LOCUS HUMADH1CB 1400 bp mRNA linear HUM 08-JUN-1995
DEFINITION Homo sapiens class I alcohol dehydrogenase (ADH1) alpha subunit
mRNA, complete cds.
ACCESSION M12271
VERSION M12271.1
KEYWORDS ADH1 gene; alcohol dehydrogenase; alcohol dehydrogenase I;
dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1400)
AUTHORS Ikuta,T., Szeto,S. and Yoshida,A.
TITLE Three human alcohol dehydrogenase subunits: cDNA structure and
molecular and evolutionary divergence
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (3), 634-638 (1986)
PUBMED 2935875
COMMENT Original source text: Homo sapiens (clone: pUCADH-alpha-15L) liver
cDNA to mRNA.
A draft entry and printed copy of the sequence in [1] were kindly
provided by A.Yoshida, 30-MAY-1986.
The other human class I ADH1 alpha subunit sequence is found under
accession M11307.
FEATURES Location/Qualifiers
source 1..1400
/db_xref="H-InvDB:HIT000194151"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q21-q23"
/clone="pUCADH-alpha-15L"
/tissue_type="liver"
gene 1..1400
/gene="ADH1"
mRNA <1..1400
/gene="ADH1"
/note="G00-119-650"
CDS 16..1143
/gene="ADH1"
/EC_number="1.1.1.1"
/note="alpha subunit"
/codon_start=1
/product="alcohol dehydrogenase 1"
/protein_id="AAA68131.1"
/db_xref="GDB:G00-119-650"
/translation="MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAV
GICGTDDHVVSGTMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCR
ICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAK
IDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAA
RIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTM
MASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVA
DFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF"
BASE COUNT 400 a 294 c 340 g 366 t
ORIGIN 52 bp upstream of PvuII site; chromosome 4q21.
1 gaagacagaa tcaacatgag cacagcagga aaagtaatca aatgcaaagc agctgtgcta
61 tgggagttaa agaaaccctt ttccattgag gaggtggagg ttgcacctcc taaggcccat
121 gaagttcgta ttaagatggt ggctgtagga atctgtggca cagatgacca cgtggttagt
181 ggtaccatgg tgaccccact tcctgtgatt ttaggccatg aggcagccgg catcgtggag
241 agtgttggag aaggggtgac tacagtcaaa ccaggtgata aagtcatccc actcgctatt
301 cctcagtgtg gaaaatgcag aatttgtaaa aacccggaga gcaactactg cttgaaaaac
361 gatgtaagca atcctcaggg gaccctgcag gatggcacca gcaggttcac ctgcaggagg
421 aagcccatcc accacttcct tggcatcagc accttctcac agtacacagt ggtggatgaa
481 aatgcagtag ccaaaattga tgcagcctcg cctctagaga aagtctgtct cattggctgt
541 ggattttcaa ctggttatgg gtctgcagtc aatgttgcca aggtcacccc aggctctacc
601 tgtgctgtgt ttggcctggg aggggtcggc ctatctgcta ttatgggctg taaagcagct
661 ggggcagcca gaatcattgc ggtggacatc aacaaggaca aatttgcaaa ggccaaagag
721 ttgggggcca ctgaatgcat caaccctcaa gactacaaga aacccatcca ggaggtgcta
781 aaggaaatga ctgatggagg tgtggatttt tcatttgaag tcatcggtcg gcttgacacc
841 atgatggctt ccctgttatg ttgtcatgag gcatgtggca caagtgtcat cgtaggggta
901 cctcctgatt cccaaaacct ctcaatgaac cctatgctgc tactgactgg acgtacctgg
961 aagggagcta ttcttggtgg ctttaaaagt aaagaatgtg tcccaaaact tgtggctgat
1021 tttatggcta agaagttttc attggatgca ttaataaccc atgttttacc ttttgaaaaa
1081 ataaatgaag gatttgacct gcttcactct gggaaaagta tccgtaccat tctgatgttt
1141 tgagacaata cagatgtttt cccttgtggc agtcttcagc ctcctctacc ctacatgatc
1201 tggagcaaca gctgggaaat atcattaatt ctgctcatca cagattttat caataaatta
1261 catttggggg ctttccaaag aaatggaaat tgatgtaaaa ttatttttca agcaaatgtt
1321 taaaatccaa atgagaacta aataaagtgt tgaacatcag ctggggaatt gaagccaata
1381 aaccttcctt cttaaccatt
//