LOCUS       HUMAPOB                 4634 bp    mRNA    linear   HUM 31-OCT-1994
DEFINITION  Human apolipoprotein B100 mRNA, partial cds.
ACCESSION   M10374
VERSION     M10374.1
KEYWORDS    apolipoprotein; apolipoprotein B; glycoprotein; lipoprotein; low
            density lipoprotein; very low density lipoprotein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4634)
  AUTHORS   Knott,T.J., Rall,S.C. Jr., Innerarity,T.L., Jacobson,S.F.,
            Urdea,M.S., Levy-Wilson,B., Powell,L.M., Pease,R.J., Eddy,R.,
            Nakai,H., Byers,M., Priestley,L.M., Robertson,E., Rall,L.B.,
            Betsholtz,C., Shows,T.B., Mahley,R.W. and Scott,J.
  TITLE     Human apolipoprotein B: structure of carboxyl-terminal domains,
            sites of gene expression, and chromosomal localization
  JOURNAL   Science 230 (4721), 37-43 (1985)
   PUBMED   2994225
COMMENT     Original source text: Human (adult human liver cDNA library), cDNA
            to mRNA.
            Apolipoprotein B100 is the largest of the lipoproteins. It is a
            constituent of the low density and very low density lipoproteins
            (LDL, VLDL) and of the chylomicrons. In [1], protein modification
            sites and binding sites are tentatively identified, and the apo B
            gene is assigned to the p24 region of chromosome 2.  The end of
            this sequence is upstream from the mRNA terminus.
FEATURES             Location/Qualifiers
     source          1..4634
                     /db_xref="H-InvDB:HIT000194080"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="2p24-p23"
     gene            1..4634
                     /gene="APOB"
     CDS             <1..4368
                     /gene="APOB"
                     /note="apolipoprotein B100"
                     /codon_start=1
                     /protein_id="AAA51750.1"
                     /db_xref="GDB:G00-119-686"
                     /translation="NIMEAHVGINGEANLDFLNIPLTIPEMRLPYTIITTPPLKDFSL
                     WEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLAVLCEFISQSIKSFDRHFEK
                     NRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGYTVPVVNVEVSPFTIEMS
                     AFGYVFPKAVSMPSFSILGSDVRVPSYTLILPSLELPVLHVPRNLKLSLPHFKELCTI
                     SHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHLLSSSSSVIDALQYKLEGT
                     TRLTRKRGLKLATALSLSNKFVEGSHNSTVSLTTKNMEVSVAKTTKAEIPILRMNFKQ
                     ELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDV
                     KGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDDIWNLEVKENFAGEATLQR
                     IYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALVQVHASQPSSFHDFPDL
                     GQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHLDIAGSLEGHLRFLKN
                     IILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSFSIPVKVLADKFIT
                     PGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSSFALNLPTLPEVK
                     FPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSRFTLPKSVSDGIAALDLNAVANKIA
                     DFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSASLKNKA
                     DYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTLAHRDFSAEYEEDGKF
                     EGLQEWEGKAHLNIKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDEDDDFSKW
                     NFYYSPQSSPDKKLTIFKTELRVRESDEETQIKVNWEEEAASGLLTSLKDNVPKATGV
                     LYDYVNKYHWEHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTT
                     GTYQEWKDKAQNLYQELLTQEGQASFQGLKDNVFDGLVRVTQKFHMKVKHLIDSLIDF
                     LNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLVITLP
                     FELRKHKLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIED
                     NIKQLKEMKFTYLINYIQDEINTIFNDYIPYVFKLLKENLCLNLHKFNEFIQNELQEA
                     SQELQQIHQYIMALREEYFDPSIVGWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVS
                     ASNFTSQLSSQVEQFLHRNIQEYLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKK
                     IISDYHQQFRYKLQDFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQS
                     TTVMNPYMKLAPGELTIIL"
BASE COUNT         1479 a         1029 c          885 g         1241 t
ORIGIN      154 bp upstream of EcoRI site; chromosome 2pter-p23.
        1 aacattatgg aggcccatgt aggaataaat ggagaagcaa atctggattt cttaaacatt
       61 cctttaacaa ttcctgaaat gcgtctacct tacacaataa tcacaactcc tccactgaaa
      121 gatttctctc tatgggaaaa aacaggcttg aaggaattct tgaaaacgac aaagcaatca
      181 tttgatttaa gtgtaaaagc tcagtataag aaaaacaaac acaggcattc catcacaaat
      241 cctttggctg tgctttgtga gtttatcagt cagagcatca aatcctttga caggcatttt
      301 gaaaaaaaca gaaacaatgc attagatttt gtcaccaaat cctataatga aacaaaaatt
      361 aagtttgata agtacaaagc tgaaaaatct cacgacgagc tccccaggac ctttcaaatt
      421 cctggataca ctgttccagt tgtcaatgtt gaagtgtctc cattcaccat agagatgtcg
      481 gcattcggct atgtgttccc aaaagcagtc agcatgccta gtttctccat cctaggttct
      541 gacgtccgtg tgccttcata cacattaatc ctgccatcat tagagctgcc agtccttcat
      601 gtccctagaa atctcaagct ttctcttcca catttcaagg aattgtgtac cataagccat
      661 atttttattc ctgccatggg caatattacc tatgatttct cctttaaatc aagtgtcatc
      721 acactgaata ccaatgctga actttttaac cagtcagata ttgttgctca tctcctttct
      781 tcatcttcat ctgtcattga tgcactgcag tacaaattag agggcaccac aagattgaca
      841 agaaaaaggg gattgaagtt agccacagct ctgtctctga gcaacaaatt tgtggagggt
      901 agtcataaca gtactgtgag cttaaccacg aaaaatatgg aagtgtcagt ggcaaaaacc
      961 acaaaagccg aaattccaat tttgagaatg aatttcaagc aagaacttaa tggaaatacc
     1021 aagtcaaaac ctactgtctc ttcctccatg gaatttaagt atgatttcaa ttcttcaatg
     1081 ctgtactcta ccgctaaagg agcagttgac cacaagctta gcttggaaag cctcacctct
     1141 tacttttcca ttgagtcatc taccaaagga gatgtcaagg gttcggttct ttctcgggaa
     1201 tattcaggaa ctattgctag tgaggccaac acttacttga attccaagag cacacggtct
     1261 tcagtgaagc tgcagggcac ttccaaaatt gatgatatct ggaaccttga agtaaaagaa
     1321 aattttgctg gagaagccac actccaacgc atatattccc tctgggagca cagtacgaaa
     1381 aaccacttac agctagaggg cctctttttc accaacggag aacatacaag caaagccacc
     1441 ctggaactct ctccatggca aatgtcagct cttgttcagg tccatgcaag tcagcccagt
     1501 tccttccatg atttccctga ccttggccag gaagtggccc tgaatgctaa cactaagaac
     1561 cagaagatca gatggaaaaa tgaagtccgg attcattctg ggtctttcca gagccaggtc
     1621 gagctttcca atgaccaaga aaaggcacac cttgacattg caggatcctt agaaggacac
     1681 ctaaggttcc tcaaaaatat catcctacca gtctatgaca agagcttatg ggatttccta
     1741 aagctggatg taaccaccag cattggtagg agacagcatc ttcgtgtttc aactgccttt
     1801 gtgtacacca aaaaccccaa tggctattca ttctccatcc ctgtaaaagt tttggctgat
     1861 aaattcatta ctcctgggct gaaactaaat gatctaaatt cagttcttgt catgcctacg
     1921 ttccatgtcc catttacaga tcttcaggtt ccatcgtgca aacttgactt cagagaaata
     1981 caaatctata agaagctgag aacttcatca tttgccctca acctaccaac actccccgag
     2041 gtaaaattcc ctgaagttga tgtgttaaca aaatattctc aaccagaaga ctccttgatt
     2101 cccttttttg agataaccgt gcctgaatct cagttaactg tgtcccgatt cacgcttcca
     2161 aaaagtgttt cagatggcat tgctgctttg gatctaaatg cagtagccaa caagatcgca
     2221 gactttgagt tgcccaccat catcgtgcct gagcagacca ttgagattcc ctccattaag
     2281 ttctctgtac ctgctggaat tgtcattcct tcctttcaag cactgactgc acgctttgag
     2341 gtagactctc ccgtgtataa tgccacttgg agtgccagtt tgaaaaacaa agcagattat
     2401 gttgaaacag tcctggattc cacatgcagc tcaaccgtac agttcctaga atatgaacta
     2461 aatgttttgg gaacacacaa aatcgaagat ggtacgttag cctctaagac taaaggaaca
     2521 cttgcacacc gtgacttcag tgcagaatat gaagaagatg gcaaatttga aggacttcag
     2581 gaatgggaag gaaaagcgca cctcaatatc aaaagcccag cgttcaccga tctccatctg
     2641 cgctaccaga aagacaagaa aggcatctcc acctcagcag cctccccagc cgtaggcacc
     2701 gtgggcatgg atatggatga agatgacgac ttttctaaat ggaacttcta ctacagccct
     2761 cagtcctctc cagataaaaa actcaccata ttcaaaactg agttgagggt ccgggaatct
     2821 gatgaggaaa ctcagatcaa agttaattgg gaagaagagg cagcttctgg cttgctaacc
     2881 tctctgaaag acaacgtgcc caaggccaca ggggtccttt atgattatgt caacaagtac
     2941 cactgggaac acacagggct caccctgaga gaagtgtctt caaagctgag aagaaatctg
     3001 cagaacaatg ctgagtgggt ttatcaaggg gccattaggc aaattgatga tatcgacgtg
     3061 aggttccaga aagcagccag tggcaccact gggacctacc aagagtggaa ggacaaggcc
     3121 cagaatctgt accaggaact gttgactcag gaaggccaag ccagtttcca gggactcaag
     3181 gataacgtgt ttgatggctt ggtacgagtt actcaaaaat tccatatgaa agtcaagcat
     3241 ctgattgact cactcattga ttttctgaac ttccccagat tccagtttcc ggggaaacct
     3301 gggatataca ctagggagga actttgcact atgttcataa gggaggtagg gacggtactg
     3361 tcccaggtat attcgaaagt ccataatggt tcagaaatac tgttttccta tttccaagac
     3421 ctagtgatta cacttccttt cgagttaagg aaacataaac taatagatgt aatctcgatg
     3481 tatagggaac tgttgaaaga tttatcaaaa gaagcccaag aggtatttaa agccattcag
     3541 tctctcaaga ccacagaggt gctacgtaat cttcaggacc ttttacaatt cattttccaa
     3601 ctaatagaag ataacattaa acagctgaaa gagatgaaat ttacttatct tattaattat
     3661 atccaagatg agatcaacac aatcttcaat gattatatcc catatgtttt taaattgttg
     3721 aaagaaaacc tatgccttaa tcttcataag ttcaatgaat ttattcaaaa cgagcttcag
     3781 gaagcttctc aagagttaca gcagatccat caatacatta tggcccttcg tgaagaatat
     3841 tttgatccaa gtatagttgg ctggacagtg aaatattatg aacttgaaga aaagatagtc
     3901 agtctgatca agaacctgtt agttgctctt aaggacttcc attctgaata tattgtcagt
     3961 gcctctaact ttacttccca actctcaagt caagttgagc aatttctgca cagaaatatt
     4021 caggaatatc ttagcatcct taccgatcca gatggaaaag ggaaagagaa gattgcagag
     4081 ctttctgcca ctgctcagga aataattaaa agccaggcca ttgcgacgaa gaaaataatt
     4141 tctgattacc accagcagtt tagatataaa ctgcaagatt tttcagacca actctctgat
     4201 tactatgaaa aatttattgc tgaatccaaa agattgattg acctgtccat tcaaaactac
     4261 cacacatttc tgatatacat cacggagtta ctgaaaaagc tgcaatcaac cacagtcatg
     4321 aacccctaca tgaagcttgc tccaggagaa cttactatca tcctctaatt ttttaaaaga
     4381 aatctcatta tctctttcca atgaacttca catagcacag aaaaaatcaa actgcctata
     4441 ttgataaaac catacagtga gccagccttg cagtaggcag tagactataa gcagaagcac
     4501 atatgaactg gacctgcacc aaagctggca ccagggctcg gaaggtctct gaactcagaa
     4561 ggatggcatt ttttgcaagt taaagaaaat caggatctga gttattttgc taaacttggg
     4621 ggaggaggaa caaa
//