LOCUS HUMBHAA 2113 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human alpha-polypeptide of N-acetyl-alpha-glucosaminidase (HEXA),
mRNA, 3'end.
ACCESSION M13520
VERSION M13520.1
KEYWORDS N-acetyl-alpha-glucosaminidase; alpha-hexosaminidase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2113)
AUTHORS Korneluk,R.G., Mahuran,D.J., Neote,K., Klavins,M.H., O'Dowd,B.F.,
Tropak,M., Willard,H.F., Anderson,M.J., Lowden,J.A. and Gravel,R.A.
TITLE Isolation of cDNA clones coding for the alpha-subunit of human
beta-hexosaminidase. Extensive homology between the alpha- and
beta-subunits and studies on Tay-Sachs disease
JOURNAL J. Biol. Chem. 261 (18), 8407-8413 (1986)
PUBMED 3013851
COMMENT Original source text: Human fibroblast, cDNA to mRNA, clone pHexA.
FEATURES Location/Qualifiers
source 1..2113
/db_xref="H-InvDB:HIT000194222"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="15q23-q24"
gene 1..2113
/gene="HEXA"
CDS <1..1475
/gene="HEXA"
/note="N-acetyl-alpha-glucosaminidase prepro-polypeptide"
/codon_start=2
/protein_id="AAA51827.1"
/db_xref="GDB:G00-120-040"
/translation="YPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYL
TGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLET
FSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLN
VFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEF
DTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDF
YLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVW
QEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDW
KDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKL
TSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT"
BASE COUNT 470 a 545 c 537 g 561 t
ORIGIN Chromosome 15q23-q24.
1 ttacccgaac aactttcaat tccagtacga tgtcagctcg gccgcgcagc ccggctgctc
61 agtcctcgac gaggccttcc agcgctatcg tgacctgctt ttcggttccg ggtcttggcc
121 ccgtccttac ctcacaggga aacggcatac actggagaag aatgtgttgg ttgtctctgt
181 agtcacacct ggatgtaacc agcttcctac tttggagtca gtggagaatt ataccctgac
241 cataaatgat gaccagtgtt tactcctctc tgagactgtc tggggagctc tccgaggtct
301 ggagactttt agccagcttg tttggaaatc tgctgagggc acattcttta tcaacaagac
361 tgagattgag gactttcccc gctttcctca ccggggcttg ctgttggata catctcgcca
421 ttacctgcca ctctctagca tcctggacac tctggatgtc atggcgtaca ataaattgaa
481 cgtgttccac tggcatctgg tagatgatcc ttccttccca tatgagagct tcacttttcc
541 agagctcatg agaaaggggt cctacaaccc tgtcacccac atctacacag cacaggatgt
601 gaaggaggtc attgaatacg cacggctccg gggtatccgt gtgcttgcag agtttgacac
661 tcctggccac actttgtcct ggggaccagg tatccctgga ttactgactc cttgctactc
721 tgggtctgag ccctctggca cctttggacc agtgaatccc agtctcaata atacctatga
781 gttcatgagc acattcttct tagaagtcag ctctgtcttc ccagattttt atcttcatct
841 tggaggagat gaggttgatt tcacctgctg gaagtccaac ccagagatcc aggactttat
901 gaggaagaaa ggcttcggtg aggacttcaa gcagctggag tccttctaca tccagacgct
961 gctggacatc gtctcttctt atggcaaggg ctatgtggtc tggcaggagg tgtttgataa
1021 taaagtaaag attcagccag acacaatcat acaggtgtgg cgagaggata ttccagtgaa
1081 ctatatgaag gagctggaac tggtcaccaa ggccggcttc cgggcccttc tctctgcccc
1141 ctggtacctg aaccgtatat cctatggccc tgactggaag gatttctacg tagtggaacc
1201 cctggcattt gaaggtaccc ctgagcagaa ggctctggtg attggtggag aggcttgtat
1261 gtggggagaa tatgtggaca acacaaacct ggtccccagg ctctggccca gagcaggggc
1321 tgttgccgaa aggctgtgga gcaacaagtt gacatctgac ctgacatttg cctatgaacg
1381 tttgtcacac ttccgctgtg agttgctgag gcgaggtgtc caggcccaac ccctcaatgt
1441 aggcttctgt gagcaggagt ttgaacagac ctgagcccca ggcaccgagg agggtgctgg
1501 ctgtaggtga atggtagtgg agccaggctt ccactgcatc ctggccaggg gacggagccc
1561 cttgccttcg tgccccttgc ctgcgtgccc ctgtgcttgg agagaaaggg gccggtgctg
1621 gcgctcgcat tcaataaaga gtaatgtggc atttttctat aataaacatg gattacctgt
1681 gtttaaaaaa aaaagtgtga atggcgttag ggtaagggca cagccaggct ggagtcagtg
1741 tctgcccctg aggtctttta agttgagggc tgggaatgaa acctatagcc tttgtgctgt
1801 tctgccttgc ctgtgagcta tgtcactccc ctcccactcc tgaccatatt ccagacacct
1861 gccctaatcc tcagcctgct cacttcactt ctgcattata tctccaaggc gttggtatat
1921 ggaaaaagat gtaggggctt ggaggtgttc tggacagtgg ggagggctcc agacccaacc
1981 tggtcacaaa agagcctctc ccccatgcat actcatccac ctccctcccc tagagctatt
2041 ctcctttggg tttcttgctg ctgcaatttt atacaaccat tatttaaata ttattaaaca
2101 catattgttc tct
//