LOCUS       HUMALAD                 1154 bp    mRNA    linear   HUM 31-OCT-1994
DEFINITION  Human delta-aminolevulinate dehydratase mRNA, complete cds.
ACCESSION   M13928
VERSION     M13928.1
KEYWORDS    delta-aminolevulinate dehydratase; heme biosynthetic enzyme;
            porphobilinogen synthase; zinc metalloenzyme.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Wetmur,J.G., Bishop,D.F., Cantelmo,C. and Desnick,R.J.
  TITLE     Human delta-aminolevulinate dehydratase: nucleotide sequence of a
            full-length cDNA clone
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (20), 7703-7707 (1986)
   PUBMED   3463993
COMMENT     Original source text: Human adult liver, cDNA to mRNA (library of
            S.Orkin), clone pKT218-ALA-D.
            Draft entry and sequence in computer-readable form for [1] kindly
            provided by J.G.Wetmur, 08-DEC-1986.
FEATURES             Location/Qualifiers
     source          1..1154
                     /db_xref="H-InvDB:HIT000194278"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="9q32-q34"
     gene            1..1154
                     /gene="ALAD"
     mRNA            <1..1153
                     /gene="ALAD"
                     /product="ALAD mRNA"
     CDS             67..1059
                     /gene="ALAD"
                     /note="delta-aminolevulinate dehydratase (EC 4.2.1.24)"
                     /codon_start=1
                     /protein_id="AAA51687.1"
                     /db_xref="GDB:G00-119-665"
                     /translation="MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDI
                     QPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAI
                     EAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKA
                     GCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAF
                     GDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVY
                     HVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE"
BASE COUNT          243 a          346 c          334 g          231 t
ORIGIN      1040 bp upstream of PstI site; chromosome 9q34.
        1 gcagccaaag ccccaggagc cctaggttcc aaccaactga tgcccctgtg cccactggcc
       61 cacgccatgc agccccagtc cgttctgcac agcggctact tccacccact acttcgggcc
      121 tggcagacag ccaccaccac cctcaatgcc tccaacctca tctaccccat ctttgtcacg
      181 gatgttcctg atgacataca gcctatcacc agcctcccag gagtggccag gtatggtgtg
      241 aagcggctgg aagagatgct gaggcccttg gtggaagagg gcctacgctg tgtcttgatc
      301 tttggcgtcc ccagcagagt tcccaaggac gagcggggtt ccgcagctga ctccgaggag
      361 tccccagcta ttgaggcaat ccatctgttg aggaagacct tccccaacct cctggtggcc
      421 tgtgatgtct gcctgtgtcc ctacacctcc catggtcact gcgggctcct gagtgaaaac
      481 ggagcattcc gggctgagga gagccgccag cggctggctg aggtggcatt ggcgtatgcc
      541 aaggcaggat gtcaggtggt agccccgtcg gacatgatgg atggacgcgt ggaagccatc
      601 aaagaggccc tgatggcaca tggacttggc aacagggtat cggtgatgag ctacagtgcc
      661 aaatttgctt cctgtttcta tggccctttc cgggatgcag ctaagtcaag cccagctttt
      721 ggggaccgcc gctgctacca gctgccccct ggagcacgag gcctggctct ccgagctgtg
      781 gaccgggatg tacgggaagg agctgacatg ctcatggtga agccgggaat gccctacctg
      841 gacatcgtgc gggaggtaaa ggacaagcac cctgacctcc ctctcgccgt gtaccacgtc
      901 tctggagagt ttgccatgct gtggcatgga gcccaggccg gggcatttga tctcaaggct
      961 gccgtactgg aggccatgac tgccttccgc agagcaggtg ctgacatcat catcacctac
     1021 tacacaccgc agctgctgca gtggctgaag gaggaatgat ggaggacagt gccaggccca
     1081 agaactagaa ctttcaaacg ttcccggggc ctcagacaag tgacaaccaa agtaaatgct
     1141 gcttttagaa ctgt
//