LOCUS HUMTBG 1872 bp mRNA linear HUM 13-JAN-1995
DEFINITION Human thyroxine-binding globulin mRNA, complete cds.
ACCESSION M14091
VERSION M14091.1
KEYWORDS thyroxine-binding globulin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1872)
AUTHORS Flink,I.L., Bailey,T.J., Gustafson,T.A., Markham,B.E. and Morkin,E.
TITLE Complete amino acid sequence of human thyroxine-binding globulin
deduced from cloned DNA: close homology to the serine antiproteases
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (20), 7708-7712 (1986)
PUBMED 3094014
COMMENT Original source text: Human liver, cDNA to mRNA, clone
lambda-gTBG8; and DNA, clone lambda-gTBG2.
Draft entry and clean copy sequence for [1] kindly provided by
I.L.Flink, 06-JAN-1987.
FEATURES Location/Qualifiers
source 1..1872
/db_xref="H-InvDB:HIT000194299"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xq21-q22"
gene 1..1872
/gene="TBG"
mRNA 93..1872
/gene="TBG"
/product="TBG mRNA"
CDS 331..1578
/gene="TBG"
/note="thyroxine-binding globulin precursor"
/codon_start=1
/protein_id="AAA60616.1"
/db_xref="GDB:G00-120-399"
/translation="MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSS
INADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTD
TPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFS
TDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTTMVLVNYIHFKAQWANPFDPSK
TEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQ
MESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENAD
FSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFM
LLILERSTRSILFLGKVVNPTEA"
sig_peptide 331..390
/gene="TBG"
/note="thyroxine-binding globulin signal peptide"
mat_peptide 391..1575
/gene="TBG"
/product="thyroxine-binding globulin"
BASE COUNT 520 a 418 c 388 g 546 t
ORIGIN Chromosome Xq21-q22; 15 bp upstream of HinfI site.
1 ttcagaaaaa aagtgattca atttccataa atttaattta ctcacagcgt tttcataatg
61 ttgctataac atctgaatga cagtccatgg catattcctg gttgcagcaa gcactctcct
121 actccctgtc catattagat gcatctcctg ttttcaaggg agagaaaccc ctgctcagcc
181 cctgatgagc acatcatcaa atatttacta ttgttttatt aatcaatgtg ggtggttatt
241 atgtgtctct ggctcaggga gtgtttcatc caactaagct ccctcagtgg ttgtctcact
301 tcatctctta tagattaact tccttccaaa atgtcaccat tcctgtacct ggttctcttg
361 gtacttgggc ttcatgctac aatccactgt gcatcacctg aaggcaaagt aacagcctgc
421 cattcatccc aaccaaatgc cactctctac aagatgtcat ccattaatgc tgactttgca
481 ttcaatctgt accggaggtt cactgtggag accccagata agaacatctt cttttcccct
541 gtgagcattt ctgcagcttt ggttatgctt tcctttgggg cctgctgcag cacccaaact
601 gagattgtgg agaccttggg gttcaacctc acagacactc caatggtaga gatccagcat
661 ggcttccagc atctgatctg ttcactgaat tttccaaaga aggaactgga attgcagata
721 ggaaatgccc tcttcattgg caagcatctg aaaccactgg caaagttctt gaatgatgtc
781 aagaccctct atgagactga agtcttttct accgacttct ccaacatttc tgcagccaag
841 caggagatta acagtcatgt ggagatgcaa accaaaggga aagttgtggg tctaattcaa
901 gacctcaagc caaacaccac tatggtctta gtgaactata ttcactttaa agcccagtgg
961 gcaaatcctt ttgatccatc caagacagaa gacagttcca gcttcttaat agacaagacc
1021 accactgttc aagtgcccat gatgcaccag atggaacaat actatcacct agtggatatg
1081 gaattgaact gcacagttct gcaaatggac tacagcaaga atgctctggc actctttgtt
1141 cttcccaagg agggacagat ggagtcagtg gaagctgcca tgtcatctaa aacactgaag
1201 aagtggaacc gcttactaca gaagggatgg gttgacttgt ttgttccaaa gttttccatt
1261 tctgccacat atgaccttgg agccacactt ttgaagatgg gcattcagca tgcctattct
1321 gaaaatgctg atttttctgg actcacagag gacaatggtc tgaaactttc caatgctgcc
1381 cataaggctg tgctgcacat tggtgaaaag ggaactgaag ctgcagctgt ccctgaagtt
1441 gaactttcgg atcagcctga aaacactttc ctacacccta ttatccaaat tgatagatct
1501 ttcatgttgt tgattttgga gagaagcaca aggagtattc tctttctagg gaaagttgtg
1561 aacccaacgg aagcgtagtt gggaaaaagg ccattggcta attgcacgtg tgtattgcaa
1621 tgggaaataa ataaataata tagcctggtg tgattgatgt gagcttggac ttgcattccc
1681 ttatgatggg atgaagattg aaccctggct gaactttgtt ggctgtggaa gaggccaatc
1741 ctatggcaga gcattcagaa tgtcaatgag taattcatta ttatccaaag cataggaagg
1801 ctctatgttt gtatatttct ctttgtcaga atacccctca actcatttgc tctaataaat
1861 ttgactgggt tg
//