cagtgtgagc tttctactga aatggccctt ggactttgtg
4861 gttcattcat actcagtggt ctagcttgta ctacttttga gaatgcaaag ctt
//