LOCUS       HUMHCII                 2182 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human heparin cofactor II (HC-II) mRNA, complete cds.
ACCESSION   M12849 M19241
VERSION     M12849.1
KEYWORDS    heparin cofactor II; protease inhibitor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1025 to 2182)
  AUTHORS   Inhorn,R.C. and Tollefsen,D.M.
  JOURNAL   Unpublished
REFERENCE   2  (bases 1025 to 2182)
  AUTHORS   Inhorn,R.C. and Tollefsen,D.M.
  TITLE     Isolation and characterization of a partial cDNA clone for heparin
            cofactor II1
  JOURNAL   Biochem. Biophys. Res. Commun. 137 (1), 431-436 (1986)
   PUBMED   3755044
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Blinder,M.A., Marasa,J.C., Reynolds,C.H., Deaven,L.L. and
            Tollefsen,D.M.
  TITLE     Heparin cofactor II: cDNA sequence, chromosome localization,
            restriction fragment length polymorphism, and expression in
            Escherichia coli
  JOURNAL   Biochemistry 27 (2), 752-759 (1988)
   PUBMED   2894851
COMMENT     Original source text: Human fetal liver, cDNA to mRNA, clone
            lambda-HCII.7 [1]; adult liver, cDNA to mRNA, clone lambda HCII.7.1
            [3].
            [1]  revises [2].
            Draft entry and computer-readable sequence of [2] kindly provided
            by D.M.Tollefsen, 18-AUG-1986.
            Draft entry and computer-readable sequence of [3] kindly provided
            by Blinder,M.A. 24-MAR-1988.
FEATURES             Location/Qualifiers
     source          1..2182
                     /db_xref="H-InvDB:HIT000194183"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="22q11.2"
     gene            1..2182
                     /gene="HCF2"
     mRNA            <1..2182
                     /gene="HCF2"
                     /product="heparin cofactor II mRNA"
     CDS             29..1528
                     /gene="HCF2"
                     /note="heparin cofactor II precursor"
                     /codon_start=1
                     /protein_id="AAA52642.1"
                     /db_xref="GDB:G00-120-038"
                     /translation="MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQ
                     LNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVS
                     PTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGIST
                     AMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTL
                     RSVNDLYIQKQFPILLDFRTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKD
                     ALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLA
                     ANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREV
                     LLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGT
                     QATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS"
     sig_peptide     29..85
                     /gene="HCF2"
                     /note="heparin cofactor II signal protein"
     mat_peptide     86..1525
                     /gene="HCF2"
                     /product="heparin cofactor II"
BASE COUNT          603 a          581 c          500 g          498 t
ORIGIN      142 bp upstream from PstI site; chromosome 22.
        1 cgaaacacag agctttagct ccgccaaaat gaaacactca ttaaacgcac ttctcatttt
       61 cctcatcata acatctgcgt ggggtgggag caaaggcccg ctggatcagc tagagaaagg
      121 aggggaaact gctcagtctg cagatcccca gtgggagcag ttaaataaca aaaacctgag
      181 catgcctctt ctccctgccg acttccacaa ggaaaacacc gtcaccaacg actggattcc
      241 agagggggag gaggacgacg actatctgga cctggagaag atattcagtg aagacgacga
      301 ctacatcgac atcgtcgaca gtctgtcagt ttccccgaca gactctgatg tgagtgctgg
      361 gaacatcctc cagctttttc atggcaagag ccggatccag cgtcttaaca tcctcaacgc
      421 caagttcgct ttcaacctct accgagtgct gaaagaccag gtcaacactt tcgataacat
      481 cttcatagca cccgttggca tttctactgc gatgggtatg atttccttag gtctgaaggg
      541 agagacccat gaacaagtgc actcgatttt gcattttaaa gactttgtta atgccagcag
      601 caagtatgaa atcacgacca ttcataatct cttccgtaag ctgactcatc gcctcttcag
      661 gaggaatttt gggtacacac tgcggtcagt caatgacctt tatatccaga agcagtttcc
      721 aatcctgctt gacttcagaa ctaaagtaag agagtattac tttgctgagg cccagatagc
      781 tgacttctca gaccctgcct tcatatcaaa aaccaacaac cacatcatga agctcaccaa
      841 gggcctcata aaagatgctc tggagaatat agaccctgct acccagatga tgattctcaa
      901 ctgcatctac ttcaaaggat cctgggtgaa taaattccca gtggaaatga cacacaacca
      961 caacttccgg ctgaatgaga gagaggtagt taaggtttcc atgatgcaga ccaaggggaa
     1021 cttcctcgca gcaaatgacc aggagctgga ctgcgacatc ctccagctgg aatacgtggg
     1081 gggcatcagc atgctaattg tggtcccaca caagatgtct gggatgaaga ccctcgaagc
     1141 gcaactgaca ccccgggtgg tggagagatg gcaaaaaagc atgacaaaca gaactcgaga
     1201 agtgcttctg ccgaaattca agctggagaa gaactacaat ctagtggagt ccctgaagtt
     1261 gatggggatc aggatgctgt ttgacaaaaa tggcaacatg gcaggcatct cagaccaaag
     1321 gatcgccatc gacctgttca agcaccaagg cacgatcaca gtgaacgagg aaggcaccca
     1381 agccaccact gtgaccacgg tggggttcat gccgctgtcc acccaagtcc gcttcactgt
     1441 cgaccgcccc tttcttttcc tcatctacga gcaccgcacc agctgcctgc tcttcatggg
     1501 aagagtggcc aaccccagca ggtcctagag gtggaggtct aggtgtctga agtgccttgg
     1561 gggcaccctc attttgtttc cattccaaca acgagaacag agatgttctg gcatcattta
     1621 cgtagtttac gctaccaatc tgaattcgag gcccatatga gaggagctta gaaacgacca
     1681 agaagagagg cttgttggaa tcaattctgc acaatagccc atgctgtaag ctcatagaag
     1741 tcactgtaac tgtagtgtgt ctgctgttac ctagagggtc tcacctcccc actcttcaca
     1801 gcaaacctga gcagcgcgtc ctaagcacct cccgctccgg tgaccccatc cttgcacacc
     1861 tgactctgtc actcaagcct ttctccacca ggcccctcat ctgaatacca agcacagaaa
     1921 tgagtggtgt gactaattcc ttacctctcc caaggagggt acacaactag caccattctt
     1981 gatgtccagg gaagaagcca cctcaagaca tatgaggggt gccctgggct aatgttaggg
     2041 cttaattttc tcaaagcctg acctttcaaa tccatgatga atgccatcag tccctcctgc
     2101 tgttgcctcc ctgtgacctg gaggacagtg tgtgccatgt ctcccatact agagataaat
     2161 aaatgtagcc acatttactg tg
//