LOCUS HUMHCII 2182 bp mRNA linear HUM 08-NOV-1994 DEFINITION Human heparin cofactor II (HC-II) mRNA, complete cds. ACCESSION M12849 M19241 VERSION M12849.1 KEYWORDS heparin cofactor II; protease inhibitor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1025 to 2182) AUTHORS Inhorn,R.C. and Tollefsen,D.M. JOURNAL Unpublished REFERENCE 2 (bases 1025 to 2182) AUTHORS Inhorn,R.C. and Tollefsen,D.M. TITLE Isolation and characterization of a partial cDNA clone for heparin cofactor II1 JOURNAL Biochem. Biophys. Res. Commun. 137 (1), 431-436 (1986) PUBMED 3755044 REFERENCE 3 (bases 1 to 2182) AUTHORS Blinder,M.A., Marasa,J.C., Reynolds,C.H., Deaven,L.L. and Tollefsen,D.M. TITLE Heparin cofactor II: cDNA sequence, chromosome localization, restriction fragment length polymorphism, and expression in Escherichia coli JOURNAL Biochemistry 27 (2), 752-759 (1988) PUBMED 2894851 COMMENT Original source text: Human fetal liver, cDNA to mRNA, clone lambda-HCII.7 [1]; adult liver, cDNA to mRNA, clone lambda HCII.7.1 [3]. [1] revises [2]. Draft entry and computer-readable sequence of [2] kindly provided by D.M.Tollefsen, 18-AUG-1986. Draft entry and computer-readable sequence of [3] kindly provided by Blinder,M.A. 24-MAR-1988. FEATURES Location/Qualifiers source 1..2182 /db_xref="H-InvDB:HIT000194183" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="22q11.2" gene 1..2182 /gene="HCF2" mRNA <1..2182 /gene="HCF2" /product="heparin cofactor II mRNA" CDS 29..1528 /gene="HCF2" /note="heparin cofactor II precursor" /codon_start=1 /protein_id="AAA52642.1" /db_xref="GDB:G00-120-038" /translation="MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQ LNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVS PTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGIST AMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTL RSVNDLYIQKQFPILLDFRTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKD ALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLA ANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREV LLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGT QATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS" sig_peptide 29..85 /gene="HCF2" /note="heparin cofactor II signal protein" mat_peptide 86..1525 /gene="HCF2" /product="heparin cofactor II" BASE COUNT 603 a 581 c 500 g 498 t ORIGIN 142 bp upstream from PstI site; chromosome 22. 1 cgaaacacag agctttagct ccgccaaaat gaaacactca ttaaacgcac ttctcatttt 61 cctcatcata acatctgcgt ggggtgggag caaaggcccg ctggatcagc tagagaaagg 121 aggggaaact gctcagtctg cagatcccca gtgggagcag ttaaataaca aaaacctgag 181 catgcctctt ctccctgccg acttccacaa ggaaaacacc gtcaccaacg actggattcc 241 agagggggag gaggacgacg actatctgga cctggagaag atattcagtg aagacgacga 301 ctacatcgac atcgtcgaca gtctgtcagt ttccccgaca gactctgatg tgagtgctgg 361 gaacatcctc cagctttttc atggcaagag ccggatccag cgtcttaaca tcctcaacgc 421 caagttcgct ttcaacctct accgagtgct gaaagaccag gtcaacactt tcgataacat 481 cttcatagca cccgttggca tttctactgc gatgggtatg atttccttag gtctgaaggg 541 agagacccat gaacaagtgc actcgatttt gcattttaaa gactttgtta atgccagcag 601 caagtatgaa atcacgacca ttcataatct cttccgtaag ctgactcatc gcctcttcag 661 gaggaatttt gggtacacac tgcggtcagt caatgacctt tatatccaga agcagtttcc 721 aatcctgctt gacttcagaa ctaaagtaag agagtattac tttgctgagg cccagatagc 781 tgacttctca gaccctgcct tcatatcaaa aaccaacaac cacatcatga agctcaccaa 841 gggcctcata aaagatgctc tggagaatat agaccctgct acccagatga tgattctcaa 901 ctgcatctac ttcaaaggat cctgggtgaa taaattccca gtggaaatga cacacaacca 961 caacttccgg ctgaatgaga gagaggtagt taaggtttcc atgatgcaga ccaaggggaa 1021 cttcctcgca gcaaatgacc aggagctgga ctgcgacatc ctccagctgg aatacgtggg 1081 gggcatcagc atgctaattg tggtcccaca caagatgtct gggatgaaga ccctcgaagc 1141 gcaactgaca ccccgggtgg tggagagatg gcaaaaaagc atgacaaaca gaactcgaga 1201 agtgcttctg ccgaaattca agctggagaa gaactacaat ctagtggagt ccctgaagtt 1261 gatggggatc aggatgctgt ttgacaaaaa tggcaacatg gcaggcatct cagaccaaag 1321 gatcgccatc gacctgttca agcaccaagg cacgatcaca gtgaacgagg aaggcaccca 1381 agccaccact gtgaccacgg tggggttcat gccgctgtcc acccaagtcc gcttcactgt 1441 cgaccgcccc tttcttttcc tcatctacga gcaccgcacc agctgcctgc tcttcatggg 1501 aagagtggcc aaccccagca ggtcctagag gtggaggtct aggtgtctga agtgccttgg 1561 gggcaccctc attttgtttc cattccaaca acgagaacag agatgttctg gcatcattta 1621 cgtagtttac gctaccaatc tgaattcgag gcccatatga gaggagctta gaaacgacca 1681 agaagagagg cttgttggaa tcaattctgc acaatagccc atgctgtaag ctcatagaag 1741 tcactgtaac tgtagtgtgt ctgctgttac ctagagggtc tcacctcccc actcttcaca 1801 gcaaacctga gcagcgcgtc ctaagcacct cccgctccgg tgaccccatc cttgcacacc 1861 tgactctgtc actcaagcct ttctccacca ggcccctcat ctgaatacca agcacagaaa 1921 tgagtggtgt gactaattcc ttacctctcc caaggagggt acacaactag caccattctt 1981 gatgtccagg gaagaagcca cctcaagaca tatgaggggt gccctgggct aatgttaggg 2041 cttaattttc tcaaagcctg acctttcaaa tccatgatga atgccatcag tccctcctgc 2101 tgttgcctcc ctgtgacctg gaggacagtg tgtgccatgt ctcccatact agagataaat 2161 aaatgtagcc acatttactg tg //