LOCUS       HUMPAIB                 2937 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human beta-migrating plasminogen activator inhibitor I mRNA, 3'
            end.
ACCESSION   M14083
VERSION     M14083.1
KEYWORDS    Alu repeat; plasminogen activator inhibitor 1; repeat region;
            serine protease inhibitor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Ny,T., Sawdey,M., Lawrence,D., Millan,J.L. and Loskutoff,D.J.
  TITLE     Cloning and sequence of a cDNA coding for the human beta-migrating
            endothelial-cell-type plasminogen activator inhibitor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (18), 6776-6780 (1986)
   PUBMED   3092219
COMMENT     Original source text: Human placenta, cDNA to mRNA, clone lamda-3.
            Clean copy sequence for [1] kindly provided by M.Sawdey,
            05-JAN-1987.
FEATURES             Location/Qualifiers
     source          1..2937
                     /db_xref="H-InvDB:HIT000194297"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="7q21.3-q22.1"
     gene            1..2937
                     /gene="PAI1"
     mRNA            <1..2937
                     /gene="PAI1"
                     /product="PIA-b mRNA"
     CDS             <1..1152
                     /gene="PAI1"
                     /note="prebeta-migrating plasminogen activator inhibitor"
                     /codon_start=1
                     /protein_id="AAA60008.1"
                     /translation="EGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVA
                     SVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIF
                     VQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGA
                     VDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFT
                     TPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRL
                     LVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNE
                     SGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP"
     sig_peptide     <1..12
                     /gene="PAI1"
                     /note="beta-migrating plasminogen inhibitor activator
                     signal peptide"
     mat_peptide     13..1149
                     /gene="PAI1"
                     /product="beta-migrating plasminogen inhibitor activator"
     repeat_region   2530..2630
                     /gene="PAI1"
                     /note="Alu repeat"
BASE COUNT          727 a          784 c          728 g          698 t
ORIGIN      Unreported.
        1 gaagggtctg ctgtgcacca tcccccatcc tacgtggccc acctggcctc agacttcggg
       61 gtgagggtgt ttcagcaggt ggcgcaggcc tccaaggacc gcaacgtggt tttctcaccc
      121 tatggggtgg cctcggtgtt ggccatgctc cagctgacaa caggaggaga aacccagcag
      181 cagattcaag cagctatggg attcaagatt gatgacaagg gcatggcccc cgccctccgg
      241 catctgtaca aggagctcat ggggccatgg aacaaggatg agatcagcac cacagacgcg
      301 atcttcgtcc agcgggatct gaagctggtc cagggcttca tgccccactt cttcaggctg
      361 ttccggagca cggtcaagca agtggacttt tcagaggtgg agagagccag attcatcatc
      421 aatgactggg tgaagacaca cacaaaaggt atgatcagca acttgcttgg gaaaggagcc
      481 gtggaccagc tgacacggct ggtgctggtg aatgccctct acttcaacgg ccagtggaag
      541 actcccttcc ccgactccag cacccaccgc cgcctcttcc acaaatcaga cggcagcact
      601 gtctctgtgc ccatgatggc tcagaccaac aagttcaact atactgagtt caccacgccc
      661 gatggccatt actacgacat cctggaactg ccctaccacg gggacaccct cagcatgttc
      721 attgctgccc cttatgaaaa agaggtgcct ctctctgccc tcaccaacat tctgagtgcc
      781 cagctcatca gccactggaa aggcaacatg accaggctgc cccgcctcct ggttctgccc
      841 aagttctccc tggagactga agtcgacctc aggaagcccc tagagaacct gggaatgacc
      901 gacatgttca gacagtttca ggctgacttc acgagtcttt cagaccaaga gcctctccac
      961 gtcgcgcagg cgctgcagaa agtgaagatc gaggtgaacg agagtggcac ggtggcctcc
     1021 tcatccacag ctgtcatagt ctcagcccgc atggcccccg aggagatcat catggacaga
     1081 cccttcctct ttgtggtccg gcacaacccc acaggaacag tccttttcat gggccaagtg
     1141 atggaaccct gaccctgggg aaagacgcct tcatctggga caaaactgga gatgcatcgg
     1201 gaaagaagaa actccgaaga aaagaatttt agtgttaatg actctttctg aaggaagaga
     1261 agacatttgc cttttgttaa aagatggtaa accagatctg tctccaagac cttggcctct
     1321 ccttggagga cctttaggtc aaactcccta gtctccacct gagaccctgg gagagaagtt
     1381 tgaagcacaa ctcccttaag gtctccaaac cagacggtga cgcctgcggg accatctggg
     1441 gcacctgctt ccacccgtct ctctgcccac tcgggtctgc agacctggtt cccactgagg
     1501 ccctttgcag gacggaacta cggggcttac aggagctttt gtgtgcctgg tagaaactat
     1561 ttctgttcca gtcacattgc catcactctt gtactgcctg ccaccgcgga ggaggctggt
     1621 gacaggccaa aggccagtgg aagaaacacc ctttcatctc agagtccact gtggcactgg
     1681 ccacccctcc ccagtacagg ggtgctgcag gtggcagagt gaatgtcccc catcatgtgg
     1741 cccaactctc ctggcctggc catctccctc cccagaaaca gtgtgcatgg gttattttgg
     1801 agtgtaggtg acttgtttac tcattgaagc agatttctgc ttccttttat ttttatagga
     1861 atagaggaag aaaggtcaga tgcgtgccca gctcttcacc ccccaatctc ttggtgggga
     1921 ggggtgtacc taaatattta tcatatcctt gcccttgagt gcttgttaga gagaaagaga
     1981 actactaagg aaaataatat tatttaaact cgctcctagt gtttctttgt ggtctgtgtc
     2041 accgtatctc aggaagtcca gccacttgac tggcacacac ccctccggac atccagcgtg
     2101 acggagccca cactgccacc ttgtggccgc ctgagaccct cgcgcccccc gcgccccccg
     2161 cgcccctctt tttccccttg atggaaattg accatacaat ttcatcctcc ttcaggggat
     2221 caaaaggacg gagtgggggg acagagactc agatgaggac agagtggttt ccaatgtgtt
     2281 caatagattt aggagcagaa atgcaagggg ctgcatgacc taccaggaca gaactttccc
     2341 caattacagg gtgactcaca gccgcattgg tgactcactt caatgtgtca tttccggctg
     2401 ctgtgtgtga gcagtggaca cgtgaggggg gggtgggtga gagagacagg cagctcggat
     2461 tcaactacct tagataatat ttctgaaaac ctaccagcca gagggtaggg cacaaagatg
     2521 gatgtaatgc actttgggag gccaaggcag gaggattgct tgagcccagg agttcaagac
     2581 cagcctgggc aacataccaa gacccccgtc tctttaaaaa tatatatatt ttaaatatac
     2641 ttaaatatat atttctaata tctttaaata tatatatata ttttaaagac caatttatgg
     2701 gagaattgca cacagatgtg aaatgaatgt aatctaatag aagcctaatc agcccaccat
     2761 gttctccact gaaaaatcct ctttctttgg ggtttttctt tctttctttt ttgattttgc
     2821 actggacggt gacgtcagcc atgtacagga tccacagggg tggtgtcaaa tgctattgaa
     2881 attgtgttga attgtatgct ttttcacttt tgataaataa acatgtaaaa atgtttc
//