LOCUS HUMADHIG 1486 bp mRNA linear HUM 08-JUN-1995
DEFINITION Homo sapiens alcohol dehydrogenase class I gamma subunit (ADH3)
mRNA, complete cds.
ACCESSION M12272 M12273
VERSION M12272.1
KEYWORDS ADH3 gene; alcohol dehydrogenase; alcohol dehydrogenase I;
dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1486)
AUTHORS Ikuta,T., Szeto,S. and Yoshida,A.
TITLE Three human alcohol dehydrogenase subunits: cDNA structure and
molecular and evolutionary divergence
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (3), 634-638 (1986)
PUBMED 2935875
REFERENCE 2 (sites)
AUTHORS Cheung,B., Anderson,J.K., Holmes,R.S. and Beacham,I.R.
TITLE Human stomach class IV alcohol dehydrogenase: molecular genetic
analysis
JOURNAL Alcohol. Clin. Exp. Res. 19 (1), 185-186 (1995)
PUBMED 7771649
COMMENT Original source text: Homo sapiens (clone: pUCADH-gamma-21) liver
cDNA to mRNA.
A draft entry and printed copy of the sequence in [1] were kindly
provided by A.Yoshida, 30-MAY-1986.
FEATURES Location/Qualifiers
source 1..1486
/db_xref="H-InvDB:HIT000194152"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q21-q23"
/clone="pUCADH-gamma-21"
/tissue_type="liver"
gene 1..1486
/gene="ADH3"
CDS 81..1208
/gene="ADH3"
/EC_number="1.1.1.1"
/note="gamma subunit"
/codon_start=1
/product="alcohol dehydrogenase 1"
/protein_id="AAC41757.1"
/db_xref="GDB:G00-119-652"
/translation="MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAA
GICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCR
ICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAK
IDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAA
RIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTM
MASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVA
DFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF"
BASE COUNT 437 a 315 c 361 g 373 t
ORIGIN 1 bp upstream of EcoRI site; chromosome 4q21-q25.
1 gaattccaaa tgcactcaag cagagaagaa atccacaagt actcaccagc ctcctggtct
61 gcagagaaga cagaatcaat atgagcacag caggaaaagt aatcaaatgc aaagcagctg
121 tgctatggga gttaaagaaa cccttttcca ttgaggaggt agaggttgca cctcctaagg
181 ctcatgaagt tcgcattaag atggtggctg caggaatctg tcgttcagat gagcatgtgg
241 ttagtggcaa cctggtgacc ccccttcctg tgattttagg ccatgaggca gccggcatcg
301 tggaaagtgt tggagaaggg gtgactacag tcaaaccagg tgataaagtc atcccgctct
361 ttactcctca gtgtggaaaa tgcagaattt gtaaaaaccc agaaagcaac tactgcttga
421 aaaatgatct aggcaatcct cgggggaccc tgcaggatgg caccaggagg ttcacctgca
481 gcgggaagcc catccaccac ttcgtcggcg tcagcacctt ctcccagtac acagtggtgg
541 atgagaatgc agtggccaaa attgatgcag cctcgcccct ggagaaagtc tgcctcattg
601 gctgtggatt ttcgactggt tatgggtctg cagtcaaagt tgccaaggtc accccagggt
661 ctacctgtgc tgtgtttggc ctgggagggg tcggcctatc tgttgttatg ggctgtaaag
721 cagctggagc agccagaatc attgctgtgg acatcaacaa ggacaaattt gcaaaggcta
781 aagagttggg ggccactgaa tgcatcaacc ctcaagacta caagaaaccc attcaggaag
841 tgctaaagga aatgactgat ggaggtgtgg atttttcgtt tgaagtcatc ggtcggcttg
901 acaccatgat ggcttccctg ttatgttgtc atgaggcatg tggcacaagt gtcattgtag
961 gggtacctcc tgattcccag aacctctcaa taaaccctat gctgctactg actggacgca
1021 cgtggaaagg agctattttt ggaggcttta agagtaaaga atctgtcccg aaacttgtgg
1081 ctgactttat ggctaagaag ttttcactgg atgcattaat aacaaatatt ttaccttttg
1141 aaaaaataaa tgaaggattt gacctgcttc gctctggaaa gagtatccgt accgtcctga
1201 cgttttgaaa caatacagat gccttccctt gtagcagttt tcagcctcct ctaccctaca
1261 tgatctggag caacagctag gaaatatcat taattctgct cttcagagat gttaaaaata
1321 aattacacgt gggagctttc caaagaaatg gaaattgatg ggaaattatt tgtcaagcaa
1381 atgtttaaaa tccaaatgag aactaaataa agtgttgaac atcaactggg gaattgaagc
1441 caataaacct tccttcttaa ccattcaaaa aaaaaaaaag gaattc
//