LOCUS HUMTCBCE 2008 bp DNA linear HUM 13-JAN-1995
DEFINITION Human T-cell receptor germline beta-chain gene C-region C-beta-2.
ACCESSION M12888
VERSION M12888.1
KEYWORDS T-cell; T-cell receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2008)
AUTHORS Tunnacliffe,A., Kefford,R., Milstein,C., Forster,A. and
Rabbitts,T.H.
TITLE Sequence and evolution of the human T-cell antigen receptor
beta-chain genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (15), 5068-5072 (1985)
PUBMED 3860845
COMMENT Original source text: Human DNA, T-cell leukemia cell line MOLT-4
and colon carcinoma cell line COLO 320.
FEATURES Location/Qualifiers
source 1..2008
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="7q35"
intron <1..153
/gene="TCRB"
/note="intron J-C; G00-120-405"
gene join(154..540,1057..1074,1218..1324,1616..1642)
/gene="TCRB"
CDS join(154..540,1057..1074,1218..1324,1616..1642)
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2"
/codon_start=3
/protein_id="AAA60662.1"
/db_xref="GDB:G00-120-405"
/translation="DLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSW
WVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGL
SENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAV
LVSALVLMAMVKRKDSRG"
exon <154..540
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2; G00-120-405"
/number=1
exon 154..540
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2, exon 1;
G00-120-405; putative"
intron 541..1056
/note="TCR C-beta-2, intron A; G00-120-405"
exon <1057..1074
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2; G00-120-405"
/number=2
exon 1057..1074
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2, exon 2;
G00-120-405; putative"
intron 1075..1217
/note="TCR C-beta-2, intron B; G00-120-405"
exon 1218..1324
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2, exon 3;
G00-120-405; putative"
exon 1218..>1324
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2; G00-120-405"
intron 1325..1615
/note="TCR C-beta-2, intron C; G00-120-405"
exon 1616..>1642
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2; G00-120-405"
/number=4
exon 1616..1642
/gene="TCRB"
/note="T-cell receptor C-region C-beta-2, exon 4;
G00-120-405; putative"
BASE COUNT 487 a 562 c 495 g 464 t
ORIGIN
1 atggcgtagt ccccaaagaa cgaggaccta gtaacataat tgtgcttcat tatggtcctt
61 tcccggcctt ctctctcaca catacacaga gcccctacca ggaccagaca gctctcagag
121 caaccctagc cccattacct cttccctttc cagaggacct gaaaaacgtg ttcccacccg
181 aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag gccacactgg
241 tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg gtgaatggga
301 aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag cccgccctca
361 atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc tggcagaacc
421 cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat gacgagtgga
481 cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag
541 gtgagtgggg cctggggaga tgcctggagg agattaggtg agaccagcta ccagggaaaa
601 tggaaagatc caggtagcgg acaagactag atccagaaga aagccagagt ggacaaggtg
661 ggatgatcaa ggttcacagg gtcagcaaag cacggtgtgc acttccccca ccaagaagca
721 tagaggctga atggagcacc tcaagctcat tcttccttca gatcctgaca ccttagagct
781 aagctttcaa gtctccctga ggaccagcca tacagctcag catctgagtg gtgtgcatcc
841 cattctcttc tggggtcctg gtttcctaag atcatagtga ccacttcgct ggcactggag
901 cagcatgagg gagacagaac cagggctatc aaaggaggct gactttgtac tatctgatat
961 gcatgtgttt gtggcctgtg agtctgtgat gtaaggctca atgtccttac aaagcagcat
1021 tctctcatcc atttttcttc ccctgttttc tttcagactg tggcttcacc tccggtaagt
1081 gagtctctcc tttttctctc tatctttcgc cgtctctgct ctcgaaccag ggcatggaga
1141 atccacggac acaggggcgt gagggaggcc agagccacct gtgcacaggt acctacatgc
1201 tctgttcttg tcaacagagt cttaccagca aggggtcctg tctgccacca tcctctatga
1261 gatcttgcta gggaaggcca ccttgtatgc cgtgctggtc agtgccctcg tgctgatggc
1321 catggtaagg aggagggtgg gatagggcag atgatggggg caggggatgg aacatcacac
1381 atgggcataa aggaatctca gagccagagc acagcctaat atatcctatc acctcaatga
1441 aaccataatg aagccagact ggggagaaaa tgcagggaat atcacagaat gcatcatggg
1501 aggatggaga caaccagcga gccctactca aattaggcct cagagcccgc ctcccctgcc
1561 ctactcctgc tgtgccatag cccctgaaac cctgaaaatg ttctctcttc cacaggtcaa
1621 gagaaaggat tccagaggct agctccaaaa ccatcccagg tcattcttca tcctcaccca
1681 ggattctcct gtacctgctc ccaatctgtg ttcctaaaag tgattctcac tctgcttctc
1741 atctcctact tacatgaata cttctctctt ttttctgttt ccctgaagat tgagctccca
1801 acccccaagt acgaaatagg ctaaaccaat aaaaaattgt gtgttgggcc tggttgcatt
1861 tcaggagtgt ctgtggagtt ctgctcatca ctgacctatc ttctgattta gggaaagcag
1921 cattcgcttg gacatctgaa gtgacagccc tctttctctc cacccaatgc tgctttctcc
1981 tgttcatcct gatggaagtc tcaacaca
//