LOCUS AH002883 6728 bp DNA linear HUM 01-AUG-2016
DEFINITION Homo sapiens pseuda-OHase mRNA gene, pseudo-OHase (CYP21P)
pseudogene, complete sequence; and steroid 21-hydroxylase (CYP21P)
gene, complete cds.
ACCESSION AH002883 M13935 M13936
VERSION AH002883.2
KEYWORDS cytochrome; cytochrome P450; pseudogene; steroid 21-hydroxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6728)
AUTHORS White,P.C., New,M.I. and Dupont,B.
TITLE Structure of human steroid 21-hydroxylase genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (14), 5111-5115 (1986)
PUBMED 3487786
COMMENT On or before Aug 1, 2016 this sequence version replaced M13935.1,
M13936.1, AH002883.1.
FEATURES Location/Qualifiers
source 1..6728
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="6p21.3"
mRNA 200..>3206
/product="pseuda-OHase mRNA"
gene 214..6228
/gene="CYP21P"
CDS join(214..415,512..601,891..1037,1145..1246,1335..1436,
1538..1624,1794..1995,2196..2374,2458..2561,2658..2923)
/gene="CYP21P"
/note="pseudo-OHase"
/pseudo
/codon_start=1
/db_xref="GDB:G00-120-606"
exon <214..415
/gene="CYP21P"
/note="pseudo-OHase"
/number=1
intron 416..511
/gene="CYP21P"
/note="pseudo-OHase intron A"
exon 512..601
/gene="CYP21P"
/number=2
/pseudo
intron 602..890
/gene="CYP21P"
/note="pseudo-OHase intron B"
exon 891..1037
/gene="CYP21P"
/number=3
/pseudo
misc_feature 929..930
/gene="CYP21P"
/note="8 bp frameshift deletion"
misc_feature 989..991
/gene="CYP21P"
/note="pseudo-OHase frameshift internal stop codon"
intron 1038..1144
/gene="CYP21P"
/note="pseudo-OHase intron C"
exon 1145..1246
/gene="CYP21P"
/number=4
/pseudo
intron 1247..1334
/gene="CYP21P"
/note="pseudo-OHase intron D"
exon 1335..1436
/gene="CYP21P"
/number=5
/pseudo
intron 1437..1537
/gene="CYP21P"
/note="pseudo-OHase intron E"
exon 1538..1624
/gene="CYP21P"
/number=6
/pseudo
intron 1625..1793
/gene="CYP21P"
/note="pseudo-OHase intron F"
exon 1794..1995
/gene="CYP21P"
/number=7
/pseudo
misc_feature 1976..1978
/gene="CYP21P"
/note="ttt in pseudo-OHase; tt in OHase"
intron 1996..2195
/gene="CYP21P"
/note="pseudo-OHase intron G"
exon 2196..2374
/gene="CYP21P"
/number=8
/pseudo
intron 2375..2457
/gene="CYP21P"
/note="pseudo-OHase intron H"
exon 2458..2561
/gene="CYP21P"
/number=9
/pseudo
intron 2562..2657
/gene="CYP21P"
/note="pseudo-OHase intron I"
exon 2658..>2923
/gene="CYP21P"
/note="pseudo-OHase"
/number=10
gap 3207..3306
/estimated_length=unknown
prim_transcript 3505..6728
/note="OHase mRNA"
CDS join(3519..3717,3815..3904,4187..4341,4450..4551,
4640..4741,4843..4929,5099..5299,5501..5679,5763..5866,
5964..6229)
/gene="CYP21P"
/note="steroid 21-hydroxylase"
/codon_start=1
/protein_id="AAA59695.1"
/db_xref="GDB:G00-120-606"
/translation="MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDL
PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSK
NYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAI
EEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF
PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQL
LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRV
PYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAH
LDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFT
LLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ"
exon <3519..3717
/gene="CYP21P"
/note="steroid 21-hydroxylase"
/number=1
intron 3718..3814
/gene="CYP21P"
/note="OHase intron A"
exon 3815..3904
/gene="CYP21P"
/number=2
intron 3905..4186
/gene="CYP21P"
/note="OHase intron B"
exon 4187..4341
/gene="CYP21P"
/number=3
intron 4342..4449
/gene="CYP21P"
/note="OHase intron C"
exon 4450..4551
/gene="CYP21P"
/number=4
intron 4552..4639
/gene="CYP21P"
/note="OHase intron D"
exon 4640..4741
/gene="CYP21P"
/number=5
intron 4742..4842
/gene="CYP21P"
/note="OHase intron E"
exon 4843..4929
/gene="CYP21P"
/number=6
intron 4930..5098
/gene="CYP21P"
/note="OHase intron F"
exon 5099..5299
/gene="CYP21P"
/number=7
intron 5300..5500
/gene="CYP21P"
/note="OHase intron G"
exon 5501..5679
/gene="CYP21P"
/number=8
intron 5680..5762
/gene="CYP21P"
/note="OHase intron H"
exon 5763..5866
/gene="CYP21P"
/number=9
intron 5867..5963
/gene="CYP21P"
/note="OHase intron I"
exon 5964..>6229
/note="steroid 21-hydroxylase"
/number=10
BASE COUNT 1191 a 2126 c 1954 g 1357 t
ORIGIN 1 bp upstream of TaqI site; chromosome 6.
1 tcgatgggtg attaattttt tttgaaatac ggacgtccca aggccaatga ggactggtgt
61 cattccagaa aagggccact ctgtgggcgg gtcggtggga aggcacctga gggtggggtc
121 aagggaggcc ccaaaacagt ctacacagca ggagggatgg ctggggctct tgagctataa
181 gtggcacctc agggccctga cgggcttctc gccatgctgc tcctgggcct gctgctgctg
241 ctgcccctgc tggctggcgc ccgcctgctg tggaactggt ggaagctccg gagcctccac
301 ctcctgcctc ttgccccggg cttcttgcac ctgctgcagc ccgacctccc catctatctg
361 cttggcctga ctcagaaatt cgggcccatc tacaggctcc accttgggct gcaaggtgag
421 aggctgatct cgctctggcc ctcaccatag gagggggcgg aggtgacgga gagggtcctc
481 tctccgtgac gctgctttgg ctgtctccca gatgtggtgg tgctgaactc caagaggacc
541 attgaggaag ccatggtcaa aaagtgggca gactttgctg gcagacctga gccacttacc
601 tgtaagggcc gggggcattt tttctttctt aaacaaattt tttttttgtt agagatgggg
661 tcttgctatg ttgcccaggc tggtcttgaa ttcctggtct caagtgatcc tcccacctcg
721 gcctcaagtg ggagccacct tcgggggctt ccccaatcct ccaggtcact ggaagctctt
781 ggggggcata tctgtcagga gaagaagatg gtgttaggga ggacgaagaa ggtcaggccc
841 tcggcttcct tggtcagttc ccaccctcca ggccccagct cctcctgcag acaagctggt
901 gtctaagaac tacccggact tgtcgttggt ctctgctctg gaaagcccac aagaagctca
961 cccgctcagc cctgctgctg ggcatccgtg actccatgga gccagtggtg gagcagctga
1021 cccaggagtt ctgtgaggta aggctgggct cctgaggcca cctcgggtca gcctcgcctc
1081 tcacagtagc ccccgccctg cccgctgcac agcggcctgc tgaactcaca ctgtttctcc
1141 acagcgcatg agagcccagc ccggcacccc tgtggccatt gaggaggaat tctctctcct
1201 cacctgcagc atcaactgtt acctcacctt cggagacaag atcaaggtgc ctcacagccc
1261 ctcaggccca gccccagccc ctccctgagc ctctccttgt cctgaactga aagtactcca
1321 tcctttcctg gcaggaggac aacttaatgc ctgcctatta caaatgtatc caggaggtgt
1381 taaaaacctg gagccactgg tccatccaaa ttgtggacgt gattcccttt ctcagggtga
1441 ggacctggag cctagacacc cctgggttgt aggggagagg ctggggtgga gggagaggct
1501 ccttcccaca gctgcattct catgcttcct gccgcagttc ttccccaatc caggtctccg
1561 gaggctgaag caggccatag agaagaggga ccacaacgag gagaagcagc tgaggcagca
1621 caaggtgggg actctacgtg gacggcctcc cctcggccca cagccagtga tgctaccggc
1681 ctcagcattg ctatgaggcg ggttcttttg cataccccag ttatgggcct gttgccactc
1741 tgtactcctc tccccaggcc agccgctcag cccgctcctt tcaccctctg caggagagcc
1801 tcgtggcagg ccagtggagg gacatgatgg actacatgct ccaaggggtg gcgcagccga
1861 gcatggaaga gggctctgga cagctcctgg aagggcactt gcacatggct gcagtggacc
1921 tcctgatcgg tggcactgag accacagcaa acaccctctc ctgggccgtg gttttttttg
1981 cttcaccacc ctgaggtgcg tcctgcggac aagcaaaagg ctccttccca gcaacctggc
2041 cagggcggtg ggcaccctca ctcagctctg agcactgtgc ggctggggct gtgcttgcct
2101 caccggccac tcaggcctca ctggcttgct gagggagcgg ctggaggctg ggcagctgtg
2161 ggctgctggg gaggatccac ccgatcattc cccagattca gcagcgactg taggaggagc
2221 tagaccacga actgggccct ggtgcctcca gctcccgggt cccctacaag gaccgtgcac
2281 ggctgccctt gctcaatgcc accatcgccg aggtgctgcg cctgtggccc gttgtgccct
2341 tagccttgcc ccaccgcacc acacggccca gcaggtgact cccgagggtt ggggatgagt
2401 gaggaaagcc cgagcccagg gaggtcctgg ccagcctcta actccagccc ccttcagcat
2461 ctctggctac gacatccctg agggcacagt catcattccg aacctccaag gcgcccacct
2521 ggatgagacg gtctgggaga ggccacatga gttctggcct ggtatgtggg gggccggggg
2581 cctgccgtga aaatgtggtg gaggctggtc cccgctgccg ctgaacgcct ccccacccac
2641 ctgtccaccg cccgcagatc gcttcctgga gccaggcaag aactccagag ctctggcctt
2701 cggctgcggt gcccgcgtgt gcctgggcga gccgttggcg cgcctggagc tcttcgtggt
2761 gctgacccga ctgctgcagg ccttcacgct gctgccctcc ggggacgccc tgccctccct
2821 gcagcccctg ccccactgca gtgtcatcct caagatgcag cctttccaag tgcggctgca
2881 gccccggggg atgggggccc acagcccagg ccagaaccag tgatggggca ggaccgatgc
2941 cagccgggta cctcagtttc tcctttattg ctcccgtacg aacccctccc ctcccccctg
3001 taaacacagt gctgcgagat cgctggcaga gaaggcttcc tccagcggct gggtggtgaa
3061 ggaccctggc tcttctctcg gggcgacccc tcagtgctcg gcagtcatac tggggtgcga
3121 aggtgggcag cagctcagcc tccccgctgg ggagcgaaag tttcttggtc tcagcttcat
3181 ttccgtgaag ggcaccgaga actcgannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3301 nnnnnnttga tgggtgatca atttttttga aatacggacg tcccaaggcc aatgaggact
3361 ggtgtcattc cagaaaaggg ccactctgtg ggcgggtcgg tgggagggta cctgaaggtg
3421 gggccaaggg aggccccaaa acagtctaca cagcaggagg gatggctggg gctcttgagc
3481 tataagtggc acctcagggc cctgacgggc gtctcgccat gctgctcctg ggcctgctgc
3541 tgctgcccct gctggctggc gcccgcctgc tgtggaactg gtggaagctc cggagcctcc
3601 acctcccgcc tcttgccccg ggcttcttgc acctgctgca gcccgacctc cccatctatc
3661 tgcttggcct gactcagaaa ttcgggccca tctacaggct ccaccttggg ctgcaaggtg
3721 agaggctgat ctcgctctgg ccctcaccat aggagggggc ggaggtgacg gagagggtcc
3781 tctctccgct gacgctgctt tggctgtctc ccagatgtgg tggtgctgaa ctccaagagg
3841 accattgagg aagccatggt caaaaagtgg gcagactttg ctggcagacc tgagccactt
3901 acctgtaagg gctgggggca ttttttcttt cttaaacaaa ttttttttta agagatgggt
3961 tcttgctatg ctgcccaggc tggtcttaaa ttcctagtct caaatgatcc tcccacctca
4021 gcctcaagtg tgagccacct ttggggcatc cccaatccag gtccctggaa gctcttcggg
4081 ggggcatatc tggtgggaga aagctggggt tggggaggcc gaagaaggtc aggccctcag
4141 ctgccttcat cagttcccac cctccagccc ccaactcctc ctgcagacaa gctggtgtct
4201 aagaactacc cggacttgtc cttgggagac tactccctgc tctggaaagc ccacaagaag
4261 ctcacccgct cagccctgct gctgggcatc cgtgactcca tggagccagt ggtggagcag
4321 ctgacccagg agttctgtga ggtaaggctg ggctcctgag gccacctcgg gtcagcctcg
4381 cctctcacag tagcccccgc cctgcccgct gcacagcggc ctgctggaac tcacactgtt
4441 tctccacagc gcatgagagc ccagcccggc acccctgtgg ccattgagga ggaattctct
4501 ctcctcacct gcagcatcat ctgttacctc accttcggag acaagatcaa ggtgcctcac
4561 agcccctcag gcccaccccc agcccctccc tgagcctctc cttgtcctga actgaaagta
4621 ctccctcctt ttctggcagg acgacaactt aatgcctgcc tattacaaat gtatccagga
4681 ggtgttaaaa acctggagcc actggtccat ccaaattgtg gacgtgattc cctttctcag
4741 ggtgaggacc tggagcctag acacccctgg gttgtagggg agaggctggg gtggagggag
4801 aggctccttc ccacagctgc attctcatgc ttcctgccgc agttcttccc caatccaggt
4861 ctccggaggc tgaagcaggc catagagaag agggatcaca tcgtggagat gcagctgagg
4921 cagcacaagg tggggactct acgtggacgg cctcccctcg gcccacagcc agtgatgcta
4981 ccggcctcag cattgctatg aggcgggttc ttttgcatac cccagttatg ggcctgttgc
5041 cactctgtac tcctctcccc aggccagccg ctcagcccgc tcctttcacc ctctgcagga
5101 gagcctcgtg gcaggccagt ggagggacat gatggactac atgctccaag gggtggcgca
5161 gccgagcatg gaagagggct ctggacagct cctggaaggg cacgtgcaca tggctgcagt
5221 ggacctcctg atcggtggca ctgagaccac agcaaacacc ctctcctggg ccgtggtttt
5281 tttgcttcac caccctgagg tgcgtcctgg ggacaagcaa aaggctcctt cccagcaacc
5341 tggccagggc ggtgggcacc ctcactcagc tctgagcact gtgcggctgg ggctgtgctt
5401 gcctcaccgg ccactcaggc tcactgggtt gctgagggag cggctggagg ctgggcagct
5461 gtgggctgct ggggcaggac tccacccgat cattccccag attcagcagc gactgcagga
5521 ggagctagac cacgaactgg gccctggtgc ctccagctcc cgggtcccct acaaggaccg
5581 tgcacggctg cccttgctca atgccaccat cgccgaggtg ctgcgcctgc ggcccgttgt
5641 gcccttagcc ttgccccacc gcaccacacg gcccagcagg tgactcccga gggttgggga
5701 tgagtgagga aagcccgagc ccagggaggt cctggccagc ctctaactcc agcccccttc
5761 agcatctctg gctacgacat ccctgagggc acagtcatca ttccgaacct ccaaggcgcc
5821 cacctggatg agacggtctg ggagaggcca catgagttct ggcctggtat gtggggggcc
5881 gggggcctgc cgtgaaaatg tggtggaggc tggtccccgc tgccgctgaa cgcctcccca
5941 cccacctgtc cacccgcccg cagatcgctt cctggagcca ggcaagaact ccagagctct
6001 ggccttcggc tgcggtgccc gcgtgtgcct gggcgagccg ttggcgcgcc tggagctctt
6061 cgtggtgctg acccgactgc tgcaggcctt cacgctgctg ccctccgggg acgccctgcc
6121 ctccctgcag cccctgcccc actgcagtgt catcctcaag atgcagcctt tccaagtgcg
6181 gctgcagccc cgggggatgg gggcccacag cccgggccag aaccagtgat ggggcaggac
6241 cgatgccagc cgggtacctc agtttctcct ttattgctcc cgtacgaacc cctcccctcc
6301 cccctgtaaa cacagtgctg gcgagatcgc tggcagagaa ggcttcctcc agcggctggg
6361 tggtgaagga ccctggctct tctctcgggg cgacccctca gtgctcggca gtcatactgg
6421 ggtgcgagag gtgggcagca gctcagcctc cccgctgggg agcgaaagtt tcttggtctc
6481 agcttcattt ccgtgaaggg caccgagaac tcgaagccct tccagtggta ccagctcact
6541 ccctgggaaa ggggttgtca agagagagtc aaagccggat gtcccatctg gtcttcccgt
6601 tccccttaag gaggtagctc ccagcactca acctccccgc agagctccct tcctgaccct
6661 ccgctgcaga ggattgaggc ttaattctga gctggccctt tccagttaat aaatcaactc
6721 cagctccc
//