LOCUS HUMPKG 1146 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human (clone lambda-hPKC-gamma6) protein kinase C-gamma (PRKCG)
mRNA, 5' end cds.
ACCESSION M13977
VERSION M13977.1
KEYWORDS protein kinase C-gamma.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1146)
AUTHORS Coussens,L., Parker,P.J., Rhee,L., Yang-Feng,T.L., Chen,E.,
Waterfield,M.D., Francke,U. and Ullrich,A.
TITLE Multiple, distinct forms of bovine and human protein kinase C
suggest diversity in cellular signaling pathways
JOURNAL Science 233 (4766), 859-866 (1986)
PUBMED 3755548
REFERENCE 2 (sites)
AUTHORS McSwine-Kennick,R.L., McKeegan,E.M., Johnson,M.D. and Morin,M.J.
TITLE Phorbol diester-induced alterations in the expression of protein
kinase C isozymes and their mRNAs. Analysis in wild-type and
phorbol diester-resistant HL-60 cell clones
JOURNAL J. Biol. Chem. 266 (23), 15135-15143 (1991)
PUBMED 1714454
COMMENT Original source text: Homo sapiens fetal brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1146
/db_xref="H-InvDB:HIT000194284"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
/dev_stage="fetal"
gene 1..1146
/gene="PRKCG"
/map="19q13.4"
mRNA 1..>1146
/gene="PRKCG"
gene 196..1146
/gene="PRKACG"
/map="9q13"
CDS 196..>1146
/gene="PRKACG"
/codon_start=1
/map="9q13"
/product="protein kinase C-gamma"
/protein_id="AAA60102.1"
/db_xref="GDB:G00-120-719"
/translation="MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFK
QPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHK
FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGR
LQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKAT
LNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYK
LLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYEVSRT"
BASE COUNT 218 a 357 c 336 g 235 t
ORIGIN 19q13.4.
1 ccttgcggag ccggcgcgcc cggggtgccg ctccctgcct ggcgcgctcc gcacctggag
61 gtgccttgcc cctctcctgc ccacctcgga atttccctgt ggctcctttg atccttcgag
121 tctccagctc ctctcccttc cacctgtttc ccccaagaaa ggcaggatcc tggtccctgc
181 tacgtttctg gggccatggc tggtctgggc cccggcgtag gcgattcaga ggggggaccc
241 cggcccctgt tctgcagaaa gggggctctg aggcagaagg tggtccacga agtcaagagc
301 cacaagttca ccgctcgctt cttcaagcag cccaccttct gcagccactg caccgacttc
361 atctggggta tcggaaagca gggcctgcaa tgtcaagtct gcagctttgt ggttcatcga
421 cgatgccacg aatttgtgac cttcgagtgt ccaggcgctg ggaagggccc ccagacggac
481 gacccccgga acaaacacaa gttccgcctg catagctaca gcagccccac cttctgcgac
541 cactgtggct ccctcctcta cgggcttgtg caccagggca tgaaatgttc ttgctgcgag
601 atgaacgtgc accggcgctg tgtgcgtagc gtgccctctc tgtgcggtgt ggaccacacc
661 gagcgccgcg ggcgcctgca gctggagatc cgggctccca cagcagatga gatccacgta
721 actgttggcg aggcccgtaa cctaattcct atggacccca atggtctctc tgatccctat
781 gtgaaactga agctcatccc agaccctcgg aacctgacga aacagaagac ccgaacggtg
841 aaagccacgc taaaccctgt gtggaatgag acctttgtgt tcaacctgaa gccaggggat
901 gtggagcgcc ggctcagcgt ggaggtgtgg gactgggacc ggacctcccg caacgacttc
961 atgggggcca tgtcctttgg cgtctcggag ctgctcaagg cgcccgtgga tggctggtac
1021 aagttactga accaggagga gggcgagtat tacaatgtgc cggtggctga tgctgacaac
1081 tgcagcctcc tccagaagtt tgaggcttgt aactaccccc tggaattgta tgaggtgagt
1141 agaacc
//