LOCUS HUMFXI 2087 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human factor XI (blood coagulation factor) mRNA, complete cds.
ACCESSION M13142
VERSION M13142.1
KEYWORDS blood coagulation factor; factor XI; serine protease; serum
glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2087)
AUTHORS Fujikawa,K., Chung,D.W., Hendrickson,L.E. and Davie,E.W.
TITLE Amino acid sequence of human factor XI, a blood coagulation factor
with four tandem repeats that are highly homologous with plasma
prekallikrein
JOURNAL Biochemistry 25 (9), 2417-2424 (1986)
PUBMED 3636155
COMMENT Original source text: Human liver, cDNA to mRNA, clone
lambda-HXI-12.
During activation of factor XI an internal peptide bond is cleaved
in each of the two chains, resulting in factor XI-a, a serine
protease composed of two heavy and two light chains held together
by disulfide bonds.
FEATURES Location/Qualifiers
source 1..2087
/db_xref="H-InvDB:HIT000194200"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q35"
gene 1..2087
/gene="F11"
mRNA <1..2087
/gene="F11"
/product="FXI mRNA"
CDS 44..1921
/gene="F11"
/note="preprofactor XI"
/codon_start=1
/protein_id="AAA52487.1"
/db_xref="GDB:G00-119-891"
/translation="MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAK
YCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQ
CSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLE
HRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSV
MAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALS
GFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTP
AQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGT
ASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILN
QSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRN
VIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREG
GKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQA
V"
sig_peptide 44..97
/gene="F11"
/note="factor XI signal peptide"
mat_peptide 98..1204
/gene="F11"
/product="factor XI heavy chain"
mat_peptide 1205..1918
/gene="F11"
/product="factor XI light chain"
BASE COUNT 605 a 467 c 494 g 521 t
ORIGIN 247 bp upstream of BamHI site.
1 ttattaagaa ttgcagcaag taagccaaca aggtcttttc aggatgattt tcttatatca
61 agtggtacat ttcattttat ttacttcagt ttctggtgaa tgtgtgactc agttgttgaa
121 ggacacctgc tttgaaggag gggacattac tacggtcttc acaccaagcg ccaagtactg
181 ccaggtagtc tgcacttacc acccaagatg tttactcttc actttcacgg cggaatcacc
241 atctgaggat cccacccgat ggtttacttg tgtcctgaaa gacagtgtta cagaaacact
301 gccaagagtg aataggacag cagcgatttc tgggtattct ttcaagcaat gctcacacca
361 aataagcgct tgcaacaaag acatttatgt ggacctagac atgaagggca taaactataa
421 cagctcagtt gccaagagtg ctcaagaatg ccaagaaaga tgcacggatg acgtccactg
481 ccactttttc acgtacgcca caaggcagtt tcccagcctg gagcatcgta acatttgtct
541 actgaagcac acccaaacag ggacaccaac cagaataacg aagctcgata aagtggtgtc
601 tggattttca ctgaaatcct gtgcactttc taatctggct tgtattaggg acattttccc
661 taatacggtg tttgcagaca gcaacatcga cagtgtcatg gctcccgatg cttttgtctg
721 tggccgaatc tgcactcatc atcccggttg cttgtttttt accttctttt cccaggaatg
781 gcccaaagaa tctcaaagaa atctttgtct ccttaaaaca tctgagagtg gattgcccag
841 tacacgcatt aaaaagagca aagctctttc tggtttcagt ctacaaagct gcaggcacag
901 catcccagtg ttctgccatt cttcatttta ccatgacact gatttcttgg gagaagaact
961 ggatattgtt gctgcaaaaa gtcacgaggc ctgccagaaa ctgtgcacca atgccgtccg
1021 ctgccagttt tttacctata ccccagccca agcatcctgc aacgaaggga agggcaagtg
1081 ttacttaaag ctttcttcaa acggatctcc aactaaaata cttcacggga gaggaggcat
1141 ctctggatac acattaaggt tgtgtaaaat ggataatgag tgtaccacca aaatcaagcc
1201 caggatcgtt ggaggaactg cgtctgttcg tggtgagtgg ccgtggcagg tgaccctgca
1261 cacaacctca cccactcaga gacacctgtg tggaggctcc atcattggaa accagtggat
1321 attaacagcc gctcactgtt tctatggggt agagtcacct aagattttgc gtgtctacag
1381 tggcatttta aatcaatctg aaataaaaga ggacacatct ttctttgggg ttcaagaaat
1441 aataatccat gatcagtata aaatggcaga aagcgggtat gatattgcct tgttgaaact
1501 ggaaaccaca gtgaattaca cagattctca acgacccata tgcctgcctt ccaaaggaga
1561 tagaaatgta atatacactg attgctgggt gactggatgg gggtacagaa aactaagaga
1621 caaaatacaa aatactctcc agaaagccaa gataccctta gtgaccaacg aagagtgcca
1681 gaagagatac agaggacata aaataaccca taagatgatc tgtgccggct acagggaagg
1741 agggaaggac gcttgcaagg gagattcggg aggccctctg tcctgcaaac acaatgaggt
1801 ctggcatctg gtaggcatca cgagctgggg cgaaggctgt gctcaaaggg agcggccagg
1861 tgtttacacc aacgtggtcg agtacgtgga ctggattctg gagaaaactc aagcagtgtg
1921 aatgggttcc caggggccat tggagtccct gaaggaccca ggatttgctg ggagagggtg
1981 ttgagttcac tgtgccagca tgcttcctcc acagtaacac gctgaagggg cttggtgttt
2041 gtaagaaaat gctagaagaa aacaaactgt cacaagttgt tatgtcc
//