LOCUS HUMADH1CA 1450 bp mRNA linear HUM 30-OCT-1994
DEFINITION Human class I alcohol dehydrogenase (ADH1) alpha subunit mRNA,
complete cds.
ACCESSION M12963
VERSION M12963.1
KEYWORDS alcohol dehydrogenase; dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1450)
AUTHORS Von Bahr-Lindstroem,H., Hoeoeg,J.-V., Heden,L.-O., Kaiser,R.,
Fleetwood,L., Larsson,K., Lake,M., Holmquist,B., Holmgren,A.,
Hempel,J., Vallee,B.L. and Joernvall,H.
TITLE cDNA and protein structure for the alpha subunit of human liver
alcohol dehydrogenase
JOURNAL Biochemistry 25 (9), 2465-2470 (1986)
PUBMED 3013304
COMMENT Original source text: Human liver, cDNA to mRNA, clones pADH6 and
pADH11.
Draft entry and sequence for [1] kindly provided in
computer-readable form by H.von Bahr-Lindstroem, 26-AUG-1986. The
other human class I ADH1 alpha subunit sequence is found under
accession M12271.
FEATURES Location/Qualifiers
source 1..1450
/db_xref="H-InvDB:HIT000194194"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q21-q23"
gene 1..1450
/gene="ADH1"
mRNA <1..1450
/gene="ADH1"
/product="aADH mRNA"
CDS 73..1200
/gene="ADH1"
/note="alcohol dehydrogenase alpha subunit (EC 1.1.1.1)"
/codon_start=1
/protein_id="AAA51590.1"
/db_xref="GDB:G00-119-650"
/translation="MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAV
GICGTDDHVVSGTMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCR
ICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAK
IDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAA
RIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTM
MASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVA
DFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF"
BASE COUNT 414 a 307 c 354 g 375 t
ORIGIN 55 bp upstream from PstI site; chrosome 4q21.
1 gatgcacttg agcagggaag aaatccacaa ggactcacca gtctcctggt ctgcagagaa
61 gacagaatca acatgagcac agcaggaaaa gtaatcaaat gcaaagcagc tgtgctatgg
121 gagttaaaga aacccttttc cattgaggag gtggaggttg cacctcctaa ggcccatgaa
181 gttcgtatta agatggtggc tgtaggaatc tgtggcacag atgaccacgt ggttagtggt
241 accatggtga ccccacttcc tgtgatttta ggccatgagg cagccggcat cgtggagagt
301 gttggagaag gggtgactac agtcaaacca ggtgataaag tcatcccact cgctattcct
361 cagtgtggaa aatgcagaat ttgtaaaaac ccggagagca actactgctt gaaaaacgat
421 gtaagcaatc ctcaggggac cctgcaggat ggcaccagca ggttcacctg caggaggaag
481 cccatccacc acttccttgg catcagcacc ttctcacagt acacagtggt ggatgaaaat
541 gcagtagcca aaattgatgc agcctcgcct ctagagaaag tctgtctcat tggctgtgga
601 ttttcaactg gttatgggtc tgcagtcaat gttgccaagg tcaccccagg ctctacctgt
661 gctgtgtttg gcctgggagg ggtcggccta tctgctatta tgggctgtaa agcagctggg
721 gcagccagaa tcattgcggt ggacatcaac aaggacaaat ttgcaaaggc caaagagttg
781 ggtgccactg aatgcatcaa ccctcaagac tacaagaaac ccatccagga ggtgctaaag
841 gaaatgactg atggaggtgt ggatttttca tttgaagtca tcggtcggct tgacaccatg
901 atggcttccc tgttatgttg tcatgaggca tgtggcacaa gtgtcatcgt aggggtacct
961 cctgattccc aaaacctctc aatgaaccct atgctgctac tgactggacg tacctggaag
1021 ggagctattc ttggtggctt taaaagtaaa gaatgtgtcc caaaacttgt ggctgatttt
1081 atggctaaga agttttcatt ggatgcatta ataacccatg ttttaccttt tgaaaaaata
1141 aatgaaggat ttgacctgct tcactctggg aaaagtatcc gtaccattct gatgttttga
1201 gacaatacag atgttttccc ttgtggcagt cttcagcctc ctctacccta catgatctgg
1261 agcaacagct gggaaatatc attaattctg ctcatcacag attttatcaa taaattacat
1321 ttgggggctt tccaaagaaa tggaaattga tgtaaaatta tttttcaagc aaatgtttaa
1381 aatccaaatg agaactaaat aaagtgttga acatcagctg gggaattgaa gccaataaac
1441 cttccttctt
//