LOCUS HUMLAMC 1953 bp mRNA linear HUM 11-JUN-1993
DEFINITION Human lamin C mRNA, complete cds.
ACCESSION M13451
VERSION M13451.1
KEYWORDS lamin C.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1953)
AUTHORS Fisher,D.Z., Chaudhary,N. and Blobel,G.
TITLE cDNA sequencing of nuclear lamins A and C reveals primary and
secondary structural homology to intermediate filament proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (17), 6450-6454 (1986)
PUBMED 3462705
COMMENT Original source text: Human hepatoma, cDNA to mRNA.
Draft entry and computer-readable sequence of [1] kindly provided
by D.Z.Fisher, 21-OCT-1986.
FEATURES Location/Qualifiers
source 1..1953
/db_xref="H-InvDB:HIT000194218"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 135..1853
/note="lamin C protein"
/codon_start=1
/protein_id="AAA36164.1"
/translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
QLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG
ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET
KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGK
FVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSP
PTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHH
VSGSRR"
BASE COUNT 429 a 580 c 654 g 290 t
ORIGIN 133 bp upstream of NcoI site.
1 acgcctgcca ggagcaagcc gaagagccag ccggccggcg cactccgact ccgagcagtc
61 tctgtccttc gacccgagcc ccgcgccctt tccgggaccc ctgccccgcg ggcagcgctg
121 ccaacctgcc ggccatggag accccgtccc agcggcgcgc cacccgcagc ggggcgcagg
181 ccagctccac tccgctgtcg cccacccgca tcacccggct gcaggagaag gaggacctgc
241 aggagctcaa tgatcgcttg gcggtctaca tcgaccgtgt gcgctcgctg gaaacggaga
301 acgcagggct gcgccttcgc atcaccgagt ctgaagaggt ggtcagccgc gaggtgtccg
361 gcatcaaggc cgcctacgag gccgagctcg gggatgcccg caagaccctt gactcagtag
421 ccaaggagcg cgcccgcctg cagctggagc tgagcaaagt gcgtgaggag tttaaggagc
481 tgaaagcgcg caataccaag aaggagggtg acctgatagc tgctcaggct cggctgaagg
541 acctggaggc tctgctgaac tccaaggagg ccgcactgag cactgctctc agtgagaagc
601 gcacgctgga gggcgagctg catgatctgc ggggccaggt ggccaagctt gaggcagccc
661 taggtgaggc caagaagcaa cttcaggatg agatgctgcg gcgggtggat gctgagaaca
721 ggctgcagac catgaaggag gaactggact tccagaagaa catctacagt gaggagctgc
781 gtgagaccaa gcgccgtcat gagacccgac tggtggagat tgacaatggg aagcagcgtg
841 agtttgagag ccggctggcg gatgcgctgc aggaactgcg ggcccagcat gaggaccagg
901 tggagcagta taagaaggag ctggagaaga cttattctgc caagctggac aatgccaggc
961 agtctgctga gaggaacagc aacctggtgg gggctgccca cgaggagctg cagcagtcgc
1021 gcatccgcat cgacagcctc tctgcccagc tcagccagct ccagaagcag ctggcagcca
1081 aggaggcgaa gcttcgagac ctggaggact cactggcccg tgagcgggac accagccggc
1141 ggctgctggc ggaaaaggag cgggagatgg ccgagatgcg ggcaaggatg cagcagcagc
1201 tggacgagta ccaggagctt ctggacatca agctggccct ggacatggag atccacgcct
1261 accgcaagct cttggagggc gaggaggaga ggctacgcct gtcccccagc cctacctcgc
1321 agcgcagccg tggccgtgct tcctctcact catcccagac acagggtggg ggcagcgtca
1381 ccaaaaagcg caaactggag tccactgaga gccgcagcag cttctcacag cacgcacgca
1441 ctagcgggcg cgtggccgtg gaggaggtgg atgaggaggg caagtttgtc cggctgcgca
1501 acaagtccaa tgaggaccag tccatgggca attggcagat caagcgccag aatggagatg
1561 atcccttgct gacttaccgg ttcccaccaa agttcaccct gaaggctggg caggtggtga
1621 cgatctgggc tgcaggagct ggggccaccc acagcccccc taccgacctg gtgtggaagg
1681 cacagaacac ctggggctgc gggaacagcc tgcgtacggc tctcatcaac tccactgggg
1741 aagaagtggc catgcgcaag ctggtgcgct cagtgactgt ggttgaggac gacgaggatg
1801 aggatggaga tgacctgctc catcaccacc acgtgagtgg tagccgccgc tgaggccgag
1861 cctgcactgg ggccaccagc caggcctggg ggcagcctct ccccagcctc cccgtgccaa
1921 aaatcttttc attaaagaat gttttggaac ttt
//