LOCUS HUMBHAB 1832 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human N-acetyl-beta-glucosaminidase (HEXB) mRNA, 3' end.
ACCESSION M13519
VERSION M13519.1
KEYWORDS N-acetyl-beta-glucosaminidase; beta-hexosaminidase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1832)
AUTHORS Korneluk,R.G., Mahuran,D.J., Neote,K., Klavins,M.H., O'Dowd,B.F.,
Tropak,M., Willard,H.F., Anderson,M.J., Lowden,J.A. and Gravel,R.A.
TITLE Isolation of cDNA clones coding for the alpha-subunit of human
beta-hexosaminidase. Extensive homology between the alpha- and
beta-subunits and studies on Tay-Sachs disease
JOURNAL J. Biol. Chem. 261 (18), 8407-8413 (1986)
PUBMED 3013851
COMMENT Original source text: Human fibroblast, cDNA to mRNA, clone pHexB.
FEATURES Location/Qualifiers
source 1..1832
/db_xref="H-InvDB:HIT000194221"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="5q13"
gene 1..1832
/gene="HEXB"
CDS <1..1719
/gene="HEXB"
/note="N-acetyl-beta-glucosaminidase prepro-polypeptide"
/codon_start=1
/protein_id="AAA51828.1"
/db_xref="GDB:G00-119-308"
/translation="VPRLRLGRPGGKQPSGHGAVRAGAAPAAHAAGAAVGDMLAAMLA
LLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNST
AGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNIS
SDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSH
RGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSY
SLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDS
FGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGF
GTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELS
RVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEY
VDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGY
CNHENM"
BASE COUNT 500 a 397 c 435 g 500 t
ORIGIN Chromosome 5q13.
1 gtcccgaggc tccggctcgg cagaccgggc ggaaagcagc cgagcggcca tggagctgtg
61 cgggctgggg ctgccccggc cgcccatgct gctggcgctg ctgttggcga catgctggcg
121 gcgatgttgg cgctgctgac tcaggtggcg ctggtggtgc aggtggcgga ggcggctcgg
181 gccccgagcg tctcggccaa gccggggccg gcgctgtggc ccctgccgct ctcggtgaag
241 atgaccccga acctgctgca tctcgccccg gagaacttct acatcagcca cagccccaat
301 tccacggcgg gcccctcctg caccctgctg gaggaagcgt ttcgacgata tcatggctat
361 atttttggtt tctacaagtg gcatcatgaa cctgctgaat tccaggctaa aacccaggtt
421 cagcaacttc ttgtctcaat cacccttcag tcagagtgtg atgctttccc caacatatct
481 tcagatgagt cttatacttt acttgtgaaa gaaccagtgg ctgtccttaa ggccaacaga
541 gtttggggag cattacgagg tttagagacc tttagccagt tagtttatca agattcttat
601 ggaactttca ccatcaatga atccaccatt attgattctc caaggttttc tcacagagga
661 attttgattg atacatccag acattatctg ccagttaaga ttattcttaa aactctggat
721 gccatggctt ttaataagtt taatgttctt cactggcaca tagttgatga ccagtctttc
781 ccatatcaga gcatcacttt tcctgagtta agcaataaag gaagctattc tttgtctcat
841 gtttatacac caaatgatgt ccgtatggtg attgaatatg ccagattacg aggaattcga
901 gtcctgccag aatttgatac ccctgggcat acactatctt ggggaaaagg tcagaaagac
961 ctcctgactc catgttacag tagacaaaac aagttggact cttttggacc tataaaccct
1021 actctgaata caacatacag cttccttact acatttttca aagaaattag tgaggtgttt
1081 ccagatcaat tcattcattt gggaggagat gaagtggaat ttaaatgttg ggaatcaaat
1141 ccaaaaattc aagatttcat gaggcaaaaa ggctttggca cagattttaa gaaactagaa
1201 tctttctaca ttcaaaaggt tttggatatt attgcaacca taaacaaggg atccattgtc
1261 tggcaggagg tttttgatga taaagcaaag cttgcgccgg gcacaatagt tgaagtatgg
1321 aaagacagcg catatcctga ggaactcagt agagtcacag catctggctt ccctgtaatc
1381 ctttctgctc cttggtactt agatttgatt agctatggac aagattggag gaaatactat
1441 aaagtggaac ctcttgattt tggcggtact cagaaacaga aacaactttt cattggtgga
1501 gaagcttgtc tatggggaga atatgtggat gcaactaacc tcactccaag attatggcct
1561 cgggcaagtg ctgttggtga gagactctgg agttccaaag atgtcagaga tatggatgac
1621 gcctatgaca gactgacaag gcaccgctgc aggatggtcg aacgtggaat agctgcacaa
1681 cctctttatg ctggatattg taaccatgag aacatgtaaa aaatggaggg gaaaaaggcc
1741 acagcaatct gtactacaat caactttatt ttgaaatcat gtaaaataag atattagact
1801 gttttttgaa taaaatattt ttattgattg aa
//