LOCUS HUMSISPDG 3798 bp mRNA linear HUM 13-JAN-1995 DEFINITION Human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) mRNA, complete cds. ACCESSION M12783 M16288 VERSION M12783.1 KEYWORDS growth factor; platelet-derived growth factor; proto-oncogene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3798) AUTHORS Rao,C.D., Igarashi,H., Pech,M.W., Robbins,K.C. and Aaronson,S.A. TITLE Oncogenic potential of the human platelet-derived growth factor transcriptional unit JOURNAL Cold Spring Harb. Symp. Quant. Biol. 51 (Pt 2), 959-966 (1986) PUBMED 3472769 REFERENCE 2 (bases 1 to 3798) AUTHORS Rao,C.D., Igarashi,H., Chiu,I.M., Robbins,K.C. and Aaronson,S.A. TITLE Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (8), 2392-2396 (1986) PUBMED 3517869 COMMENT Original source text: Human placenta, cDNA to mRNA, clone pSD1; DNA, clone pc-sis RH-9. Computer-readable sequence kindly provided by C.D.Rao, 31-JUL-1986. The first 70 and last 355 nucleotides in the sequence presented below were derived from DNA. The normal human SIS/PDGF2 coding sequence has the capacity to efficiently transform cells responsive to its growth-promoting activity. The SIS/PDGF2 mRNA has been detected in tumors such as glioblastomas and fibrosarcomas, whose normal counterparts possess PDGF receptors and are responsive to the growth-promoting action of the SIS/PDGF2 gene product. FEATURES Location/Qualifiers source 1..3798 /db_xref="H-InvDB:HIT000194179" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="22q12.3-q13.1" /tissue_type="placenta" gene 1..3798 /gene="PDGFB" mRNA 71..3443 /gene="PDGFB" /note="G00-120-709" CDS 1093..1818 /gene="PDGFB" /codon_start=1 /product="c-sis/platelet-derived growth factor 2" /protein_id="AAA60553.1" /db_xref="GDB:G00-120-709" /translation="MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDL QRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTE VFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVR KKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRP PKGKHRKFKHTHDKTALKETLGA" sig_peptide 1093..1137 /gene="PDGFB" /note="G00-120-709" mat_peptide 1138..1815 /gene="PDGFB" /product="c-sis/platelet-derived growth factor 2" /note="G00-120-709" BASE COUNT 745 a 1216 c 1073 g 764 t ORIGIN 666 bp upstream of DdeI site. 1 gaggaaaggc tgtctccacc cacctctcgc actctccctt ctcctttata aaggccggaa 61 cagctgaaag ggtggcaact tctcctcctg cggccgggag cggcctgcct gcctccctgc 121 gcacccgcag cctcccccgc tgcctcccta gggctcccct ccggccgcca gcgcccattt 181 ttcattccct agatagagat actttgcgcg cacacacata catacgcgcg caaaaaggaa 241 aaaaaaaaaa aaaagcccac cctccagcct cgctgcaaag agaaaaccgg agcagccgca 301 gctcgcagct cgcagctcgc agcccgcagc ccgcagagga cgcccagagc ggcgagcagg 361 cgggcagacg gaccgacgga ctcgcgccgc gtccacctgt cggccgggcc cagccgagcg 421 cgcagcgggc acgccgcgcg cgcggagcag ccgtgcccgc cgcccgggcc cgccgccagg 481 gcgcacacgc tcccgccccc ctacccggcc cgggcgggag tttgcacctc tccctgcccg 541 ggtgctcgag ctgccgttgc aaagccaact ttggaaaaag ttttttgggg gagacttggg 601 ccttgaggtg cccagctccg cgctttccga ttttgggggc ctttccagaa aatgttgcaa 661 aaaagctaag ccggcgggca gaggaaaacg cctgtagccg gcgagtgaag acgaaccatc 721 gactgccgtg ttccttttcc tcttggaggt tggagtcccc tgggcgcccc cacacggcta 781 gacgcctcgg ctggttcgcg acgcagcccc ccggccgtgg atgctgcact cgggctcggg 841 atccgcccag gtagccggcc tcggacccag gtcctgcgcc caggtcctcc cctgcccccc 901 agcgacggag ccggggccgg gggcggcggc gccgggggca tgcgggtgag ccgcggctgc 961 agaggcctga gcgcctgatc gccgcggacc tgagccgagc ccacccccct ccccagcccc 1021 ccaccctggc cgcgggggcg gcgcgctcga tctacgcgtc cggggccccg cggggccggg 1081 cccggagtcg gcatgaatcg ctgctgggcg ctcttcctgt ctctctgctg ctacctgcgt 1141 ctggtcagcg ccgaggggga ccccattccc gaggagcttt atgagatgct gagtgaccac 1201 tcgatccgct cctttgatga tctccaacgc ctgctgcacg gagaccccgg agaggaagat 1261 ggggccgagt tggacctgaa catgacccgc tcccactctg gaggcgagct ggagagcttg 1321 gctcgtggaa gaaggagcct gggttccctg accattgctg agccggccat gatcgccgag 1381 tgcaagacgc gcaccgaggt gttcgagatc tcccggcgcc tcatagaccg caccaacgcc 1441 aacttcctgg tgtggccgcc ctgtgtggag gtgcagcgct gctccggctg ctgcaacaac 1501 cgcaacgtgc agtgccgccc cacccaggtg cagctgcgac ctgtccaggt gagaaagatc 1561 gagattgtgc ggaagaagcc aatctttaag aaggccacgg tgacgctgga agaccacctg 1621 gcatgcaagt gtgagacagt ggcagctgca cggcctgtga cccgaagccc ggggggttcc 1681 caggagcagc gagccaaaac gccccaaact cgggtgacca ttcggacggt gcgagtccgc 1741 cggcccccca agggcaagca ccggaaattc aagcacacgc atgacaagac ggcactgaag 1801 gagacccttg gagcctaggg gcatcggcag gagagtgtgt gggcagggtt atttaatatg 1861 gtatttgctg tattgccccc atggggtcct tggagtgata atattgtttc cctcgtccgt 1921 ctgtctcgat gcctgattcg gacggccaat ggtgcttccc ccacccctcc acgtgtccgt 1981 ccacccttcc atcagcgggt ctcctcccag cggcctccgg tcttgcccag cagctcaaag 2041 aagaaaaaga aggactgaac tccatcgcca tcttcttccc ttaactccaa gaacttggga 2101 taagagtgtg agagagactg atggggtcgc tctttggggg aaacgggttc cttcccctgc 2161 acctggcctg ggccacacct gagcgctgtg gactgtcctg aggagccctg aggacctctc 2221 agcatagcct gcctgatccc tgaacccctg gccagctctg aggggaggca cctccaggca 2281 ggccaggctg cctcggactc catggctaag accacagacg ggcacacaga ctggagaaaa 2341 cccctcccac ggtgcccaaa caccagtcac ctcgtctccc tggtgcctct gtgcacagtg 2401 gcttcttttc gttttcgttt tgaagacgtg gactcctctt ggtgggtgtg gccagcacac 2461 caagtggctg ggtgccctct caggtgggtt agagatggag tttgctgttg aggtggtgta 2521 gatggtgacc tgggtatccc ctgcctcctg ccaccccttc ctccccatac tccactctga 2581 ttcacctctt cctctggttc ctttcatctc tctacctcca ccctgcattt tcctcttgtc 2641 ctggcccttc agtctgctcc accaaggggc tcttgaaccc cttattaagg ccccagatga 2701 ccccagtcac tcctctctag ggcagaagac tagaggccag ggcagcaagg gacctgctca 2761 tcatattcca acccagccac gactgccatg taaggttgtg cagggtgtgt actgcacaag 2821 gacattgtat gcagggagca ctgttcacat catagataaa gctgatttgt atatttatta 2881 tgacaatttc tggcagatgt aggtaaagag gaaaaggatc cttttcctaa ttcacacaaa 2941 gactccttgt ggactggctg tgcccctgat gcagcctgtg gctggagtgg ccaaatagga 3001 gggagactgt ggtaggggca gggaggcaac actgctgtcc acatgacctc catttcccaa 3061 agtcctctgc tccagcaact gcccttccag gtgggtgtgg gacacctggg agaaggtctc 3121 caagggaggg tgcagccctc ttgcccgcac ccctccctgc ttgcacactt ccccatcttt 3181 gatccttctg agctccacct ctggtggctc ctcctaggaa accagctcgt gggctgggaa 3241 tgggggagag aagggaaaag atccccaaga ccccctgggg tgggatctga gctcccacct 3301 cccttcccac ctactgcact ttcccccttc ccgccttcca aaacctgctt ccttcagttt 3361 gtaaagtcgg tgattatatt tttgggggct ttccttttat tttttaaatg taaaatttat 3421 ttatattccg tatttaaagt tgtaaaaaaa aataaccaca aaataaaacc aaatgaatcc 3481 gccggaggtc tgtctgttgg catcgtgcgt gacaattaac ctttctgcct tggcaggatg 3541 tgccgacagc ttgcggcgtg ttcctctcac tctgggagcc tcaggcgtga tctcacacac 3601 tggcgtgcac atacacacac acacacatac atgctcacac atgcgtgcac atacacgcag 3661 gcctgcaact tgggggaggc ctctgtctgg cgggaagaag agacacacag gctactctgt 3721 tggtcttggt cctggcacag ctcctgacac gtgaacttgt gcgtgtctct ggcagtgacg 3781 agagataaat ttctgcag //