LOCUS HUMPRP 2415 bp mRNA linear HUM 08-JAN-1995
DEFINITION Human prion protein (PrP) mRNA, complete cds.
ACCESSION M13899
VERSION M13899.1
KEYWORDS prion protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2415)
AUTHORS Kretzschmar,H.A., Stowring,L.E., Westaway,D., Stubblebine,W.H.,
Prusiner,S.B. and Dearmond,S.J.
TITLE Molecular cloning of a human prion protein cDNA
JOURNAL DNA 5 (4), 315-324 (1986)
PUBMED 3755672
COMMENT Original source text: Human retina, cDNA to mRNA, library
J.Nathans, clone HuPrPcDNA-[1,2].
FEATURES Location/Qualifiers
source 1..2415
/db_xref="H-InvDB:HIT000194276"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="20pter-p12"
gene 1..2415
/gene="PRNP"
mRNA <1..2415
/gene="PRNP"
/product="PRP mRNA"
CDS 50..811
/gene="PRNP"
/codon_start=1
/product="prion protein"
/protein_id="AAA60182.1"
/db_xref="GDB:G00-120-720"
/translation="MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKP
SKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQ
VYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQY
ERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG"
sig_peptide 50..115
/gene="PRNP"
/note="prion protein signal peptide"
mat_peptide 116..808
/gene="PRNP"
/product="prion protein (PrP 33-35-C)"
unsure 1965
/gene="PRNP"
/note="t may be absent [1]"
BASE COUNT 666 a 499 c 578 g 672 t
ORIGIN Unreported.
1 cggcgccgcg agcttctcct ctcctcacga ccgaggcaga gcagtcatta tggcgaacct
61 tggctgctgg atgctggttc tctttgtggc cacatggagt gacctgggcc tctgcaagaa
121 gcgcccgaag cctggaggat ggaacactgg gggcagccga tacccggggc agggcagccc
181 tggaggcaac cgctacccac ctcagggcgg tggtggctgg gggcagcctc atggtggtgg
241 ctgggggcag cctcatggtg gtggctgggg gcagccccat ggtggtggct ggggacagcc
301 tcatggtggt ggctggggtc aaggaggtgg cacccacagt cagtggaaca agccgagtaa
361 gccaaaaacc aacatgaagc acatggctgg tgctgcagca gctggggcag tggtgggggg
421 ccttggcggc tacatgctgg gaagtgccat gagcaggccc atcatacatt tcggcagtga
481 ctatgaggac cgttactatc gtgaaaacat gcaccgttac cccaaccaag tgtactacag
541 gcccatggat gagtacagca accagaacaa ctttgtgcac gactgcgtca atatcacaat
601 caagcagcac acggtcacca caaccaccaa gggggagaac ttcaccgaga ccgacgttaa
661 gatgatggag cgcgtggttg agcagatgtg tatcacccag tacgagaggg aatctcaggc
721 ctattaccag agaggatcga gcatggtcct cttctcctct ccacctgtga tcctcctgat
781 ctctttcctc atcttcctga tagtgggatg aggaaggtct tcctgttttc accatctttc
841 taatcttttt ccagcttgag ggaggcggta tccacctgca gcccttttag tggtggtgtc
901 tcactctttc ttctctcttt gtcccggata ggctaatcaa tacccttggc actgatgggc
961 actggaaaac atagagtaga cctgagatgc tggtcaagcc ccctttgatt gagttcatca
1021 tgagccgttg ctaatgccag gccagtaaaa gtataacagc aaataaccat tggttaatct
1081 ggacttattt ttggacttag tgcaacaggt tgaggctaaa acaaatctca gaacagtctg
1141 aaataccttt gcctggatac ctctggctcc ttcagcagct agagctcagt atactaatgc
1201 cctatcttag tagagatttc atagctattt agagatattt tccattttaa gaaaacccga
1261 caacatttct gccaggtttg ttaggaggcc acatgatact tattcaaaaa aatcctagag
1321 attcttagct cttgggatgc aggctcagcc cgctggagca tgagctctgt gtgtaccgag
1381 aactggggtg atgttttact tttcacagta tgggctacac agcagctgtt caacaagagt
1441 aaatattgtc acaacactga acctctggct agaggacata ttcacagtga acataactgt
1501 aacatatatg aaaggcttct gggacttgaa atcaaatgtt tgggaatggt gcccttggag
1561 gcaacctccc attttagatg tttaaaggac cctatatgtg gcattccttt ctttaaacta
1621 taggtaatta aggcagctga aaagtaaatt gccttctaga cactgaaggc aaatctcctt
1681 tgtccattta cctggaaacc agaatgattt tgacatacag gagagctgca gttgtgaaag
1741 caccatcatc atagaggatg atgtaattaa aaaatggtca gtgtgcaaag aaaagaactg
1801 cttgcatttc tttatttctg tctcataatt gtcaaaaacc agaattaggt caagttcata
1861 gtttctgtaa ttggcttttg aatcaaagaa tagggagaca atctaaaaaa tatcttaggt
1921 tggagatgac agaaatatga ttgatttgaa gtggaaaaag aaattctgtt aatgttaatt
1981 aaagtaaaat tattccctga attgtttgat attgtcacct agcagatatg tattactttt
2041 ctgcaatgtt attattggct tgcactttgt gagtatctat gtaaaaatat atatgtatat
2101 aaaatatata ttgcatagga cagacttagg agttttgttt agagcagtta acatctgaag
2161 tgtctaatgc attaactttt gtaaggtact gaatacttaa tatgtgggaa acccttttgc
2221 gtggtcctta ggcttacaat gtgcactgaa tcgtttcatg taagaatcca aagtggacac
2281 cattaacagg tctttgaaat atgcatgtac tttatatttt ctatatttgt aactttgcat
2341 gttcttgttt tgttatataa aaaaattgta aatgtttaat atctgactga aattaaacga
2401 gcgaagatga gcacc
//